BDBM8875 (5Z)-5-(1H-Imidazol-5-ylmethylene)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile::(5Z)-5-(1H-imidazol-5-ylmethylidene)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile::Imidazolylmethylenetetrahydronaphthalene 4b

SMILES N#Cc1ccc2C(CCCc2c1)=Cc1cnc[nH]1

InChI Key InChIKey=AEBLXEQBDHHLKP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8875   

TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8875((5Z)-5-(1H-Imidazol-5-ylmethylene)-5,6,7,8-tetrahy...)
Affinity DataIC50:  6.90nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8875((5Z)-5-(1H-Imidazol-5-ylmethylene)-5,6,7,8-tetrahy...)
Affinity DataAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8875((5Z)-5-(1H-Imidazol-5-ylmethylene)-5,6,7,8-tetrahy...)
Affinity DataIC50:  125nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta,2beta-3H]testosterone during aromatization. After incubation, the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8875((5Z)-5-(1H-Imidazol-5-ylmethylene)-5,6,7,8-tetrahy...)
Affinity DataIC50:  22.7nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed