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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 432.3
BDBM215084
Wt: 432.3
BDBM215090
Wt: 420.3
BDBM215091
Wt: 446.3
BDBM215092
Wt: 434.3
BDBM215093
Wt: 431.3
BDBM215097
Wt: 431.3
BDBM215108
Wt: 437.3
BDBM215112
Wt: 438.3
BDBM215113
Wt: 434.3
BDBM215403
Wt: 446.3
BDBM215121
Wt: 434.3
BDBM215122
Wt: 434.3
BDBM215430
Wt: 434.3
BDBM215431
Wt: 435.3
BDBM215442
Displayed 1 to 15 (of 405 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 26 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM215431
PNG
(US9296736, 419 | US9593129, Example 419)
Show SMILES CC(C)N1C(=O)[C@@H](CC(O)=O)C[C@H](c2cccc(Cl)c2)[C@@]1(C)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25Cl2NO3/c1-14(2)26-22(29)16(13-21(27)28)12-20(15-5-4-6-19(25)11-15)23(26,3)17-7-9-18(24)10-8-17/h4-11,14,16,20H,12-13H2,1-3H3,(H,27,28)/t16-,20-,23-/m1/s1
GoogleScholar
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PC cid
PC sid
UniChem
n/an/a 3.40n/an/an/an/an/an/a



Amgen, Inc.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9593129 (2017)

More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215431
PNG
(US9296736, 419 | US9593129, Example 419)
Show SMILES CC(C)N1C(=O)[C@@H](CC(O)=O)C[C@H](c2cccc(Cl)c2)[C@@]1(C)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25Cl2NO3/c1-14(2)26-22(29)16(13-21(27)28)12-20(15-5-4-6-19(25)11-15)23(26,3)17-7-9-18(24)10-8-17/h4-11,14,16,20H,12-13H2,1-3H3,(H,27,28)/t16-,20-,23-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 3.40n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215403
PNG
(US9296736, 391)
Show SMILES CC(C)N1[C@@H]([C@H](C[C@](C)(CC=C)C1=O)c1ccc(F)c(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H26Cl2FNO/c1-5-12-24(4)14-19(17-8-11-21(27)20(26)13-17)22(28(15(2)3)23(24)29)16-6-9-18(25)10-7-16/h5-11,13,15,19,22H,1,12,14H2,2-4H3/t19-,22-,24+/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 5n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM215122
PNG
(US9296736, 73 | US9593129, Example 73)
Show SMILES CC(C)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25Cl2NO3/c1-14(2)26-21(15-7-9-17(24)10-8-15)19(16-5-4-6-18(25)11-16)12-23(3,22(26)29)13-20(27)28/h4-11,14,19,21H,12-13H2,1-3H3,(H,27,28)/t19-,21-,23-/m1/s1
GoogleScholar
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PC sid
UniChem
n/an/a 6n/an/an/an/an/an/a



Amgen, Inc.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9593129 (2017)

More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215122
PNG
(US9296736, 73 | US9593129, Example 73)
Show SMILES CC(C)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25Cl2NO3/c1-14(2)26-21(15-7-9-17(24)10-8-15)19(16-5-4-6-18(25)11-16)12-23(3,22(26)29)13-20(27)28/h4-11,14,19,21H,12-13H2,1-3H3,(H,27,28)/t19-,21-,23-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 6n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM215430
PNG
(US9296736, 418 | US9593129, Example 418)
Show SMILES CC(C)N1C(=O)[C@H](CC(O)=O)C[C@H](c2cccc(Cl)c2)[C@@]1(C)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25Cl2NO3/c1-14(2)26-22(29)16(13-21(27)28)12-20(15-5-4-6-19(25)11-15)23(26,3)17-7-9-18(24)10-8-17/h4-11,14,16,20H,12-13H2,1-3H3,(H,27,28)/t16-,20+,23+/m0/s1
GoogleScholar
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PC cid
PC sid
UniChem
n/an/a 18.3n/an/an/an/an/an/a



Amgen, Inc.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9593129 (2017)

More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215430
PNG
(US9296736, 418 | US9593129, Example 418)
Show SMILES CC(C)N1C(=O)[C@H](CC(O)=O)C[C@H](c2cccc(Cl)c2)[C@@]1(C)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25Cl2NO3/c1-14(2)26-22(29)16(13-21(27)28)12-20(15-5-4-6-19(25)11-15)23(26,3)17-7-9-18(24)10-8-17/h4-11,14,16,20H,12-13H2,1-3H3,(H,27,28)/t16-,20+,23+/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 18.3n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM215442
PNG
(US9296736, 430 | US9593129, Example 430)
Show SMILES CN(C)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24Cl2N2O3/c1-22(13-19(27)28)12-18(15-5-4-6-17(24)11-15)20(26(21(22)29)25(2)3)14-7-9-16(23)10-8-14/h4-11,18,20H,12-13H2,1-3H3,(H,27,28)/t18-,20-,22-/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 20n/an/an/an/an/an/a



Amgen, Inc.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9593129 (2017)

More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215442
PNG
(US9296736, 430 | US9593129, Example 430)
Show SMILES CN(C)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24Cl2N2O3/c1-22(13-19(27)28)12-18(15-5-4-6-17(24)11-15)20(26(21(22)29)25(2)3)14-7-9-16(23)10-8-14/h4-11,18,20H,12-13H2,1-3H3,(H,27,28)/t18-,20-,22-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 20n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215084
PNG
(US9296736, 35)
Show SMILES OC(=O)C[C@H]1CC([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO3/c24-18-8-6-15(7-9-18)22-20(16-2-1-3-19(25)10-16)11-17(12-21(27)28)23(29)26(22)13-14-4-5-14/h1-3,6-10,14,17,20,22H,4-5,11-13H2,(H,27,28)/t17-,20?,22-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 30n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM215122
PNG
(US9296736, 73 | US9593129, Example 73)
Show SMILES CC(C)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25Cl2NO3/c1-14(2)26-21(15-7-9-17(24)10-8-15)19(16-5-4-6-18(25)11-16)12-23(3,22(26)29)13-20(27)28/h4-11,14,19,21H,12-13H2,1-3H3,(H,27,28)/t19-,21-,23-/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 30n/an/an/an/an/an/a



Amgen, Inc.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9593129 (2017)

More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215122
PNG
(US9296736, 73 | US9593129, Example 73)
Show SMILES CC(C)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25Cl2NO3/c1-14(2)26-21(15-7-9-17(24)10-8-15)19(16-5-4-6-18(25)11-16)12-23(3,22(26)29)13-20(27)28/h4-11,14,19,21H,12-13H2,1-3H3,(H,27,28)/t19-,21-,23-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 30n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM215121
PNG
(US9296736, 72 | US9593129, Example 72)
Show SMILES C[C@]1(CC(O)=O)C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C24H25Cl2NO3/c1-24(13-21(28)29)12-20(17-3-2-4-19(26)11-17)22(16-7-9-18(25)10-8-16)27(23(24)30)14-15-5-6-15/h2-4,7-11,15,20,22H,5-6,12-14H2,1H3,(H,28,29)/t20-,22-,24-/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 60n/an/an/an/an/an/a



Amgen, Inc.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9593129 (2017)

More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215121
PNG
(US9296736, 72 | US9593129, Example 72)
Show SMILES C[C@]1(CC(O)=O)C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C24H25Cl2NO3/c1-24(13-21(28)29)12-20(17-3-2-4-19(26)11-17)22(16-7-9-18(25)10-8-16)27(23(24)30)14-15-5-6-15/h2-4,7-11,15,20,22H,5-6,12-14H2,1H3,(H,28,29)/t20-,22-,24-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 60n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215084
PNG
(US9296736, 35)
Show SMILES OC(=O)C[C@H]1CC([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO3/c24-18-8-6-15(7-9-18)22-20(16-2-1-3-19(25)10-16)11-17(12-21(27)28)23(29)26(22)13-14-4-5-14/h1-3,6-10,14,17,20,22H,4-5,11-13H2,(H,27,28)/t17-,20?,22-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 150n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215113
PNG
(US9296736, 64)
Show SMILES OC(=O)C[C@@H]1CC([C@H](N(CC2CC2)C1=O)c1ccc(Cl)s1)c1cccc(Cl)c1
Show InChI InChI=1S/C21H21Cl2NO3S/c22-15-3-1-2-13(8-15)16-9-14(10-19(25)26)21(27)24(11-12-4-5-12)20(16)17-6-7-18(23)28-17/h1-3,6-8,12,14,16,20H,4-5,9-11H2,(H,25,26)/t14-,16?,20-/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
n/an/a 220n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215090
PNG
(US9296736, 41)
Show SMILES OC(=O)C[C@@H]1CC([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO3/c24-18-8-6-15(7-9-18)22-20(16-2-1-3-19(25)10-16)11-17(12-21(27)28)23(29)26(22)13-14-4-5-14/h1-3,6-10,14,17,20,22H,4-5,11-13H2,(H,27,28)/t17-,20?,22+/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
n/an/a 320n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215091
PNG
(US9296736, 42)
Show SMILES CCCN1[C@@H](C(C[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23Cl2NO3/c1-2-10-25-21(14-6-8-17(23)9-7-14)19(15-4-3-5-18(24)11-15)12-16(22(25)28)13-20(26)27/h3-9,11,16,19,21H,2,10,12-13H2,1H3,(H,26,27)/t16-,19?,21+/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
n/an/a 410n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215112
PNG
(US9296736, 63)
Show SMILES OC(=O)C[C@H]1C[C@@H]([C@H](C(CC2CC2)C1=O)c1ccc(Cl)s1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H22Cl2O3S/c23-15-3-1-2-13(9-15)16-10-14(11-20(25)26)22(27)17(8-12-4-5-12)21(16)18-6-7-19(24)28-18/h1-3,6-7,9,12,14,16-17,21H,4-5,8,10-11H2,(H,25,26)/t14-,16-,17?,21-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
n/an/a 430n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215093
PNG
(US9296736, 44 | US9593129, Example 44)
Show SMILES CC(C)CN1[C@@H](C(C[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25Cl2NO3/c1-14(2)13-26-22(15-6-8-18(24)9-7-15)20(16-4-3-5-19(25)10-16)11-17(23(26)29)12-21(27)28/h3-10,14,17,20,22H,11-13H2,1-2H3,(H,27,28)/t17-,20?,22+/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
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PC cid
PC sid
UniChem
n/an/a 450n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM215093
PNG
(US9296736, 44 | US9593129, Example 44)
Show SMILES CC(C)CN1[C@@H](C(C[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25Cl2NO3/c1-14(2)13-26-22(15-6-8-18(24)9-7-15)20(16-4-3-5-19(25)10-16)11-17(23(26)29)12-21(27)28/h3-10,14,17,20,22H,11-13H2,1-2H3,(H,27,28)/t17-,20?,22+/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 450n/an/an/an/an/an/a



Amgen, Inc.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9593129 (2017)

More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215108
PNG
(US9296736, 59 | US9593129, Example 59)
Show SMILES NC(=O)C[C@@H]1C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H24Cl2N2O2/c24-18-8-6-15(7-9-18)22-20(16-2-1-3-19(25)10-16)11-17(12-21(26)28)23(29)27(22)13-14-4-5-14/h1-3,6-10,14,17,20,22H,4-5,11-13H2,(H2,26,28)/t17-,20+,22+/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 870n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM215108
PNG
(US9296736, 59 | US9593129, Example 59)
Show SMILES NC(=O)C[C@@H]1C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H24Cl2N2O2/c24-18-8-6-15(7-9-18)22-20(16-2-1-3-19(25)10-16)11-17(12-21(26)28)23(29)27(22)13-14-4-5-14/h1-3,6-10,14,17,20,22H,4-5,11-13H2,(H2,26,28)/t17-,20+,22+/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 870n/an/an/an/an/an/a



Amgen, Inc.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9593129 (2017)

More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215097
PNG
(US9296736, 48)
Show SMILES NC(=O)C[C@H]1C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H24Cl2N2O2/c24-18-8-6-15(7-9-18)22-20(16-2-1-3-19(25)10-16)11-17(12-21(26)28)23(29)27(22)13-14-4-5-14/h1-3,6-10,14,17,20,22H,4-5,11-13H2,(H2,26,28)/t17-,20-,22-/m1/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 1.37E+3n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM215092
PNG
(US9296736, 43 | US9593129, Example 43)
Show SMILES OC(=O)C[C@@H]1CC([C@H](N(CC2CCC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C24H25Cl2NO3/c25-19-9-7-16(8-10-19)23-21(17-5-2-6-20(26)11-17)12-18(13-22(28)29)24(30)27(23)14-15-3-1-4-15/h2,5-11,15,18,21,23H,1,3-4,12-14H2,(H,28,29)/t18-,21?,23+/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 1.97E+3n/an/an/an/an/an/a



Amgen, Inc.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9593129 (2017)

More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215092
PNG
(US9296736, 43 | US9593129, Example 43)
Show SMILES OC(=O)C[C@@H]1CC([C@H](N(CC2CCC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C24H25Cl2NO3/c25-19-9-7-16(8-10-19)23-21(17-5-2-6-20(26)11-17)12-18(13-22(28)29)24(30)27(23)14-15-3-1-4-15/h2,5-11,15,18,21,23H,1,3-4,12-14H2,(H,28,29)/t18-,21?,23+/m0/s1
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 1.97E+3n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair