BDBM8964 CHEMBL75274::Homodimeric Tacrine Analog 3c::N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]-1,2,3,4-tetrahydroacridin-9-amine::Tacrine Dimer 3c::Tacrine-Based Inhibitor 2g

SMILES C(CCCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12

InChI Key InChIKey=ZIDVXYDWJIVBSC-UHFFFAOYSA-N

Data  2 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 8964   

TargetAcetylcholinesterase(Homo sapiens (Human))
Universita Di Siena

LigandPNGBDBM8964(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Affinity DataKi:  1.90nM ΔG°:  -11.9kcal/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Universita Di Siena

LigandPNGBDBM8964(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Affinity DataKi:  2nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Hong Kong University Of Science And Technology

LigandPNGBDBM8964(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Affinity DataIC50:  7.80nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Hong Kong University Of Science And Technology

LigandPNGBDBM8964(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Affinity DataIC50:  0.660nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Institute Of Science

Curated by ChEMBL
LigandPNGBDBM8964(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Affinity DataIC50:  105nMAssay Description:Inhibition of rat serum BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Hong Kong University Of Science And Technology

LigandPNGBDBM8964(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of rat brain AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universita Di Siena

LigandPNGBDBM8964(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Julius-Maximilians-University Of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM8964(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Affinity DataIC50:  1.69E+4nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate measured for 10 mins by spectrofluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Institute Of Science

Curated by ChEMBL
LigandPNGBDBM8964(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Affinity DataIC50:  340nMAssay Description:Inhibition of rat serum butyrylcholinesterase using butyrylthiocholine as substrate in presence of AChE inhibitor BW284C51 by spectrophotometric meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
National Defense Medical Center

LigandPNGBDBM8964(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Affinity DataIC50:  53nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Hong Kong University Of Science And Technology

LigandPNGBDBM8964(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Affinity DataIC50:  1.60nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Institute Of Science

Curated by ChEMBL
LigandPNGBDBM8964(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Affinity DataIC50:  105nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed