BDBM8182 N-Phenyl-4-{2-[4-(trifluoromethyl)phenyl]pyrazolo-[1,5-b]pyridazin-3-yl}pyrimidin-2-amine::N-phenyl-4-{2-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine::pyrazolo[1,5-b]pyridazine deriv. 73

SMILES FC(F)(F)c1ccc(cc1)-c1nn2ncccc2c1-c1ccnc(Nc2ccccc2)n1

InChI Key InChIKey=DNLDFDFYEYJYCL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8182   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8182(N-Phenyl-4-{2-[4-(trifluoromethyl)phenyl]pyrazolo-...)
Affinity DataIC50: >2.00E+4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8182(N-Phenyl-4-{2-[4-(trifluoromethyl)phenyl]pyrazolo-...)
Affinity DataIC50: <3.16E+4nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8182(N-Phenyl-4-{2-[4-(trifluoromethyl)phenyl]pyrazolo-...)
Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8182(N-Phenyl-4-{2-[4-(trifluoromethyl)phenyl]pyrazolo-...)
Affinity DataIC50: >3.16E+4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed