BDBM9053 6-chloro-N-{6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl}-1,2,3,4-tetrahydroacridin-9-amine::Hexylene-Linked Bis-(6-chloro)tacrine::Homodimeric Tacrine Analog 3g

SMILES Clc1ccc2c(NCCCCCCNc3c4CCCCc4nc4cc(Cl)ccc34)c3CCCCc3nc2c1

InChI Key InChIKey=IXRJZUFMXJZPOC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 9053   

TargetAcetylcholinesterase(Rattus norvegicus (rat))
National Defense Medical Center

LigandPNGBDBM9053(6-chloro-N-{6-[(6-chloro-1,2,3,4-tetrahydroacridin...)
Affinity DataIC50:  0.600nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Julius-Maximilians-University Of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM9053(6-chloro-N-{6-[(6-chloro-1,2,3,4-tetrahydroacridin...)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate measured for 10 mins by spectrofluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM9053(6-chloro-N-{6-[(6-chloro-1,2,3,4-tetrahydroacridin...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
National Defense Medical Center

LigandPNGBDBM9053(6-chloro-N-{6-[(6-chloro-1,2,3,4-tetrahydroacridin...)
Affinity DataIC50:  312nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed