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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 309.3
BDBM47096
Wt: 311.3
BDBM142682
Wt: 297.3
BDBM142683
Wt: 321.3
BDBM142653
Wt: 309.3
BDBM142655
Wt: 310.3
BDBM142656
Wt: 310.3
BDBM142688
Wt: 308.3
BDBM142658
Wt: 323.3
BDBM142661
Wt: 309.3
BDBM142672
Wt: 322.3
BDBM47095
Purchase
Wt: 322.3
BDBM47097
Wt: 322.3
BDBM47098
Wt: 323.3
BDBM142676
Wt: 312.3
BDBM142677
Displayed 1 to 15 (of 51 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 68 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM142655
PNG
(US8937068, 43)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(O)cc1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-8-7-12-15(20-14)19-13(9-18-12)10-3-5-11(22)6-4-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 6n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM142653
PNG
(US8937068, 25)
Show SMILES Oc1ccc(cc1)-c1cnc2ccc(NC(=O)NCC=C)nc2n1
Show InChI InChI=1S/C17H15N5O2/c1-2-9-18-17(24)22-15-8-7-13-16(21-15)20-14(10-19-13)11-3-5-12(23)6-4-11/h2-8,10,23H,1,9H2,(H2,18,20,21,22,24)
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n/an/a 76n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM47096
PNG
(US8937068, 1 | US8937068, 151)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-7-6-12-15(20-14)19-13(9-18-12)10-4-3-5-11(22)8-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 104n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM47096
PNG
(US8937068, 1 | US8937068, 151)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-7-6-12-15(20-14)19-13(9-18-12)10-4-3-5-11(22)8-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 104n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM142683
PNG
(US8937068, 173)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C14H15N7O/c1-3-15-14(22)20-12-5-4-10-13(19-12)18-11(7-16-10)9-6-17-21(2)8-9/h4-8H,3H2,1-2H3,(H2,15,18,19,20,22)
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n/an/a 107n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM47095
PNG
(US8937068, 150)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(C)cc3)nc2n1
Show InChI InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-9-8-13-16(21-14)22-15(10-19-13)20-12-6-4-11(2)5-7-12/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24)
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n/an/a 129n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM47097
PNG
(US8937068, 157)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3cccc(C)c3)nc2n1
Show InChI InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-8-7-13-16(21-14)22-15(10-19-13)20-12-6-4-5-11(2)9-12/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24)
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n/an/a 348n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM142682
PNG
(US8937068, 172)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1c(C)n[nH]c1C
Show InChI InChI=1S/C15H17N7O/c1-4-16-15(23)20-12-6-5-10-14(19-12)18-11(7-17-10)13-8(2)21-22-9(13)3/h5-7H,4H2,1-3H3,(H,21,22)(H2,16,18,19,20,23)
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n/an/a 410n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM142661
PNG
(US8937068, 147)
Show SMILES OCCCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C17H17N5O2/c23-10-4-9-18-17(24)22-15-8-7-13-16(21-15)20-14(11-19-13)12-5-2-1-3-6-12/h1-3,5-8,11,23H,4,9-10H2,(H2,18,20,21,22,24)
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n/an/a 711n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM142688
PNG
(US8937068, 181)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3cnccn3)nc2n1
Show InChI InChI=1S/C14H14N8O/c1-2-16-14(23)22-10-4-3-9-13(20-10)21-12(8-18-9)19-11-7-15-5-6-17-11/h3-8H,2H2,1H3,(H3,16,17,19,20,21,22,23)
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n/an/a 739n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM47096
PNG
(US8937068, 1 | US8937068, 151)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-7-6-12-15(20-14)19-13(9-18-12)10-4-3-5-11(22)8-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 900n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM142658
PNG
(US8937068, 82)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(N)cc1
Show InChI InChI=1S/C16H16N6O/c1-2-18-16(23)22-14-8-7-12-15(21-14)20-13(9-19-12)10-3-5-11(17)6-4-10/h3-9H,2,17H2,1H3,(H2,18,20,21,22,23)
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n/an/a 944n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM47096
PNG
(US8937068, 1 | US8937068, 151)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-7-6-12-15(20-14)19-13(9-18-12)10-4-3-5-11(22)8-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM142672
PNG
(US8937068, 161)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3cccnc3)nc2n1
Show InChI InChI=1S/C15H15N7O/c1-2-17-15(23)22-12-6-5-11-14(20-12)21-13(9-18-11)19-10-4-3-7-16-8-10/h3-9H,2H2,1H3,(H3,17,19,20,21,22,23)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM142658
PNG
(US8937068, 82)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(N)cc1
Show InChI InChI=1S/C16H16N6O/c1-2-18-16(23)22-14-8-7-12-15(21-14)20-13(9-19-12)10-3-5-11(17)6-4-10/h3-9H,2,17H2,1H3,(H2,18,20,21,22,23)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM142676
PNG
(US8937068, 165)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(C)cn3)nc2n1
Show InChI InChI=1S/C16H17N7O/c1-3-17-16(24)23-13-7-5-11-15(21-13)22-14(9-18-11)20-12-6-4-10(2)8-19-12/h4-9H,3H2,1-2H3,(H3,17,19,20,21,22,23,24)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM142677
PNG
(US8937068, 166)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccn(C)n3)nc2n1
Show InChI InChI=1S/C14H16N8O/c1-3-15-14(23)20-10-5-4-9-13(18-10)19-12(8-16-9)17-11-6-7-22(2)21-11/h4-8H,3H2,1-2H3,(H3,15,17,18,19,20,21,23)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM142653
PNG
(US8937068, 25)
Show SMILES Oc1ccc(cc1)-c1cnc2ccc(NC(=O)NCC=C)nc2n1
Show InChI InChI=1S/C17H15N5O2/c1-2-9-18-17(24)22-15-8-7-13-16(21-15)20-14(10-19-13)11-3-5-12(23)6-4-11/h2-8,10,23H,1,9H2,(H2,18,20,21,22,24)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM47096
PNG
(US8937068, 1 | US8937068, 151)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-7-6-12-15(20-14)19-13(9-18-12)10-4-3-5-11(22)8-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM142656
PNG
(US8937068, 44)
Show SMILES CNC(=S)Nc1ccc2ncc(nc2n1)-c1ccc(N)cc1
Show InChI InChI=1S/C15H14N6S/c1-17-15(22)21-13-7-6-11-14(20-13)19-12(8-18-11)9-2-4-10(16)5-3-9/h2-8H,16H2,1H3,(H2,17,19,20,21,22)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM47096
PNG
(US8937068, 1 | US8937068, 151)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-7-6-12-15(20-14)19-13(9-18-12)10-4-3-5-11(22)8-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM142688
PNG
(US8937068, 181)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3cnccn3)nc2n1
Show InChI InChI=1S/C14H14N8O/c1-2-16-14(23)22-10-4-3-9-13(20-10)21-12(8-18-9)19-11-7-15-5-6-17-11/h3-8H,2H2,1H3,(H3,16,17,19,20,21,22,23)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM142683
PNG
(US8937068, 173)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C14H15N7O/c1-3-15-14(22)20-12-5-4-10-13(19-12)18-11(7-16-10)9-6-17-21(2)8-9/h4-8H,3H2,1-2H3,(H2,15,18,19,20,22)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM142656
PNG
(US8937068, 44)
Show SMILES CNC(=S)Nc1ccc2ncc(nc2n1)-c1ccc(N)cc1
Show InChI InChI=1S/C15H14N6S/c1-17-15(22)21-13-7-6-11-14(20-13)19-12(8-18-11)9-2-4-10(16)5-3-9/h2-8H,16H2,1H3,(H2,17,19,20,21,22)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM47098
PNG
(US8937068, 160)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccccc3C)nc2n1
Show InChI InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-9-8-13-16(21-14)22-15(10-19-13)20-12-7-5-4-6-11(12)2/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM47096
PNG
(US8937068, 1 | US8937068, 151)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-7-6-12-15(20-14)19-13(9-18-12)10-4-3-5-11(22)8-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM47096
PNG
(US8937068, 1 | US8937068, 151)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-7-6-12-15(20-14)19-13(9-18-12)10-4-3-5-11(22)8-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM142683
PNG
(US8937068, 173)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C14H15N7O/c1-3-15-14(22)20-12-5-4-10-13(19-12)18-11(7-16-10)9-6-17-21(2)8-9/h4-8H,3H2,1-2H3,(H2,15,18,19,20,22)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM142656
PNG
(US8937068, 44)
Show SMILES CNC(=S)Nc1ccc2ncc(nc2n1)-c1ccc(N)cc1
Show InChI InChI=1S/C15H14N6S/c1-17-15(22)21-13-7-6-11-14(20-13)19-12(8-18-11)9-2-4-10(16)5-3-9/h2-8H,16H2,1H3,(H2,17,19,20,21,22)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM142682
PNG
(US8937068, 172)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1c(C)n[nH]c1C
Show InChI InChI=1S/C15H17N7O/c1-4-16-15(23)20-12-6-5-10-14(19-12)18-11(7-17-10)13-8(2)21-22-9(13)3/h5-7H,4H2,1-3H3,(H,21,22)(H2,16,18,19,20,23)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM142682
PNG
(US8937068, 172)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1c(C)n[nH]c1C
Show InChI InChI=1S/C15H17N7O/c1-4-16-15(23)20-12-6-5-10-14(19-12)18-11(7-17-10)13-8(2)21-22-9(13)3/h5-7H,4H2,1-3H3,(H,21,22)(H2,16,18,19,20,23)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM142661
PNG
(US8937068, 147)
Show SMILES OCCCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C17H17N5O2/c23-10-4-9-18-17(24)22-15-8-7-13-16(21-15)20-14(11-19-13)12-5-2-1-3-6-12/h1-3,5-8,11,23H,4,9-10H2,(H2,18,20,21,22,24)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM142688
PNG
(US8937068, 181)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3cnccn3)nc2n1
Show InChI InChI=1S/C14H14N8O/c1-2-16-14(23)22-10-4-3-9-13(20-10)21-12(8-18-9)19-11-7-15-5-6-17-11/h3-8H,2H2,1H3,(H3,16,17,19,20,21,22,23)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM142655
PNG
(US8937068, 43)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(O)cc1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-8-7-12-15(20-14)19-13(9-18-12)10-3-5-11(22)6-4-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM47098
PNG
(US8937068, 160)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccccc3C)nc2n1
Show InChI InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-9-8-13-16(21-14)22-15(10-19-13)20-12-7-5-4-6-11(12)2/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM142655
PNG
(US8937068, 43)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(O)cc1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-8-7-12-15(20-14)19-13(9-18-12)10-3-5-11(22)6-4-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 6.20E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM142658
PNG
(US8937068, 82)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(N)cc1
Show InChI InChI=1S/C16H16N6O/c1-2-18-16(23)22-14-8-7-12-15(21-14)20-13(9-19-12)10-3-5-11(17)6-4-10/h3-9H,2,17H2,1H3,(H2,18,20,21,22,23)
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n/an/a 6.40E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM142677
PNG
(US8937068, 166)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccn(C)n3)nc2n1
Show InChI InChI=1S/C14H16N8O/c1-3-15-14(23)20-10-5-4-9-13(18-10)19-12(8-16-9)17-11-6-7-22(2)21-11/h4-8H,3H2,1-2H3,(H3,15,17,18,19,20,21,23)
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n/an/a 1.37E+4n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM142661
PNG
(US8937068, 147)
Show SMILES OCCCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C17H17N5O2/c23-10-4-9-18-17(24)22-15-8-7-13-16(21-15)20-14(11-19-13)12-5-2-1-3-6-12/h1-3,5-8,11,23H,4,9-10H2,(H2,18,20,21,22,24)
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n/an/a 1.42E+4n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM47095
PNG
(US8937068, 150)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(C)cc3)nc2n1
Show InChI InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-9-8-13-16(21-14)22-15(10-19-13)20-12-6-4-11(2)5-7-12/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24)
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n/an/a 1.81E+4n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM47095
PNG
(US8937068, 150)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(C)cc3)nc2n1
Show InChI InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-9-8-13-16(21-14)22-15(10-19-13)20-12-6-4-11(2)5-7-12/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24)
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n/an/a 1.87E+4n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM142676
PNG
(US8937068, 165)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(C)cn3)nc2n1
Show InChI InChI=1S/C16H17N7O/c1-3-17-16(24)23-13-7-5-11-15(21-13)22-14(9-18-11)20-12-6-4-10(2)8-19-12/h4-9H,3H2,1-2H3,(H3,17,19,20,21,22,23,24)
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n/an/a 1.94E+4n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM142677
PNG
(US8937068, 166)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccn(C)n3)nc2n1
Show InChI InChI=1S/C14H16N8O/c1-3-15-14(23)20-10-5-4-9-13(18-10)19-12(8-16-9)17-11-6-7-22(2)21-11/h4-8H,3H2,1-2H3,(H3,15,17,18,19,20,21,23)
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n/an/a 2.19E+4n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM142676
PNG
(US8937068, 165)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(C)cn3)nc2n1
Show InChI InChI=1S/C16H17N7O/c1-3-17-16(24)23-13-7-5-11-15(21-13)22-14(9-18-11)20-12-6-4-10(2)8-19-12/h4-9H,3H2,1-2H3,(H3,17,19,20,21,22,23,24)
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n/an/a 2.71E+4n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM47097
PNG
(US8937068, 157)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3cccc(C)c3)nc2n1
Show InChI InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-8-7-13-16(21-14)22-15(10-19-13)20-12-6-4-5-11(2)9-12/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24)
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n/an/a 2.85E+4n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM47098
PNG
(US8937068, 160)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccccc3C)nc2n1
Show InChI InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-9-8-13-16(21-14)22-15(10-19-13)20-12-7-5-4-6-11(12)2/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24)
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n/an/a>3.16E+4n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM47096
PNG
(US8937068, 1 | US8937068, 151)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-7-6-12-15(20-14)19-13(9-18-12)10-4-3-5-11(22)8-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a>3.16E+4n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM142658
PNG
(US8937068, 82)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(N)cc1
Show InChI InChI=1S/C16H16N6O/c1-2-18-16(23)22-14-8-7-12-15(21-14)20-13(9-19-12)10-3-5-11(17)6-4-10/h3-9H,2,17H2,1H3,(H2,18,20,21,22,23)
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n/an/a>3.16E+4n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM47098
PNG
(US8937068, 160)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccccc3C)nc2n1
Show InChI InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-9-8-13-16(21-14)22-15(10-19-13)20-12-7-5-4-6-11(12)2/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24)
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n/an/a>3.16E+4n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Jnk1 & Jnk2


(Homo sapiens (human))
BDBM142653
PNG
(US8937068, 25)
Show SMILES Oc1ccc(cc1)-c1cnc2ccc(NC(=O)NCC=C)nc2n1
Show InChI InChI=1S/C17H15N5O2/c1-2-9-18-17(24)22-15-8-7-13-16(21-15)20-14(10-19-13)11-3-5-12(23)6-4-11/h2-8,10,23H,1,9H2,(H2,18,20,21,22,24)
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n/an/a>3.16E+4n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
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