BDBM60622 BDBM50300355::US11753371, Compound JZL-184::US9133148, A
SMILES OC(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+]([O-])=O)(c1ccc2OCOc2c1)c1ccc2OCOc2c1
InChI Key InChIKey=SEGYOKHGGFKMCX-UHFFFAOYSA-N
Data 38 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 38 hits for monomerid = 60622
Affinity DataIC50: 4.70E+3nMT: 2°CAssay Description:Proteomes (mouse brain membrane fraction or cell lysates) (50 uL, 1.0 mg/mL total protein concentration) were preincubated with varying concentration...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:The compounds II-2a to II-2m and controls in Table II were tested in 10-dose IC50 mode, with 3-fold serial dilution at a starting concentration of 10...More data for this Ligand-Target Pair
Affinity DataIC50: 285nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate incubated f...More data for this Ligand-Target Pair
Affinity DataIC50: 4.44E+3nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate preincubate...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human MGLMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Louvain Drug Research Institute
Curated by ChEMBL
Louvain Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.27E+3nMAssay Description:Inhibition of ABHD6 in mouse brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 4.69E+3nMAssay Description:Inhibition of FAAH in mouse brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of MAGL in mouse brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of MAGL in C57B1/6J mouse brain membrane after 30 mins by using 2-AG as a substrate by LC-MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of FAAH in C57B1/6J mouse brain membrane after 20 mins by using oleamide as a substrate by LC-MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant MAGL expressed in Cos7 cells after 30 mins by using 2-AG as a substrate by LC-MS methodMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Louvain Drug Research Institute
Curated by ChEMBL
Louvain Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant FAAH expressed in Cos7 cells after 30 mins by using anandamide as a substrate by LC-MS methodMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Louvain Drug Research Institute
Curated by ChEMBL
Louvain Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of FAAHMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse recombinant MAGL expressed in african green monkey COS7 cells assessed as inhibition of 2-AG hydrolysis after 30 mins by LC-MS an...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Louvain Drug Research Institute
Curated by ChEMBL
Louvain Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.63E+4nMAssay Description:Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Louvain Drug Research Institute
Curated by ChEMBL
Louvain Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 4.69E+3nMAssay Description:Inhibition of FAAHMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human MAGL expressed in COS7 cells using endogenous 2-AG substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Inhibition of human N-terminal histidine tagged full length MAGL expressed in Escherichia coli by by coumarin ester substrate fluorescence assayMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Northeastern University
Curated by ChEMBL
Northeastern University
Curated by ChEMBL
Affinity DataIC50: 974nMAssay Description:Inhibition of rat histidine tagged FAAH expressed in Escherichia coli by coumarin ester substrate fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant MAGL-mediated 1,3-dihydroxypropan-1-yl 4-pyren-1-ylbutanoate conversion to 4-pyren-1-ylbutanoic acid preincubated for...More data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:Inhibition of human recombinant MAGLMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of FAAH in mouse brain membrane using oleamide as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of rat MAGL expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human MAGL expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant MAGL (unknown origin) expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain membranes preincubated for 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Louvain Drug Research Institute
Curated by ChEMBL
Louvain Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of recombinant human FAAH using fluorogenic arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured...More data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of human recombinant MAGL using 4-NPA as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse MAGLMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of MAGL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of human recombinant MAGL using 4-NPA substrate incubated for 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of MAGL in mouse brain membrane using 2-AG as substrate by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human His-tagged MAGL assessed as formation of arachidonic acid using 2-acylglycerol incubated for 10 mins by mass spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FAAH in mouse brain membrane using [13C]oleamide as substrate by LC-MS analysisMore data for this Ligand-Target Pair