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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 189.0
BDBM50350309
Wt: 174.9
BDBM50350311
Purchase
Wt: 174.9
BDBM50427901
Purchase
Wt: 204.0
BDBM50431953
Wt: 219.0
BDBM50431957
Wt: 205.0
BDBM50431958
Wt: 217.0
BDBM50431960
Wt: 203.0
BDBM50431961
Wt: 215.0
BDBM290365
Wt: 215.0
BDBM290366
Wt: 217.0
BDBM290367
Wt: 217.0
BDBM290368
Wt: 216.0
BDBM290372
Wt: 216.0
BDBM290373
Wt: 216.0
BDBM290374
Displayed 1 to 15 (of 110 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 41 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
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8.5n/an/an/an/an/an/an/an/a



Drexel University

Curated by ChEMBL


Assay Description
Binding affinity to human arginase 2


J Med Chem 54: 5432-43 (2011)


Article DOI: 10.1021/jm200443b
BindingDB Entry DOI: 10.7270/Q2TH8N21
More data for this
Ligand-Target Pair
Arginase


(Plasmodium falciparum)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
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1.00E+4n/an/an/an/an/an/an/an/a



Drexel University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum arginase using L-arginine as substrate by colorimetric assay


J Med Chem 54: 5432-43 (2011)


Article DOI: 10.1021/jm200443b
BindingDB Entry DOI: 10.7270/Q2TH8N21
More data for this
Ligand-Target Pair
Arginase


(Plasmodium falciparum)
BDBM50350309
PNG
(CHEMBL1812662)
Show SMILES CC([NH3+])(CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C7H16BNO4/c1-7(9,6(10)11)4-2-3-5-8(12)13/h12-13H,2-5,9H2,1H3,(H,10,11)
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2.60E+5n/an/an/an/an/an/an/an/a



Drexel University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum arginase using L-arginine as substrate by colorimetric assay


J Med Chem 54: 5432-43 (2011)


Article DOI: 10.1021/jm200443b
BindingDB Entry DOI: 10.7270/Q2TH8N21
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290368
PNG
((2S,3S)-3-amino-2-(3-boronopropyl)tetrahydrofuran-...)
Show SMILES N[C@]1(CCO[C@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H16BNO5/c10-8(7(11)12)3-5-15-6(8)2-1-4-9(13)14/h6,13-14H,1-5,10H2,(H,11,12)/t6-,8-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290368
PNG
((2S,3S)-3-amino-2-(3-boronopropyl)tetrahydrofuran-...)
Show SMILES N[C@]1(CCO[C@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H16BNO5/c10-8(7(11)12)3-5-15-6(8)2-1-4-9(13)14/h6,13-14H,1-5,10H2,(H,11,12)/t6-,8-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290372
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-ca...)
Show SMILES N[C@]1(CNC[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H17BN2O4/c10-8(7(12)13)5-11-4-6(8)2-1-3-9(14)15/h6,11,14-15H,1-5,10H2,(H,12,13)/t6-,8-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290372
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-ca...)
Show SMILES N[C@]1(CNC[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H17BN2O4/c10-8(7(12)13)5-11-4-6(8)2-1-3-9(14)15/h6,11,14-15H,1-5,10H2,(H,12,13)/t6-,8-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290365
PNG
((1S,2S)-1-amino-2-(3-boronopropyl)cyclopentanecarb...)
Show SMILES N[C@]1(CCC[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C9H18BNO4/c11-9(8(12)13)5-1-3-7(9)4-2-6-10(14)15/h7,14-15H,1-6,11H2,(H,12,13)/t7-,9+/m1/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290365
PNG
((1S,2S)-1-amino-2-(3-boronopropyl)cyclopentanecarb...)
Show SMILES N[C@]1(CCC[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C9H18BNO4/c11-9(8(12)13)5-1-3-7(9)4-2-6-10(14)15/h7,14-15H,1-6,11H2,(H,12,13)/t7-,9+/m1/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg1


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431953
PNG
(CHEMBL2348490)
Show SMILES NCC(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C7H17BN2O4/c9-5-7(10,6(11)12)3-1-2-4-8(13)14/h13-14H,1-5,9-10H2,(H,11,12)
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n/an/a 1.35E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50427901
PNG
(CHEMBL2326088)
Show SMILES N[C@H](CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m1/s1
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n/an/a 1.45E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
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n/an/a 1.45E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length Arg1 using L-arginine as substrate assessed as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
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n/an/a 1.47E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290373
PNG
((3R,4R)-3-amino-4-(3-boronopropyl)pyrrolidine-3-ca...)
Show SMILES N[C@]1(CNC[C@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H17BN2O4/c10-8(7(12)13)5-11-4-6(8)2-1-3-9(14)15/h6,11,14-15H,1-5,10H2,(H,12,13)/t6-,8+/m1/s1
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n/an/a 1.50E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290373
PNG
((3R,4R)-3-amino-4-(3-boronopropyl)pyrrolidine-3-ca...)
Show SMILES N[C@]1(CNC[C@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H17BN2O4/c10-8(7(12)13)5-11-4-6(8)2-1-3-9(14)15/h6,11,14-15H,1-5,10H2,(H,12,13)/t6-,8+/m1/s1
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n/an/a 1.50E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290367
PNG
((2R,3S)-3-amino-2-(3-boronopropyl)tetrahydrofuran-...)
Show SMILES N[C@]1(CCO[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H16BNO5/c10-8(7(11)12)3-5-15-6(8)2-1-4-9(13)14/h6,13-14H,1-5,10H2,(H,11,12)/t6-,8+/m1/s1
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n/an/a 1.50E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427901
PNG
(CHEMBL2326088)
Show SMILES N[C@H](CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m1/s1
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n/an/a 1.92E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
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n/an/a 1.92E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50431953
PNG
(CHEMBL2348490)
Show SMILES NCC(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C7H17BN2O4/c9-5-7(10,6(11)12)3-1-2-4-8(13)14/h13-14H,1-5,9-10H2,(H,11,12)
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n/an/a 2.07E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length Arg1 using L-arginine as substrate assessed as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
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n/an/a 2.15E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50431958
PNG
(CHEMBL2348496)
Show SMILES NC(CO)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C7H16BNO5/c9-7(5-10,6(11)12)3-1-2-4-8(13)14/h10,13-14H,1-5,9H2,(H,11,12)
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n/an/a 2.25E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length Arg1 using L-arginine as substrate assessed as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50350309
PNG
(CHEMBL1812662)
Show SMILES CC([NH3+])(CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C7H16BNO4/c1-7(9,6(10)11)4-2-3-5-8(12)13/h12-13H,2-5,9H2,1H3,(H,10,11)
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n/an/a 3.43E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length Arg1 using L-arginine as substrate assessed as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290367
PNG
((2R,3S)-3-amino-2-(3-boronopropyl)tetrahydrofuran-...)
Show SMILES N[C@]1(CCO[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H16BNO5/c10-8(7(11)12)3-5-15-6(8)2-1-4-9(13)14/h6,13-14H,1-5,10H2,(H,11,12)/t6-,8+/m1/s1
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n/an/a 3.50E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50431961
PNG
(CHEMBL2348498)
Show SMILES CCC(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H18BNO4/c1-2-8(10,7(11)12)5-3-4-6-9(13)14/h13-14H,2-6,10H2,1H3,(H,11,12)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length Arg1 using L-arginine as substrate assessed as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431958
PNG
(CHEMBL2348496)
Show SMILES NC(CO)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C7H16BNO5/c9-7(5-10,6(11)12)3-1-2-4-8(13)14/h10,13-14H,1-5,9H2,(H,11,12)
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n/an/a 4.28E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431961
PNG
(CHEMBL2348498)
Show SMILES CCC(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H18BNO4/c1-2-8(10,7(11)12)5-3-4-6-9(13)14/h13-14H,2-6,10H2,1H3,(H,11,12)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290366
PNG
((1S,2R)-1-amino-2-(3-boronopropyl)cyclopentanecarb...)
Show SMILES N[C@]1(CCC[C@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C9H18BNO4/c11-9(8(12)13)5-1-3-7(9)4-2-6-10(14)15/h7,14-15H,1-6,11H2,(H,12,13)/t7-,9-/m0/s1
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n/an/a>5.00E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290374
PNG
((2R,3S)-3-amino-2-(3-boronopropyl)pyrrolidine-3-ca...)
Show SMILES N[C@]1(CCN[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H17BN2O4/c10-8(7(12)13)3-5-11-6(8)2-1-4-9(14)15/h6,11,14-15H,1-5,10H2,(H,12,13)/t6-,8+/m1/s1
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n/an/a>5.00E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290374
PNG
((2R,3S)-3-amino-2-(3-boronopropyl)pyrrolidine-3-ca...)
Show SMILES N[C@]1(CCN[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H17BN2O4/c10-8(7(12)13)3-5-11-6(8)2-1-4-9(14)15/h6,11,14-15H,1-5,10H2,(H,12,13)/t6-,8+/m1/s1
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n/an/a>5.00E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290366
PNG
((1S,2R)-1-amino-2-(3-boronopropyl)cyclopentanecarb...)
Show SMILES N[C@]1(CCC[C@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C9H18BNO4/c11-9(8(12)13)5-1-3-7(9)4-2-6-10(14)15/h7,14-15H,1-6,11H2,(H,12,13)/t7-,9-/m0/s1
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n/an/a>5.00E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50350309
PNG
(CHEMBL1812662)
Show SMILES CC([NH3+])(CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C7H16BNO4/c1-7(9,6(10)11)4-2-3-5-8(12)13/h12-13H,2-5,9H2,1H3,(H,10,11)
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n/an/a 5.07E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50427901
PNG
(CHEMBL2326088)
Show SMILES N[C@H](CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human arginase 1 transfected in CHO cells assessed as inhibition of urea formation after 24 hrs by spectrophotometric analysis


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50431960
PNG
(CHEMBL2348499)
Show SMILES CC(C)C(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C9H20BNO4/c1-7(2)9(11,8(12)13)5-3-4-6-10(14)15/h7,14-15H,3-6,11H2,1-2H3,(H,12,13)
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n/an/a 1.12E+4n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length Arg1 using L-arginine as substrate assessed as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431960
PNG
(CHEMBL2348499)
Show SMILES CC(C)C(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C9H20BNO4/c1-7(2)9(11,8(12)13)5-3-4-6-10(14)15/h7,14-15H,3-6,11H2,1-2H3,(H,12,13)
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n/an/a 1.55E+4n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50431957
PNG
(CHEMBL2348494)
Show SMILES NC(CCO)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H18BNO5/c10-8(4-6-11,7(12)13)3-1-2-5-9(14)15/h11,14-15H,1-6,10H2,(H,12,13)
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n/an/a 1.90E+4n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length Arg1 using L-arginine as substrate assessed as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50431957
PNG
(CHEMBL2348494)
Show SMILES NC(CCO)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H18BNO5/c10-8(4-6-11,7(12)13)3-1-2-5-9(14)15/h11,14-15H,1-6,10H2,(H,12,13)
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n/an/a 5.70E+4n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
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n/an/an/a 18n/an/an/an/an/a



Drexel University

Curated by ChEMBL


Assay Description
Binding affinity to human arginase 1 using L-arginine as substrate by surface plasmon resonance assay


J Med Chem 54: 5432-43 (2011)


Article DOI: 10.1021/jm200443b
BindingDB Entry DOI: 10.7270/Q2TH8N21
More data for this
Ligand-Target Pair
Arginase


(Plasmodium falciparum)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
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n/an/an/a 1.10E+4n/an/an/an/an/a



Drexel University

Curated by ChEMBL


Assay Description
Binding affinity to Plasmodium falciparum arginase


J Med Chem 54: 5432-43 (2011)


Article DOI: 10.1021/jm200443b
BindingDB Entry DOI: 10.7270/Q2TH8N21
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
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n/an/an/a 5n/an/an/an/an/a



Drexel University

Curated by ChEMBL


Assay Description
Binding affinity to human arginase 1


J Med Chem 54: 5432-43 (2011)


Article DOI: 10.1021/jm200443b
BindingDB Entry DOI: 10.7270/Q2TH8N21
More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM50350309
PNG
(CHEMBL1812662)
Show SMILES CC([NH3+])(CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C7H16BNO4/c1-7(9,6(10)11)4-2-3-5-8(12)13/h12-13H,2-5,9H2,1H3,(H,10,11)
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n/an/an/a 880n/an/an/an/an/a



Drexel University

Curated by ChEMBL


Assay Description
Binding affinity to human arginase 1 using L-arginine as substrate by surface plasmon resonance assay


J Med Chem 54: 5432-43 (2011)


Article DOI: 10.1021/jm200443b
BindingDB Entry DOI: 10.7270/Q2TH8N21
More data for this
Ligand-Target Pair