BDBM99917 4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)phenylcarbamothioyl)benzamide::US8501991, Tenovin 6
SMILES CN(C)CCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1
InChI Key InChIKey=BVJSXSQRIUSRCO-UHFFFAOYSA-O
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 99917
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Court Of The University Of Dundee
US Patent
University Court Of The University Of Dundee
US Patent
Affinity DataIC50: 2.10E+4nMAssay Description:SIRT1 inhibition assay.More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
City University Of Hong Kong
Curated by ChEMBL
City University Of Hong Kong
Curated by ChEMBL
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of recombinant human SIRT2 using KTcr-I as substrate preincubated for 30 mins followed by substrate addition and measured after 3 hrs in p...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
City University Of Hong Kong
Curated by ChEMBL
City University Of Hong Kong
Curated by ChEMBL
Affinity DataIC50: 2.97E+4nMAssay Description:Inhibition of human recombinant C-terminal His-tagged SIRT2 (13 to 319 amino acid) after 45 mins by spectrophotometry relative to controlMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Court Of The University Of Dundee
US Patent
University Court Of The University Of Dundee
US Patent
Affinity DataIC50: 3.75E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
City University Of Hong Kong
Curated by ChEMBL
City University Of Hong Kong
Curated by ChEMBL
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Court Of The University Of Dundee
US Patent
University Court Of The University Of Dundee
US Patent
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human SIRT1 assessed as deacetylation activity using acetylated lysine as substrate measured after 1 hr in presence of NAD+ by by Fluor...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
City University Of Hong Kong
Curated by ChEMBL
City University Of Hong Kong
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SIRT2 assessed as deacetylation activity using acetylated lysine as substrate measured after 1 hr in presence of NAD+ by by Fluor...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Court Of The University Of Dundee
US Patent
University Court Of The University Of Dundee
US Patent
Affinity DataIC50: 2.97E+4nMAssay Description:Inhibition of recombinant human GST or His6-tagged SIRT1 using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate incubated for 10 mins in presence...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
City University Of Hong Kong
Curated by ChEMBL
City University Of Hong Kong
Curated by ChEMBL
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of recombinant human His6-tagged SIRT2 using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate incubated for 12 mins in presence of bet...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University
Curated by ChEMBL
Jiangsu University
Curated by ChEMBL
Affinity DataIC50: 2.57E+4nMAssay Description:Inhibition of recombinant human His6-tagged SIRT3 using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate incubated for 10 mins in presence of bet...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Court Of The University Of Dundee
US Patent
University Court Of The University Of Dundee
US Patent
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of yeast Hst2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Court Of The University Of Dundee
US Patent
University Court Of The University Of Dundee
US Patent
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of sirtuin 1 (unknown origin)More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
City University Of Hong Kong
Curated by ChEMBL
City University Of Hong Kong
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of sirtuin 2 (unknown origin)More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University
Curated by ChEMBL
Jiangsu University
Curated by ChEMBL
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of sirtuin 3 (unknown origin)More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Court Of The University Of Dundee
US Patent
University Court Of The University Of Dundee
US Patent
Affinity DataIC50: 5.81E+4nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged SIRT1 (193 to 741 amino acid) after 45 mins by spectrophotometry relative to controlMore data for this Ligand-Target Pair