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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 215.2
BDBM50044876
Wt: 199.2
BDBM50044889
Wt: 199.2
BDBM50072191
Wt: 199.2
BDBM50072192
Wt: 189.2
BDBM50091702
Wt: 211.2
BDBM50092486
Wt: 213.2
BDBM50092493
Wt: 213.2
BDBM50092497
Wt: 213.2
BDBM50092502
Wt: 213.2
BDBM50092504
Wt: 213.2
BDBM50092505
Wt: 202.2
BDBM50103877
Wt: 202.2
BDBM50103881
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Wt: 210.2
BDBM50403605
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Wt: 213.2
BDBM50403173
Displayed 1 to 15 (of 433 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 28 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50403605
PNG
(CHEMBL144346)
Show SMILES OC(=O)c1ccc-2c(Cc3ccccc-23)c1
Show InChI InChI=1S/C14H10O2/c15-14(16)10-5-6-13-11(8-10)7-9-3-1-2-4-12(9)13/h1-6,8H,7H2,(H,15,16)
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>2.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of type-1 human steroid 5-alpha-reductase


Bioorg Med Chem Lett 6: 481-484 (1996)


Article DOI: 10.1016/0960-894X(96)00054-6
BindingDB Entry DOI: 10.7270/Q2BZ661K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50403605
PNG
(CHEMBL144346)
Show SMILES OC(=O)c1ccc-2c(Cc3ccccc-23)c1
Show InChI InChI=1S/C14H10O2/c15-14(16)10-5-6-13-11(8-10)7-9-3-1-2-4-12(9)13/h1-6,8H,7H2,(H,15,16)
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1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of type-2 human steroid 5-alpha-reductase.


Bioorg Med Chem Lett 6: 481-484 (1996)


Article DOI: 10.1016/0960-894X(96)00054-6
BindingDB Entry DOI: 10.7270/Q2BZ661K
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50103881
PNG
(8-Allyl-7-hydroxy-chromen-2-one | CHEMBL77650)
Show SMILES Oc1ccc2ccc(=O)oc2c1CC=C
Show InChI InChI=1S/C12H10O3/c1-2-3-9-10(13)6-4-8-5-7-11(14)15-12(8)9/h2,4-7,13H,1,3H2
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n/an/a 0.200n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-alpha-reductase type 1 in cell culture system using LNCaP cells (androgen-sensitive human prostatic cancer cell line)


Bioorg Med Chem Lett 11: 2361-3 (2001)


Article DOI: 10.1016/s0960-894x(01)00429-2
BindingDB Entry DOI: 10.7270/Q2RR1ZS9
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50103877
PNG
(6-Allyl-7-hydroxy-chromen-2-one | CHEMBL76373)
Show SMILES Oc1cc2oc(=O)ccc2cc1CC=C
Show InChI InChI=1S/C12H10O3/c1-2-3-8-6-9-4-5-12(14)15-11(9)7-10(8)13/h2,4-7,13H,1,3H2
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n/an/a 1.70n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-alpha-reductase type 1 in cell culture system using LNCaP cells (androgen-sensitive human prostatic cancer cell line)


Bioorg Med Chem Lett 11: 2361-3 (2001)


Article DOI: 10.1016/s0960-894x(01)00429-2
BindingDB Entry DOI: 10.7270/Q2RR1ZS9
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50092504
PNG
(8-methyl-3,4,5,6-Tetrahydrobenzo[c]quinolizin-3-(4...)
Show SMILES Cc1ccc2N3C=CC(=O)CC3CCc2c1
Show InChI InChI=1S/C14H15NO/c1-10-2-5-14-11(8-10)3-4-12-9-13(16)6-7-15(12)14/h2,5-8,12H,3-4,9H2,1H3
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n/an/a 176n/an/an/an/an/an/a



Universit£ di Firenze

Curated by ChEMBL


Assay Description
Inhibition of recombinant steroid 5-alpha-reductase type I expressed in CHO cells


J Med Chem 43: 3718-35 (2000)


Article DOI: 10.1021/jm000945r
BindingDB Entry DOI: 10.7270/Q25B036J
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50092502
PNG
(4-Methyl-1,2,5,6-tetrahydro-pyrido[1,2-a]quinolin-...)
Show SMILES CC1=C2CCc3ccccc3N2CCC1=O
Show InChI InChI=1S/C14H15NO/c1-10-12-7-6-11-4-2-3-5-13(11)15(12)9-8-14(10)16/h2-5H,6-9H2,1H3
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n/an/a 185n/an/an/an/an/an/a



University of Florence

Curated by ChEMBL


Assay Description
Inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells usin...


J Med Chem 47: 3546-60 (2004)


Article DOI: 10.1021/jm031131o
BindingDB Entry DOI: 10.7270/Q24J0DKZ
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50092502
PNG
(4-Methyl-1,2,5,6-tetrahydro-pyrido[1,2-a]quinolin-...)
Show SMILES CC1=C2CCc3ccccc3N2CCC1=O
Show InChI InChI=1S/C14H15NO/c1-10-12-7-6-11-4-2-3-5-13(11)15(12)9-8-14(10)16/h2-5H,6-9H2,1H3
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n/an/a 185n/an/an/an/an/an/a



Universit£ di Firenze

Curated by ChEMBL


Assay Description
Inhibition of recombinant steroid 5-alpha-reductase type I expressed in CHO cells


J Med Chem 43: 3718-35 (2000)


Article DOI: 10.1021/jm000945r
BindingDB Entry DOI: 10.7270/Q25B036J
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50072191
PNG
(1,2,5,6-Tetrahydro-pyrido[1,2-a]quinolin-3-one | 1...)
Show SMILES O=C1CCN2C(CCc3ccccc23)=C1
Show InChI InChI=1S/C13H13NO/c15-12-7-8-14-11(9-12)6-5-10-3-1-2-4-13(10)14/h1-4,9H,5-8H2
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n/an/a 298n/an/an/an/an/an/a



University of Florence

Curated by ChEMBL


Assay Description
Inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells usin...


J Med Chem 47: 3546-60 (2004)


Article DOI: 10.1021/jm031131o
BindingDB Entry DOI: 10.7270/Q24J0DKZ
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50072191
PNG
(1,2,5,6-Tetrahydro-pyrido[1,2-a]quinolin-3-one | 1...)
Show SMILES O=C1CCN2C(CCc3ccccc23)=C1
Show InChI InChI=1S/C13H13NO/c15-12-7-8-14-11(9-12)6-5-10-3-1-2-4-13(10)14/h1-4,9H,5-8H2
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n/an/a 298n/an/an/an/an/an/a



Universit£ di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 1 from recombinant CHO cells


Bioorg Med Chem Lett 8: 2871-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00505-8
BindingDB Entry DOI: 10.7270/Q2CC1169
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50072191
PNG
(1,2,5,6-Tetrahydro-pyrido[1,2-a]quinolin-3-one | 1...)
Show SMILES O=C1CCN2C(CCc3ccccc23)=C1
Show InChI InChI=1S/C13H13NO/c15-12-7-8-14-11(9-12)6-5-10-3-1-2-4-13(10)14/h1-4,9H,5-8H2
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n/an/a 298n/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Inhibition of human Steroid 5-alpha-reductase type I


Bioorg Med Chem Lett 10: 353-6 (2000)


Article DOI: 10.1016/s0960-894x(99)00698-8
BindingDB Entry DOI: 10.7270/Q2K35SVJ
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50072191
PNG
(1,2,5,6-Tetrahydro-pyrido[1,2-a]quinolin-3-one | 1...)
Show SMILES O=C1CCN2C(CCc3ccccc23)=C1
Show InChI InChI=1S/C13H13NO/c15-12-7-8-14-11(9-12)6-5-10-3-1-2-4-13(10)14/h1-4,9H,5-8H2
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n/an/a 298n/an/an/an/an/an/a



Universit£ di Firenze

Curated by ChEMBL


Assay Description
Inhibition of recombinant steroid 5-alpha-reductase type I expressed in CHO cells


J Med Chem 43: 3718-35 (2000)


Article DOI: 10.1021/jm000945r
BindingDB Entry DOI: 10.7270/Q25B036J
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50092497
PNG
(8-Methyl-1,2,5,6-tetrahydro-pyrido[1,2-a]quinolin-...)
Show SMILES Cc1ccc2N3CCC(=O)C=C3CCc2c1
Show InChI InChI=1S/C14H15NO/c1-10-2-5-14-11(8-10)3-4-12-9-13(16)6-7-15(12)14/h2,5,8-9H,3-4,6-7H2,1H3
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n/an/a 376n/an/an/an/an/an/a



Universit£ di Firenze

Curated by ChEMBL


Assay Description
Inhibition of recombinant steroid 5-alpha-reductase type I expressed in CHO cells


J Med Chem 43: 3718-35 (2000)


Article DOI: 10.1021/jm000945r
BindingDB Entry DOI: 10.7270/Q25B036J
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50092497
PNG
(8-Methyl-1,2,5,6-tetrahydro-pyrido[1,2-a]quinolin-...)
Show SMILES Cc1ccc2N3CCC(=O)C=C3CCc2c1
Show InChI InChI=1S/C14H15NO/c1-10-2-5-14-11(8-10)3-4-12-9-13(16)6-7-15(12)14/h2,5,8-9H,3-4,6-7H2,1H3
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n/an/a 376n/an/an/an/an/an/a



University of Florence

Curated by ChEMBL


Assay Description
Inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells usin...


J Med Chem 47: 3546-60 (2004)


Article DOI: 10.1021/jm031131o
BindingDB Entry DOI: 10.7270/Q24J0DKZ
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50044876
PNG
((4aR,10bR)-4-Methyl-1,4,4a,5,6,10b-hexahydro-2H-be...)
Show SMILES CN1[C@@H]2CCc3ccccc3[C@H]2CCC1=O
Show InChI InChI=1S/C14H17NO/c1-15-13-8-6-10-4-2-3-5-11(10)12(13)7-9-14(15)16/h2-5,12-13H,6-9H2,1H3/t12-,13-/m1/s1
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n/an/a 560n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.


J Med Chem 36: 421-3 (1993)


Article DOI: 10.1021/jm00055a014
BindingDB Entry DOI: 10.7270/Q2T43TQX
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50044876
PNG
((4aR,10bR)-4-Methyl-1,4,4a,5,6,10b-hexahydro-2H-be...)
Show SMILES CN1[C@@H]2CCc3ccccc3[C@H]2CCC1=O
Show InChI InChI=1S/C14H17NO/c1-15-13-8-6-10-4-2-3-5-11(10)12(13)7-9-14(15)16/h2-5,12-13H,6-9H2,1H3/t12-,13-/m1/s1
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n/an/a 560n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Steroid 5-alpha-reductase type I


Bioorg Med Chem Lett 10: 1909-11 (2001)


Article DOI: 10.1016/s0960-894x(00)00368-1
BindingDB Entry DOI: 10.7270/Q2M044PB
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50044876
PNG
((4aR,10bR)-4-Methyl-1,4,4a,5,6,10b-hexahydro-2H-be...)
Show SMILES CN1[C@@H]2CCc3ccccc3[C@H]2CCC1=O
Show InChI InChI=1S/C14H17NO/c1-15-13-8-6-10-4-2-3-5-11(10)12(13)7-9-14(15)16/h2-5,12-13H,6-9H2,1H3/t12-,13-/m1/s1
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n/an/a 562n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration required to inhibit Steroid 5-alpha-reductase type 1 in cultured Hs 68 human foreskin fibroblast cells


Bioorg Med Chem Lett 3: 1157-1162 (1993)


Article DOI: 10.1016/S0960-894X(00)80306-6
BindingDB Entry DOI: 10.7270/Q2VD70NP
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50103881
PNG
(8-Allyl-7-hydroxy-chromen-2-one | CHEMBL77650)
Show SMILES Oc1ccc2ccc(=O)oc2c1CC=C
Show InChI InChI=1S/C12H10O3/c1-2-3-9-10(13)6-4-8-5-7-11(14)15-12(8)9/h2,4-7,13H,1,3H2
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n/an/a 990n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-alpha-reductase type 1 in cell culture system using LNCaP cells (androgen-sensitive human prostatic cancer cell line)


Bioorg Med Chem Lett 11: 2361-3 (2001)


Article DOI: 10.1016/s0960-894x(01)00429-2
BindingDB Entry DOI: 10.7270/Q2RR1ZS9
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50403173
PNG
(CHEMBL16248)
Show SMILES CN1C(=O)CCC2=C1CCc1ccccc21
Show InChI InChI=1S/C14H15NO/c1-15-13-8-6-10-4-2-3-5-11(10)12(13)7-9-14(15)16/h2-5H,6-9H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration required to inhibit Steroid 5-alpha-reductase type 1 in cultured Hs 68 human foreskin fibroblast cells


Bioorg Med Chem Lett 3: 1157-1162 (1993)


Article DOI: 10.1016/S0960-894X(00)80306-6
BindingDB Entry DOI: 10.7270/Q2VD70NP
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50092486
PNG
(4-Methyl-5,6-dihydro-pyrido[1,2-a]quinolin-3-one |...)
Show SMILES Cc1c2CCc3ccccc3-n2ccc1=O
Show InChI InChI=1S/C14H13NO/c1-10-12-7-6-11-4-2-3-5-13(11)15(12)9-8-14(10)16/h2-5,8-9H,6-7H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Universit£ di Firenze

Curated by ChEMBL


Assay Description
Inhibition of recombinant Steroid 5-alpha-reductase type I expressed in CHO cells


J Med Chem 43: 3718-35 (2000)


Article DOI: 10.1021/jm000945r
BindingDB Entry DOI: 10.7270/Q25B036J
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50091702
PNG
(1-Methyl-5-phenyl-piperidin-2-one | CHEMBL55261)
Show SMILES CN1CC(CCC1=O)c1ccccc1
Show InChI InChI=1S/C12H15NO/c1-13-9-11(7-8-12(13)14)10-5-3-2-4-6-10/h2-6,11H,7-9H2,1H3
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n/an/a 2.48E+3n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Steroid 5-alpha-reductase type I


Bioorg Med Chem Lett 10: 1909-11 (2001)


Article DOI: 10.1016/s0960-894x(00)00368-1
BindingDB Entry DOI: 10.7270/Q2M044PB
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50092493
PNG
(4-(alpha)methyl-3,4,5,6-Tetrahydrobenzo[c]quinoliz...)
Show SMILES C[C@H]1C2CCc3ccccc3N2C=CC1=O
Show InChI InChI=1S/C14H15NO/c1-10-12-7-6-11-4-2-3-5-13(11)15(12)9-8-14(10)16/h2-5,8-10,12H,6-7H2,1H3/t10-,12?/m0/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Universit£ di Firenze

Curated by ChEMBL


Assay Description
Inhibition of recombinant steroid 5-alpha-reductase type I expressed in CHO cells


J Med Chem 43: 3718-35 (2000)


Article DOI: 10.1021/jm000945r
BindingDB Entry DOI: 10.7270/Q25B036J
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50092505
PNG
(4-(beta)methyl-3,4,5,6-Tetrahydrobenzo[c]quinolizi...)
Show SMILES CC1C2CCc3ccccc3N2C=CC1=O
Show InChI InChI=1S/C14H15NO/c1-10-12-7-6-11-4-2-3-5-13(11)15(12)9-8-14(10)16/h2-5,8-10,12H,6-7H2,1H3
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n/an/a 4.30E+3n/an/an/an/an/an/a



Universit£ di Firenze

Curated by ChEMBL


Assay Description
Inhibition of recombinant Steroid 5-alpha-reductase type I expressed in CHO cells


J Med Chem 43: 3718-35 (2000)


Article DOI: 10.1021/jm000945r
BindingDB Entry DOI: 10.7270/Q25B036J
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50072192
PNG
(3,4,5,6-Tetrahydrobenzo[c]quinolizin-3-(4aH)-one |...)
Show SMILES O=C1CC2CCc3ccccc3N2C=C1
Show InChI InChI=1S/C13H13NO/c15-12-7-8-14-11(9-12)6-5-10-3-1-2-4-13(10)14/h1-4,7-8,11H,5-6,9H2
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n/an/a 5.13E+3n/an/an/an/an/an/a



Universit£ di Firenze

Curated by ChEMBL


Assay Description
Inhibition of recombinant steroid 5-alpha-reductase type I expressed in CHO cells


J Med Chem 43: 3718-35 (2000)


Article DOI: 10.1021/jm000945r
BindingDB Entry DOI: 10.7270/Q25B036J
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50072192
PNG
(3,4,5,6-Tetrahydrobenzo[c]quinolizin-3-(4aH)-one |...)
Show SMILES O=C1CC2CCc3ccccc3N2C=C1
Show InChI InChI=1S/C13H13NO/c15-12-7-8-14-11(9-12)6-5-10-3-1-2-4-13(10)14/h1-4,7-8,11H,5-6,9H2
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n/an/a 5.13E+3n/an/an/an/an/an/a



Universit£ di Firenze

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 1 from recombinant CHO cells


Bioorg Med Chem Lett 8: 2871-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00505-8
BindingDB Entry DOI: 10.7270/Q2CC1169
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50072192
PNG
(3,4,5,6-Tetrahydrobenzo[c]quinolizin-3-(4aH)-one |...)
Show SMILES O=C1CC2CCc3ccccc3N2C=C1
Show InChI InChI=1S/C13H13NO/c15-12-7-8-14-11(9-12)6-5-10-3-1-2-4-13(10)14/h1-4,7-8,11H,5-6,9H2
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n/an/a 5.13E+3n/an/an/an/an/an/a



Università di Firenze

Curated by ChEMBL


Assay Description
Inhibition of human Steroid 5-alpha-reductase type I


Bioorg Med Chem Lett 10: 353-6 (2000)


Article DOI: 10.1016/s0960-894x(99)00698-8
BindingDB Entry DOI: 10.7270/Q2K35SVJ
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50044889
PNG
(1,4,5,6-Tetrahydro-2H-benzo[f]quinolin-3-one | CHE...)
Show SMILES O=C1CCC2=C(CCc3ccccc23)N1
Show InChI InChI=1S/C13H13NO/c15-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)14-13/h1-4H,5-8H2,(H,14,15)
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n/an/a 6.50E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibitory concentration was tested on human 5-alpha reductase 1 isozyme


J Med Chem 40: 1293-315 (1997)


Article DOI: 10.1021/jm960697s
BindingDB Entry DOI: 10.7270/Q2W096MN
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50044889
PNG
(1,4,5,6-Tetrahydro-2H-benzo[f]quinolin-3-one | CHE...)
Show SMILES O=C1CCC2=C(CCc3ccccc23)N1
Show InChI InChI=1S/C13H13NO/c15-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)14-13/h1-4H,5-8H2,(H,14,15)
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n/an/a 6.50E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.


J Med Chem 36: 421-3 (1993)


Article DOI: 10.1021/jm00055a014
BindingDB Entry DOI: 10.7270/Q2T43TQX
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50103877
PNG
(6-Allyl-7-hydroxy-chromen-2-one | CHEMBL76373)
Show SMILES Oc1cc2oc(=O)ccc2cc1CC=C
Show InChI InChI=1S/C12H10O3/c1-2-3-8-6-9-4-5-12(14)15-11(9)7-10(8)13/h2,4-7,13H,1,3H2
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n/an/a 8.40E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-alpha-reductase type 1 in cell culture system using LNCaP cells (androgen-sensitive human prostatic cancer cell line)


Bioorg Med Chem Lett 11: 2361-3 (2001)


Article DOI: 10.1016/s0960-894x(01)00429-2
BindingDB Entry DOI: 10.7270/Q2RR1ZS9
More data for this
Ligand-Target Pair