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BDBM85209 DL-THA

SMILES: N[C@@H]([C@H](O)C(O)=O)C(O)=O

InChI Key: InChIKey=YYLQUHNPNCGKJQ-LWMBPPNESA-N

Data: 3 KI  8 IC50

PDB links: 7 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 85209   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GRIA3


(RAT)
BDBM85209
PNG
(DL-THA)
Show SMILES N[C@@H]([C@H](O)C(O)=O)C(O)=O
Show InChI InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Suntory Institute for Bioorganic Research

Curated by PDSP Ki Database




Mol Pharmacol 53: 195-201 (1998)


Article DOI: 10.1124/mol.53.2.195
BindingDB Entry DOI: 10.7270/Q2RF5SJH
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM85209
PNG
(DL-THA)
Show SMILES N[C@@H]([C@H](O)C(O)=O)C(O)=O
Show InChI InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Suntory Institute for Bioorganic Research

Curated by PDSP Ki Database




Mol Pharmacol 53: 195-201 (1998)


Article DOI: 10.1124/mol.53.2.195
BindingDB Entry DOI: 10.7270/Q2RF5SJH
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM85209
PNG
(DL-THA)
Show SMILES N[C@@H]([C@H](O)C(O)=O)C(O)=O
Show InChI InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Suntory Institute for Bioorganic Research

Curated by PDSP Ki Database




Mol Pharmacol 53: 195-201 (1998)


Article DOI: 10.1124/mol.53.2.195
BindingDB Entry DOI: 10.7270/Q2RF5SJH
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM85209
PNG
(DL-THA)
Show SMILES N[C@@H]([C@H](O)C(O)=O)C(O)=O
Show InChI InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
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n/an/a 9.60E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 4


(Rattus norvegicus)
BDBM85209
PNG
(DL-THA)
Show SMILES N[C@@H]([C@H](O)C(O)=O)C(O)=O
Show InChI InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
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n/an/a 2.82E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 4


(Rattus norvegicus)
BDBM85209
PNG
(DL-THA)
Show SMILES N[C@@H]([C@H](O)C(O)=O)C(O)=O
Show InChI InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM85209
PNG
(DL-THA)
Show SMILES N[C@@H]([C@H](O)C(O)=O)C(O)=O
Show InChI InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
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n/an/a 9.60E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM85209
PNG
(DL-THA)
Show SMILES N[C@@H]([C@H](O)C(O)=O)C(O)=O
Show InChI InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
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PubMed
n/an/a 9.55E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM85209
PNG
(DL-THA)
Show SMILES N[C@@H]([C@H](O)C(O)=O)C(O)=O
Show InChI InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
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PubMed
n/an/a 3.89E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM85209
PNG
(DL-THA)
Show SMILES N[C@@H]([C@H](O)C(O)=O)C(O)=O
Show InChI InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
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PubMed
n/an/a 9.55E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM85209
PNG
(DL-THA)
Show SMILES N[C@@H]([C@H](O)C(O)=O)C(O)=O
Show InChI InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
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CHEBI
KEGG
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PubMed
n/an/a 3.90E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair