BDBM7680 4-[2-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-hydrazino]benzenesulfonamide::4-{2-[(3Z)-5-bromo-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzene-1-sulfonamide::Oxindole-Based Inhibitor 16

SMILES NS(=O)(=O)c1ccc(NN=C2C(=O)Nc3ccc(Br)cc23)cc1

InChI Key InChIKey=ODZNNZYRBRRREX-UHFFFAOYSA-N

Data  2 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 7680   

TargetTyrosine-protein kinase ZAP-70(Human)
Sandia National Laboratories

Curated by ChEMBL
LigandPNGBDBM7680(4-[2-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant ZAP70 using EEEEYEEEE as substrate by ESI-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Sandia National Laboratories

Curated by ChEMBL
LigandPNGBDBM7680(4-[2-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant PYK2 by ESI-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM7680(4-[2-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene...)
Affinity DataIC50:  780nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM7680(4-[2-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene...)
Affinity DataIC50:  60nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM7680(4-[2-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene...)
Affinity DataIC50:  60nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
LigandPNGBDBM7680(4-[2-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene...)
Affinity DataIC50:  780nMpH: 7.5 T: 22°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM7680(4-[2-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene...)
Affinity DataIC50:  60nMAssay Description:Evaluated for inhibition of human cyclin dependent kinase 2More data for this Ligand-Target Pair