BDBM6987 6-substituted quinazoline 37::N-tert-butyl-2,6-bis(trifluoromethyl)quinazolin-4-amine

SMILES CC(C)(C)Nc1nc(nc2ccc(cc12)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=AETVKDYDELIZIP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6987   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6987(6-substituted quinazoline 37 | N-tert-butyl-2,6-bi...)
Affinity DataIC50:  790nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6987(6-substituted quinazoline 37 | N-tert-butyl-2,6-bi...)
Affinity DataIC50: >3.70E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed