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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 89.0
BDBM23222
Purchase
Wt: 129.0
BDBM23242
Wt: 146.1
BDBM23251
Purchase
Wt: 260.2
BDBM50031638
Wt: 246.2
BDBM50066980
Wt: 260.2
BDBM50066977
Wt: 232.2
BDBM50066978
Wt: 188.1
BDBM50219487
Purchase
Wt: 253.2
BDBM50339605
Wt: 253.2
BDBM50339606
Wt: 232.2
BDBM50425802
Purchase
Wt: 199.2
BDBM50425804
Purchase
Wt: 213.2
BDBM50425805
Purchase
Wt: 262.3
BDBM50052419
Wt: 264.3
BDBM50052421
Displayed 1 to 15 (of 303 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 60 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lactate Dehydrogenase


(Plasmodium falciparum)
BDBM23251
PNG
(1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiaz...)
Show SMILES OC(=O)c1ns[nH]c1=O
Show InChI InChI=1S/C3H2N2O3S/c6-2-1(3(7)8)4-9-5-2/h(H,5,6)(H,7,8)
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Article
PubMed
290 -37.3 140n/an/an/an/a7.525



University of Bristol



Assay Description
An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou...


J Biol Chem 279: 31429-39 (2004)


Article DOI: 10.1074/jbc.M402433200
BindingDB Entry DOI: 10.7270/Q2CR5RN4
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Lactate Dehydrogenase


(Plasmodium falciparum)
BDBM23242
PNG
(1,2(1,5)-Isoxazole, IOA1 | 3-hydroxy-1,2-oxazole-4...)
Show SMILES OC(=O)c1co[nH]c1=O
Show InChI InChI=1S/C4H3NO4/c6-3-2(4(7)8)1-9-5-3/h1H,(H,5,6)(H,7,8)
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Article
PubMed
470 -36.1 1.10E+3n/an/an/an/a7.525



University of Bristol



Assay Description
An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou...


J Biol Chem 279: 31429-39 (2004)


Article DOI: 10.1074/jbc.M402433200
BindingDB Entry DOI: 10.7270/Q2CR5RN4
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM50066977
PNG
(2,3-Dihydroxy-6-methyl-4-propyl-naphthalene-1-carb...)
Show SMILES CCCc1c(O)c(O)c(C(O)=O)c2ccc(C)cc12
Show InChI InChI=1S/C15H16O4/c1-3-4-10-11-7-8(2)5-6-9(11)12(15(18)19)14(17)13(10)16/h5-7,16-17H,3-4H2,1-2H3,(H,18,19)
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1.00E+3n/an/an/an/an/an/an/an/a



University of New Mexico School of Medicine

Curated by ChEMBL


Assay Description
inhibitory activity against Human Lactate Dehydrogenase (LDH-M)


J Med Chem 41: 3879-87 (1998)


Article DOI: 10.1021/jm980334n
BindingDB Entry DOI: 10.7270/Q298864G
More data for this
Ligand-Target Pair
L-lactate dehydrogenase A chain


(Homo sapiens (Human))
BDBM50066977
PNG
(2,3-Dihydroxy-6-methyl-4-propyl-naphthalene-1-carb...)
Show SMILES CCCc1c(O)c(O)c(C(O)=O)c2ccc(C)cc12
Show InChI InChI=1S/C15H16O4/c1-3-4-10-11-7-8(2)5-6-9(11)12(15(18)19)14(17)13(10)16/h5-7,16-17H,3-4H2,1-2H3,(H,18,19)
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1.00E+3n/an/an/an/an/an/an/an/a



National Cancer Institute-CRO

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH5 in presence of NADH


J Med Chem 59: 487-96 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00168
BindingDB Entry DOI: 10.7270/Q2B27X41
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM50031638
PNG
(2,3-Dihydroxy-4-isopropyl-6-methyl-naphthalene-1-c...)
Show SMILES CC(C)c1c(O)c(O)c(C(O)=O)c2ccc(C)cc12
Show InChI InChI=1S/C15H16O4/c1-7(2)11-10-6-8(3)4-5-9(10)12(15(18)19)14(17)13(11)16/h4-7,16-17H,1-3H3,(H,18,19)
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2.00E+3n/an/an/an/an/an/an/an/a



University of New Mexico School of Medicine

Curated by ChEMBL


Assay Description
inhibitory activity against P. falciparum lactate dehydrogenase (pLDH)


J Med Chem 41: 3879-87 (1998)


Article DOI: 10.1021/jm980334n
BindingDB Entry DOI: 10.7270/Q298864G
More data for this
Ligand-Target Pair
L-lactate dehydrogenase A chain


(Homo sapiens (Human))
BDBM50031638
PNG
(2,3-Dihydroxy-4-isopropyl-6-methyl-naphthalene-1-c...)
Show SMILES CC(C)c1c(O)c(O)c(C(O)=O)c2ccc(C)cc12
Show InChI InChI=1S/C15H16O4/c1-7(2)11-10-6-8(3)4-5-9(10)12(15(18)19)14(17)13(11)16/h4-7,16-17H,1-3H3,(H,18,19)
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PubMed
3.00E+3n/an/an/an/an/an/an/an/a



National Cancer Institute-CRO

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH5 in presence of NADH


J Med Chem 59: 487-96 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00168
BindingDB Entry DOI: 10.7270/Q2B27X41
More data for this
Ligand-Target Pair
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM50031638
PNG
(2,3-Dihydroxy-4-isopropyl-6-methyl-naphthalene-1-c...)
Show SMILES CC(C)c1c(O)c(O)c(C(O)=O)c2ccc(C)cc12
Show InChI InChI=1S/C15H16O4/c1-7(2)11-10-6-8(3)4-5-9(10)12(15(18)19)14(17)13(11)16/h4-7,16-17H,1-3H3,(H,18,19)
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3.00E+3n/an/an/an/an/an/an/an/a



University of New Mexico School of Medicine

Curated by ChEMBL


Assay Description
inhibitory activity against Human Lactate Dehydrogenase (LDH-M)


J Med Chem 41: 3879-87 (1998)


Article DOI: 10.1021/jm980334n
BindingDB Entry DOI: 10.7270/Q298864G
More data for this
Ligand-Target Pair
L-lactate dehydrogenase A chain


(Homo sapiens (Human))
BDBM50066980
PNG
(2,3-Dihydroxy-4,6,7-trimethyl-naphthalene-1-carbox...)
Show SMILES Cc1cc2c(C)c(O)c(O)c(C(O)=O)c2cc1C
Show InChI InChI=1S/C14H14O4/c1-6-4-9-8(3)12(15)13(16)11(14(17)18)10(9)5-7(6)2/h4-5,15-16H,1-3H3,(H,17,18)
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4.00E+3n/an/an/an/an/an/an/an/a



National Cancer Institute-CRO

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH5 in presence of NADH


J Med Chem 59: 487-96 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00168
BindingDB Entry DOI: 10.7270/Q2B27X41
More data for this
Ligand-Target Pair
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM50066980
PNG
(2,3-Dihydroxy-4,6,7-trimethyl-naphthalene-1-carbox...)
Show SMILES Cc1cc2c(C)c(O)c(O)c(C(O)=O)c2cc1C
Show InChI InChI=1S/C14H14O4/c1-6-4-9-8(3)12(15)13(16)11(14(17)18)10(9)5-7(6)2/h4-5,15-16H,1-3H3,(H,17,18)
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4.00E+3n/an/an/an/an/an/an/an/a



University of New Mexico School of Medicine

Curated by ChEMBL


Assay Description
inhibitory activity against Human Lactate Dehydrogenase (LDH-M)


J Med Chem 41: 3879-87 (1998)


Article DOI: 10.1021/jm980334n
BindingDB Entry DOI: 10.7270/Q298864G
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM50066977
PNG
(2,3-Dihydroxy-6-methyl-4-propyl-naphthalene-1-carb...)
Show SMILES CCCc1c(O)c(O)c(C(O)=O)c2ccc(C)cc12
Show InChI InChI=1S/C15H16O4/c1-3-4-10-11-7-8(2)5-6-9(11)12(15(18)19)14(17)13(10)16/h5-7,16-17H,3-4H2,1-2H3,(H,18,19)
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6.00E+3n/an/an/an/an/an/an/an/a



University of New Mexico School of Medicine

Curated by ChEMBL


Assay Description
inhibitory activity against P. falciparum lactate dehydrogenase (pLDH)


J Med Chem 41: 3879-87 (1998)


Article DOI: 10.1021/jm980334n
BindingDB Entry DOI: 10.7270/Q298864G
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM50339605
PNG
(1-Hydroxy-5-phenyl-1H-indole-2-carboxylic Acid | C...)
Show SMILES OC(=O)c1cc2cc(ccc2n1O)-c1ccccc1
Show InChI InChI=1S/C15H11NO3/c17-15(18)14-9-12-8-11(6-7-13(12)16(14)19)10-4-2-1-3-5-10/h1-9,19H,(H,17,18)
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PubMed
1.04E+4n/an/an/an/an/an/an/an/a



Universita` di Pisa

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH-A using NADH as substrate after 5 mins by calorimetric assay relative to control


J Med Chem 54: 1599-612 (2011)


Article DOI: 10.1021/jm101007q
BindingDB Entry DOI: 10.7270/Q2J38SVC
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM50066980
PNG
(2,3-Dihydroxy-4,6,7-trimethyl-naphthalene-1-carbox...)
Show SMILES Cc1cc2c(C)c(O)c(O)c(C(O)=O)c2cc1C
Show InChI InChI=1S/C14H14O4/c1-6-4-9-8(3)12(15)13(16)11(14(17)18)10(9)5-7(6)2/h4-5,15-16H,1-3H3,(H,17,18)
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1.30E+4n/an/an/an/an/an/an/an/a



University of New Mexico School of Medicine

Curated by ChEMBL


Assay Description
inhibitory activity against P. falciparum lactate dehydrogenase (pLDH)


J Med Chem 41: 3879-87 (1998)


Article DOI: 10.1021/jm980334n
BindingDB Entry DOI: 10.7270/Q298864G
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM50339605
PNG
(1-Hydroxy-5-phenyl-1H-indole-2-carboxylic Acid | C...)
Show SMILES OC(=O)c1cc2cc(ccc2n1O)-c1ccccc1
Show InChI InChI=1S/C15H11NO3/c17-15(18)14-9-12-8-11(6-7-13(12)16(14)19)10-4-2-1-3-5-10/h1-9,19H,(H,17,18)
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PubMed
1.57E+4n/an/an/an/an/an/an/an/a



Universita` di Pisa

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH-A using pyruvate as substrate after 5 mins by calorimetric assay relative to control


J Med Chem 54: 1599-612 (2011)


Article DOI: 10.1021/jm101007q
BindingDB Entry DOI: 10.7270/Q2J38SVC
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM50339606
PNG
(1-Hydroxy-6-phenyl-1H-indole-2-carboxylic Acid | C...)
Show SMILES OC(=O)c1cc2ccc(cc2n1O)-c1ccccc1
Show InChI InChI=1S/C15H11NO3/c17-15(18)14-9-12-7-6-11(8-13(12)16(14)19)10-4-2-1-3-5-10/h1-9,19H,(H,17,18)
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1.98E+4n/an/an/an/an/an/an/an/a



Universita` di Pisa

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH-A using NADH as substrate after 5 mins by calorimetric assay relative to control


J Med Chem 54: 1599-612 (2011)


Article DOI: 10.1021/jm101007q
BindingDB Entry DOI: 10.7270/Q2J38SVC
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM50066978
PNG
(2,3-Dihydroxy-4,6-dimethyl-naphthalene-1-carboxyli...)
Show SMILES Cc1ccc2c(C(O)=O)c(O)c(O)c(C)c2c1
Show InChI InChI=1S/C13H12O4/c1-6-3-4-8-9(5-6)7(2)11(14)12(15)10(8)13(16)17/h3-5,14-15H,1-2H3,(H,16,17)
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2.20E+4n/an/an/an/an/an/an/an/a



University of New Mexico School of Medicine

Curated by ChEMBL


Assay Description
inhibitory activity against P. falciparum lactate dehydrogenase (pLDH)


J Med Chem 41: 3879-87 (1998)


Article DOI: 10.1021/jm980334n
BindingDB Entry DOI: 10.7270/Q298864G
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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Article
PubMed
2.60E+4n/an/an/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human LDH-A


J Med Chem 56: 1023-40 (2013)


Article DOI: 10.1021/jm3014844
BindingDB Entry DOI: 10.7270/Q2QC04TB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM50066978
PNG
(2,3-Dihydroxy-4,6-dimethyl-naphthalene-1-carboxyli...)
Show SMILES Cc1ccc2c(C(O)=O)c(O)c(O)c(C)c2c1
Show InChI InChI=1S/C13H12O4/c1-6-3-4-8-9(5-6)7(2)11(14)12(15)10(8)13(16)17/h3-5,14-15H,1-2H3,(H,16,17)
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3.40E+4n/an/an/an/an/an/an/an/a



University of New Mexico School of Medicine

Curated by ChEMBL


Assay Description
inhibitory activity against Human Lactate Dehydrogenase (LDH-M)


J Med Chem 41: 3879-87 (1998)


Article DOI: 10.1021/jm980334n
BindingDB Entry DOI: 10.7270/Q298864G
More data for this
Ligand-Target Pair
L-lactate dehydrogenase A chain


(Homo sapiens (Human))
BDBM50066978
PNG
(2,3-Dihydroxy-4,6-dimethyl-naphthalene-1-carboxyli...)
Show SMILES Cc1ccc2c(C(O)=O)c(O)c(O)c(C)c2c1
Show InChI InChI=1S/C13H12O4/c1-6-3-4-8-9(5-6)7(2)11(14)12(15)10(8)13(16)17/h3-5,14-15H,1-2H3,(H,16,17)
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3.40E+4n/an/an/an/an/an/an/an/a



National Cancer Institute-CRO

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH5 in presence of NADH


J Med Chem 59: 487-96 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00168
BindingDB Entry DOI: 10.7270/Q2B27X41
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM50339606
PNG
(1-Hydroxy-6-phenyl-1H-indole-2-carboxylic Acid | C...)
Show SMILES OC(=O)c1cc2ccc(cc2n1O)-c1ccccc1
Show InChI InChI=1S/C15H11NO3/c17-15(18)14-9-12-7-6-11(8-13(12)16(14)19)10-4-2-1-3-5-10/h1-9,19H,(H,17,18)
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3.54E+4n/an/an/an/an/an/an/an/a



Universita` di Pisa

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH-A using pyruvate as substrate after 5 mins by calorimetric assay relative to control


J Med Chem 54: 1599-612 (2011)


Article DOI: 10.1021/jm101007q
BindingDB Entry DOI: 10.7270/Q2J38SVC
More data for this
Ligand-Target Pair
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM50066977
PNG
(2,3-Dihydroxy-6-methyl-4-propyl-naphthalene-1-carb...)
Show SMILES CCCc1c(O)c(O)c(C(O)=O)c2ccc(C)cc12
Show InChI InChI=1S/C15H16O4/c1-3-4-10-11-7-8(2)5-6-9(11)12(15(18)19)14(17)13(10)16/h5-7,16-17H,3-4H2,1-2H3,(H,18,19)
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4.90E+4n/an/an/an/an/an/an/an/a



University of New Mexico School of Medicine

Curated by ChEMBL


Assay Description
inhibitory activity against Human Lactate Dehydrogenase (LDH-H)


J Med Chem 41: 3879-87 (1998)


Article DOI: 10.1021/jm980334n
BindingDB Entry DOI: 10.7270/Q298864G
More data for this
Ligand-Target Pair
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM50066977
PNG
(2,3-Dihydroxy-6-methyl-4-propyl-naphthalene-1-carb...)
Show SMILES CCCc1c(O)c(O)c(C(O)=O)c2ccc(C)cc12
Show InChI InChI=1S/C15H16O4/c1-3-4-10-11-7-8(2)5-6-9(11)12(15(18)19)14(17)13(10)16/h5-7,16-17H,3-4H2,1-2H3,(H,18,19)
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4.90E+4n/an/an/an/an/an/an/an/a



National Cancer Institute-CRO

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH1 in presence of NADH


J Med Chem 59: 487-96 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00168
BindingDB Entry DOI: 10.7270/Q2B27X41
More data for this
Ligand-Target Pair
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM50031638
PNG
(2,3-Dihydroxy-4-isopropyl-6-methyl-naphthalene-1-c...)
Show SMILES CC(C)c1c(O)c(O)c(C(O)=O)c2ccc(C)cc12
Show InChI InChI=1S/C15H16O4/c1-7(2)11-10-6-8(3)4-5-9(10)12(15(18)19)14(17)13(11)16/h4-7,16-17H,1-3H3,(H,18,19)
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9.10E+4n/an/an/an/an/an/an/an/a



University of New Mexico School of Medicine

Curated by ChEMBL


Assay Description
inhibitory activity against Human Lactate Dehydrogenase (LDH-H)


J Med Chem 41: 3879-87 (1998)


Article DOI: 10.1021/jm980334n
BindingDB Entry DOI: 10.7270/Q298864G
More data for this
Ligand-Target Pair
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM50031638
PNG
(2,3-Dihydroxy-4-isopropyl-6-methyl-naphthalene-1-c...)
Show SMILES CC(C)c1c(O)c(O)c(C(O)=O)c2ccc(C)cc12
Show InChI InChI=1S/C15H16O4/c1-7(2)11-10-6-8(3)4-5-9(10)12(15(18)19)14(17)13(11)16/h4-7,16-17H,1-3H3,(H,18,19)
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9.20E+4n/an/an/an/an/an/an/an/a



National Cancer Institute-CRO

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH1 in presence of NADH


J Med Chem 59: 487-96 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00168
BindingDB Entry DOI: 10.7270/Q2B27X41
More data for this
Ligand-Target Pair
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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9.44E+4n/an/an/an/an/an/an/an/a



National Cancer Institute-CRO

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH1 in presence of NADH


J Med Chem 59: 487-96 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00168
BindingDB Entry DOI: 10.7270/Q2B27X41
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
L-lactate dehydrogenase A chain


(Homo sapiens (Human))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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1.36E+5n/an/an/an/an/an/an/an/a



National Cancer Institute-CRO

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH5 in presence of NADH


J Med Chem 59: 487-96 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00168
BindingDB Entry DOI: 10.7270/Q2B27X41
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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1.38E+5n/an/an/an/an/an/an/an/a



Universita` di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to control


J Med Chem 54: 1599-612 (2011)


Article DOI: 10.1021/jm101007q
BindingDB Entry DOI: 10.7270/Q2J38SVC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM50066980
PNG
(2,3-Dihydroxy-4,6,7-trimethyl-naphthalene-1-carbox...)
Show SMILES Cc1cc2c(C)c(O)c(O)c(C(O)=O)c2cc1C
Show InChI InChI=1S/C14H14O4/c1-6-4-9-8(3)12(15)13(16)11(14(17)18)10(9)5-7(6)2/h4-5,15-16H,1-3H3,(H,17,18)
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1.90E+5n/an/an/an/an/an/an/an/a



University of New Mexico School of Medicine

Curated by ChEMBL


Assay Description
inhibitory activity against Human Lactate Dehydrogenase (LDH-H)


J Med Chem 41: 3879-87 (1998)


Article DOI: 10.1021/jm980334n
BindingDB Entry DOI: 10.7270/Q298864G
More data for this
Ligand-Target Pair
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM50066980
PNG
(2,3-Dihydroxy-4,6,7-trimethyl-naphthalene-1-carbox...)
Show SMILES Cc1cc2c(C)c(O)c(O)c(C(O)=O)c2cc1C
Show InChI InChI=1S/C14H14O4/c1-6-4-9-8(3)12(15)13(16)11(14(17)18)10(9)5-7(6)2/h4-5,15-16H,1-3H3,(H,17,18)
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1.90E+5n/an/an/an/an/an/an/an/a



National Cancer Institute-CRO

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH1 in presence of NADH


J Med Chem 59: 487-96 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00168
BindingDB Entry DOI: 10.7270/Q2B27X41
More data for this
Ligand-Target Pair
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM50066978
PNG
(2,3-Dihydroxy-4,6-dimethyl-naphthalene-1-carboxyli...)
Show SMILES Cc1ccc2c(C(O)=O)c(O)c(O)c(C)c2c1
Show InChI InChI=1S/C13H12O4/c1-6-3-4-8-9(5-6)7(2)11(14)12(15)10(8)13(16)17/h3-5,14-15H,1-2H3,(H,16,17)
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>2.50E+5n/an/an/an/an/an/an/an/a



University of New Mexico School of Medicine

Curated by ChEMBL


Assay Description
inhibitory activity against Human Lactate Dehydrogenase (LDH-H)


J Med Chem 41: 3879-87 (1998)


Article DOI: 10.1021/jm980334n
BindingDB Entry DOI: 10.7270/Q298864G
More data for this
Ligand-Target Pair
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM50066978
PNG
(2,3-Dihydroxy-4,6-dimethyl-naphthalene-1-carboxyli...)
Show SMILES Cc1ccc2c(C(O)=O)c(O)c(O)c(C)c2c1
Show InChI InChI=1S/C13H12O4/c1-6-3-4-8-9(5-6)7(2)11(14)12(15)10(8)13(16)17/h3-5,14-15H,1-2H3,(H,16,17)
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2.50E+5n/an/an/an/an/an/an/an/a



National Cancer Institute-CRO

Curated by ChEMBL


Assay Description
Competitive inhibition of human LDH1 in presence of NADH


J Med Chem 59: 487-96 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00168
BindingDB Entry DOI: 10.7270/Q2B27X41
More data for this
Ligand-Target Pair
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM23251
PNG
(1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiaz...)
Show SMILES OC(=O)c1ns[nH]c1=O
Show InChI InChI=1S/C3H2N2O3S/c6-2-1(3(7)8)4-9-5-2/h(H,5,6)(H,7,8)
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n/an/a 7.80E+3n/an/an/an/a7.521



AstraZeneca



Assay Description
Enzyme assay using lactate dehydrogenase A (LDHA).


J Med Chem 55: 3285-306 (2012)


Article DOI: 10.1021/jm201734r
BindingDB Entry DOI: 10.7270/Q21J9896
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM23251
PNG
(1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiaz...)
Show SMILES OC(=O)c1ns[nH]c1=O
Show InChI InChI=1S/C3H2N2O3S/c6-2-1(3(7)8)4-9-5-2/h(H,5,6)(H,7,8)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Universita` di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to control


J Med Chem 54: 1599-612 (2011)


Article DOI: 10.1021/jm101007q
BindingDB Entry DOI: 10.7270/Q2J38SVC
More data for this
Ligand-Target Pair
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM23251
PNG
(1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiaz...)
Show SMILES OC(=O)c1ns[nH]c1=O
Show InChI InChI=1S/C3H2N2O3S/c6-2-1(3(7)8)4-9-5-2/h(H,5,6)(H,7,8)
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n/an/a 1.03E+4n/an/an/an/an/an/a



University of Bristol



Assay Description
An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou...


