BDBM6859 7-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20-nonaene-12,14-dione::Indolocarbazole deriv. 4(c)

SMILES Brc1ccc2[nH]c3c4[nH]c5ccccc5c4c4C(=O)NC(=O)c4c3c2c1

InChI Key InChIKey=SZSACUHPMFYGKC-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 6859   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM6859(7-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^...)
Affinity DataIC50:  4.40E+3nMpH: 7.0 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM6859(7-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^...)
Affinity DataIC50:  4.30E+3nMpH: 7.0 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Eli Lilly

LigandPNGBDBM6859(7-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^...)
Affinity DataIC50: >2.00E+4nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM6859(7-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^...)
Affinity DataIC50:  1.94E+4nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6859(7-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^...)
Affinity DataIC50: <1.25E+3nM EC50:  70nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed