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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 201.2
BDBM50008427
Wt: 129.2
BDBM50008429
Purchase
Wt: 216.2
BDBM50017484
Wt: 201.2
BDBM50017473
Wt: 148.2
BDBM50022743
Wt: 147.2
BDBM50022745
Wt: 132.2
BDBM50022746
Purchase
Wt: 133.2
BDBM50022748
Purchase
Wt: 117.1
BDBM50022749
Purchase
Wt: 209.2
BDBM50022750
Wt: 131.2
BDBM50022753
Purchase
Wt: 166.2
BDBM50036829
Wt: 163.2
BDBM50036831
Wt: 148.2
BDBM50036814
Purchase
Wt: 218.2
BDBM50010209
Purchase
Displayed 1 to 15 (of 106 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 39 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase B


(Homo sapiens)
BDBM50036831
PNG
(6-Amino-2-mercapto-hexanoic acid | CHEMBL432852)
Show SMILES NCCCCC(S)C(O)=O
Show InChI InChI=1S/C6H13NO2S/c7-4-2-1-3-5(10)6(8)9/h5,10H,1-4,7H2,(H,8,9)
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0.900n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of arginylaminopeptidase (aminopeptidase B)


J Med Chem 37: 1339-46 (1994)


Article DOI: 10.1021/jm00035a014
BindingDB Entry DOI: 10.7270/Q2K074ZR
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50022743
PNG
(2,6-Diamino-hexane-1-thiol | CHEMBL68509)
Show SMILES NCCCC[C@@H](N)CS
Show InChI InChI=1S/C6H16N2S/c7-4-2-1-3-6(8)5-9/h6,9H,1-5,7-8H2/t6-/m1/s1
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0.910n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase B


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aminopeptidase B


(Homo sapiens)
BDBM50036829
PNG
(2-Mercapto-4-methylsulfanyl-butyric acid | CHEMBL2...)
Show SMILES CSCCC(S)C(O)=O
Show InChI InChI=1S/C5H10O2S2/c1-9-3-2-4(8)5(6)7/h4,8H,2-3H2,1H3,(H,6,7)
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11n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of arginylaminopeptidase (aminopeptidase B)


J Med Chem 37: 1339-46 (1994)


Article DOI: 10.1021/jm00035a014
BindingDB Entry DOI: 10.7270/Q2K074ZR
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50022748
PNG
(2-Amino-4-methyl-pentane-1-thiol | CHEMBL69349)
Show SMILES CC(C)C[C@@H](N)CS
Show InChI InChI=1S/C6H15NS/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m1/s1
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20n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Aminopeptidase M


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aminopeptidase B


(Homo sapiens)
BDBM50036814
PNG
(2-Mercapto-4-methyl-pentanoic acid | CHEMBL27010)
Show SMILES CC(C)CC(S)C(O)=O
Show InChI InChI=1S/C6H12O2S/c1-4(2)3-5(9)6(7)8/h4-5,9H,3H2,1-2H3,(H,7,8)
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51n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of arginylaminopeptidase (aminopeptidase B)


J Med Chem 37: 1339-46 (1994)


Article DOI: 10.1021/jm00035a014
BindingDB Entry DOI: 10.7270/Q2K074ZR
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50022743
PNG
(2,6-Diamino-hexane-1-thiol | CHEMBL68509)
Show SMILES NCCCC[C@@H](N)CS
Show InChI InChI=1S/C6H16N2S/c7-4-2-1-3-6(8)5-9/h6,9H,1-5,7-8H2/t6-/m1/s1
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110n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Aminopeptidase M


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50022748
PNG
(2-Amino-4-methyl-pentane-1-thiol | CHEMBL69349)
Show SMILES CC(C)C[C@@H](N)CS
Show InChI InChI=1S/C6H15NS/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m1/s1
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130n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase B


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50017484
PNG
(5,9-Diamino-2-methyl-4-oxo-nonanoic acid | CHEMBL2...)
Show SMILES CC(CC(=O)[C@@H](N)CCCCN)C(O)=O
Show InChI InChI=1S/C10H20N2O3/c1-7(10(14)15)6-9(13)8(12)4-2-3-5-11/h7-8H,2-6,11-12H2,1H3,(H,14,15)/t7?,8-/m0/s1
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2.00E+3n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Competitive inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50022745
PNG
(3-Amino-5-methyl-hexane-2-thiol | CHEMBL69814)
Show SMILES CC(C)C[C@H](N)C(C)S
Show InChI InChI=1S/C7H17NS/c1-5(2)4-7(8)6(3)9/h5-7,9H,4,8H2,1-3H3/t6?,7-/m0/s1
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6.00E+3n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Aminopeptidase M


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50022745
PNG
(3-Amino-5-methyl-hexane-2-thiol | CHEMBL69814)
Show SMILES CC(C)C[C@H](N)C(C)S
Show InChI InChI=1S/C7H17NS/c1-5(2)4-7(8)6(3)9/h5-7,9H,4,8H2,1-3H3/t6?,7-/m0/s1
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7.00E+3n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase B


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50022750
PNG
(3-Amino-2-hydroxy-4-phenyl-butyric acid methyl est...)
Show SMILES COC(=O)C(O)[C@H](N)Cc1ccccc1
Show InChI InChI=1S/C11H15NO3/c1-15-11(14)10(13)9(12)7-8-5-3-2-4-6-8/h2-6,9-10,13H,7,12H2,1H3/t9-,10?/m1/s1
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3.30E+4n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50022746
PNG
(2,6-Diamino-hexan-1-ol | CHEMBL69146)
Show SMILES NCCCC[C@@H](N)CO
Show InChI InChI=1S/C6H16N2O/c7-4-2-1-3-6(8)5-9/h6,9H,1-5,7-8H2/t6-/m1/s1
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1.00E+5n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase B


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aminopeptidase B


(Homo sapiens)
BDBM50008427
PNG
(5-Amino-2,7-dimethyl-4-oxo-octanoic acid | CHEMBL3...)
Show SMILES CC(C)C[C@H](N)C(=O)CC(C)C(O)=O
Show InChI InChI=1S/C10H19NO3/c1-6(2)4-8(11)9(12)5-7(3)10(13)14/h6-8H,4-5,11H2,1-3H3,(H,13,14)/t7?,8-/m0/s1
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1.30E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards arginyl aminopeptidase


J Med Chem 35: 451-6 (1992)


Article DOI: 10.1021/jm00081a005
BindingDB Entry DOI: 10.7270/Q2CR5SBH
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50017473
PNG
(5-Amino-2,7-dimethyl-4-oxo-octanoic acid | CHEMBL2...)
Show SMILES CC(C)CC(N)C(=O)CC(C)C(O)=O
Show InChI InChI=1S/C10H19NO3/c1-6(2)4-8(11)9(12)5-7(3)10(13)14/h6-8H,4-5,11H2,1-3H3,(H,13,14)
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1.30E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Competitive inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50022753
PNG
(3-Amino-5-methyl-hexan-2-ol | CHEMBL68511)
Show SMILES CC(C)C[C@H](N)C(C)O
Show InChI InChI=1S/C7H17NO/c1-5(2)4-7(8)6(3)9/h5-7,9H,4,8H2,1-3H3/t6?,7-/m0/s1
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>2.00E+5n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase B


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50022753
PNG
(3-Amino-5-methyl-hexan-2-ol | CHEMBL68511)
Show SMILES CC(C)C[C@H](N)C(C)O
Show InChI InChI=1S/C7H17NO/c1-5(2)4-7(8)6(3)9/h5-7,9H,4,8H2,1-3H3/t6?,7-/m0/s1
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PubMed
3.55E+5n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Aminopeptidase M


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50008429
PNG
((3S)-3-amino-5-methylhexan-2-one | 3-Amino-5-methy...)
Show SMILES CC(C)C[C@H](N)C(C)=O
Show InChI InChI=1S/C7H15NO/c1-5(2)4-7(8)6(3)9/h5,7H,4,8H2,1-3H3/t7-/m0/s1
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4.30E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards microsomal aminopeptidase


J Med Chem 35: 451-6 (1992)


Article DOI: 10.1021/jm00081a005
BindingDB Entry DOI: 10.7270/Q2CR5SBH
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50022748
PNG
(2-Amino-4-methyl-pentane-1-thiol | CHEMBL69349)
Show SMILES CC(C)C[C@@H](N)CS
Show InChI InChI=1S/C6H15NS/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m1/s1
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4.50E+5n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50022745
PNG
(3-Amino-5-methyl-hexane-2-thiol | CHEMBL69814)
Show SMILES CC(C)C[C@H](N)C(C)S
Show InChI InChI=1S/C7H17NS/c1-5(2)4-7(8)6(3)9/h5-7,9H,4,8H2,1-3H3/t6?,7-/m0/s1
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>5.00E+5n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50022753
PNG
(3-Amino-5-methyl-hexan-2-ol | CHEMBL68511)
Show SMILES CC(C)C[C@H](N)C(C)O
Show InChI InChI=1S/C7H17NO/c1-5(2)4-7(8)6(3)9/h5-7,9H,4,8H2,1-3H3/t6?,7-/m0/s1
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5.07E+5n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aspartyl aminopeptidase


(Homo sapiens)
BDBM50008429
PNG
((3S)-3-amino-5-methylhexan-2-one | 3-Amino-5-methy...)
Show SMILES CC(C)C[C@H](N)C(C)=O
Show InChI InChI=1S/C7H15NO/c1-5(2)4-7(8)6(3)9/h5,7H,4,8H2,1-3H3/t7-/m0/s1
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>6.00E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards Cytosolic aminopeptidase


J Med Chem 35: 451-6 (1992)


Article DOI: 10.1021/jm00081a005
BindingDB Entry DOI: 10.7270/Q2CR5SBH
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens)
BDBM50008427
PNG
(5-Amino-2,7-dimethyl-4-oxo-octanoic acid | CHEMBL3...)
Show SMILES CC(C)C[C@H](N)C(=O)CC(C)C(O)=O
Show InChI InChI=1S/C10H19NO3/c1-6(2)4-8(11)9(12)5-7(3)10(13)14/h6-8H,4-5,11H2,1-3H3,(H,13,14)/t7?,8-/m0/s1
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6.60E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards microsomal aminopeptidase; Kii was reported


J Med Chem 35: 451-6 (1992)


Article DOI: 10.1021/jm00081a005
BindingDB Entry DOI: 10.7270/Q2CR5SBH
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50017473
PNG
(5-Amino-2,7-dimethyl-4-oxo-octanoic acid | CHEMBL2...)
Show SMILES CC(C)CC(N)C(=O)CC(C)C(O)=O
Show InChI InChI=1S/C10H19NO3/c1-6(2)4-8(11)9(12)5-7(3)10(13)14/h6-8H,4-5,11H2,1-3H3,(H,13,14)
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6.60E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Non-competitive inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50017473
PNG
(5-Amino-2,7-dimethyl-4-oxo-octanoic acid | CHEMBL2...)
Show SMILES CC(C)CC(N)C(=O)CC(C)C(O)=O
Show InChI InChI=1S/C10H19NO3/c1-6(2)4-8(11)9(12)5-7(3)10(13)14/h6-8H,4-5,11H2,1-3H3,(H,13,14)
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9.40E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Non-competitive inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the intercept effect(Kii)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50008427
PNG
(5-Amino-2,7-dimethyl-4-oxo-octanoic acid | CHEMBL3...)
Show SMILES CC(C)C[C@H](N)C(=O)CC(C)C(O)=O
Show InChI InChI=1S/C10H19NO3/c1-6(2)4-8(11)9(12)5-7(3)10(13)14/h6-8H,4-5,11H2,1-3H3,(H,13,14)/t7?,8-/m0/s1
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9.40E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards microsomal aminopeptidase; Kii was reported


J Med Chem 35: 451-6 (1992)


Article DOI: 10.1021/jm00081a005
BindingDB Entry DOI: 10.7270/Q2CR5SBH
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50022749
PNG
(2-Amino-4-methyl-pentan-1-ol | CHEMBL71171 | D-Leu...)
Show SMILES CC(C)C[C@@H](N)CO
Show InChI InChI=1S/C6H15NO/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m1/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50022750
PNG
(3-Amino-2-hydroxy-4-phenyl-butyric acid methyl est...)
Show SMILES COC(=O)C(O)[C@H](N)Cc1ccccc1
Show InChI InChI=1S/C11H15NO3/c1-15-11(14)10(13)9(12)7-8-5-3-2-4-6-8/h2-6,9-10,13H,7,12H2,1H3/t9-,10?/m1/s1
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1.00E+6n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Aminopeptidase M


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50022749
PNG
(2-Amino-4-methyl-pentan-1-ol | CHEMBL71171 | D-Leu...)
Show SMILES CC(C)C[C@@H](N)CO
Show InChI InChI=1S/C6H15NO/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m1/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Aminopeptidase M


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50022750
PNG
(3-Amino-2-hydroxy-4-phenyl-butyric acid methyl est...)
Show SMILES COC(=O)C(O)[C@H](N)Cc1ccccc1
Show InChI InChI=1S/C11H15NO3/c1-15-11(14)10(13)9(12)7-8-5-3-2-4-6-8/h2-6,9-10,13H,7,12H2,1H3/t9-,10?/m1/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase B


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Aminopeptidase B


(Homo sapiens)
BDBM50008429
PNG
((3S)-3-amino-5-methylhexan-2-one | 3-Amino-5-methy...)
Show SMILES CC(C)C[C@H](N)C(C)=O
Show InChI InChI=1S/C7H15NO/c1-5(2)4-7(8)6(3)9/h5,7H,4,8H2,1-3H3/t7-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards arginyl aminopeptidase


J Med Chem 35: 451-6 (1992)


Article DOI: 10.1021/jm00081a005
BindingDB Entry DOI: 10.7270/Q2CR5SBH
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50022749
PNG
(2-Amino-4-methyl-pentan-1-ol | CHEMBL71171 | D-Leu...)
Show SMILES CC(C)C[C@@H](N)CO
Show InChI InChI=1S/C6H15NO/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m1/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase B


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50022743
PNG
(2,6-Diamino-hexane-1-thiol | CHEMBL68509)
Show SMILES NCCCC[C@@H](N)CS
Show InChI InChI=1S/C6H16N2S/c7-4-2-1-3-6(8)5-9/h6,9H,1-5,7-8H2/t6-/m1/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)


Article DOI: 10.1021/jm00119a022
BindingDB Entry DOI: 10.7270/Q2Z038RM
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50017473
PNG
(5-Amino-2,7-dimethyl-4-oxo-octanoic acid | CHEMBL2...)
Show SMILES CC(C)CC(N)C(=O)CC(C)C(O)=O
Show InChI InChI=1S/C10H19NO3/c1-6(2)4-8(11)9(12)5-7(3)10(13)14/h6-8H,4-5,11H2,1-3H3,(H,13,14)
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1.10E+6n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Competitive inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Aspartyl aminopeptidase


(Homo sapiens)
BDBM50008427
PNG
(5-Amino-2,7-dimethyl-4-oxo-octanoic acid | CHEMBL3...)
Show SMILES CC(C)C[C@H](N)C(=O)CC(C)C(O)=O
Show InChI InChI=1S/C10H19NO3/c1-6(2)4-8(11)9(12)5-7(3)10(13)14/h6-8H,4-5,11H2,1-3H3,(H,13,14)/t7?,8-/m0/s1
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1.10E+6n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards cytosolic aminopeptidase


J Med Chem 35: 451-6 (1992)


Article DOI: 10.1021/jm00081a005
BindingDB Entry DOI: 10.7270/Q2CR5SBH
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50010209
PNG
(CHEMBL3251694 | L-Isoseryl-L-leucine hydrochloride...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)CN)C(O)=O
Show InChI InChI=1S/C9H18N2O4/c1-5(2)3-6(9(14)15)11-8(13)7(12)4-10/h5-7,12H,3-4,10H2,1-2H3,(H,11,13)(H,14,15)/t6-,7-/m0/s1
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n/an/a 1.99E+5n/an/an/an/an/an/a



Shan Dong University



Assay Description
The samples and positive controls were serial diluted to various concentrations: 1280 μg/mL, 320 μg/mL, 80 μg/mL, and 20 μg/mL, 5...


J Enzyme Inhib Med Chem 27: 302-10 (2012)


Article DOI: 10.3109/14756361003698147
BindingDB Entry DOI: 10.7270/Q2R21083
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50017484
PNG
(5,9-Diamino-2-methyl-4-oxo-nonanoic acid | CHEMBL2...)
Show SMILES CC(CC(=O)[C@@H](N)CCCCN)C(O)=O
Show InChI InChI=1S/C10H20N2O3/c1-7(10(14)15)6-9(13)8(12)4-2-3-5-11/h7-8H,2-6,11-12H2,1H3,(H,14,15)/t7?,8-/m0/s1
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n/an/a>2.00E+5n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50010209
PNG
(CHEMBL3251694 | L-Isoseryl-L-leucine hydrochloride...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)CN)C(O)=O
Show InChI InChI=1S/C9H18N2O4/c1-5(2)3-6(9(14)15)11-8(13)7(12)4-10/h5-7,12H,3-4,10H2,1-2H3,(H,11,13)(H,14,15)/t6-,7-/m0/s1
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n/an/a 3.64E+5n/an/an/an/a8.525



Shan Dong University



Assay Description
The compound samples were assayed for inhibitory activity against MMP-2 in 96-well microplates using succinylated gelatin as the substrate. The compo...


J Enzyme Inhib Med Chem 27: 302-10 (2012)


Article DOI: 10.3109/14756361003698147
BindingDB Entry DOI: 10.7270/Q2R21083
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50010209
PNG
(CHEMBL3251694 | L-Isoseryl-L-leucine hydrochloride...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)CN)C(O)=O
Show InChI InChI=1S/C9H18N2O4/c1-5(2)3-6(9(14)15)11-8(13)7(12)4-10/h5-7,12H,3-4,10H2,1-2H3,(H,11,13)(H,14,15)/t6-,7-/m0/s1
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n/an/a 6.40E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of rat liver aminopeptidase B using 0.2 mM L-leucine-beta-naphthylamide by colorimetry


J Med Chem 20: 510-5 (1977)


Article DOI: 10.1021/jm00214a010
BindingDB Entry DOI: 10.7270/Q29W0H11
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50017484
PNG
(5,9-Diamino-2-methyl-4-oxo-nonanoic acid | CHEMBL2...)
Show SMILES CC(CC(=O)[C@@H](N)CCCCN)C(O)=O
Show InChI InChI=1S/C10H20N2O3/c1-7(10(14)15)6-9(13)8(12)4-2-3-5-11/h7-8H,2-6,11-12H2,1H3,(H,14,15)/t7?,8-/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair