BDBM8218 3-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2,5-dione::4-arylmaleimide deriv. 6a

SMILES O=C1NC(=O)C(=C1Nc1ccccc1)c1ccccc1

InChI Key InChIKey=ACQZMAJVOPRMQJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8218   

TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8218(3-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2,...)
Affinity DataIC50:  529nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Jordan

Curated by ChEMBL
LigandPNGBDBM8218(3-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2,...)
Affinity DataIC50:  590nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Jordan

Curated by ChEMBL
LigandPNGBDBM8218(3-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2,...)
Affinity DataIC50:  520nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed