BDBM60887 US9200020, Table 3, Compound 2B

SMILES COC(=O)CCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O

InChI Key

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 60887   

TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
The University Of Queensland

US Patent
LigandPNGBDBM60887(US9200020, Table 3, Compound 2B)
Affinity DataKi:  100nM ΔG°:  -9.93kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxanthine phosphoribosyltransferase(Plasmodium vivax)
The University Of Queensland

US Patent
LigandPNGBDBM60887(US9200020, Table 3, Compound 2B)
Affinity DataKi:  2.10E+4nM ΔG°:  -6.63kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
The University Of Queensland

US Patent
LigandPNGBDBM60887(US9200020, Table 3, Compound 2B)
Affinity DataKi: >2.00E+5nM ΔG°: >-5.25kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent