BDBM8857 3-{4-[4-amino-6-(pyridin-4-ylmethyl)thieno[2,3-d]pyrimidin-5-yl]phenyl}-1-(3-methylphenyl)urea::N-{4-[4-Amino-6-(pyridin-4-ylmethyl)thieno[2,3-d]-pyrimidin-5-yl]phenyl}-N -(3-methylphenyl)urea::Thienopyrimidine deriv. 83

SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2c(Cc3ccncc3)sc3ncnc(N)c23)c1

InChI Key InChIKey=MXHHCGBNNWOCGV-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 8857   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8857(3-{4-[4-amino-6-(pyridin-4-ylmethyl)thieno[2,3-d]p...)
Affinity DataIC50:  53nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8857(3-{4-[4-amino-6-(pyridin-4-ylmethyl)thieno[2,3-d]p...)
Affinity DataIC50:  960nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8857(3-{4-[4-amino-6-(pyridin-4-ylmethyl)thieno[2,3-d]p...)
Affinity DataIC50:  270nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8857(3-{4-[4-amino-6-(pyridin-4-ylmethyl)thieno[2,3-d]p...)
Affinity DataIC50:  955nMAssay Description:Inhibition of cKITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8857(3-{4-[4-amino-6-(pyridin-4-ylmethyl)thieno[2,3-d]p...)
Affinity DataIC50:  269nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8857(3-{4-[4-amino-6-(pyridin-4-ylmethyl)thieno[2,3-d]p...)
Affinity DataIC50:  52.5nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8857(3-{4-[4-amino-6-(pyridin-4-ylmethyl)thieno[2,3-d]p...)
Affinity DataIC50:  960nMAssay Description:Inhibition of c-Kit by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed