BDBM9023 CHEMBL225198::Indole-Tacrine Heterodimer 6::N-[7-(6-Chloro-1,2,3,4-tetrahydroacridin-9-ylamino)-heptyl]-3-(1H-indol-3-yl)propionamide::N-{7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptyl}-3-(1H-indol-3-yl)propanamide

SMILES Clc1ccc2c(NCCCCCCCNC(=O)CCc3c[nH]c4ccccc34)c3CCCCc3nc2c1

InChI Key InChIKey=FHBDDQZHQPRYJX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 9023   

TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9023(CHEMBL225198 | Indole-Tacrine Heterodimer 6 | N-[7...)
Affinity DataIC50:  0.0600nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM9023(CHEMBL225198 | Indole-Tacrine Heterodimer 6 | N-[7...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human AchE-induced amyloid beta aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM9023(CHEMBL225198 | Indole-Tacrine Heterodimer 6 | N-[7...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of human AchEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9023(CHEMBL225198 | Indole-Tacrine Heterodimer 6 | N-[7...)
Affinity DataIC50:  0.100nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed