BDBM8370 N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropanecarboxamide::indazole analogue 12

SMILES Oc1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1

InChI Key InChIKey=RXQXACYMRVINQU-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 8370   

TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8370(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Affinity DataIC50:  15nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8370(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Affinity DataIC50:  5nMAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Jordan

Curated by ChEMBL
LigandPNGBDBM8370(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM8370(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Affinity DataIC50: <2.51E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate pretreated for 15 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Human)
University of North Carolina At Chapel Hill (Unc-Ch)

Curated by ChEMBL
LigandPNGBDBM8370(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Affinity DataIC50:  280nMAssay Description:Inhibition of AAK1 (unknown origin) using Fos-Nfluc, Cfluc-kinase and rabbit reticulate lysate system after 1 hr by split luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Jordan

Curated by ChEMBL
LigandPNGBDBM8370(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0-ATP synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM8370(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Affinity DataIC50: <2.51E+4nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate pretreated for 15 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM8370(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Affinity DataIC50:  2.51E+4nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate pretreated for 15 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM8370(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Affinity DataIC50: <2.51E+4nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate pretreated for 15 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8370(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Affinity DataIC50:  501nMAssay Description:Inhibition of PIM1 (unknown origin) using TAMRA-ERMRPRKRQGSVRRRV-NH2 as substrate pretreated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed