BDBM7742 4-[2-(7-Oxo-6,7-dihydro[1,2,3]triazolo[4,5-e]indol-8(3H)-ylidene)hydrazino]benzenesulfonamide::4-{2-[(12Z)-11-oxo-3,4,5,10-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-1,3,6,8-tetraen-12-ylidene]hydrazin-1-yl}benzene-1-sulfonamide::CS242::Oxindole-Based Inhibitor 78

SMILES NS(=O)(=O)c1ccc(cc1)N=Nc1c2c(ccc3[nH][nH]nc23)[nH]c1=O

InChI Key InChIKey=YEJVJNPGUUFGLZ-UHFFFAOYSA-N

Data  4 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 7742   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM7742(4-[2-(7-Oxo-6,7-dihydro[1,2,3]triazolo[4,5-e]indol...)
Affinity DataIC50:  150nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM7742(4-[2-(7-Oxo-6,7-dihydro[1,2,3]triazolo[4,5-e]indol...)
Affinity DataIC50:  9.5nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Csar

LigandPNGBDBM7742(4-[2-(7-Oxo-6,7-dihydro[1,2,3]triazolo[4,5-e]indol...)
Affinity DataKd:  465nMpH: 7.5 T: 2°CAssay Description:ThermofluorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Csar

LigandPNGBDBM7742(4-[2-(7-Oxo-6,7-dihydro[1,2,3]triazolo[4,5-e]indol...)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM7742(4-[2-(7-Oxo-6,7-dihydro[1,2,3]triazolo[4,5-e]indol...)
Affinity DataKd:  191nMpH: 7.5 T: 2°CAssay Description:OctetRedMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University Of Zurich

Curated by ChEMBL
LigandPNGBDBM7742(4-[2-(7-Oxo-6,7-dihydro[1,2,3]triazolo[4,5-e]indol...)
Affinity DataIC50:  150nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Csar

LigandPNGBDBM7742(4-[2-(7-Oxo-6,7-dihydro[1,2,3]triazolo[4,5-e]indol...)
Affinity DataKd:  528nMpH: 7.5 T: 2°CAssay Description:OctetRedMore data for this Ligand-Target Pair
In DepthDetails PubMed