J Biol Chem 279: 31429-39 (2004)


Article DOI: 10.1074/jbc.M402433200
BindingDB Entry DOI: 10.7270/Q2CR5RN4
More data for this
Ligand-Target Pair
L-lactate:NAD+ oxidoreductase C (LDH-C4)


(Mus musculus (Mouse))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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n/an/a 3.00E+4n/an/an/an/a7.4n/a



Instituto Politécnico Nacional



Assay Description
Lactate dehydrogenase activity was determined by recording the absorbance change at 340 nm produced by the oxidation of NADH. Assays were performed a...


J Enzyme Inhib Med Chem 26: 579-86 (2011)


Article DOI: 10.3109/14756366.2011.566221
BindingDB Entry DOI: 10.7270/Q2R78D36
More data for this
Ligand-Target Pair
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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n/an/a 3.38E+4n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carboxy-terminal His-tagged LDHB by UV endpoint assay


Bioorg Med Chem Lett 24: 3764-71 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.076
BindingDB Entry DOI: 10.7270/Q2445P46
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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n/an/a 3.38E+4n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carboxy-terminal his-tagged LDHB (1 to 333) expressed in insect cells using pyruvate as substrate after 10 mins by UV...


Bioorg Med Chem Lett 23: 3186-94 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.001
BindingDB Entry DOI: 10.7270/Q29C6ZTT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lactate dehydrogenase B (LDHB)


(Homo sapiens (human))
BDBM23242
PNG
(1,2(1,5)-Isoxazole, IOA1 | 3-hydroxy-1,2-oxazole-4...)
Show SMILES OC(=O)c1co[nH]c1=O
Show InChI InChI=1S/C4H3NO4/c6-3-2(4(7)8)1-9-5-3/h1H,(H,5,6)(H,7,8)
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n/an/a 5.40E+4n/an/an/an/an/an/a



University of Bristol



Assay Description
An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou...


J Biol Chem 279: 31429-39 (2004)


Article DOI: 10.1074/jbc.M402433200
BindingDB Entry DOI: 10.7270/Q2CR5RN4
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM23242
PNG
(1,2(1,5)-Isoxazole, IOA1 | 3-hydroxy-1,2-oxazole-4...)
Show SMILES OC(=O)c1co[nH]c1=O
Show InChI InChI=1S/C4H3NO4/c6-3-2(4(7)8)1-9-5-3/h1H,(H,5,6)(H,7,8)
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n/an/a 5.40E+4n/an/an/an/an/an/a



Universita` di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to control


J Med Chem 54: 1599-612 (2011)


Article DOI: 10.1021/jm101007q
BindingDB Entry DOI: 10.7270/Q2J38SVC
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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n/an/a 5.72E+4n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assay


Bioorg Med Chem Lett 24: 3764-71 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.076
BindingDB Entry DOI: 10.7270/Q2445P46
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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n/an/a 5.72E+4n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carboxy-terminal his-tagged LDHA (1 to 331) expressed in Escherichia coli using pyruvate as substrate after 10 mins b...


Bioorg Med Chem Lett 23: 3186-94 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.001
BindingDB Entry DOI: 10.7270/Q29C6ZTT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
L-lactate:NAD+ oxidoreductase B (LDH-B4)


(Mus musculus (Mouse))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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n/an/a 6.00E+4n/an/an/an/a7.4n/a



Instituto Politécnico Nacional



Assay Description
Lactate dehydrogenase activity was determined by recording the absorbance change at 340 nm produced by the oxidation of NADH. Assays were performed a...


J Enzyme Inhib Med Chem 26: 579-86 (2011)


Article DOI: 10.3109/14756366.2011.566221
BindingDB Entry DOI: 10.7270/Q2R78D36
More data for this
Ligand-Target Pair
L-lactate:NAD+ oxidoreductase A (LDH-A4)


(Mus musculus (Mouse))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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n/an/a 8.00E+4n/an/an/an/a7.4n/a



Instituto Politécnico Nacional



Assay Description
Lactate dehydrogenase activity was determined by recording the absorbance change at 340 nm produced by the oxidation of NADH. Assays were performed a...


J Enzyme Inhib Med Chem 26: 579-86 (2011)


Article DOI: 10.3109/14756366.2011.566221
BindingDB Entry DOI: 10.7270/Q2R78D36
More data for this
Ligand-Target Pair
Lactate Dehydrogenase


(Plasmodium falciparum)
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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n/an/a 9.25E+4n/an/an/an/a7.025



University of Mississippi



Assay Description
LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia...


J Med Chem 50: 3841-50 (2007)


Article DOI: 10.1021/jm070336k
BindingDB Entry DOI: 10.7270/Q2HH6HCV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lactate dehydrogenase (LDH)


(Plasmodium falciparum)
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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n/an/a 9.44E+4n/an/an/an/an/an/a



University of Mississippi



Assay Description
Enzyme assay using recombinant pfLDH and mLDH (bovine heart).


J Comb Chem 9: 292-300


Article DOI: 10.1021/cc060110n
BindingDB Entry DOI: 10.7270/Q23J3BKZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM50052421
PNG
(CHEMBL3318506)
Show SMILES OCCSC1=C(O)CC(CC1=O)c1ccccc1
Show InChI InChI=1S/C14H16O3S/c15-6-7-18-14-12(16)8-11(9-13(14)17)10-4-2-1-3-5-10/h1-5,11,15-16H,6-9H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assay


Bioorg Med Chem Lett 24: 3764-71 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.076
BindingDB Entry DOI: 10.7270/Q2445P46
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM50052419
PNG
(CHEMBL3318504)
Show SMILES CC(C)SC1=C(O)CC(CC1=O)c1ccccc1
Show InChI InChI=1S/C15H18O2S/c1-10(2)18-15-13(16)8-12(9-14(15)17)11-6-4-3-5-7-11/h3-7,10,12,16H,8-9H2,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assay


Bioorg Med Chem Lett 24: 3764-71 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.076
BindingDB Entry DOI: 10.7270/Q2445P46
More data for this
Ligand-Target Pair
Lactate dehydrogenase (LDH)


(Bos taurus (Bovine))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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n/an/a 1.16E+5n/an/an/an/an/an/a



University of Mississippi



Assay Description
Enzyme assay using recombinant pfLDH and mLDH (bovine heart).


J Comb Chem 9: 292-300


Article DOI: 10.1021/cc060110n
BindingDB Entry DOI: 10.7270/Q23J3BKZ
More data for this
Ligand-Target Pair
Lactate Dehydrogenase


(Bos taurus (bovine))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
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n/an/a 1.23E+5n/an/an/an/a7.025



University of Mississippi



Assay Description
LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia...


J Med Chem 50: 3841-50 (2007)


Article DOI: 10.1021/jm070336k
BindingDB Entry DOI: 10.7270/Q2HH6HCV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM23251
PNG
(1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiaz...)
Show SMILES OC(=O)c1ns[nH]c1=O
Show InChI InChI=1S/C3H2N2O3S/c6-2-1(3(7)8)4-9-5-2/h(H,5,6)(H,7,8)
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n/an/a 4.50E+5n/an/an/an/a7.521



AstraZeneca



Assay Description
Enzyme assay using lactate dehydrogenase A (LDHA).


J Med Chem 55: 3285-306 (2012)


Article DOI: 10.1021/jm201734r
BindingDB Entry DOI: 10.7270/Q21J9896
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM50219487
PNG
(1-hydroxy-2-naphthoate | 1-hydroxy-2-naphthoic aci...)
Show SMILES OC(=O)c1ccc2ccccc2c1O
Show InChI InChI=1S/C11H8O3/c12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h1-6,12H,(H,13,14)
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n/an/a>5.00E+5n/an/an/an/a7.521



AstraZeneca



Assay Description
Enzyme assay using lactate dehydrogenase A (LDHA).


J Med Chem 55: 3285-306 (2012)


Article DOI: 10.1021/jm201734r
BindingDB Entry DOI: 10.7270/Q21J9896
More data for this
Ligand-Target Pair
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