BDBM6145 US8802686, 2::US8802686, C2

SMILES C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)S(C)(=O)=O)ncc1C(F)(F)F

InChI Key InChIKey=JLMIHNJHBAEFKC-NXEZZACHSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 6145   

TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  4nMpH: 8.0 T: 2°CAssay Description:CDK1/CycB (200 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 and within the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  4nMpH: 8.0 T: 2°CAssay Description:CDK2/CycE (50 mg/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 uM, and within ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  35nMpH: 7.0 T: 2°CAssay Description:Recombinant CDK4 and CycD1-GST fusion proteins, purified from baculovirus-infected insect cells (Sf9), were purchased from ProQinase GmbH, Freiburg. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  92nMpH: 5.5 T: 2°CAssay Description:VEGF receptor tyrosine kinase (90 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substance...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  9nMpH: 8.0 T: 2°CAssay Description:CDK1/CycB (200 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 and within the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 using 4-nitrophenyl acetate as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  24nMpH: 7.0 T: 2°CAssay Description:Recombinant CDK4 and CycD1-GST fusion proteins, purified from baculovirus-infected insect cells (Sf9), were purchased from ProQinase GmbH, Freiburg. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  480nMpH: 5.5 T: 2°CAssay Description:VEGF receptor tyrosine kinase (90 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substance...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  9nMAssay Description:Inhibition of GST-tagged recombinant human CDK1/GST-tagged human cyclin B expressed in Sf-9 cells incubated for 10 mins by scintillation counting met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  8nMAssay Description:Inhibition of GST-tagged recombinant human CDK2/GST-tagged human cyclin E expressed in Sf-9 cells incubated for 10 mins by scintillation counting met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  477nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf-9 cells incubated for 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  8nMpH: 8.0 T: 2°CAssay Description:CDK2/CycE (50 mg/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 uM, and within ...More data for this Ligand-Target Pair
In DepthDetails US Patent