BDBM7966 2-(1H-imidazol-4-yl)ethan-1-amine::CHEMBL544208::CHEMBL90::Ceplene::Ergotidine::HISTAMINE::HISTAMINE DIHYDROCHLORIDE::Histamine::L-histamine::Peremin::[3H]histamine
InChI string: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
SMILES: NCCc1cnc[nH]1
InChI Key: InChIKey=NTYJJOPFIAHURM-UHFFFAOYSA-N
Data: 78 KI 1 IC50 10 Kd 36 EC50
PDB links: 50 PDB IDs contain this monomer as substructures. 50 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target (Institution) | Ligand | Target Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H1 receptor (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Amsterdam Curated by ChEMBL | Assay Description Inhibitory activity against human Histamine H1 receptor | J Med Chem 46: 5812-24 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 receptor (RAT) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article | n/a | n/a | n/a | 1.17E+5 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Affinity to the Histamine H2 receptor was determined expressed in CHO cell using [125I]iodoaminopotentidine as radioligand | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 190 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay | J Med Chem 51: 7193-204 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 Receptor (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay | J Med Chem 51: 7193-204 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 receptor (Cavia porcellus (domestic guinea pig)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay | J Med Chem 51: 7193-204 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine receptor (H3) (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 25.1 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, G-beta-1-gamma-2 and RGS4 by steady-state GTPase act... | J Med Chem 51: 7193-204 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine receptor (H4) (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 11.6 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s... | J Med Chem 51: 7193-204 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Cavia porcellus (domestic guinea pig)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | PubMed | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM | J Med Chem 43: 1071-84 (2000) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Cavia porcellus (domestic guinea pig)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | PubMed | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM | J Med Chem 43: 1071-84 (2000) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Cavia porcellus (domestic guinea pig)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | PubMed | n/a | n/a | n/a | 0.851 | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM | J Med Chem 43: 1071-84 (2000) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Cavia porcellus (domestic guinea pig)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | PubMed | n/a | n/a | n/a | 0.776 | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM | J Med Chem 43: 1071-84 (2000) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 receptor (Cavia porcellus (domestic guinea pig)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity | J Med Chem 51: 7193-204 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 191 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assay | J Med Chem 52: 6297-313 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 Receptor (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at human histamine H2 receptor expressed in Sf9 cells coexpressing GsalphaS protein by steady-state GTPase assay | J Med Chem 52: 6297-313 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine receptor (H3) (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 25.1 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at human histamine H3 receptor expressed in Sf9 cells coexpressing Gialpha-2-Gbeta-1-gamma-2 and RGS4 proteins protein by steady-sta... | J Med Chem 52: 6297-313 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine receptor (H4) (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 12.0 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay | J Med Chem 52: 6297-313 (2009) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Cavia porcellus (domestic guinea pig)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | PubMed | n/a | n/a | n/a | 0.776 | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta. | Bioorg Med Chem Lett 8: 2583-8 (1999) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 receptor (Cavia porcellus (domestic guinea pig)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at histamine H2 receptor in spontaneously beating guinea pig atrium | Bioorg Med Chem Lett 20: 3173-6 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 Receptor (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at GsalphaS-fused human histamine H2 receptor expressed in Sf9 cells by [35S]GTPgammaS binding assay | Bioorg Med Chem Lett 20: 3173-6 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 receptor (Cavia porcellus (domestic guinea pig)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at GsalphaS-fused guinea pig histamine H2 receptor expressed in Sf9 cells by [35S]GTPgammaS binding assay | Bioorg Med Chem Lett 20: 3173-6 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 191 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay | Bioorg Med Chem Lett 20: 3173-6 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine receptor (H3) (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 12.9 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 and RGS4 by steady-state GTPase activit... | Bioorg Med Chem Lett 20: 3173-6 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine receptor (H4) (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 9.12 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activ... | Bioorg Med Chem Lett 20: 3173-6 (2010) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Cavia porcellus (domestic guinea pig)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Relative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta | J Med Chem 46: 5458-70 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine receptor (H3) (Homo sapiens (human)) | BDBM7966![]() (2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | n/a | n/a | 15.8 | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Agonist activity at human histamine H3 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferas... | J Med Chem 54: 1693-703 (2011) | |||||||||||
More data for this Ligand-Target Pair |
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