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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 304.8
BDBM119029
Wt: 272.3
BDBM119031
Wt: 366.4
BDBM119010
Wt: 362.3
BDBM119035
Wt: 361.4
BDBM119048
Wt: 332.3
BDBM119065
Wt: 363.4
BDBM50443129
Wt: 364.3
BDBM50443130
Wt: 364.4
BDBM50443133
Wt: 336.3
BDBM50443134
Wt: 364.4
BDBM50443136
Wt: 364.4
BDBM50443147
Wt: 364.3
BDBM50443148
Wt: 363.4
BDBM50443150
Wt: 335.3
BDBM50443151
Displayed 1 to 15 (of 244 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 27 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50443147
PNG
(CHEMBL3086165)
Show SMILES CC(O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C21H24N4O2/c1-13(26)15-4-5-18(25-20(27)19-23-12-16(11-22)24-19)17(10-15)14-6-8-21(2,3)9-7-14/h4-6,10,12-13,26H,7-9H2,1-3H3,(H,23,24)(H,25,27)
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n/an/a 1.40n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50443148
PNG
(CHEMBL3086164)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C(O)=O
Show InChI InChI=1S/C20H20N4O3/c1-20(2)7-5-12(6-8-20)15-9-13(19(26)27)3-4-16(15)24-18(25)17-22-11-14(10-21)23-17/h3-5,9,11H,6-8H2,1-2H3,(H,22,23)(H,24,25)(H,26,27)
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n/an/a 1.5n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119048
PNG
(US8674100, 68)
Show SMILES CNCC(=C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C21H23N5O/c1-14(12-23-2)16-8-9-19(18(10-16)15-6-4-3-5-7-15)26-21(27)20-24-13-17(11-22)25-20/h6,8-10,13,23H,1,3-5,7,12H2,2H3,(H,24,25)(H,26,27)
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n/an/a 1.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50443150
PNG
(CHEMBL3086162)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C(N)=O
Show InChI InChI=1S/C20H21N5O2/c1-20(2)7-5-12(6-8-20)15-9-13(17(22)26)3-4-16(15)25-19(27)18-23-11-14(10-21)24-18/h3-5,9,11H,6-8H2,1-2H3,(H2,22,26)(H,23,24)(H,25,27)
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n/an/a 2.20n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443129
PNG
(CHEMBL3085980 | US8674100, 7)
Show SMILES NC(=O)CCc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H21N5O2/c21-11-15-12-23-19(24-15)20(27)25-17-8-6-13(7-9-18(22)26)10-16(17)14-4-2-1-3-5-14/h4,6,8,10,12H,1-3,5,7,9H2,(H2,22,26)(H,23,24)(H,25,27)
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n/an/a 2.70n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50443129
PNG
(CHEMBL3085980 | US8674100, 7)
Show SMILES NC(=O)CCc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H21N5O2/c21-11-15-12-23-19(24-15)20(27)25-17-8-6-13(7-9-18(22)26)10-16(17)14-4-2-1-3-5-14/h4,6,8,10,12H,1-3,5,7,9H2,(H2,22,26)(H,23,24)(H,25,27)
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n/an/a 2.70n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50443151
PNG
(CHEMBL3086325)
Show SMILES NC(=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C18H17N5O2/c19-9-13-10-21-17(22-13)18(25)23-15-7-6-12(16(20)24)8-14(15)11-4-2-1-3-5-11/h4,6-8,10H,1-3,5H2,(H2,20,24)(H,21,22)(H,23,25)
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n/an/a 3.60n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50443136
PNG
(CHEMBL3086171)
Show SMILES CC(C)(O)Cc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C21H24N4O2/c1-21(2,27)11-14-8-9-18(17(10-14)15-6-4-3-5-7-15)25-20(26)19-23-13-16(12-22)24-19/h6,8-10,13,27H,3-5,7,11H2,1-2H3,(H,23,24)(H,25,26)
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n/an/a 3.70n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119035
PNG
(US8674100, 48)
Show SMILES OC(=O)C=Cc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H18N4O3/c21-11-15-12-22-19(23-15)20(27)24-17-8-6-13(7-9-18(25)26)10-16(17)14-4-2-1-3-5-14/h4,6-10,12H,1-3,5H2,(H,22,23)(H,24,27)(H,25,26)/b9-7+
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n/an/a 3.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119031
PNG
(US8674100, 44)
Show SMILES Nc1ccc(CN2CCOCC2)cc1C1=CCCCC1
Show InChI InChI=1S/C17H24N2O/c18-17-7-6-14(13-19-8-10-20-11-9-19)12-16(17)15-4-2-1-3-5-15/h4,6-7,12H,1-3,5,8-11,13,18H2
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n/an/a 4.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50443133
PNG
(CHEMBL3086174)
Show SMILES CC1(C)CCC(=CC1)c1cc(CCO)ccc1NC(=O)c1ncc([nH]1)C#N
Show InChI InChI=1S/C21H24N4O2/c1-21(2)8-5-15(6-9-21)17-11-14(7-10-26)3-4-18(17)25-20(27)19-23-13-16(12-22)24-19/h3-5,11,13,26H,6-10H2,1-2H3,(H,23,24)(H,25,27)
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n/an/a 4.60n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119035
PNG
(US8674100, 48)
Show SMILES OC(=O)C=Cc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H18N4O3/c21-11-15-12-22-19(23-15)20(27)24-17-8-6-13(7-9-18(25)26)10-16(17)14-4-2-1-3-5-14/h4,6-10,12H,1-3,5H2,(H,22,23)(H,24,27)(H,25,26)/b9-7+
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n/an/a 5.30n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443130
PNG
(CHEMBL3085979 | US8674100, 8)
Show SMILES OC(=O)CCc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H20N4O3/c21-11-15-12-22-19(23-15)20(27)24-17-8-6-13(7-9-18(25)26)10-16(17)14-4-2-1-3-5-14/h4,6,8,10,12H,1-3,5,7,9H2,(H,22,23)(H,24,27)(H,25,26)
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n/an/a 5.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50443130
PNG
(CHEMBL3085979 | US8674100, 8)
Show SMILES OC(=O)CCc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H20N4O3/c21-11-15-12-22-19(23-15)20(27)24-17-8-6-13(7-9-18(25)26)10-16(17)14-4-2-1-3-5-14/h4,6,8,10,12H,1-3,5,7,9H2,(H,22,23)(H,24,27)(H,25,26)
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n/an/a 5.90n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50443134
PNG
(CHEMBL3086173)
Show SMILES OCCc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C19H20N4O2/c20-11-15-12-21-18(22-15)19(25)23-17-7-6-13(8-9-24)10-16(17)14-4-2-1-3-5-14/h4,6-7,10,12,24H,1-3,5,8-9H2,(H,21,22)(H,23,25)
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n/an/a 6.80n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119029
PNG
(US8674100, 41)
Show SMILES CCOC(=O)c1nc(Cl)cn1COCC[Si](C)(C)C
Show InChI InChI=1S/C12H21ClN2O3Si/c1-5-18-12(16)11-14-10(13)8-15(11)9-17-6-7-19(2,3)4/h8H,5-7,9H2,1-4H3
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n/an/a 8.20n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443133
PNG
(CHEMBL3086174)
Show SMILES CC1(C)CCC(=CC1)c1cc(CCO)ccc1NC(=O)c1ncc([nH]1)C#N
Show InChI InChI=1S/C21H24N4O2/c1-21(2)8-5-15(6-9-21)17-11-14(7-10-26)3-4-18(17)25-20(27)19-23-13-16(12-22)24-19/h3-5,11,13,26H,6-10H2,1-2H3,(H,23,24)(H,25,27)
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n/an/a 18n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS in mouse BMDM cells


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443150
PNG
(CHEMBL3086162)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C(N)=O
Show InChI InChI=1S/C20H21N5O2/c1-20(2)7-5-12(6-8-20)15-9-13(17(22)26)3-4-16(15)25-19(27)18-23-11-14(10-21)24-18/h3-5,9,11H,6-8H2,1-2H3,(H2,22,26)(H,23,24)(H,25,27)
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n/an/a 32n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS in mouse BMDM cells


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443136
PNG
(CHEMBL3086171)
Show SMILES CC(C)(O)Cc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C21H24N4O2/c1-21(2,27)11-14-8-9-18(17(10-14)15-6-4-3-5-7-15)25-20(26)19-23-13-16(12-22)24-19/h6,8-10,13,27H,3-5,7,11H2,1-2H3,(H,23,24)(H,25,26)
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n/an/a 32n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS in mouse BMDM cells


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119065
PNG
(US8674100, 2)
Show SMILES CC(=C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H20N4O/c1-13(2)15-8-9-18(17(10-15)14-6-4-3-5-7-14)24-20(25)19-22-12-16(11-21)23-19/h6,8-10,12H,1,3-5,7H2,2H3,(H,22,23)(H,24,25)
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n/an/a 32.9n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443151
PNG
(CHEMBL3086325)
Show SMILES NC(=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C18H17N5O2/c19-9-13-10-21-17(22-13)18(25)23-15-7-6-12(16(20)24)8-14(15)11-4-2-1-3-5-11/h4,6-8,10H,1-3,5H2,(H2,20,24)(H,21,22)(H,23,25)
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n/an/a 34n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS in mouse BMDM cells


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443134
PNG
(CHEMBL3086173)
Show SMILES OCCc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C19H20N4O2/c20-11-15-12-21-18(22-15)19(25)23-17-7-6-13(8-9-24)10-16(17)14-4-2-1-3-5-14/h4,6-7,10,12,24H,1-3,5,8-9H2,(H,21,22)(H,23,25)
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n/an/a 40n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS in mouse BMDM cells


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443129
PNG
(CHEMBL3085980 | US8674100, 7)
Show SMILES NC(=O)CCc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H21N5O2/c21-11-15-12-23-19(24-15)20(27)25-17-8-6-13(7-9-18(22)26)10-16(17)14-4-2-1-3-5-14/h4,6,8,10,12H,1-3,5,7,9H2,(H2,22,26)(H,23,24)(H,25,27)
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n/an/a>50n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS in mouse BMDM cells


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119010
PNG
(US8674100, 11)
Show SMILES OCC(CO)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H22N4O3/c21-9-16-10-22-19(23-16)20(27)24-18-7-6-14(15(11-25)12-26)8-17(18)13-4-2-1-3-5-13/h4,6-8,10,15,25-26H,1-3,5,11-12H2,(H,22,23)(H,24,27)
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n/an/a 60n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443147
PNG
(CHEMBL3086165)
Show SMILES CC(O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C21H24N4O2/c1-13(26)15-4-5-18(25-20(27)19-23-12-16(11-22)24-19)17(10-15)14-6-8-21(2,3)9-7-14/h4-6,10,12-13,26H,7-9H2,1-3H3,(H,23,24)(H,25,27)
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Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS in mouse BMDM cells


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443130
PNG
(CHEMBL3085979 | US8674100, 8)
Show SMILES OC(=O)CCc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H20N4O3/c21-11-15-12-22-19(23-15)20(27)24-17-8-6-13(7-9-18(25)26)10-16(17)14-4-2-1-3-5-14/h4,6,8,10,12H,1-3,5,7,9H2,(H,22,23)(H,24,27)(H,25,26)
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Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS in mouse BMDM cells


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443148
PNG
(CHEMBL3086164)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C(O)=O
Show InChI InChI=1S/C20H20N4O3/c1-20(2)7-5-12(6-8-20)15-9-13(19(26)27)3-4-16(15)24-18(25)17-22-11-14(10-21)23-17/h3-5,9,11H,6-8H2,1-2H3,(H,22,23)(H,24,25)(H,26,27)
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Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS in mouse BMDM cells


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair