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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 201.2
BDBM50008427
Wt: 211.0
BDBM50075327
Wt: 215.1
BDBM50316049
Wt: 215.1
BDBM50025048
Wt: 140.0
BDBM50170885
Wt: 222.2
BDBM50170890
Wt: 208.1
BDBM50170893
Wt: 224.1
BDBM50170895
Wt: 211.1
BDBM50170898
Wt: 183.1
BDBM50170899
Wt: 210.1
BDBM50170901
Wt: 167.1
BDBM50190109
Wt: 167.1
BDBM50190114
Wt: 154.1
BDBM50170886
Wt: 182.1
BDBM50170888
Displayed 1 to 15 (of 152 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 65 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Homo sapiens)
BDBM50025048
PNG
(CHEMBL3355099)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)/t9-/m1/s1
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PubMed
0.230n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50316049
PNG
(1-amino-3-phenylpropylphosphonic acid | CHEMBL1090...)
Show SMILES NC(CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)
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0.790n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50316049
PNG
(1-amino-3-phenylpropylphosphonic acid | CHEMBL1090...)
Show SMILES NC(CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)
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4n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50025048
PNG
(CHEMBL3355099)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)/t9-/m1/s1
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4.10n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50316049
PNG
(1-amino-3-phenylpropylphosphonic acid | CHEMBL1090...)
Show SMILES NC(CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)
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4.60n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025048
PNG
(CHEMBL3355099)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)/t9-/m1/s1
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5n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
BindingDB Entry DOI: 10.7270/Q2CF9RQF
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170898
PNG
(CHEMBL3805964)
Show SMILES CN(C)CCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C6H18N3O3P/c1-9(2)4-3-8-5-6(7)13(10,11)12/h6,8H,3-5,7H2,1-2H3,(H2,10,11,12)
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500n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured f...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens)
BDBM50170893
PNG
(CHEMBL3804843)
Show SMILES NC(CN1CCCCC1)P(O)(O)=O
Show InChI InChI=1S/C7H17N2O3P/c8-7(13(10,11)12)6-9-4-2-1-3-5-9/h7H,1-6,8H2,(H2,10,11,12)
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622n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50170890
PNG
(CHEMBL3806072)
Show SMILES NC(CNC1CCCCC1)P(O)(O)=O
Show InChI InChI=1S/C8H19N2O3P/c9-8(14(11,12)13)6-10-7-4-2-1-3-5-7/h7-8,10H,1-6,9H2,(H2,11,12,13)
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691n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50170895
PNG
(CHEMBL3805487)
Show SMILES NC(CNCC1CCCO1)P(O)(O)=O
Show InChI InChI=1S/C7H17N2O4P/c8-7(14(10,11)12)5-9-4-6-2-1-3-13-6/h6-7,9H,1-5,8H2,(H2,10,11,12)
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782n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170890
PNG
(CHEMBL3806072)
Show SMILES NC(CNC1CCCCC1)P(O)(O)=O
Show InChI InChI=1S/C8H19N2O3P/c9-8(14(11,12)13)6-10-7-4-2-1-3-5-7/h7-8,10H,1-6,9H2,(H2,11,12,13)
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870n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50170888
PNG
(CHEMBL3805557)
Show SMILES CCCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C5H15N2O3P/c1-2-3-7-4-5(6)11(8,9)10/h5,7H,2-4,6H2,1H3,(H2,8,9,10)
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PubMed
1.66E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170888
PNG
(CHEMBL3805557)
Show SMILES CCCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C5H15N2O3P/c1-2-3-7-4-5(6)11(8,9)10/h5,7H,2-4,6H2,1H3,(H2,8,9,10)
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1.91E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170885
PNG
(CHEMBL3806121)
Show SMILES NCC(N)P(O)(O)=O
Show InChI InChI=1S/C2H9N2O3P/c3-1-2(4)8(5,6)7/h2H,1,3-4H2,(H2,5,6,7)
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2.88E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured f...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170895
PNG
(CHEMBL3805487)
Show SMILES NC(CNCC1CCCO1)P(O)(O)=O
Show InChI InChI=1S/C7H17N2O4P/c8-7(14(10,11)12)5-9-4-6-2-1-3-13-6/h6-7,9H,1-5,8H2,(H2,10,11,12)
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3.64E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured f...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50190109
PNG
(LEUCINE PHOSPHONIC ACID | Leucine Phosphonic acid)
Show SMILES CC(C)C[C@H](N)P(O)(O)=O
Show InChI InChI=1S/C5H14NO3P/c1-4(2)3-5(6)10(7,8)9/h4-5H,3,6H2,1-2H3,(H2,7,8,9)/t5-/m1/s1
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5.08E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ERAP1 using L-AMC as substrate measured for 15 to 30 mins by fluorescence analysis


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50025048
PNG
(CHEMBL3355099)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)/t9-/m1/s1
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5.55E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50170898
PNG
(CHEMBL3805964)
Show SMILES CN(C)CCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C6H18N3O3P/c1-9(2)4-3-8-5-6(7)13(10,11)12/h6,8H,3-5,7H2,1-2H3,(H2,10,11,12)
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5.74E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50170893
PNG
(CHEMBL3804843)
Show SMILES NC(CN1CCCCC1)P(O)(O)=O
Show InChI InChI=1S/C7H17N2O3P/c8-7(13(10,11)12)6-9-4-2-1-3-5-9/h7H,1-6,8H2,(H2,10,11,12)
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6.04E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50170886
PNG
(CHEMBL3804959)
Show SMILES CNCC(N)P(O)(O)=O
Show InChI InChI=1S/C3H11N2O3P/c1-5-2-3(4)9(6,7)8/h3,5H,2,4H2,1H3,(H2,6,7,8)
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7.42E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens)
BDBM50170890
PNG
(CHEMBL3806072)
Show SMILES NC(CNC1CCCCC1)P(O)(O)=O
Show InChI InChI=1S/C8H19N2O3P/c9-8(14(11,12)13)6-10-7-4-2-1-3-5-7/h7-8,10H,1-6,9H2,(H2,11,12,13)
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8.19E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50170885
PNG
(CHEMBL3806121)
Show SMILES NCC(N)P(O)(O)=O
Show InChI InChI=1S/C2H9N2O3P/c3-1-2(4)8(5,6)7/h2H,1,3-4H2,(H2,5,6,7)
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1.06E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170893
PNG
(CHEMBL3804843)
Show SMILES NC(CN1CCCCC1)P(O)(O)=O
Show InChI InChI=1S/C7H17N2O3P/c8-7(13(10,11)12)6-9-4-2-1-3-5-9/h7H,1-6,8H2,(H2,10,11,12)
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1.47E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50316049
PNG
(1-amino-3-phenylpropylphosphonic acid | CHEMBL1090...)
Show SMILES NC(CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)
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1.59E+4n/an/an/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of pig kidney microsomal aminopeptidase N


Antimicrob Agents Chemother 52: 3221-8 (2008)


Article DOI: 10.1128/AAC.01327-07
BindingDB Entry DOI: 10.7270/Q2S75GMX
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens)
BDBM50170885
PNG
(CHEMBL3806121)
Show SMILES NCC(N)P(O)(O)=O
Show InChI InChI=1S/C2H9N2O3P/c3-1-2(4)8(5,6)7/h2H,1,3-4H2,(H2,5,6,7)
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1.69E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170885
PNG
(CHEMBL3806121)
Show SMILES NCC(N)P(O)(O)=O
Show InChI InChI=1S/C2H9N2O3P/c3-1-2(4)8(5,6)7/h2H,1,3-4H2,(H2,5,6,7)
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1.90E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50316049
PNG
(1-amino-3-phenylpropylphosphonic acid | CHEMBL1090...)
Show SMILES NC(CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)
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2.69E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170899
PNG
(CHEMBL3806100)
Show SMILES NCCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C4H14N3O3P/c5-1-2-7-3-4(6)11(8,9)10/h4,7H,1-3,5-6H2,(H2,8,9,10)
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3.24E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured f...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50170901
PNG
(CHEMBL3805587)
Show SMILES NC(CN1CCOCC1)P(O)(O)=O
Show InChI InChI=1S/C6H15N2O4P/c7-6(13(9,10)11)5-8-1-3-12-4-2-8/h6H,1-5,7H2,(H2,9,10,11)
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3.77E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50170899
PNG
(CHEMBL3806100)
Show SMILES NCCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C4H14N3O3P/c5-1-2-7-3-4(6)11(8,9)10/h4,7H,1-3,5-6H2,(H2,8,9,10)
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4.11E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170886
PNG
(CHEMBL3804959)
Show SMILES CNCC(N)P(O)(O)=O
Show InChI InChI=1S/C3H11N2O3P/c1-5-2-3(4)9(6,7)8/h3,5H,2,4H2,1H3,(H2,6,7,8)
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4.60E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50025048
PNG
(CHEMBL3355099)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)/t9-/m1/s1
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4.70E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170895
PNG
(CHEMBL3805487)
Show SMILES NC(CNCC1CCCO1)P(O)(O)=O
Show InChI InChI=1S/C7H17N2O4P/c8-7(14(10,11)12)5-9-4-6-2-1-3-13-6/h6-7,9H,1-5,8H2,(H2,10,11,12)
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6.91E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170898
PNG
(CHEMBL3805964)
Show SMILES CN(C)CCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C6H18N3O3P/c1-9(2)4-3-8-5-6(7)13(10,11)12/h6,8H,3-5,7H2,1-2H3,(H2,10,11,12)
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7.26E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170901
PNG
(CHEMBL3805587)
Show SMILES NC(CN1CCOCC1)P(O)(O)=O
Show InChI InChI=1S/C6H15N2O4P/c7-6(13(9,10)11)5-8-1-3-12-4-2-8/h6H,1-5,7H2,(H2,9,10,11)
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9.42E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured f...


Eur J Med Chem 117: 187-96 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.018
BindingDB Entry DOI: 10.7270/Q2BC41F8
More data for this
Ligand-Target Pair
Aminopeptidase B


(Homo sapiens)
BDBM50008427
PNG
(5-Amino-2,7-dimethyl-4-oxo-octanoic acid | CHEMBL3...)
Show SMILES CC(C)C[C@H](N)C(=O)CC(C)C(O)=O
Show InChI InChI=1S/C10H19NO3/c1-6(2)4-8(11)9(12)5-7(3)10(13)14/h6-8H,4-5,11H2,1-3H3,(H,13,14)/t7?,8-/m0/s1
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1.30E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards arginyl aminopeptidase


J Med Chem 35: 451-6 (1992)


Article DOI: 10.1021/jm00081a005
BindingDB Entry DOI: 10.7270/Q2CR5SBH
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50190114
PNG
(CHEMBL288165)
Show SMILES CC(C)C[C@@H](N)P(O)(O)=O
Show InChI InChI=1S/C5H14NO3P/c1-4(2)3-5(6)10(7,8)9/h4-5H,3,6H2,1-2H3,(H2,7,8,9)/t5-/m0/s1
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2.49E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50170885
PNG
(CHEMBL3806121)
Show SMILES NCC(N)P(O)(O)=O
Show InChI InChI=1S/C2H9N2O3P/c3-1-2(4)8(5,6)7/h2H,1,3-4H2,(H2,5,6,7)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ERAP1 using L-AMC as substrate measured for 15 to 30 mins by fluorescence analysis


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50170901
PNG
(CHEMBL3805587)
Show SMILES NC(CN1CCOCC1)P(O)(O)=O
Show InChI InChI=1S/C6H15N2O4P/c7-6(13(9,10)11)5-8-1-3-12-4-2-8/h6H,1-5,7H2,(H2,9,10,11)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50170886
PNG
(CHEMBL3804959)
Show SMILES CNCC(N)P(O)(O)=O
Show InChI InChI=1S/C3H11N2O3P/c1-5-2-3(4)9(6,7)8/h3,5H,2,4H2,1H3,(H2,6,7,8)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ERAP1 using L-AMC as substrate measured for 15 to 30 mins by fluorescence analysis


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50170888
PNG
(CHEMBL3805557)
Show SMILES CCCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C5H15N2O3P/c1-2-3-7-4-5(6)11(8,9)10/h5,7H,2-4,6H2,1H3,(H2,8,9,10)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ERAP1 using L-AMC as substrate measured for 15 to 30 mins by fluorescence analysis


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50170895
PNG
(CHEMBL3805487)
Show SMILES NC(CNCC1CCCO1)P(O)(O)=O
Show InChI InChI=1S/C7H17N2O4P/c8-7(14(10,11)12)5-9-4-6-2-1-3-13-6/h6-7,9H,1-5,8H2,(H2,10,11,12)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50170893
PNG
(CHEMBL3804843)
Show SMILES NC(CN1CCCCC1)P(O)(O)=O
Show InChI InChI=1S/C7H17N2O3P/c8-7(13(10,11)12)6-9-4-2-1-3-5-9/h7H,1-6,8H2,(H2,10,11,12)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50170888
PNG
(CHEMBL3805557)
Show SMILES CCCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C5H15N2O3P/c1-2-3-7-4-5(6)11(8,9)10/h5,7H,2-4,6H2,1H3,(H2,8,9,10)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50170886
PNG
(CHEMBL3804959)
Show SMILES CNCC(N)P(O)(O)=O
Show InChI InChI=1S/C3H11N2O3P/c1-5-2-3(4)9(6,7)8/h3,5H,2,4H2,1H3,(H2,6,7,8)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50170901
PNG
(CHEMBL3805587)
Show SMILES NC(CN1CCOCC1)P(O)(O)=O
Show InChI InChI=1S/C6H15N2O4P/c7-6(13(9,10)11)5-8-1-3-12-4-2-8/h6H,1-5,7H2,(H2,9,10,11)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50170898
PNG
(CHEMBL3805964)
Show SMILES CN(C)CCNCC(N)P(O)(O)=O
Show InChI InChI=1S/C6H18N3O3P/c1-9(2)4-3-8-5-6(7)13(10,11)12/h6,8H,3-5,7H2,1-2H3,(H2,10,11,12)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50190109
PNG
(LEUCINE PHOSPHONIC ACID | Leucine Phosphonic acid)
Show SMILES CC(C)C[C@H](N)P(O)(O)=O
Show InChI InChI=1S/C5H14NO3P/c1-4(2)3-5(6)10(7,8)9/h4-5H,3,6H2,1-2H3,(H2,7,8,9)/t5-/m1/s1
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50170890
PNG
(CHEMBL3806072)
Show SMILES NC(CNC1CCCCC1)P(O)(O)=O
Show InChI InChI=1S/C8H19N2O3P/c9-8(14(11,12)13)6-10-7-4-2-1-3-5-7/h7-8,10H,1-6,9H2,(H2,11,12,13)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ERAP1 using L-AMC as substrate measured for 15 to 30 mins by fluorescence analysis


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50170895
PNG
(CHEMBL3805487)
Show SMILES NC(CNCC1CCCO1)P(O)(O)=O
Show InChI InChI=1S/C7H17N2O4P/c8-7(14(10,11)12)5-9-4-6-2-1-3-13-6/h6-7,9H,1-5,8H2,(H2,10,11,12)
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>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
BindingDB Entry DOI: 10.7270/Q2TT4SW1
More data for this
Ligand-Target Pair
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