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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 230.2
BDBM50380233
Wt: 255.7
BDBM50380237
Wt: 221.2
BDBM50016136
Wt: 235.2
BDBM50016138
Wt: 250.2
BDBM50016116
Wt: 249.2
BDBM50016118
Wt: 234.2
BDBM50016123
Purchase
Wt: 248.3
BDBM50016124
Purchase
Wt: 249.2
BDBM50016140
Wt: 235.2
BDBM50016147
Wt: 229.2
BDBM50016159
Wt: 250.2
BDBM50016150
Wt: 251.2
BDBM50016155
Wt: 249.2
BDBM50016156
Purchase
Wt: 255.3
BDBM50016158
Displayed 1 to 15 (of 121 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 38 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50380233
PNG
(CHEMBL2016859)
Show SMILES O=C1NCCc2sc(cc12)-c1ccncc1
Show InChI InChI=1S/C12H10N2OS/c15-12-9-7-11(8-1-4-13-5-2-8)16-10(9)3-6-14-12/h1-2,4-5,7H,3,6H2,(H,14,15)
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n/an/a 33n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr


ACS Med Chem Lett 2: 720-723 (2011)


Article DOI: 10.1021/ml200029w
BindingDB Entry DOI: 10.7270/Q2SQ91CR
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016147
PNG
(CHEMBL3261499)
Show SMILES COc1nc(sc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O2S/c1-15-9-7(8(11)14)16-10(13-9)6-2-4-12-5-3-6/h2-5H,1H3,(H2,11,14)
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n/an/a 96n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016136
PNG
(CHEMBL3261488)
Show SMILES NC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C9H7N3O2S/c10-7(13)6-8(14)12-9(15-6)5-1-3-11-4-2-5/h1-4,14H,(H2,10,13)
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n/an/a 115n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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n/an/a 300n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.023 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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n/an/a 316n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.75 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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n/an/a 318n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 1.5 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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n/an/a 323n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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n/an/a 405n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.047 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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n/an/a 419n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 3 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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n/an/a 528n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.094 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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n/an/a 546n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.375 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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n/an/a 547n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.188 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016118
PNG
(CHEMBL3261230)
Show SMILES CCOC(=O)c1sc(nc1N)-c1ccncc1
Show InChI InChI=1S/C11H11N3O2S/c1-2-16-11(15)8-9(12)14-10(17-8)7-3-5-13-6-4-7/h3-6H,2,12H2,1H3
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n/an/a 4.20E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50016147
PNG
(CHEMBL3261499)
Show SMILES COc1nc(sc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O2S/c1-15-9-7(8(11)14)16-10(13-9)6-2-4-12-5-3-6/h2-5H,1H3,(H2,11,14)
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n/an/a 5.71E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016138
PNG
(CHEMBL3261490)
Show SMILES CNC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O2S/c1-11-8(14)7-9(15)13-10(16-7)6-2-4-12-5-3-6/h2-5,15H,1H3,(H,11,14)
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n/an/a 8.98E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016147
PNG
(CHEMBL3261499)
Show SMILES COc1nc(sc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O2S/c1-15-9-7(8(11)14)16-10(13-9)6-2-4-12-5-3-6/h2-5H,1H3,(H2,11,14)
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n/an/a 9.93E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016123
PNG
(CHEMBL3261235)
Show SMILES CCOC(=O)c1cnc(s1)-c1ccncc1
Show InChI InChI=1S/C11H10N2O2S/c1-2-15-11(14)9-7-13-10(16-9)8-3-5-12-6-4-8/h3-7H,2H2,1H3
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n/an/a 2.40E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016140
PNG
(CHEMBL3261492)
Show SMILES CN(C)C(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H11N3O2S/c1-14(2)11(16)8-9(15)13-10(17-8)7-3-5-12-6-4-7/h3-6,15H,1-2H3
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n/an/a 2.44E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50380237
PNG
(CHEMBL2017003)
Show SMILES Clc1cc2c(s1)C1(CCCCC1)CNC2=O
Show InChI InChI=1S/C12H14ClNOS/c13-9-6-8-10(16-9)12(7-14-11(8)15)4-2-1-3-5-12/h6H,1-5,7H2,(H,14,15)
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hr


ACS Med Chem Lett 2: 720-723 (2011)


Article DOI: 10.1021/ml200029w
BindingDB Entry DOI: 10.7270/Q2SQ91CR
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016124
PNG
(CHEMBL3261236)
Show SMILES CCOC(=O)c1sc(nc1C)-c1ccncc1
Show InChI InChI=1S/C12H12N2O2S/c1-3-16-12(15)10-8(2)14-11(17-10)9-4-6-13-7-5-9/h4-7H,3H2,1-2H3
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n/an/a 2.51E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016155
PNG
(CHEMBL3261507)
Show SMILES CCOC(=O)c1sc(nc1O)-c1cnccn1
Show InChI InChI=1S/C10H9N3O3S/c1-2-16-10(15)7-8(14)13-9(17-7)6-5-11-3-4-12-6/h3-5,14H,2H2,1H3
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n/an/a 2.65E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016158
PNG
(CHEMBL3261509)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccsc1
Show InChI InChI=1S/C10H9NO3S2/c1-2-14-10(13)7-8(12)11-9(16-7)6-3-4-15-5-6/h3-5,12H,2H2,1H3
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n/an/a 2.96E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016156
PNG
(CHEMBL65312)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccccc1
Show InChI InChI=1S/C12H11NO3S/c1-2-16-12(15)9-10(14)13-11(17-9)8-6-4-3-5-7-8/h3-7,14H,2H2,1H3
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n/an/a 4.67E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016136
PNG
(CHEMBL3261488)
Show SMILES NC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C9H7N3O2S/c10-7(13)6-8(14)12-9(15-6)5-1-3-11-4-2-5/h1-4,14H,(H2,10,13)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50016159
PNG
(CHEMBL3261510)
Show SMILES CCOC(=O)c1sc(nc1O)C(C)(C)C
Show InChI InChI=1S/C10H15NO3S/c1-5-14-8(13)6-7(12)11-9(15-6)10(2,3)4/h12H,5H2,1-4H3
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016150
PNG
(CHEMBL3261502)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccccn1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-5-3-4-6-12-7/h3-6,14H,2H2,1H3
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50016158
PNG
(CHEMBL3261509)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccsc1
Show InChI InChI=1S/C10H9NO3S2/c1-2-14-10(13)7-8(12)11-9(16-7)6-3-4-15-5-6/h3-5,12H,2H2,1H3
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50016156
PNG
(CHEMBL65312)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccccc1
Show InChI InChI=1S/C12H11NO3S/c1-2-16-12(15)9-10(14)13-11(17-9)8-6-4-3-5-7-8/h3-7,14H,2H2,1H3
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50016155
PNG
(CHEMBL3261507)
Show SMILES CCOC(=O)c1sc(nc1O)-c1cnccn1
Show InChI InChI=1S/C10H9N3O3S/c1-2-16-10(15)7-8(14)13-9(17-7)6-5-11-3-4-12-6/h3-5,14H,2H2,1H3
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50016150
PNG
(CHEMBL3261502)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccccn1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-5-3-4-6-12-7/h3-6,14H,2H2,1H3
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50016140
PNG
(CHEMBL3261492)
Show SMILES CN(C)C(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H11N3O2S/c1-14(2)11(16)8-9(15)13-10(17-8)7-3-5-12-6-4-7/h3-6,15H,1-2H3
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50016138
PNG
(CHEMBL3261490)
Show SMILES CNC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O2S/c1-11-8(14)7-9(15)13-10(16-7)6-2-4-12-5-3-6/h2-5,15H,1H3,(H,11,14)
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50016136
PNG
(CHEMBL3261488)
Show SMILES NC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C9H7N3O2S/c10-7(13)6-8(14)12-9(15-6)5-1-3-11-4-2-5/h1-4,14H,(H2,10,13)
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50016124
PNG
(CHEMBL3261236)
Show SMILES CCOC(=O)c1sc(nc1C)-c1ccncc1
Show InChI InChI=1S/C12H12N2O2S/c1-3-16-12(15)10-8(2)14-11(17-10)9-4-6-13-7-5-9/h4-7H,3H2,1-2H3
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50016123
PNG
(CHEMBL3261235)
Show SMILES CCOC(=O)c1cnc(s1)-c1ccncc1
Show InChI InChI=1S/C11H10N2O2S/c1-2-15-11(14)9-7-13-10(16-9)8-3-5-12-6-4-8/h3-7H,2H2,1H3
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50016159
PNG
(CHEMBL3261510)
Show SMILES CCOC(=O)c1sc(nc1O)C(C)(C)C
Show InChI InChI=1S/C10H15NO3S/c1-5-14-8(13)6-7(12)11-9(15-6)10(2,3)4/h12H,5H2,1-4H3
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM50016118
PNG
(CHEMBL3261230)
Show SMILES CCOC(=O)c1sc(nc1N)-c1ccncc1
Show InChI InChI=1S/C11H11N3O2S/c1-2-16-11(15)8-9(12)14-10(17-8)7-3-5-13-6-4-7/h3-6H,2,12H2,1H3
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair