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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 491.5
BDBM276741
Wt: 477.5
BDBM276742
Wt: 461.5
BDBM276743

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM276742
PNG
(US10071991, Compound (I-M7))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(CO)C1
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
UniChem
n/an/a 10n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM276743
PNG
(US10071991, Compound (P))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
UniChem
n/an/a 10n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM276741
PNG
(US10071991, Compound (I-M2))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C1)C(O)=O
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
UniChem
n/an/a 11n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Rattus norvegicus (Rat))
BDBM276743
PNG
(US10071991, Compound (P))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
GoogleScholar
AffyNet 
UniChem
n/an/a 11n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair
Colony stimulating factor 1 receptor


(Canis lupus familiaris (Dog) (Canis familiaris))
BDBM276743
PNG
(US10071991, Compound (P))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
GoogleScholar
AffyNet 
UniChem
n/an/a 16n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM276743
PNG
(US10071991, Compound (P))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
UniChem
n/an/a 18n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair