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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 277.3
BDBM50008434
Wt: 216.2
BDBM50017484
Wt: 201.2
BDBM50017473
Wt: 292.3
BDBM50017476
Wt: 273.3
BDBM50046316
Wt: 277.3
BDBM50405948
Wt: 294.3
BDBM50449024
Wt: 294.3
BDBM50449025
Wt: 298.2
BDBM50449034
Wt: 265.2
BDBM50449021
Wt: 279.3
BDBM50076814
Wt: 294.3
BDBM50076974
Wt: 279.3
BDBM50077103
Wt: 268.3
BDBM271192
Wt: 296.3
BDBM271207
Displayed 1 to 15 (of 367 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 38 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase B


(Rattus norvegicus)
BDBM50017476
PNG
(5,9-Diamino-2-benzyl-4-oxo-nonanoic acid | CHEMBL2...)
Show SMILES NCCCC[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O3/c17-9-5-4-8-14(18)15(19)11-13(16(20)21)10-12-6-2-1-3-7-12/h1-3,6-7,13-14H,4-5,8-11,17-18H2,(H,20,21)/t13?,14-/m0/s1
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4n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Competitive inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50046316
PNG
(2-Amino-3-(4-benzyloxy-phenyl)-propane-1-thiol | C...)
Show SMILES N[C@H](CS)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H19NOS/c17-15(12-19)10-13-6-8-16(9-7-13)18-11-14-4-2-1-3-5-14/h1-9,15,19H,10-12,17H2/t15-/m0/s1
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18n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit amidase activity of LTA4 hydrolase (1.4 ug) purified from human leukocytes


J Med Chem 36: 211-20 (1993)


Article DOI: 10.1021/jm00054a004
BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Soluble epoxide hydrolase (sEH)


(Mus musculus (Mouse))
BDBM50046316
PNG
(2-Amino-3-(4-benzyloxy-phenyl)-propane-1-thiol | C...)
Show SMILES N[C@H](CS)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H19NOS/c17-15(12-19)10-13-6-8-16(9-7-13)18-11-14-4-2-1-3-5-14/h1-9,15,19H,10-12,17H2/t15-/m0/s1
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100n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition constant was determined against epoxide hydrolase


J Med Chem 36: 211-20 (1993)


Article DOI: 10.1021/jm00054a004
BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Aminopeptidase B


(Homo sapiens (Human))
BDBM50008434
PNG
(5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid | CH...)
Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H23NO3/c1-11(2)8-14(17)15(18)10-13(16(19)20)9-12-6-4-3-5-7-12/h3-7,11,13-14H,8-10,17H2,1-2H3,(H,19,20)/t13?,14-/m0/s1
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170n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards arginyl aminopeptidase


J Med Chem 35: 451-6 (1992)


Article DOI: 10.1021/jm00081a005
BindingDB Entry DOI: 10.7270/Q2CR5SBH
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50008434
PNG
(5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid | CH...)
Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H23NO3/c1-11(2)8-14(17)15(18)10-13(16(19)20)9-12-6-4-3-5-7-12/h3-7,11,13-14H,8-10,17H2,1-2H3,(H,19,20)/t13?,14-/m0/s1
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170n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Competitive inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50405948
PNG
(CHEMBL2114365)
Show SMILES CC(C)C[C@@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H23NO3/c1-11(2)8-14(17)15(18)10-13(16(19)20)9-12-6-4-3-5-7-12/h3-7,11,13-14H,8-10,17H2,1-2H3,(H,19,20)/t13?,14-/m1/s1
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770n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Competitive inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50017484
PNG
(5,9-Diamino-2-methyl-4-oxo-nonanoic acid | CHEMBL2...)
Show SMILES CC(CC(=O)[C@@H](N)CCCCN)C(O)=O
Show InChI InChI=1S/C10H20N2O3/c1-7(10(14)15)6-9(13)8(12)4-2-3-5-11/h7-8H,2-6,11-12H2,1H3,(H,14,15)/t7?,8-/m0/s1
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2.00E+3n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Competitive inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50449034
PNG
(CHEMBL3125948)
Show SMILES COC(=O)C1C(c2cccnc2)c2ccc(O)cc2OC1=N
Show InChI InChI=1S/C16H14N2O4/c1-21-16(20)14-13(9-3-2-6-18-8-9)11-5-4-10(19)7-12(11)22-15(14)17/h2-8,13-14,17,19H,1H3
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4.90E+3n/an/an/an/an/an/an/an/a



Monash Institute of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of IRAP in HEKT cells assessed as hydrolysis of L-leucine-4-methyl-7-coumarinylamide after 30 mins


J Med Chem 57: 1368-77 (2014)


Article DOI: 10.1021/jm401540f
BindingDB Entry DOI: 10.7270/Q2W66N8G
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50008434
PNG
(5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid | CH...)
Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H23NO3/c1-11(2)8-14(17)15(18)10-13(16(19)20)9-12-6-4-3-5-7-12/h3-7,11,13-14H,8-10,17H2,1-2H3,(H,19,20)/t13?,14-/m0/s1
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5.70E+4n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Competitive inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Aspartyl aminopeptidase


(Homo sapiens (Human))
BDBM50008434
PNG
(5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid | CH...)
Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H23NO3/c1-11(2)8-14(17)15(18)10-13(16(19)20)9-12-6-4-3-5-7-12/h3-7,11,13-14H,8-10,17H2,1-2H3,(H,19,20)/t13?,14-/m0/s1
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5.70E+4n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards cytosolic aminopeptidase


J Med Chem 35: 451-6 (1992)


Article DOI: 10.1021/jm00081a005
BindingDB Entry DOI: 10.7270/Q2CR5SBH
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50008434
PNG
(5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid | CH...)
Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H23NO3/c1-11(2)8-14(17)15(18)10-13(16(19)20)9-12-6-4-3-5-7-12/h3-7,11,13-14H,8-10,17H2,1-2H3,(H,19,20)/t13?,14-/m0/s1
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7.90E+4n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards microsomal aminopeptidase; Kis was reported


J Med Chem 35: 451-6 (1992)


Article DOI: 10.1021/jm00081a005
BindingDB Entry DOI: 10.7270/Q2CR5SBH
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50008434
PNG
(5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid | CH...)
Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H23NO3/c1-11(2)8-14(17)15(18)10-13(16(19)20)9-12-6-4-3-5-7-12/h3-7,11,13-14H,8-10,17H2,1-2H3,(H,19,20)/t13?,14-/m0/s1
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7.90E+4n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Non-competitive inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50449024
PNG
(CHEMBL3125961)
Show SMILES COc1cccc(c1)C1C(C#N)C(=N)Oc2cc(O)ccc12
Show InChI InChI=1S/C17H14N2O3/c1-21-12-4-2-3-10(7-12)16-13-6-5-11(20)8-15(13)22-17(19)14(16)9-18/h2-8,14,16,19-20H,1H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Monash Institute of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of IRAP in HEKT cells assessed as hydrolysis of L-leucine-4-methyl-7-coumarinylamide after 30 mins


J Med Chem 57: 1368-77 (2014)


Article DOI: 10.1021/jm401540f
BindingDB Entry DOI: 10.7270/Q2W66N8G
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50449021
PNG
(CHEMBL1556216)
Show SMILES Oc1ccc2C(C(C#N)C(=N)Oc2c1)c1cccnc1
Show InChI InChI=1S/C15H11N3O2/c16-7-12-14(9-2-1-5-18-8-9)11-4-3-10(19)6-13(11)20-15(12)17/h1-6,8,12,14,17,19H
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>1.00E+5n/an/an/an/an/an/an/an/a



Monash Institute of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of IRAP in HEKT cells assessed as hydrolysis of L-leucine-4-methyl-7-coumarinylamide after 30 mins


J Med Chem 57: 1368-77 (2014)


Article DOI: 10.1021/jm401540f
BindingDB Entry DOI: 10.7270/Q2W66N8G
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50449025
PNG
(CHEMBL1276538)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)Oc2cc(O)ccc12
Show InChI InChI=1S/C17H14N2O3/c1-21-12-5-2-10(3-6-12)16-13-7-4-11(20)8-15(13)22-17(19)14(16)9-18/h2-8,14,16,19-20H,1H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Monash Institute of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of IRAP in HEKT cells assessed as hydrolysis of L-leucine-4-methyl-7-coumarinylamide after 30 mins


J Med Chem 57: 1368-77 (2014)


Article DOI: 10.1021/jm401540f
BindingDB Entry DOI: 10.7270/Q2W66N8G
More data for this
Ligand-Target Pair
Aminopeptidase B


(Rattus norvegicus)
BDBM50017473
PNG
(5-Amino-2,7-dimethyl-4-oxo-octanoic acid | CHEMBL2...)
Show SMILES CC(C)CC(N)C(=O)CC(C)C(O)=O
Show InChI InChI=1S/C10H19NO3/c1-6(2)4-8(11)9(12)5-7(3)10(13)14/h6-8H,4-5,11H2,1-3H3,(H,13,14)
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1.30E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Competitive inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50405948
PNG
(CHEMBL2114365)
Show SMILES CC(C)C[C@@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H23NO3/c1-11(2)8-14(17)15(18)10-13(16(19)20)9-12-6-4-3-5-7-12/h3-7,11,13-14H,8-10,17H2,1-2H3,(H,19,20)/t13?,14-/m1/s1
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2.40E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Competitive inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50008434
PNG
(5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid | CH...)
Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H23NO3/c1-11(2)8-14(17)15(18)10-13(16(19)20)9-12-6-4-3-5-7-12/h3-7,11,13-14H,8-10,17H2,1-2H3,(H,19,20)/t13?,14-/m0/s1
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2.60E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of leucine aminopeptidase


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50008434
PNG
(5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid | CH...)
Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H23NO3/c1-11(2)8-14(17)15(18)10-13(16(19)20)9-12-6-4-3-5-7-12/h3-7,11,13-14H,8-10,17H2,1-2H3,(H,19,20)/t13?,14-/m0/s1
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2.60E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity towards microsomal aminopeptidase; Kis was reported


J Med Chem 35: 451-6 (1992)


Article DOI: 10.1021/jm00081a005
BindingDB Entry DOI: 10.7270/Q2CR5SBH
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50017473
PNG
(5-Amino-2,7-dimethyl-4-oxo-octanoic acid | CHEMBL2...)
Show SMILES CC(C)CC(N)C(=O)CC(C)C(O)=O
Show InChI InChI=1S/C10H19NO3/c1-6(2)4-8(11)9(12)5-7(3)10(13)14/h6-8H,4-5,11H2,1-3H3,(H,13,14)
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6.60E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Non-competitive inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50017473
PNG
(5-Amino-2,7-dimethyl-4-oxo-octanoic acid | CHEMBL2...)
Show SMILES CC(C)CC(N)C(=O)CC(C)C(O)=O
Show InChI InChI=1S/C10H19NO3/c1-6(2)4-8(11)9(12)5-7(3)10(13)14/h6-8H,4-5,11H2,1-3H3,(H,13,14)
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9.40E+5n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Non-competitive inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the intercept effect(Kii)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50017473
PNG
(5-Amino-2,7-dimethyl-4-oxo-octanoic acid | CHEMBL2...)
Show SMILES CC(C)CC(N)C(=O)CC(C)C(O)=O
Show InChI InChI=1S/C10H19NO3/c1-6(2)4-8(11)9(12)5-7(3)10(13)14/h6-8H,4-5,11H2,1-3H3,(H,13,14)
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1.10E+6n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Competitive inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271192
PNG
(US10059720, Example 7(2))
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O)ccn1)C(O)=O
Show InChI InChI=1S/C13H20N2O4/c1-8(2)5-11(14)13(19,12(17)18)7-9-6-10(16)3-4-15-9/h3-4,6,8,11,19H,5,7,14H2,1-2H3,(H,15,16)(H,17,18)/t11-,13+/m0/s1
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US Patent
n/an/a 200n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271207
PNG
(US10059720, Example 22)
Show SMILES COc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1C
Show InChI InChI=1S/C15H24N2O4/c1-9(2)7-13(16)15(20,14(18)19)8-11-10(3)12(21-4)5-6-17-11/h5-6,9,13,20H,7-8,16H2,1-4H3,(H,18,19)/t13-,15+/m0/s1
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US Patent
n/an/a 250n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50046316
PNG
(2-Amino-3-(4-benzyloxy-phenyl)-propane-1-thiol | C...)
Show SMILES N[C@H](CS)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H19NOS/c17-15(12-19)10-13-6-8-16(9-7-13)18-11-14-4-2-1-3-5-14/h1-9,15,19H,10-12,17H2/t15-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against aminopeptidase M


J Med Chem 36: 211-20 (1993)


Article DOI: 10.1021/jm00054a004
BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50077103
PNG
(CHEMBL3416701)
Show SMILES CCCC[C@H](N)C(=O)Nc1ccc(cc1N)C(=O)OC
Show InChI InChI=1S/C14H21N3O3/c1-3-4-5-10(15)13(18)17-12-7-6-9(8-11(12)16)14(19)20-2/h6-8,10H,3-5,15-16H2,1-2H3,(H,17,18)/t10-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



National Center for Scientific Research"Demokritos"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ERAP2 expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-arginyl-7-amido-4-methyl coumarin as s...


J Med Chem 58: 1524-43 (2015)


Article DOI: 10.1021/jm501867s
BindingDB Entry DOI: 10.7270/Q2Z321B0
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50077103
PNG
(CHEMBL3416701)
Show SMILES CCCC[C@H](N)C(=O)Nc1ccc(cc1N)C(=O)OC
Show InChI InChI=1S/C14H21N3O3/c1-3-4-5-10(15)13(18)17-12-7-6-9(8-11(12)16)14(19)20-2/h6-8,10H,3-5,15-16H2,1-2H3,(H,17,18)/t10-/m0/s1
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n/an/a 3.30E+3n/an/an/an/an/an/a



National Center for Scientific Research"Demokritos"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-leucine-7-amido-4-methyl coumarin as su...


J Med Chem 58: 1524-43 (2015)


Article DOI: 10.1021/jm501867s
BindingDB Entry DOI: 10.7270/Q2Z321B0
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50076814
PNG
(CHEMBL3416572)
Show SMILES CCCC[C@H](N)C(=O)Nc1cc(ccc1N)C(=O)OC
Show InChI InChI=1S/C14H21N3O3/c1-3-4-5-11(16)13(18)17-12-8-9(14(19)20-2)6-7-10(12)15/h6-8,11H,3-5,15-16H2,1-2H3,(H,17,18)/t11-/m0/s1
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n/an/a 7.20E+3n/an/an/an/an/an/a



National Center for Scientific Research"Demokritos"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-leucine-7-amido-4-methyl coumarin as su...


J Med Chem 58: 1524-43 (2015)


Article DOI: 10.1021/jm501867s
BindingDB Entry DOI: 10.7270/Q2Z321B0
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50076814
PNG
(CHEMBL3416572)
Show SMILES CCCC[C@H](N)C(=O)Nc1cc(ccc1N)C(=O)OC
Show InChI InChI=1S/C14H21N3O3/c1-3-4-5-11(16)13(18)17-12-8-9(14(19)20-2)6-7-10(12)15/h6-8,11H,3-5,15-16H2,1-2H3,(H,17,18)/t11-/m0/s1
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n/an/a 9.80E+3n/an/an/an/an/an/a



National Center for Scientific Research"Demokritos"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ERAP2 expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-arginyl-7-amido-4-methyl coumarin as s...


J Med Chem 58: 1524-43 (2015)


Article DOI: 10.1021/jm501867s
BindingDB Entry DOI: 10.7270/Q2Z321B0
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens (Human))
BDBM50046316
PNG
(2-Amino-3-(4-benzyloxy-phenyl)-propane-1-thiol | C...)
Show SMILES N[C@H](CS)Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C16H19NOS/c17-15(12-19)10-13-6-8-16(9-7-13)18-11-14-4-2-1-3-5-14/h1-9,15,19H,10-12,17H2/t15-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against cytosolic leucine aminopeptidase


J Med Chem 36: 211-20 (1993)


Article DOI: 10.1021/jm00054a004
BindingDB Entry DOI: 10.7270/Q2T152P3
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50076814
PNG
(CHEMBL3416572)
Show SMILES CCCC[C@H](N)C(=O)Nc1cc(ccc1N)C(=O)OC
Show InChI InChI=1S/C14H21N3O3/c1-3-4-5-11(16)13(18)17-12-8-9(14(19)20-2)6-7-10(12)15/h6-8,11H,3-5,15-16H2,1-2H3,(H,17,18)/t11-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Center for Scientific Research"Demokritos"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ERAP1 expressed in baculovirus infected Sf9 cells using L-leucine-7-amido-4-methyl coumarin as substrate after 5 to 1...


J Med Chem 58: 1524-43 (2015)


Article DOI: 10.1021/jm501867s
BindingDB Entry DOI: 10.7270/Q2Z321B0
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50076974
PNG
(CHEMBL3416703)
Show SMILES COC(=O)[C@H](CCCCN)NC(=O)c1ccc(N)c(N)c1
Show InChI InChI=1S/C14H22N4O3/c1-21-14(20)12(4-2-3-7-15)18-13(19)9-5-6-10(16)11(17)8-9/h5-6,8,12H,2-4,7,15-17H2,1H3,(H,18,19)/t12-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Center for Scientific Research"Demokritos"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ERAP1 expressed in baculovirus infected Sf9 cells using L-leucine-7-amido-4-methyl coumarin as substrate after 5 to 1...


J Med Chem 58: 1524-43 (2015)


Article DOI: 10.1021/jm501867s
BindingDB Entry DOI: 10.7270/Q2Z321B0
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50076974
PNG
(CHEMBL3416703)
Show SMILES COC(=O)[C@H](CCCCN)NC(=O)c1ccc(N)c(N)c1
Show InChI InChI=1S/C14H22N4O3/c1-21-14(20)12(4-2-3-7-15)18-13(19)9-5-6-10(16)11(17)8-9/h5-6,8,12H,2-4,7,15-17H2,1H3,(H,18,19)/t12-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Center for Scientific Research"Demokritos"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-leucine-7-amido-4-methyl coumarin as su...


J Med Chem 58: 1524-43 (2015)


Article DOI: 10.1021/jm501867s
BindingDB Entry DOI: 10.7270/Q2Z321B0
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50017484
PNG
(5,9-Diamino-2-methyl-4-oxo-nonanoic acid | CHEMBL2...)
Show SMILES CC(CC(=O)[C@@H](N)CCCCN)C(O)=O
Show InChI InChI=1S/C10H20N2O3/c1-7(10(14)15)6-9(13)8(12)4-2-3-5-11/h7-8H,2-6,11-12H2,1H3,(H,14,15)/t7?,8-/m0/s1
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n/an/a>2.00E+5n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50017476
PNG
(5,9-Diamino-2-benzyl-4-oxo-nonanoic acid | CHEMBL2...)
Show SMILES NCCCC[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O3/c17-9-5-4-8-14(18)15(19)11-13(16(20)21)10-12-6-2-1-3-7-12/h1-3,6-7,13-14H,4-5,8-11,17-18H2,(H,20,21)/t13?,14-/m0/s1
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n/an/a>6.00E+5n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50405948
PNG
(CHEMBL2114365)
Show SMILES CC(C)C[C@@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H23NO3/c1-11(2)8-14(17)15(18)10-13(16(19)20)9-12-6-4-3-5-7-12/h3-7,11,13-14H,8-10,17H2,1-2H3,(H,19,20)/t13?,14-/m1/s1
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n/an/a>8.00E+5n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50017476
PNG
(5,9-Diamino-2-benzyl-4-oxo-nonanoic acid | CHEMBL2...)
Show SMILES NCCCC[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O3/c17-9-5-4-8-14(18)15(19)11-13(16(20)21)10-12-6-2-1-3-7-12/h1-3,6-7,13-14H,4-5,8-11,17-18H2,(H,20,21)/t13?,14-/m0/s1
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n/an/a>9.00E+5n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM50017484
PNG
(5,9-Diamino-2-methyl-4-oxo-nonanoic acid | CHEMBL2...)
Show SMILES CC(CC(=O)[C@@H](N)CCCCN)C(O)=O
Show InChI InChI=1S/C10H20N2O3/c1-7(10(14)15)6-9(13)8(12)4-2-3-5-11/h7-8H,2-6,11-12H2,1H3,(H,14,15)/t7?,8-/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis)


J Med Chem 32: 1378-92 (1989)


Article DOI: 10.1021/jm00126a039
BindingDB Entry DOI: 10.7270/Q20G3KQ1
More data for this
Ligand-Target Pair