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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 480.5
BDBM145664
Wt: 480.5
BDBM145683
Wt: 482.5
BDBM145665
Wt: 469.5
BDBM145765
Wt: 469.5
BDBM145766
Wt: 455.5
BDBM145767
Wt: 479.5
BDBM145773
Wt: 469.5
BDBM145693
Wt: 469.5
BDBM145694
Wt: 471.5
BDBM145695
Wt: 473.5
BDBM145710
Wt: 487.5
BDBM145714
Wt: 487.5
BDBM145716
Wt: 476.5
BDBM145743
Wt: 487.5
BDBM145744
Displayed 1 to 15 (of 176 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 51 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145765
PNG
(US8952177, 119 | US9089569, 119 | US9695149, 119)
Show SMILES Cc1ccc(Cn2c(nc3ccc(OCc4ccc(C)cn4)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H31N3O3/c1-19-7-10-21(11-8-19)17-32-27-15-23(35-18-22-12-9-20(2)16-30-22)13-14-26(27)31-28(32)24-5-3-4-6-25(24)29(33)34/h7-16,24-25H,3-6,17-18H2,1-2H3,(H,33,34)/t24-,25+/m1/s1
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6.60n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145765
PNG
(US8952177, 119 | US9089569, 119 | US9695149, 119)
Show SMILES Cc1ccc(Cn2c(nc3ccc(OCc4ccc(C)cn4)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H31N3O3/c1-19-7-10-21(11-8-19)17-32-27-15-23(35-18-22-12-9-20(2)16-30-22)13-14-26(27)31-28(32)24-5-3-4-6-25(24)29(33)34/h7-16,24-25H,3-6,17-18H2,1-2H3,(H,33,34)/t24-,25+/m1/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145765
PNG
(US8952177, 119 | US9089569, 119 | US9695149, 119)
Show SMILES Cc1ccc(Cn2c(nc3ccc(OCc4ccc(C)cn4)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H31N3O3/c1-19-7-10-21(11-8-19)17-32-27-15-23(35-18-22-12-9-20(2)16-30-22)13-14-26(27)31-28(32)24-5-3-4-6-25(24)29(33)34/h7-16,24-25H,3-6,17-18H2,1-2H3,(H,33,34)/t24-,25+/m1/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145743
PNG
(US8952177, 97 | US9089569, 97 | US9695149, 97)
Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccn(C)n4)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C27H29FN4O3/c1-17-7-9-18(10-8-17)15-32-24-14-20(35-16-19-11-12-31(2)30-19)13-23(28)25(24)29-26(32)21-5-3-4-6-22(21)27(33)34/h7-14,21-22H,3-6,15-16H2,1-2H3,(H,33,34)/t21-,22+/m1/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145743
PNG
(US8952177, 97 | US9089569, 97 | US9695149, 97)
Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccn(C)n4)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C27H29FN4O3/c1-17-7-9-18(10-8-17)15-32-24-14-20(35-16-19-11-12-31(2)30-19)13-23(28)25(24)29-26(32)21-5-3-4-6-22(21)27(33)34/h7-14,21-22H,3-6,15-16H2,1-2H3,(H,33,34)/t21-,22+/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145743
PNG
(US8952177, 97 | US9089569, 97 | US9695149, 97)
Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccn(C)n4)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C27H29FN4O3/c1-17-7-9-18(10-8-17)15-32-24-14-20(35-16-19-11-12-31(2)30-19)13-23(28)25(24)29-26(32)21-5-3-4-6-22(21)27(33)34/h7-14,21-22H,3-6,15-16H2,1-2H3,(H,33,34)/t21-,22+/m1/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145683
PNG
(US8952177, 37 | US8952177, 39 | US9089569, 39 | US...)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)nc1
Show InChI InChI=1S/C29H28N4O3/c1-19-6-11-22(31-16-19)18-36-23-12-13-26-27(14-23)33(17-21-9-7-20(15-30)8-10-21)28(32-26)24-4-2-3-5-25(24)29(34)35/h6-14,16,24-25H,2-5,17-18H2,1H3,(H,34,35)/t24?,25-/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145683
PNG
(US8952177, 37 | US8952177, 39 | US9089569, 39 | US...)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)nc1
Show InChI InChI=1S/C29H28N4O3/c1-19-6-11-22(31-16-19)18-36-23-12-13-26-27(14-23)33(17-21-9-7-20(15-30)8-10-21)28(32-26)24-4-2-3-5-25(24)29(34)35/h6-14,16,24-25H,2-5,17-18H2,1H3,(H,34,35)/t24?,25-/m1/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145683
PNG
(US8952177, 37 | US8952177, 39 | US9089569, 39 | US...)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)nc1
Show InChI InChI=1S/C29H28N4O3/c1-19-6-11-22(31-16-19)18-36-23-12-13-26-27(14-23)33(17-21-9-7-20(15-30)8-10-21)28(32-26)24-4-2-3-5-25(24)29(34)35/h6-14,16,24-25H,2-5,17-18H2,1H3,(H,34,35)/t24?,25-/m1/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145766
PNG
(US8952177, 120 | US9089569, 120 | US9695149, 120)
Show SMILES Cc1ccc(Cn2c(nc3ccc(OCc4ccc(C)cn4)cc23)[C@H]2CCCC[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H31N3O3/c1-19-7-10-21(11-8-19)17-32-27-15-23(35-18-22-12-9-20(2)16-30-22)13-14-26(27)31-28(32)24-5-3-4-6-25(24)29(33)34/h7-16,24-25H,3-6,17-18H2,1-2H3,(H,33,34)/t24-,25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145766
PNG
(US8952177, 120 | US9089569, 120 | US9695149, 120)
Show SMILES Cc1ccc(Cn2c(nc3ccc(OCc4ccc(C)cn4)cc23)[C@H]2CCCC[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H31N3O3/c1-19-7-10-21(11-8-19)17-32-27-15-23(35-18-22-12-9-20(2)16-30-22)13-14-26(27)31-28(32)24-5-3-4-6-25(24)29(33)34/h7-16,24-25H,3-6,17-18H2,1-2H3,(H,33,34)/t24-,25-/m0/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145766
PNG
(US8952177, 120 | US9089569, 120 | US9695149, 120)
Show SMILES Cc1ccc(Cn2c(nc3ccc(OCc4ccc(C)cn4)cc23)[C@H]2CCCC[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H31N3O3/c1-19-7-10-21(11-8-19)17-32-27-15-23(35-18-22-12-9-20(2)16-30-22)13-14-26(27)31-28(32)24-5-3-4-6-25(24)29(33)34/h7-16,24-25H,3-6,17-18H2,1-2H3,(H,33,34)/t24-,25-/m0/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145714
PNG
(US8952177, 68 | US9089569, 68 | US9695149, 68)
Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccc(C)cn4)cc23)C2CCCC[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H30FN3O3/c1-18-7-10-20(11-8-18)16-33-26-14-22(36-17-21-12-9-19(2)15-31-21)13-25(30)27(26)32-28(33)23-5-3-4-6-24(23)29(34)35/h7-15,23-24H,3-6,16-17H2,1-2H3,(H,34,35)/t23?,24-/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145714
PNG
(US8952177, 68 | US9089569, 68 | US9695149, 68)
Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccc(C)cn4)cc23)C2CCCC[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H30FN3O3/c1-18-7-10-20(11-8-18)16-33-26-14-22(36-17-21-12-9-19(2)15-31-21)13-25(30)27(26)32-28(33)23-5-3-4-6-24(23)29(34)35/h7-15,23-24H,3-6,16-17H2,1-2H3,(H,34,35)/t23?,24-/m1/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145714
PNG
(US8952177, 68 | US9089569, 68 | US9695149, 68)
Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccc(C)cn4)cc23)C2CCCC[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H30FN3O3/c1-18-7-10-20(11-8-18)16-33-26-14-22(36-17-21-12-9-19(2)15-31-21)13-25(30)27(26)32-28(33)23-5-3-4-6-24(23)29(34)35/h7-15,23-24H,3-6,16-17H2,1-2H3,(H,34,35)/t23?,24-/m1/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145683
PNG
(US8952177, 37 | US8952177, 39 | US9089569, 39 | US...)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)nc1
Show InChI InChI=1S/C29H28N4O3/c1-19-6-11-22(31-16-19)18-36-23-12-13-26-27(14-23)33(17-21-9-7-20(15-30)8-10-21)28(32-26)24-4-2-3-5-25(24)29(34)35/h6-14,16,24-25H,2-5,17-18H2,1H3,(H,34,35)/t24?,25-/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145683
PNG
(US8952177, 37 | US8952177, 39 | US9089569, 39 | US...)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)nc1
Show InChI InChI=1S/C29H28N4O3/c1-19-6-11-22(31-16-19)18-36-23-12-13-26-27(14-23)33(17-21-9-7-20(15-30)8-10-21)28(32-26)24-4-2-3-5-25(24)29(34)35/h6-14,16,24-25H,2-5,17-18H2,1H3,(H,34,35)/t24?,25-/m1/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145683
PNG
(US8952177, 37 | US8952177, 39 | US9089569, 39 | US...)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)nc1
Show InChI InChI=1S/C29H28N4O3/c1-19-6-11-22(31-16-19)18-36-23-12-13-26-27(14-23)33(17-21-9-7-20(15-30)8-10-21)28(32-26)24-4-2-3-5-25(24)29(34)35/h6-14,16,24-25H,2-5,17-18H2,1H3,(H,34,35)/t24?,25-/m1/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145716
PNG
(US8952177, 70 | US9089569, 70 | US9695149, 70)
Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccc(C)cn4)cc23)C2CCCC[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H30FN3O3/c1-18-7-10-20(11-8-18)16-33-26-14-22(36-17-21-12-9-19(2)15-31-21)13-25(30)27(26)32-28(33)23-5-3-4-6-24(23)29(34)35/h7-15,23-24H,3-6,16-17H2,1-2H3,(H,34,35)/t23?,24-/m0/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145716
PNG
(US8952177, 70 | US9089569, 70 | US9695149, 70)
Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccc(C)cn4)cc23)C2CCCC[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H30FN3O3/c1-18-7-10-20(11-8-18)16-33-26-14-22(36-17-21-12-9-19(2)15-31-21)13-25(30)27(26)32-28(33)23-5-3-4-6-24(23)29(34)35/h7-15,23-24H,3-6,16-17H2,1-2H3,(H,34,35)/t23?,24-/m0/s1
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47n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145716
PNG
(US8952177, 70 | US9089569, 70 | US9695149, 70)
Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccc(C)cn4)cc23)C2CCCC[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C29H30FN3O3/c1-18-7-10-20(11-8-18)16-33-26-14-22(36-17-21-12-9-19(2)15-31-21)13-25(30)27(26)32-28(33)23-5-3-4-6-24(23)29(34)35/h7-15,23-24H,3-6,16-17H2,1-2H3,(H,34,35)/t23?,24-/m0/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145664
PNG
(US8952177, 18 | US8952177, 38 | US9089569, 38 | US...)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)nc1
Show InChI InChI=1S/C29H28N4O3/c1-19-6-11-22(31-16-19)18-36-23-12-13-26-27(14-23)33(17-21-9-7-20(15-30)8-10-21)28(32-26)24-4-2-3-5-25(24)29(34)35/h6-14,16,24-25H,2-5,17-18H2,1H3,(H,34,35)/t24?,25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145664
PNG
(US8952177, 18 | US8952177, 38 | US9089569, 38 | US...)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)nc1
Show InChI InChI=1S/C29H28N4O3/c1-19-6-11-22(31-16-19)18-36-23-12-13-26-27(14-23)33(17-21-9-7-20(15-30)8-10-21)28(32-26)24-4-2-3-5-25(24)29(34)35/h6-14,16,24-25H,2-5,17-18H2,1H3,(H,34,35)/t24?,25-/m0/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145664
PNG
(US8952177, 18 | US8952177, 38 | US9089569, 38 | US...)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)nc1
Show InChI InChI=1S/C29H28N4O3/c1-19-6-11-22(31-16-19)18-36-23-12-13-26-27(14-23)33(17-21-9-7-20(15-30)8-10-21)28(32-26)24-4-2-3-5-25(24)29(34)35/h6-14,16,24-25H,2-5,17-18H2,1H3,(H,34,35)/t24?,25-/m0/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145744
PNG
(US8952177, 98 | US9089569, 98 | US9695149, 98)
Show SMILES Cn1ccc(COc2cc(F)c3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)n1
Show InChI InChI=1S/C27H26FN5O3/c1-32-11-10-19(31-32)16-36-20-12-23(28)25-24(13-20)33(15-18-8-6-17(14-29)7-9-18)26(30-25)21-4-2-3-5-22(21)27(34)35/h6-13,21-22H,2-5,15-16H2,1H3,(H,34,35)/t21-,22+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145744
PNG
(US8952177, 98 | US9089569, 98 | US9695149, 98)
Show SMILES Cn1ccc(COc2cc(F)c3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)n1
Show InChI InChI=1S/C27H26FN5O3/c1-32-11-10-19(31-32)16-36-20-12-23(28)25-24(13-20)33(15-18-8-6-17(14-29)7-9-18)26(30-25)21-4-2-3-5-22(21)27(34)35/h6-13,21-22H,2-5,15-16H2,1H3,(H,34,35)/t21-,22+/m0/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145744
PNG
(US8952177, 98 | US9089569, 98 | US9695149, 98)
Show SMILES Cn1ccc(COc2cc(F)c3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)n1
Show InChI InChI=1S/C27H26FN5O3/c1-32-11-10-19(31-32)16-36-20-12-23(28)25-24(13-20)33(15-18-8-6-17(14-29)7-9-18)26(30-25)21-4-2-3-5-22(21)27(34)35/h6-13,21-22H,2-5,15-16H2,1H3,(H,34,35)/t21-,22+/m0/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145767
PNG
(US8952177, 121 | US9089569, 121 | US9695149, 121)
Show SMILES Cc1ccc(Cn2c(nc3ccc(OCc4ccc(C)cn4)cc23)[C@@H]2[C@H](C(O)=O)C2(C)C)cc1
Show InChI InChI=1S/C28H29N3O3/c1-17-5-8-19(9-6-17)15-31-23-13-21(34-16-20-10-7-18(2)14-29-20)11-12-22(23)30-26(31)24-25(27(32)33)28(24,3)4/h5-14,24-25H,15-16H2,1-4H3,(H,32,33)/t24-,25+/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145767
PNG
(US8952177, 121 | US9089569, 121 | US9695149, 121)
Show SMILES Cc1ccc(Cn2c(nc3ccc(OCc4ccc(C)cn4)cc23)[C@@H]2[C@H](C(O)=O)C2(C)C)cc1
Show InChI InChI=1S/C28H29N3O3/c1-17-5-8-19(9-6-17)15-31-23-13-21(34-16-20-10-7-18(2)14-29-20)11-12-22(23)30-26(31)24-25(27(32)33)28(24,3)4/h5-14,24-25H,15-16H2,1-4H3,(H,32,33)/t24-,25+/m0/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145767
PNG
(US8952177, 121 | US9089569, 121 | US9695149, 121)
Show SMILES Cc1ccc(Cn2c(nc3ccc(OCc4ccc(C)cn4)cc23)[C@@H]2[C@H](C(O)=O)C2(C)C)cc1
Show InChI InChI=1S/C28H29N3O3/c1-17-5-8-19(9-6-17)15-31-23-13-21(34-16-20-10-7-18(2)14-29-20)11-12-22(23)30-26(31)24-25(27(32)33)28(24,3)4/h5-14,24-25H,15-16H2,1-4H3,(H,32,33)/t24-,25+/m0/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145773
PNG
(US8952177, 127 | US9089569, 127 | US9695149, 127)
Show SMILES Cc1ccc(Cn2c(CC(C)(C)C(O)=O)nc3ccc(OCc4ncc(C)cc4F)cc23)c(F)c1
Show InChI InChI=1S/C27H27F2N3O3/c1-16-5-6-18(20(28)9-16)14-32-24-11-19(35-15-23-21(29)10-17(2)13-30-23)7-8-22(24)31-25(32)12-27(3,4)26(33)34/h5-11,13H,12,14-15H2,1-4H3,(H,33,34)
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145773
PNG
(US8952177, 127 | US9089569, 127 | US9695149, 127)
Show SMILES Cc1ccc(Cn2c(CC(C)(C)C(O)=O)nc3ccc(OCc4ncc(C)cc4F)cc23)c(F)c1
Show InChI InChI=1S/C27H27F2N3O3/c1-16-5-6-18(20(28)9-16)14-32-24-11-19(35-15-23-21(29)10-17(2)13-30-23)7-8-22(24)31-25(32)12-27(3,4)26(33)34/h5-11,13H,12,14-15H2,1-4H3,(H,33,34)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145773
PNG
(US8952177, 127 | US9089569, 127 | US9695149, 127)
Show SMILES Cc1ccc(Cn2c(CC(C)(C)C(O)=O)nc3ccc(OCc4ncc(C)cc4F)cc23)c(F)c1
Show InChI InChI=1S/C27H27F2N3O3/c1-16-5-6-18(20(28)9-16)14-32-24-11-19(35-15-23-21(29)10-17(2)13-30-23)7-8-22(24)31-25(32)12-27(3,4)26(33)34/h5-11,13H,12,14-15H2,1-4H3,(H,33,34)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145710
PNG
(US8952177, 64 | US9089569, 64 | US9695149, 64)
Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccc(C)cn4)cc23)C2[C@@H](C(O)=O)C2(C)C)cc1
Show InChI InChI=1S/C28H28FN3O3/c1-16-5-8-18(9-6-16)14-32-22-12-20(35-15-19-10-7-17(2)13-30-19)11-21(29)25(22)31-26(32)23-24(27(33)34)28(23,3)4/h5-13,23-24H,14-15H2,1-4H3,(H,33,34)/t23?,24-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145710
PNG
(US8952177, 64 | US9089569, 64 | US9695149, 64)
Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccc(C)cn4)cc23)C2[C@@H](C(O)=O)C2(C)C)cc1
Show InChI InChI=1S/C28H28FN3O3/c1-16-5-8-18(9-6-16)14-32-22-12-20(35-15-19-10-7-17(2)13-30-19)11-21(29)25(22)31-26(32)23-24(27(33)34)28(23,3)4/h5-13,23-24H,14-15H2,1-4H3,(H,33,34)/t23?,24-/m0/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145710
PNG
(US8952177, 64 | US9089569, 64 | US9695149, 64)
Show SMILES Cc1ccc(Cn2c(nc3c(F)cc(OCc4ccc(C)cn4)cc23)C2[C@@H](C(O)=O)C2(C)C)cc1
Show InChI InChI=1S/C28H28FN3O3/c1-16-5-8-18(9-6-16)14-32-22-12-20(35-15-19-10-7-17(2)13-30-19)11-21(29)25(22)31-26(32)23-24(27(33)34)28(23,3)4/h5-13,23-24H,14-15H2,1-4H3,(H,33,34)/t23?,24-/m0/s1
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290n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145693
PNG
(US8952177, 47 | US9089569, 47 | US9695149, 47)
Show SMILES Cn1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)n1
Show InChI InChI=1S/C27H27N5O3/c1-31-13-12-20(30-31)17-35-21-10-11-24-25(14-21)32(16-19-8-6-18(15-28)7-9-19)26(29-24)22-4-2-3-5-23(22)27(33)34/h6-14,22-23H,2-5,16-17H2,1H3,(H,33,34)/t22-,23+/m1/s1
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490n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145693
PNG
(US8952177, 47 | US9089569, 47 | US9695149, 47)
Show SMILES Cn1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)n1
Show InChI InChI=1S/C27H27N5O3/c1-31-13-12-20(30-31)17-35-21-10-11-24-25(14-21)32(16-19-8-6-18(15-28)7-9-19)26(29-24)22-4-2-3-5-23(22)27(33)34/h6-14,22-23H,2-5,16-17H2,1H3,(H,33,34)/t22-,23+/m1/s1
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490n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145693
PNG
(US8952177, 47 | US9089569, 47 | US9695149, 47)
Show SMILES Cn1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)n1
Show InChI InChI=1S/C27H27N5O3/c1-31-13-12-20(30-31)17-35-21-10-11-24-25(14-21)32(16-19-8-6-18(15-28)7-9-19)26(29-24)22-4-2-3-5-23(22)27(33)34/h6-14,22-23H,2-5,16-17H2,1H3,(H,33,34)/t22-,23+/m1/s1
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490n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145665
PNG
(US8952177, 19 | US9089569, 19 | US9695149, 19)
Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ccc(C)cn3)cc2n1Cc1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C29H30N4O3/c1-4-29(5-2,28(34)35)15-27-32-25-13-12-24(36-19-23-11-6-20(3)17-31-23)14-26(25)33(27)18-22-9-7-21(16-30)8-10-22/h6-14,17H,4-5,15,18-19H2,1-3H3,(H,34,35)
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750n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145694
PNG
(US8952177, 48 | US9089569, 48 | US9695149, 48)
Show SMILES Cn1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)n1
Show InChI InChI=1S/C27H27N5O3/c1-31-13-12-20(30-31)17-35-21-10-11-24-25(14-21)32(16-19-8-6-18(15-28)7-9-19)26(29-24)22-4-2-3-5-23(22)27(33)34/h6-14,22-23H,2-5,16-17H2,1H3,(H,33,34)/t22?,23-/m0/s1
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750n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145665
PNG
(US8952177, 19 | US9089569, 19 | US9695149, 19)
Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ccc(C)cn3)cc2n1Cc1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C29H30N4O3/c1-4-29(5-2,28(34)35)15-27-32-25-13-12-24(36-19-23-11-6-20(3)17-31-23)14-26(25)33(27)18-22-9-7-21(16-30)8-10-22/h6-14,17H,4-5,15,18-19H2,1-3H3,(H,34,35)
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750n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145665
PNG
(US8952177, 19 | US9089569, 19 | US9695149, 19)
Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ccc(C)cn3)cc2n1Cc1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C29H30N4O3/c1-4-29(5-2,28(34)35)15-27-32-25-13-12-24(36-19-23-11-6-20(3)17-31-23)14-26(25)33(27)18-22-9-7-21(16-30)8-10-22/h6-14,17H,4-5,15,18-19H2,1-3H3,(H,34,35)
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750n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145694
PNG
(US8952177, 48 | US9089569, 48 | US9695149, 48)
Show SMILES Cn1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)n1
Show InChI InChI=1S/C27H27N5O3/c1-31-13-12-20(30-31)17-35-21-10-11-24-25(14-21)32(16-19-8-6-18(15-28)7-9-19)26(29-24)22-4-2-3-5-23(22)27(33)34/h6-14,22-23H,2-5,16-17H2,1H3,(H,33,34)/t22?,23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145694
PNG
(US8952177, 48 | US9089569, 48 | US9695149, 48)
Show SMILES Cn1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)n1
Show InChI InChI=1S/C27H27N5O3/c1-31-13-12-20(30-31)17-35-21-10-11-24-25(14-21)32(16-19-8-6-18(15-28)7-9-19)26(29-24)22-4-2-3-5-23(22)27(33)34/h6-14,22-23H,2-5,16-17H2,1H3,(H,33,34)/t22?,23-/m0/s1
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750n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145695
PNG
(US8952177, 49 | US9089569, 49 | US9695149, 49)
Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ccn(C)n3)cc2n1Cc1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C27H29N5O3/c1-4-27(5-2,26(33)34)15-25-29-23-11-10-22(35-18-21-12-13-31(3)30-21)14-24(23)32(25)17-20-8-6-19(16-28)7-9-20/h6-14H,4-5,15,17-18H2,1-3H3,(H,33,34)
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1.88E+3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145695
PNG
(US8952177, 49 | US9089569, 49 | US9695149, 49)
Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ccn(C)n3)cc2n1Cc1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C27H29N5O3/c1-4-27(5-2,26(33)34)15-25-29-23-11-10-22(35-18-21-12-13-31(3)30-21)14-24(23)32(25)17-20-8-6-19(16-28)7-9-20/h6-14H,4-5,15,17-18H2,1-3H3,(H,33,34)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145695
PNG
(US8952177, 49 | US9089569, 49 | US9695149, 49)
Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ccn(C)n3)cc2n1Cc1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C27H29N5O3/c1-4-27(5-2,26(33)34)15-25-29-23-11-10-22(35-18-21-12-13-31(3)30-21)14-24(23)32(25)17-20-8-6-19(16-28)7-9-20/h6-14H,4-5,15,17-18H2,1-3H3,(H,33,34)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9695149 (2017)


BindingDB Entry DOI: 10.7270/Q2Q52MSC
More data for this
Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP)


(Homo sapiens (Human))
BDBM145664
PNG
(US8952177, 18 | US8952177, 38 | US9089569, 38 | US...)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)nc1
Show InChI InChI=1S/C29H28N4O3/c1-19-6-11-22(31-16-19)18-36-23-12-13-26-27(14-23)33(17-21-9-7-20(15-30)8-10-21)28(32-26)24-4-2-3-5-25(24)29(34)35/h6-14,16,24-25H,2-5,17-18H2,1H3,(H,34,35)/t24?,25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...


US Patent US8952177 (2015)


BindingDB Entry DOI: 10.7270/Q2G73CFW
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145664
PNG
(US8952177, 18 | US8952177, 38 | US9089569, 38 | US...)
Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)C#N)c3c2)nc1
Show InChI InChI=1S/C29H28N4O3/c1-19-6-11-22(31-16-19)18-36-23-12-13-26-27(14-23)33(17-21-9-7-20(15-30)8-10-21)28(32-26)24-4-2-3-5-25(24)29(34)35/h6-14,16,24-25H,2-5,17-18H2,1H3,(H,34,35)/t24?,25-/m0/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)


BindingDB Entry DOI: 10.7270/Q23X85DB
More data for this
Ligand-Target Pair
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