BDBM7968 2-aminoethane-1-thiol::Cysteamine

SMILES NCCS

InChI Key InChIKey=UFULAYFCSOUIOV-UHFFFAOYSA-N

Data  1 KI  3 IC50

PDB links: 16 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7968   

TargetGlutaminyl-peptide cyclotransferase(Mus musculus (mouse))
Probiodrug

LigandPNGBDBM7968(2-aminoethane-1-thiol | Cysteamine)
Affinity DataKi:  4.20E+4nM ΔG°:  -6.07kcal/molepH: 8.0 T: 2°CAssay Description:QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Radboud University

Curated by ChEMBL
LigandPNGBDBM7968(2-aminoethane-1-thiol | Cysteamine)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of wild type recombinant human histone lysine methyltransferase G9a (913 to 1193 residues) expressed in Escherichia coli Rosetta BL21 DE3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
Radboud University

Curated by ChEMBL
LigandPNGBDBM7968(2-aminoethane-1-thiol | Cysteamine)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of wild type recombinant human histone lysine methyltransferase GLP (951 to 1235 residues) expressed in Escherichia coli Rosetta BL21 DE3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM7968(2-aminoethane-1-thiol | Cysteamine)
Affinity DataIC50:  3.31E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed