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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 402.2
BDBM50364409
Wt: 423.9
BDBM50364681
Wt: 423.4
BDBM50361751
Wt: 392.9
BDBM50361765
Wt: 370.9
BDBM50361778
Wt: 415.3
BDBM50361779
Wt: 398.9
BDBM50361780
Wt: 406.8
BDBM50361782
Wt: 424.8
BDBM50361783
Wt: 412.5
BDBM50361791
Wt: 406.9
BDBM50365041
Wt: 423.9
BDBM50365042
Wt: 374.9
BDBM50365011
Wt: 388.9
BDBM50365012
Wt: 403.9
BDBM50365013
Displayed 1 to 15 (of 173 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 48 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50364681
PNG
(CHEMBL1951470)
Show SMILES CC(N1CCC2(CC1)OC(c1ccccc21)c1cc(Cl)ccn1)c1ccc(F)cn1
Show InChI InChI=1S/C24H23ClFN3O/c1-16(21-7-6-18(26)15-28-21)29-12-9-24(10-13-29)20-5-3-2-4-19(20)23(30-24)22-14-17(25)8-11-27-22/h2-8,11,14-16,23H,9-10,12-13H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human PrCP


Bioorg Med Chem Lett 22: 1550-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.002
BindingDB Entry DOI: 10.7270/Q2JS9QXQ
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50364681
PNG
(CHEMBL1951470)
Show SMILES CC(N1CCC2(CC1)OC(c1ccccc21)c1cc(Cl)ccn1)c1ccc(F)cn1
Show InChI InChI=1S/C24H23ClFN3O/c1-16(21-7-6-18(26)15-28-21)29-12-9-24(10-13-29)20-5-3-2-4-19(20)23(30-24)22-14-17(25)8-11-27-22/h2-8,11,14-16,23H,9-10,12-13H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse PrCP


Bioorg Med Chem Lett 22: 1550-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.002
BindingDB Entry DOI: 10.7270/Q2JS9QXQ
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50361783
PNG
(CHEMBL1938519)
Show SMILES FC(F)(F)C(NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClF3N2O/c23-19-8-6-18(7-9-19)21(22(24,25)26)27-20(29)12-15-28-13-10-17(11-14-28)16-4-2-1-3-5-16/h1-9,17,21H,10-15H2,(H,27,29)
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n/an/a 1.40n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50361780
PNG
(CHEMBL1938516)
Show SMILES CC(C)[C@H](NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClN2O/c1-18(2)24(21-8-10-22(25)11-9-21)26-23(28)14-17-27-15-12-20(13-16-27)19-6-4-3-5-7-19/h3-11,18,20,24H,12-17H2,1-2H3,(H,26,28)/t24-/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50361791
PNG
(CHEMBL1938527)
Show SMILES CC(NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C28H32N2O/c1-22(26-14-8-9-15-27(26)25-12-6-3-7-13-25)29-28(31)18-21-30-19-16-24(17-20-30)23-10-4-2-5-11-23/h2-15,22,24H,16-21H2,1H3,(H,29,31)
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n/an/a 2.80n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50361782
PNG
(CHEMBL1938518)
Show SMILES FC(F)C(NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H25ClF2N2O/c23-19-8-6-18(7-9-19)21(22(24)25)26-20(28)12-15-27-13-10-17(11-14-27)16-4-2-1-3-5-16/h1-9,17,21-22H,10-15H2,(H,26,28)
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n/an/a 3.20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50361780
PNG
(CHEMBL1938516)
Show SMILES CC(C)[C@H](NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClN2O/c1-18(2)24(21-8-10-22(25)11-9-21)26-23(28)14-17-27-15-12-20(13-16-27)19-6-4-3-5-7-19/h3-11,18,20,24H,12-17H2,1-2H3,(H,26,28)/t24-/m0/s1
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n/an/a 5.20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50361791
PNG
(CHEMBL1938527)
Show SMILES CC(NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C28H32N2O/c1-22(26-14-8-9-15-27(26)25-12-6-3-7-13-25)29-28(31)18-21-30-19-16-24(17-20-30)23-10-4-2-5-11-23/h2-15,22,24H,16-21H2,1H3,(H,29,31)
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n/an/a 5.70n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50365013
PNG
(CHEMBL1949687)
Show SMILES COC(=O)N[C@H]1CC[C@@H](CC1)Nc1cc(N[C@@H](C)c2ccc(Cl)cc2)ncn1
Show InChI InChI=1S/C20H26ClN5O2/c1-13(14-3-5-15(21)6-4-14)24-18-11-19(23-12-22-18)25-16-7-9-17(10-8-16)26-20(27)28-2/h3-6,11-13,16-17H,7-10H2,1-2H3,(H,26,27)(H2,22,23,24,25)/t13-,16-,17-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50361779
PNG
(CHEMBL1938515)
Show SMILES C[C@H](NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Br)cc1
Show InChI InChI=1S/C22H27BrN2O/c1-17(18-7-9-21(23)10-8-18)24-22(26)13-16-25-14-11-20(12-15-25)19-5-3-2-4-6-19/h2-10,17,20H,11-16H2,1H3,(H,24,26)/t17-/m0/s1
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n/an/a 8.40n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50361778
PNG
(CHEMBL1938514)
Show SMILES C[C@H](NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H27ClN2O/c1-17(18-7-9-21(23)10-8-18)24-22(26)13-16-25-14-11-20(12-15-25)19-5-3-2-4-6-19/h2-10,17,20H,11-16H2,1H3,(H,24,26)/t17-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50364681
PNG
(CHEMBL1951470)
Show SMILES CC(N1CCC2(CC1)OC(c1ccccc21)c1cc(Cl)ccn1)c1ccc(F)cn1
Show InChI InChI=1S/C24H23ClFN3O/c1-16(21-7-6-18(26)15-28-21)29-12-9-24(10-13-29)20-5-3-2-4-19(20)23(30-24)22-14-17(25)8-11-27-22/h2-8,11,14-16,23H,9-10,12-13H2,1H3
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n/an/a 10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PrCP in mouse plasma assessed as angiotensin 3 cleavage by whole serum shift assay


Bioorg Med Chem Lett 22: 1550-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.002
BindingDB Entry DOI: 10.7270/Q2JS9QXQ
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50361765
PNG
(CHEMBL1938501)
Show SMILES C[C@H](NC(=O)[C@@H](N)[C@@H](C)c1ccc(cc1)-c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H25ClN2O/c1-16(18-8-10-21(11-9-18)20-6-4-3-5-7-20)23(26)24(28)27-17(2)19-12-14-22(25)15-13-19/h3-17,23H,26H2,1-2H3,(H,27,28)/t16-,17-,23-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50361780
PNG
(CHEMBL1938516)
Show SMILES CC(C)[C@H](NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClN2O/c1-18(2)24(21-8-10-22(25)11-9-21)26-23(28)14-17-27-15-12-20(13-16-27)19-6-4-3-5-7-19/h3-11,18,20,24H,12-17H2,1-2H3,(H,26,28)/t24-/m0/s1
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n/an/a 12.6n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PrCP-mediated conversion of Ang3 to Ang(2-7) in mouse plasma


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50361783
PNG
(CHEMBL1938519)
Show SMILES FC(F)(F)C(NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClF3N2O/c23-19-8-6-18(7-9-19)21(22(24,25)26)27-20(29)12-15-28-13-10-17(11-14-28)16-4-2-1-3-5-16/h1-9,17,21H,10-15H2,(H,27,29)
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n/an/a 14n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50365042
PNG
(CHEMBL1950919)
Show SMILES C[C@H](Nc1cc(N[C@H]2CC[C@@H](CC2)NS(C)(=O)=O)ncn1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H26ClN5O2S/c1-13(14-3-5-15(20)6-4-14)23-18-11-19(22-12-21-18)24-16-7-9-17(10-8-16)25-28(2,26)27/h3-6,11-13,16-17,25H,7-10H2,1-2H3,(H2,21,22,23,24)/t13-,16-,17-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50361765
PNG
(CHEMBL1938501)
Show SMILES C[C@H](NC(=O)[C@@H](N)[C@@H](C)c1ccc(cc1)-c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H25ClN2O/c1-16(18-8-10-21(11-9-18)20-6-4-3-5-7-20)23(26)24(28)27-17(2)19-12-14-22(25)15-13-19/h3-17,23H,26H2,1-2H3,(H,27,28)/t16-,17-,23-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50361782
PNG
(CHEMBL1938518)
Show SMILES FC(F)C(NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H25ClF2N2O/c23-19-8-6-18(7-9-19)21(22(24)25)26-20(28)12-15-27-13-10-17(11-14-27)16-4-2-1-3-5-16/h1-9,17,21-22H,10-15H2,(H,26,28)
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n/an/a 17n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PrCP-mediated conversion of Ang3 to Ang(2-7) in mouse plasma


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50361782
PNG
(CHEMBL1938518)
Show SMILES FC(F)C(NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H25ClF2N2O/c23-19-8-6-18(7-9-19)21(22(24)25)26-20(28)12-15-27-13-10-17(11-14-27)16-4-2-1-3-5-16/h1-9,17,21-22H,10-15H2,(H,26,28)
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n/an/a 17n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50361779
PNG
(CHEMBL1938515)
Show SMILES C[C@H](NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Br)cc1
Show InChI InChI=1S/C22H27BrN2O/c1-17(18-7-9-21(23)10-8-18)24-22(26)13-16-25-14-11-20(12-15-25)19-5-3-2-4-6-19/h2-10,17,20H,11-16H2,1H3,(H,24,26)/t17-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50365013
PNG
(CHEMBL1949687)
Show SMILES COC(=O)N[C@H]1CC[C@@H](CC1)Nc1cc(N[C@@H](C)c2ccc(Cl)cc2)ncn1
Show InChI InChI=1S/C20H26ClN5O2/c1-13(14-3-5-15(21)6-4-14)24-18-11-19(23-12-22-18)25-16-7-9-17(10-8-16)26-20(27)28-2/h3-6,11-13,16-17H,7-10H2,1-2H3,(H,26,27)(H2,22,23,24,25)/t13-,16-,17-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50365012
PNG
(CHEMBL1950916)
Show SMILES C[C@H](N(C)c1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H29ClN4O/c1-15(16-7-9-18(22)10-8-16)25(4)19-12-20(24-14-23-19)26-11-5-6-17(13-26)21(2,3)27/h7-10,12,14-15,17,27H,5-6,11,13H2,1-4H3/t15-,17?/m0/s1
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n/an/a 31n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50365011
PNG
(CHEMBL1950912)
Show SMILES C[C@H](Nc1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H27ClN4O/c1-14(15-6-8-17(21)9-7-15)24-18-11-19(23-13-22-18)25-10-4-5-16(12-25)20(2,3)26/h6-9,11,13-14,16,26H,4-5,10,12H2,1-3H3,(H,22,23,24)/t14-,16?/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50365041
PNG
(CHEMBL1950918)
Show SMILES C[C@H](Nc1cc(N[C@H]2CC[C@@H](CC2)c2ccccc2)ncn1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H27ClN4/c1-17(18-7-11-21(25)12-8-18)28-23-15-24(27-16-26-23)29-22-13-9-20(10-14-22)19-5-3-2-4-6-19/h2-8,11-12,15-17,20,22H,9-10,13-14H2,1H3,(H2,26,27,28,29)/t17-,20-,22-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50361778
PNG
(CHEMBL1938514)
Show SMILES C[C@H](NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H27ClN2O/c1-17(18-7-9-21(23)10-8-18)24-22(26)13-16-25-14-11-20(12-15-25)19-5-3-2-4-6-19/h2-10,17,20H,11-16H2,1H3,(H,24,26)/t17-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50361783
PNG
(CHEMBL1938519)
Show SMILES FC(F)(F)C(NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClF3N2O/c23-19-8-6-18(7-9-19)21(22(24,25)26)27-20(29)12-15-28-13-10-17(11-14-28)16-4-2-1-3-5-16/h1-9,17,21H,10-15H2,(H,27,29)
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n/an/a 70n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50365041
PNG
(CHEMBL1950918)
Show SMILES C[C@H](Nc1cc(N[C@H]2CC[C@@H](CC2)c2ccccc2)ncn1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H27ClN4/c1-17(18-7-11-21(25)12-8-18)28-23-15-24(27-16-26-23)29-22-13-9-20(10-14-22)19-5-3-2-4-6-19/h2-8,11-12,15-17,20,22H,9-10,13-14H2,1H3,(H2,26,27,28,29)/t17-,20-,22-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50365012
PNG
(CHEMBL1950916)
Show SMILES C[C@H](N(C)c1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H29ClN4O/c1-15(16-7-9-18(22)10-8-16)25(4)19-12-20(24-14-23-19)26-11-5-6-17(13-26)21(2,3)27/h7-10,12,14-15,17,27H,5-6,11,13H2,1-4H3/t15-,17?/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50364409
PNG
(CHEMBL1950442)
Show SMILES C[C@H](NC(=O)[C@@H](N)Cc1cccc(c1)C#N)c1nc2cc(Cl)c(Cl)cc2[nH]1
Show InChI InChI=1S/C19H17Cl2N5O/c1-10(18-25-16-7-13(20)14(21)8-17(16)26-18)24-19(27)15(23)6-11-3-2-4-12(5-11)9-22/h2-5,7-8,10,15H,6,23H2,1H3,(H,24,27)(H,25,26)/t10-,15-/m0/s1
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n/an/a 102n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate for 30 mins by continuous fluorimetric assay


Bioorg Med Chem Lett 22: 1774-8 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.064
BindingDB Entry DOI: 10.7270/Q27H1K28
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50365042
PNG
(CHEMBL1950919)
Show SMILES C[C@H](Nc1cc(N[C@H]2CC[C@@H](CC2)NS(C)(=O)=O)ncn1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H26ClN5O2S/c1-13(14-3-5-15(20)6-4-14)23-18-11-19(22-12-21-18)24-16-7-9-17(10-8-16)25-28(2,26)27/h3-6,11-13,16-17,25H,7-10H2,1-2H3,(H2,21,22,23,24)/t13-,16-,17-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50365012
PNG
(CHEMBL1950916)
Show SMILES C[C@H](N(C)c1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H29ClN4O/c1-15(16-7-9-18(22)10-8-16)25(4)19-12-20(24-14-23-19)26-11-5-6-17(13-26)21(2,3)27/h7-10,12,14-15,17,27H,5-6,11,13H2,1-4H3/t15-,17?/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50365013
PNG
(CHEMBL1949687)
Show SMILES COC(=O)N[C@H]1CC[C@@H](CC1)Nc1cc(N[C@@H](C)c2ccc(Cl)cc2)ncn1
Show InChI InChI=1S/C20H26ClN5O2/c1-13(14-3-5-15(21)6-4-14)24-18-11-19(23-12-22-18)25-16-7-9-17(10-8-16)26-20(27)28-2/h3-6,11-13,16-17H,7-10H2,1-2H3,(H,26,27)(H2,22,23,24,25)/t13-,16-,17-/m0/s1
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n/an/a 159n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant PrCP assessed as angiotensin 3 cleavage after 8 mins by LC/MS analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50361782
PNG
(CHEMBL1938518)
Show SMILES FC(F)C(NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H25ClF2N2O/c23-19-8-6-18(7-9-19)21(22(24)25)26-20(28)12-15-27-13-10-17(11-14-27)16-4-2-1-3-5-16/h1-9,17,21-22H,10-15H2,(H,26,28)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50365011
PNG
(CHEMBL1950912)
Show SMILES C[C@H](Nc1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H27ClN4O/c1-14(15-6-8-17(21)9-7-15)24-18-11-19(23-13-22-18)25-10-4-5-16(12-25)20(2,3)26/h6-9,11,13-14,16,26H,4-5,10,12H2,1-3H3,(H,22,23,24)/t14-,16?/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50365011
PNG
(CHEMBL1950912)
Show SMILES C[C@H](Nc1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H27ClN4O/c1-14(15-6-8-17(21)9-7-15)24-18-11-19(23-13-22-18)25-10-4-5-16(12-25)20(2,3)26/h6-9,11,13-14,16,26H,4-5,10,12H2,1-3H3,(H,22,23,24)/t14-,16?/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50365012
PNG
(CHEMBL1950916)
Show SMILES C[C@H](N(C)c1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H29ClN4O/c1-15(16-7-9-18(22)10-8-16)25(4)19-12-20(24-14-23-19)26-11-5-6-17(13-26)21(2,3)27/h7-10,12,14-15,17,27H,5-6,11,13H2,1-4H3/t15-,17?/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50361778
PNG
(CHEMBL1938514)
Show SMILES C[C@H](NC(=O)CCN1CCC(CC1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H27ClN2O/c1-17(18-7-9-21(23)10-8-18)24-22(26)13-16-25-14-11-20(12-15-25)19-5-3-2-4-6-19/h2-10,17,20H,11-16H2,1H3,(H,24,26)/t17-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PrCP-mediated conversion of Ang3 to Ang(2-7) in mouse plasma


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50361751
PNG
(CHEMBL1938486)
Show SMILES C[C@H](NC(=O)CCN1CCC(CC1)c1nc(no1)-c1ccccn1)c1ccc(F)cc1
Show InChI InChI=1S/C23H26FN5O2/c1-16(17-5-7-19(24)8-6-17)26-21(30)11-15-29-13-9-18(10-14-29)23-27-22(28-31-23)20-4-2-3-12-25-20/h2-8,12,16,18H,9-11,13-15H2,1H3,(H,26,30)/t16-/m0/s1
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n/an/a 313n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50361751
PNG
(CHEMBL1938486)
Show SMILES C[C@H](NC(=O)CCN1CCC(CC1)c1nc(no1)-c1ccccn1)c1ccc(F)cc1
Show InChI InChI=1S/C23H26FN5O2/c1-16(17-5-7-19(24)8-6-17)26-21(30)11-15-29-13-9-18(10-14-29)23-27-22(28-31-23)20-4-2-3-12-25-20/h2-8,12,16,18H,9-11,13-15H2,1H3,(H,26,30)/t16-/m0/s1
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n/an/a 348n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PrCP-mediated conversion of Ang3 to Ang(2-7) in mouse plasma


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM50365011
PNG
(CHEMBL1950912)
Show SMILES C[C@H](Nc1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H27ClN4O/c1-14(15-6-8-17(21)9-7-15)24-18-11-19(23-13-22-18)25-10-4-5-16(12-25)20(2,3)26/h6-9,11,13-14,16,26H,4-5,10,12H2,1-3H3,(H,22,23,24)/t14-,16?/m0/s1
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n/an/a 350n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50365011
PNG
(CHEMBL1950912)
Show SMILES C[C@H](Nc1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H27ClN4O/c1-14(15-6-8-17(21)9-7-15)24-18-11-19(23-13-22-18)25-10-4-5-16(12-25)20(2,3)26/h6-9,11,13-14,16,26H,4-5,10,12H2,1-3H3,(H,22,23,24)/t14-,16?/m0/s1
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n/an/a 350n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant PrCP assessed as angiotensin 3 cleavage after 8 mins by LC/MS analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50365011
PNG
(CHEMBL1950912)
Show SMILES C[C@H](Nc1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H27ClN4O/c1-14(15-6-8-17(21)9-7-15)24-18-11-19(23-13-22-18)25-10-4-5-16(12-25)20(2,3)26/h6-9,11,13-14,16,26H,4-5,10,12H2,1-3H3,(H,22,23,24)/t14-,16?/m0/s1
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n/an/a 407n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant PrCP assessed as angiotensin 3 cleavage after 8 mins by LC/MS analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50365011
PNG
(CHEMBL1950912)
Show SMILES C[C@H](Nc1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H27ClN4O/c1-14(15-6-8-17(21)9-7-15)24-18-11-19(23-13-22-18)25-10-4-5-16(12-25)20(2,3)26/h6-9,11,13-14,16,26H,4-5,10,12H2,1-3H3,(H,22,23,24)/t14-,16?/m0/s1
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n/an/a 570n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50361765
PNG
(CHEMBL1938501)
Show SMILES C[C@H](NC(=O)[C@@H](N)[C@@H](C)c1ccc(cc1)-c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H25ClN2O/c1-16(18-8-10-21(11-9-18)20-6-4-3-5-7-20)23(26)24(28)27-17(2)19-12-14-22(25)15-13-19/h3-17,23H,26H2,1-2H3,(H,27,28)/t16-,17-,23-/m0/s1
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n/an/a 570n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PrCP-mediated conversion of Ang3 to Ang(2-7) in mouse plasma


Bioorg Med Chem Lett 22: 658-65 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.060
BindingDB Entry DOI: 10.7270/Q2B56K50
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50365012
PNG
(CHEMBL1950916)
Show SMILES C[C@H](N(C)c1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H29ClN4O/c1-15(16-7-9-18(22)10-8-16)25(4)19-12-20(24-14-23-19)26-11-5-6-17(13-26)21(2,3)27/h7-10,12,14-15,17,27H,5-6,11,13H2,1-4H3/t15-,17?/m0/s1
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n/an/a 797n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50365012
PNG
(CHEMBL1950916)
Show SMILES C[C@H](N(C)c1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H29ClN4O/c1-15(16-7-9-18(22)10-8-16)25(4)19-12-20(24-14-23-19)26-11-5-6-17(13-26)21(2,3)27/h7-10,12,14-15,17,27H,5-6,11,13H2,1-4H3/t15-,17?/m0/s1
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n/an/a 2.21E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant PrCP assessed as angiotensin 3 cleavage after 8 mins by LC/MS analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50365012
PNG
(CHEMBL1950916)
Show SMILES C[C@H](N(C)c1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H29ClN4O/c1-15(16-7-9-18(22)10-8-16)25(4)19-12-20(24-14-23-19)26-11-5-6-17(13-26)21(2,3)27/h7-10,12,14-15,17,27H,5-6,11,13H2,1-4H3/t15-,17?/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant PrCP assessed as angiotensin 3 cleavage after 8 mins by LC/MS analysis


Bioorg Med Chem Lett 22: 1727-30 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.098
BindingDB Entry DOI: 10.7270/Q2GT5NNH
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Mus musculus)
BDBM50364409
PNG
(CHEMBL1950442)
Show SMILES C[C@H](NC(=O)[C@@H](N)Cc1cccc(c1)C#N)c1nc2cc(Cl)c(Cl)cc2[nH]1
Show InChI InChI=1S/C19H17Cl2N5O/c1-10(18-25-16-7-13(20)14(21)8-17(16)26-18)24-19(27)15(23)6-11-3-2-4-12(5-11)9-22/h2-5,7-8,10,15H,6,23H2,1H3,(H,24,27)(H,25,26)/t10-,15-/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PrCP-mediated angiotensin3 cleavage in mouse plasma using Mca-Ala-Lys-Dnp as substrate for 8 mins by LC/MS analysis


Bioorg Med Chem Lett 22: 1774-8 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.064
BindingDB Entry DOI: 10.7270/Q27H1K28
More data for this
Ligand-Target Pair