BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 420.5
BDBM50189773
Wt: 388.5
BDBM50189774
Wt: 432.5
BDBM50189775
Wt: 403.5
BDBM50189776
Wt: 390.4
BDBM50189777
Wt: 402.5
BDBM50189778
Wt: 416.5
BDBM50189779
Wt: 539.6
BDBM50206401
Wt: 539.6
BDBM50206405
Wt: 539.6
BDBM50206395
Wt: 511.6
BDBM50206396
Wt: 537.6
BDBM50206397
Wt: 496.6
BDBM50206398
Wt: 357.4
BDBM50256858
Wt: 482.6
BDBM50335467
Displayed 1 to 15 (of 31 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 21 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50206401
PNG
(CHEMBL246321 | N-((S)-1-amino-3-(4-hydroxyphenyl)-...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1CCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)-c1cccnc1
Show InChI InChI=1S/C32H37N5O3/c1-32(2,3)24-12-14-25(15-13-24)37-26(20-28(36-37)23-7-6-18-34-21-23)8-4-5-9-30(39)35-29(31(33)40)19-22-10-16-27(38)17-11-22/h6-7,10-18,20-21,29,38H,4-5,8-9,19H2,1-3H3,(H2,33,40)(H,35,39)/t29-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
311n/an/an/an/an/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Displacement of [125I]-hCG from LH receptor


Bioorg Med Chem Lett 17: 2080-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.062
BindingDB Entry DOI: 10.7270/Q2VQ32B2
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50256858
PNG
(CHEMBL474041 | Cyclopentyl-carbamic acid [1,1',3',...)
Show SMILES O=C(NC1CCCC1)Oc1cc(cc(c1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H23NO2/c26-24(25-22-13-7-8-14-22)27-23-16-20(18-9-3-1-4-10-18)15-21(17-23)19-11-5-2-6-12-19/h1-6,9-12,15-17,22H,7-8,13-14H2,(H,25,26)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.30E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]Org43553 from human luteinizing hormone receptor expressed in CHOK1 cells


J Med Chem 52: 2036-42 (2009)


Article DOI: 10.1021/jm801561h
BindingDB Entry DOI: 10.7270/Q2G73DMJ
More data for this
Ligand-Target Pair
sentrin-specific protease 1


(Homo sapiens (Human))
BDBM50189778
PNG
(CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyph...)
Show SMILES COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
Show InChI InChI=1S/C19H22N4O2S2/c1-19(2,3)23-16(24)15-13(20)12-14(10-7-6-8-11(9-10)25-4)21-18(26-5)22-17(12)27-15/h6-9H,20H2,1-5H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

n/an/a 1.52E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)


BindingDB Entry DOI: 10.7270/Q2R49PCF
More data for this
Ligand-Target Pair
sentrin-specific protease 1


(Homo sapiens (Human))
BDBM50189778
PNG
(CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyph...)
Show SMILES COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
Show InChI InChI=1S/C19H22N4O2S2/c1-19(2,3)23-16(24)15-13(20)12-14(10-7-6-8-11(9-10)25-4)21-18(26-5)22-17(12)27-15/h6-9H,20H2,1-5H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

n/an/a 1.91E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)


BindingDB Entry DOI: 10.7270/Q2MC8XNQ
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50189773
PNG
(CHEMBL211129 | N-tert-butyl-5-amino-4-(2-fluoro-3-...)
Show SMILES COc1cccc(c1F)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
Show InChI InChI=1S/C19H21FN4O2S2/c1-19(2,3)24-16(25)15-13(21)11-14(22-18(27-5)23-17(11)28-15)9-7-6-8-10(26-4)12(9)20/h6-8H,21H2,1-5H3,(H,24,25)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.50E+3n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)


Article DOI: 10.1021/jm060247s
BindingDB Entry DOI: 10.7270/Q29886MR
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50189776
PNG
(CHEMBL211871 | tert-butyl 5-amino-4-(3-methoxyphen...)
Show SMILES COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)OC(C)(C)C)c(N)c12
Show InChI InChI=1S/C19H21N3O3S2/c1-19(2,3)25-17(23)15-13(20)12-14(10-7-6-8-11(9-10)24-4)21-18(26-5)22-16(12)27-15/h6-9H,20H2,1-5H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.10E+3n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)


Article DOI: 10.1021/jm060247s
BindingDB Entry DOI: 10.7270/Q29886MR
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50189774
PNG
(CHEMBL378091 | N-tert-butyl-5-amino-4-(3-hydroxyph...)
Show SMILES CSc1nc(-c2cccc(O)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C18H20N4O2S2/c1-18(2,3)22-15(24)14-12(19)11-13(9-6-5-7-10(23)8-9)20-17(25-4)21-16(11)26-14/h5-8,23H,19H2,1-4H3,(H,22,24)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.90E+3n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)


Article DOI: 10.1021/jm060247s
BindingDB Entry DOI: 10.7270/Q29886MR
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50189778
PNG
(CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyph...)
Show SMILES COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
Show InChI InChI=1S/C19H22N4O2S2/c1-19(2,3)23-16(24)15-13(20)12-14(10-7-6-8-11(9-10)25-4)21-18(26-5)22-17(12)27-15/h6-9H,20H2,1-5H3,(H,23,24)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 300n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)


Article DOI: 10.1021/jm060247s
BindingDB Entry DOI: 10.7270/Q29886MR
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50189779
PNG
(CHEMBL377399 | N-tert-butyl-5-amino-4-(3-methoxyph...)
Show SMILES COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)N(C)C(C)(C)C)c(N)c12
Show InChI InChI=1S/C20H24N4O2S2/c1-20(2,3)24(4)18(25)16-14(21)13-15(11-8-7-9-12(10-11)26-5)22-19(27-6)23-17(13)28-16/h7-10H,21H2,1-6H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 800n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)


Article DOI: 10.1021/jm060247s
BindingDB Entry DOI: 10.7270/Q29886MR
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50206405
PNG
((S)-N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-y...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(CCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)cc1-c1ccncc1
Show InChI InChI=1S/C32H37N5O3/c1-32(2,3)24-10-12-26(13-11-24)37-29(23-16-18-34-19-17-23)21-25(36-37)6-4-5-7-30(39)35-28(31(33)40)20-22-8-14-27(38)15-9-22/h8-19,21,28,38H,4-7,20H2,1-3H3,(H2,33,40)(H,35,39)/t28-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 2.30E+3n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.062
BindingDB Entry DOI: 10.7270/Q2VQ32B2
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50189775
PNG
(CHEMBL377769 | N-tert-butyl-5-amino-4-(2,3-dimetho...)
Show SMILES COc1cccc(c1OC)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
Show InChI InChI=1S/C20H24N4O3S2/c1-20(2,3)24-17(25)16-13(21)12-14(22-19(28-6)23-18(12)29-16)10-8-7-9-11(26-4)15(10)27-5/h7-9H,21H2,1-6H3,(H,24,25)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 800n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)


Article DOI: 10.1021/jm060247s
BindingDB Entry DOI: 10.7270/Q29886MR
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50206398
PNG
(CHEMBL429108 | N-(4-hydroxyphenethyl)-5-(1-(4-tert...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1CCCCC(=O)NCCc1ccc(O)cc1)-c1cccnc1
Show InChI InChI=1S/C31H36N4O2/c1-31(2,3)25-12-14-26(15-13-25)35-27(21-29(34-35)24-7-6-19-32-22-24)8-4-5-9-30(37)33-20-18-23-10-16-28(36)17-11-23/h6-7,10-17,19,21-22,36H,4-5,8-9,18,20H2,1-3H3,(H,33,37)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 80n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.062
BindingDB Entry DOI: 10.7270/Q2VQ32B2
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50206397
PNG
((S)-N-(4-amino-4-oxo-1-phenylbutan-2-yl)-5-(1-(4-t...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1CCCCC(=O)N[C@H](CC(N)=O)Cc1ccccc1)-c1ccncc1
Show InChI InChI=1S/C33H39N5O2/c1-33(2,3)26-13-15-28(16-14-26)38-29(23-30(37-38)25-17-19-35-20-18-25)11-7-8-12-32(40)36-27(22-31(34)39)21-24-9-5-4-6-10-24/h4-6,9-10,13-20,23,27H,7-8,11-12,21-22H2,1-3H3,(H2,34,39)(H,36,40)/t27-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 190n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.062
BindingDB Entry DOI: 10.7270/Q2VQ32B2
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50206396
PNG
((S)-2-{3-[2-(4-tert-butyl-phenyl)-5-pyridin-3-yl-2...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1CCC(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)-c1cccnc1
Show InChI InChI=1S/C30H33N5O3/c1-30(2,3)22-8-10-23(11-9-22)35-24(18-26(34-35)21-5-4-16-32-19-21)12-15-28(37)33-27(29(31)38)17-20-6-13-25(36)14-7-20/h4-11,13-14,16,18-19,27,36H,12,15,17H2,1-3H3,(H2,31,38)(H,33,37)/t27-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.062
BindingDB Entry DOI: 10.7270/Q2VQ32B2
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50206395
PNG
((S)-N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-y...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1CCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)-c1ccncc1
Show InChI InChI=1S/C32H37N5O3/c1-32(2,3)24-10-12-25(13-11-24)37-26(21-28(36-37)23-16-18-34-19-17-23)6-4-5-7-30(39)35-29(31(33)40)20-22-8-14-27(38)15-9-22/h8-19,21,29,38H,4-7,20H2,1-3H3,(H2,33,40)(H,35,39)/t29-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 250n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.062
BindingDB Entry DOI: 10.7270/Q2VQ32B2
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50206401
PNG
(CHEMBL246321 | N-((S)-1-amino-3-(4-hydroxyphenyl)-...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1CCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)-c1cccnc1
Show InChI InChI=1S/C32H37N5O3/c1-32(2,3)24-12-14-25(15-13-24)37-26(20-28(36-37)23-7-6-18-34-21-23)8-4-5-9-30(39)35-29(31(33)40)19-22-10-16-27(38)17-11-22/h6-7,10-18,20-21,29,38H,4-5,8-9,19H2,1-3H3,(H2,33,40)(H,35,39)/t29-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 20n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.062
BindingDB Entry DOI: 10.7270/Q2VQ32B2
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50335467
PNG
(5-amino-N-tert-butyl-2-(methylthio)-4-(3-(2-oxo-2-...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCC#C)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C23H26N6O2S2/c1-6-10-25-15(30)12-26-14-9-7-8-13(11-14)18-16-17(24)19(20(31)29-23(2,3)4)33-21(16)28-22(27-18)32-5/h1,7-9,11,26H,10,12,24H2,2-5H3,(H,25,30)(H,29,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 126n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter ge...


ACS Med Chem Lett 2: 85-89 (2011)


Article DOI: 10.1021/ml100229v
BindingDB Entry DOI: 10.7270/Q2RV0NZG
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50256858
PNG
(CHEMBL474041 | Cyclopentyl-carbamic acid [1,1',3',...)
Show SMILES O=C(NC1CCCC1)Oc1cc(cc(c1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H23NO2/c26-24(25-22-13-7-8-14-22)27-23-16-20(18-9-3-1-4-10-18)15-21(17-23)19-11-5-2-6-12-19/h1-6,9-12,15-17,22H,7-8,13-14H2,(H,25,26)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.60E+3n/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Agonist activity at human luteinizing hormone receptor expressed in CHOK1 cells assessed as c-AMP-mediated luciferase production


J Med Chem 52: 2036-42 (2009)


Article DOI: 10.1021/jm801561h
BindingDB Entry DOI: 10.7270/Q2G73DMJ
More data for this
Ligand-Target Pair
Thyroid-stimulating hormone receptor (TSH)


(Homo sapiens (Human))
BDBM50189778
PNG
(CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyph...)
Show SMILES COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
Show InChI InChI=1S/C19H22N4O2S2/c1-19(2,3)23-16(24)15-13(20)12-14(10-7-6-8-11(9-10)25-4)21-18(26-5)22-17(12)27-15/h6-9H,20H2,1-5H3,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 6.50E+3n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at TSHR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)


Article DOI: 10.1021/jm060247s
BindingDB Entry DOI: 10.7270/Q29886MR
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50335467
PNG
(5-amino-N-tert-butyl-2-(methylthio)-4-(3-(2-oxo-2-...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCC#C)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C23H26N6O2S2/c1-6-10-25-15(30)12-26-14-9-7-8-13(11-14)18-16-17(24)19(20(31)29-23(2,3)4)33-21(16)28-22(27-18)32-5/h1,7-9,11,26H,10,12,24H2,2-5H3,(H,25,30)(H,29,31)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...


ACS Med Chem Lett 2: 85-89 (2011)


Article DOI: 10.1021/ml100229v
BindingDB Entry DOI: 10.7270/Q2RV0NZG
More data for this
Ligand-Target Pair
Lutropin-choriogonadotropic hormone receptor


(Homo sapiens)
BDBM50189777
PNG
(CHEMBL212815 | N-tert-butyl-5-amino-4-(3-fluorophe...)
Show SMILES CSc1nc(-c2cccc(F)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C18H19FN4OS2/c1-18(2,3)23-15(24)14-12(20)11-13(9-6-5-7-10(19)8-9)21-17(25-4)22-16(11)26-14/h5-8H,20H2,1-4H3,(H,23,24)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.20E+3n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)


Article DOI: 10.1021/jm060247s
BindingDB Entry DOI: 10.7270/Q29886MR
More data for this
Ligand-Target Pair