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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 348.3
BDBM25524
Purchase
Wt: 332.3
BDBM25525
Purchase
Wt: 229.7
BDBM50017565
Wt: 307.7
BDBM50017568
Wt: 303.7
BDBM50017570
Wt: 319.7
BDBM50017571
Wt: 277.7
BDBM50017573
Wt: 273.7
BDBM50017575
Wt: 289.7
BDBM50017576
Wt: 324.2
BDBM50017569
Wt: 259.7
BDBM50017572
Wt: 294.1
BDBM50017574
Wt: 275.7
BDBM50017577
Wt: 348.3
BDBM50017566
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Wt: 289.7
BDBM50017567

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 36 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetylcholinesterase


(Homo sapiens (human))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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320n/an/an/an/an/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Competitive inhibition of human AChE using acetyl thiocholine iodide as substrate by Lineweaver-Burk double-reciprocal analysis


Bioorg Med Chem 20: 6669-79 (2012)


Article DOI: 10.1016/j.bmc.2012.09.040
BindingDB Entry DOI: 10.7270/Q2ZG6TBT
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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480n/an/an/an/an/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Competitive inhibition of electric eel AChE using acetyl thiocholine iodide as substrate by Lineweaver-Burk double-reciprocal analysis


Bioorg Med Chem 20: 6669-79 (2012)


Article DOI: 10.1016/j.bmc.2012.09.040
BindingDB Entry DOI: 10.7270/Q2ZG6TBT
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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660n/an/an/an/an/an/an/an/a



Temple University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 316: 869-74 (2006)


Article DOI: 10.1124/jpet.105.097303
BindingDB Entry DOI: 10.7270/Q2PN9464
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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920n/an/an/an/an/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Uncompetitive inhibition of electric eel AChE using acetyl thiocholine iodide as substrate by Lineweaver-Burk double-reciprocal analysis


Bioorg Med Chem 20: 6669-79 (2012)


Article DOI: 10.1016/j.bmc.2012.09.040
BindingDB Entry DOI: 10.7270/Q2ZG6TBT
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (human))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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1.12E+3n/an/an/an/an/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Uncompetitive inhibition of human AChE using acetyl thiocholine iodide as substrate by Lineweaver-Burk double-reciprocal analysis


Bioorg Med Chem 20: 6669-79 (2012)


Article DOI: 10.1016/j.bmc.2012.09.040
BindingDB Entry DOI: 10.7270/Q2ZG6TBT
More data for this
Ligand-Target Pair
BCL-W


(Homo sapiens (Human))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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1.06E+5n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of Flu-Bak peptide from recombinant antiapoptopic Bcl-w protein by fluorescence polarization assay


Bioorg Med Chem 15: 2167-76 (2007)


Article DOI: 10.1016/j.bmc.2006.12.020
BindingDB Entry DOI: 10.7270/Q28W3F4C
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (human))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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1.71E+5n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Displacement of Flu-Bak peptide from recombinant antiapoptopic Bcl2 protein by fluorescence polarization assay


Bioorg Med Chem 15: 2167-76 (2007)


Article DOI: 10.1016/j.bmc.2006.12.020
BindingDB Entry DOI: 10.7270/Q28W3F4C
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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n/an/a 24n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon


Proc Natl Acad Sci USA 104: 20523-8 (2007)

Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (human))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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n/an/a 1.54E+3n/an/an/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Inhibition of human AChE by Ellman's method


Bioorg Med Chem 20: 6669-79 (2012)


Article DOI: 10.1016/j.bmc.2012.09.040
BindingDB Entry DOI: 10.7270/Q2ZG6TBT
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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n/an/a 3.78E+3n/an/an/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE by Ellman's method


Bioorg Med Chem 20: 6669-79 (2012)


Article DOI: 10.1016/j.bmc.2012.09.040
BindingDB Entry DOI: 10.7270/Q2ZG6TBT
More data for this
Ligand-Target Pair
Butyrylcholinesterase (BuChE)


(Equus caballus (Horse))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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n/an/a 6.33E+3n/an/an/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Inhibition of horse BChE by Ellman's method


Bioorg Med Chem 20: 6669-79 (2012)


Article DOI: 10.1016/j.bmc.2012.09.040
BindingDB Entry DOI: 10.7270/Q2ZG6TBT
More data for this
Ligand-Target Pair
Cholinesterase


(Homo sapiens (human))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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n/an/a 1.03E+4n/an/an/an/an/an/a



Abo Akademi University

Curated by ChEMBL


Assay Description
Inhibition of human BChE by Ellman's method


Bioorg Med Chem 20: 6669-79 (2012)


Article DOI: 10.1016/j.bmc.2012.09.040
BindingDB Entry DOI: 10.7270/Q2ZG6TBT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25525
PNG
(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Show SMILES C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12
Show InChI InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1
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n/an/a 1.90E+4n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Chain E, Fragment Double-D From Human Fibrin


(Homo sapiens)
BDBM25525
PNG
(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Show SMILES C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12
Show InChI InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1
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n/an/a 2.42E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: Harvard Medical School/Massachuset...


PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2VX0F59
More data for this
Ligand-Target Pair
Cell division control protein 42 homolog


(Homo sapiens)
BDBM25525
PNG
(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Show SMILES C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12
Show InChI InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1
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n/an/a 3.20E+4n/an/an/an/an/an/a



Exonhit Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assay


Bioorg Med Chem Lett 19: 5594-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.037
BindingDB Entry DOI: 10.7270/Q27P8ZF4
More data for this
Ligand-Target Pair
Group III secretory phopholipase A2


(Homo sapiens)
BDBM25525
PNG
(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Show SMILES C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12
Show InChI InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1
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n/an/a 5.18E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...


PubChem Bioassay (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GCW
More data for this
Ligand-Target Pair
Ras-related C3 botulinum toxin substrate 1/T-lymphoma invasion and metastasis-inducing protein 1


(Homo sapiens)
BDBM25525
PNG
(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Show SMILES C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12
Show InChI InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1
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n/an/a 5.80E+4n/an/an/an/an/an/a



Exonhit Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assay


Bioorg Med Chem Lett 19: 5594-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.037
BindingDB Entry DOI: 10.7270/Q27P8ZF4
More data for this
Ligand-Target Pair
Chain E, Fragment Double-D From Human Fibrin


(Homo sapiens)
BDBM25525
PNG
(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Show SMILES C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12
Show InChI InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1
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n/an/a 8.31E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: Harvard Medical School/Massachuset...


PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2R49PFB
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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n/an/a 1.00E+5n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Ras-related C3 botulinum toxin substrate 1/T-lymphoma invasion and metastasis-inducing protein 1


(Homo sapiens)
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Exonhit Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assay


Bioorg Med Chem Lett 19: 5594-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.037
BindingDB Entry DOI: 10.7270/Q27P8ZF4
More data for this
Ligand-Target Pair
Cell division control protein 42 homolog


(Homo sapiens)
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Exonhit Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assay


Bioorg Med Chem Lett 19: 5594-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.037
BindingDB Entry DOI: 10.7270/Q27P8ZF4
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM50017577
PNG
(CHEMBL2323160)
Show SMILES [Cl-].COc1ccc2c(c1)c[n+](C)c1ccc(O)cc21
Show InChI InChI=1S/C15H13NO2.ClH/c1-16-9-10-7-12(18-2)4-5-13(10)14-8-11(17)3-6-15(14)16;/h3-9H,1-2H3;1H
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n/an/a 1.20E+5n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM50017576
PNG
(CHEMBL2323151)
Show SMILES [Cl-].COc1ccc2c(c1)c[n+](C)c1ccc(OC)cc21
Show InChI InChI=1S/C16H16NO2.ClH/c1-17-10-11-8-12(18-2)4-6-14(11)15-9-13(19-3)5-7-16(15)17;/h4-10H,1-3H3;1H/q+1;/p-1
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n/an/a 1.90E+5n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM25525
PNG
(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Show SMILES C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12
Show InChI InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1
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n/an/a 2.00E+5n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM50017565
PNG
(CHEMBL3288322)
Show SMILES [Cl-].C[n+]1cc2ccccc2c2ccccc12
Show InChI InChI=1S/C14H12N.ClH/c1-15-10-11-6-2-3-7-12(11)13-8-4-5-9-14(13)15;/h2-10H,1H3;1H/q+1;/p-1
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n/an/a 4.00E+5n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM50017573
PNG
(CHEMBL3288327)
Show SMILES [Cl-].COc1ccc2c(c1)c[n+](C)c1ccc(F)cc21
Show InChI InChI=1S/C15H13FNO.ClH/c1-17-9-10-7-12(18-2)4-5-13(10)14-8-11(16)3-6-15(14)17;/h3-9H,1-2H3;1H/q+1;/p-1
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n/an/a 5.70E+5n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM50017575
PNG
(CHEMBL3288329)
Show SMILES [Cl-].COc1ccc2c(c1)c[n+](C)c1ccc(C)cc21
Show InChI InChI=1S/C16H16NO.ClH/c1-11-4-7-16-15(8-11)14-6-5-13(18-3)9-12(14)10-17(16)2;/h4-10H,1-3H3;1H/q+1;/p-1
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n/an/a 6.00E+5n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM50017574
PNG
(CHEMBL3288328)
Show SMILES [Cl-].COc1ccc2c(c1)c[n+](C)c1ccc(Cl)cc21
Show InChI InChI=1S/C15H13ClNO.ClH/c1-17-9-10-7-12(18-2)4-5-13(10)14-8-11(16)3-6-15(14)17;/h3-9H,1-2H3;1H/q+1;/p-1
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n/an/a 9.30E+5n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM50017572
PNG
(CHEMBL3288326)
Show SMILES [Cl-].COc1ccc2c(c1)c[n+](C)c1ccccc21
Show InChI InChI=1S/C15H14NO.ClH/c1-16-10-11-9-12(17-2)7-8-13(11)14-5-3-4-6-15(14)16;/h3-10H,1-2H3;1H/q+1;/p-1
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n/an/a 9.50E+5n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM50017571
PNG
(CHEMBL2323153)
Show SMILES [Cl-].COc1ccc2[n+](C)cc3cc(OC)c(OC)cc3c2c1
Show InChI InChI=1S/C17H18NO3.ClH/c1-18-10-11-7-16(20-3)17(21-4)9-13(11)14-8-12(19-2)5-6-15(14)18;/h5-10H,1-4H3;1H/q+1;/p-1
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n/an/a 1.17E+6n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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n/an/a 1.28E+6n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM50017566
PNG
(CHEBI:7578 | NITIDINE)
Show SMILES COc1cc2c[n+](C)c3c(ccc4cc5OCOc5cc34)c2cc1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22/h4-10H,11H2,1-3H3/q+1
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n/an/a 1.34E+6n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM50017569
PNG
(CHEMBL3288324)
Show SMILES [Cl-].COc1cc2c[n+](C)c3ccc(Cl)cc3c2cc1OC
Show InChI InChI=1S/C16H15ClNO2.ClH/c1-18-9-10-6-15(19-2)16(20-3)8-12(10)13-7-11(17)4-5-14(13)18;/h4-9H,1-3H3;1H/q+1;/p-1
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n/an/a 1.39E+6n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM50017570
PNG
(CHEMBL3288325)
Show SMILES [Cl-].COc1cc2c[n+](C)c3ccc(C)cc3c2cc1OC
Show InChI InChI=1S/C17H18NO2.ClH/c1-11-5-6-15-14(7-11)13-9-17(20-4)16(19-3)8-12(13)10-18(15)2;/h5-10H,1-4H3;1H/q+1;/p-1
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n/an/a 1.49E+6n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM50017568
PNG
(CHEMBL3288323)
Show SMILES [Cl-].COc1cc2c[n+](C)c3ccc(F)cc3c2cc1OC
Show InChI InChI=1S/C16H15FNO2.ClH/c1-18-9-10-6-15(19-2)16(20-3)8-12(10)13-7-11(17)4-5-14(13)18;/h4-9H,1-3H3;1H/q+1;/p-1
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n/an/a 2.69E+6n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair
Aromatic-L-amino-acid decarboxylase


(Homo sapiens)
BDBM50017567
PNG
(CHEMBL3248107)
Show SMILES [Cl-].COc1cc2c[n+](C)c3ccccc3c2cc1OC
Show InChI InChI=1S/C16H16NO2.ClH/c1-17-10-11-8-15(18-2)16(19-3)9-13(11)12-6-4-5-7-14(12)17;/h4-10H,1-3H3;1H/q+1;/p-1
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n/an/a 3.50E+6n/an/an/an/an/an/a



Hunan Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method


Bioorg Med Chem Lett 24: 2712-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.047
BindingDB Entry DOI: 10.7270/Q29S1SKV
More data for this
Ligand-Target Pair