BDBM5832 3-{4-[methyl({2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl})amino]phenyl}-1-[4-(trifluoromethoxy)phenyl]urea::urea deriv. 23

SMILES CN(c1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1)c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1

InChI Key InChIKey=SNRUTMWCDZHKKM-UHFFFAOYSA-N

Data  1 IC50  4 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 5832   

LigandPNGBDBM5832(3-{4-[methyl({2-[(3-sulfamoylphenyl)amino]pyrimidi...)
Affinity DataIC50:  2nMpH: 7.5 T: 22°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMixed lineage kinase domain-like protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM5832(3-{4-[methyl({2-[(3-sulfamoylphenyl)amino]pyrimidi...)
Affinity DataKd:  9.30E+3nMAssay Description:Binding affinity to MLKL (unknown origin)More data for this Ligand-Target Pair
TargetMixed lineage kinase domain-like protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM5832(3-{4-[methyl({2-[(3-sulfamoylphenyl)amino]pyrimidi...)
Affinity DataKd:  530nMAssay Description:Binding affinity to full length human MLKL pseudokinase domain by Kinomescan methodMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM5832(3-{4-[methyl({2-[(3-sulfamoylphenyl)amino]pyrimidi...)
Affinity DataKd:  680nMAssay Description:Binding affinity to RIPK3 (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM5832(3-{4-[methyl({2-[(3-sulfamoylphenyl)amino]pyrimidi...)
Affinity DataKd:  64nMAssay Description:Binding affinity to RIPK1 (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails PubMed