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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 280.3
BDBM50078851
Wt: 252.3
BDBM50078852
Wt: 224.2
BDBM50078853
Wt: 196.1
BDBM50078854
Wt: 290.3
BDBM50078859
Wt: 224.2
BDBM50078861
Wt: 252.3
BDBM50078862
Wt: 280.3
BDBM50078863
Wt: 224.2
BDBM50078873
Wt: 252.3
BDBM50078874
Wt: 280.3
BDBM50078875
Wt: 238.2
BDBM50078877
Wt: 210.2
BDBM50078878
Wt: 276.3
BDBM50078880
Wt: 266.3
BDBM50078876
Displayed 1 to 15 (of 48 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 60 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078851
PNG
(CHEMBL3416163)
Show SMILES CCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C16H24O4/c1-2-3-4-5-6-7-8-9-10-12-15(19)13(17)11-14(18)16(12)20/h11,17,20H,2-10H2,1H3
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n/an/a 180n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078862
PNG
(CHEMBL3416179)
Show SMILES CCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C14H20O4/c1-4-5-6-7-8-10-13(16)12(17-2)9-11(15)14(10)18-3/h9H,4-8H2,1-3H3
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n/an/a 320n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078863
PNG
(CHEMBL3416180)
Show SMILES CCCCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C16H24O4/c1-4-5-6-7-8-9-10-12-15(18)14(19-2)11-13(17)16(12)20-3/h11H,4-10H2,1-3H3
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n/an/a 320n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078874
PNG
(CHEMBL3416355)
Show SMILES CCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C14H20O4/c1-4-5-6-7-8-10-13(16)11(15)9-12(17-2)14(10)18-3/h9H,4-8H2,1-3H3
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n/an/a 330n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078875
PNG
(CHEMBL3416356)
Show SMILES CCCCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C16H24O4/c1-4-5-6-7-8-9-10-12-15(18)13(17)11-14(19-2)16(12)20-3/h11H,4-10H2,1-3H3
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n/an/a 330n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078875
PNG
(CHEMBL3416356)
Show SMILES CCCCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C16H24O4/c1-4-5-6-7-8-9-10-12-15(18)13(17)11-14(19-2)16(12)20-3/h11H,4-10H2,1-3H3
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n/an/a 380n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078852
PNG
(CHEMBL221598)
Show SMILES CCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C14H20O4/c1-2-3-4-5-6-7-8-10-13(17)11(15)9-12(16)14(10)18/h9,15,18H,2-8H2,1H3
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n/an/a 380n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078863
PNG
(CHEMBL3416180)
Show SMILES CCCCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C16H24O4/c1-4-5-6-7-8-9-10-12-15(18)14(19-2)11-13(17)16(12)20-3/h11H,4-10H2,1-3H3
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n/an/a 570n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078852
PNG
(CHEMBL221598)
Show SMILES CCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C14H20O4/c1-2-3-4-5-6-7-8-10-13(17)11(15)9-12(16)14(10)18/h9,15,18H,2-8H2,1H3
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n/an/a 800n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078875
PNG
(CHEMBL3416356)
Show SMILES CCCCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C16H24O4/c1-4-5-6-7-8-9-10-12-15(18)13(17)11-14(19-2)16(12)20-3/h11H,4-10H2,1-3H3
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n/an/a 820n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078874
PNG
(CHEMBL3416355)
Show SMILES CCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C14H20O4/c1-4-5-6-7-8-10-13(16)11(15)9-12(17-2)14(10)18-3/h9H,4-8H2,1-3H3
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n/an/a 990n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078851
PNG
(CHEMBL3416163)
Show SMILES CCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C16H24O4/c1-2-3-4-5-6-7-8-9-10-12-15(19)13(17)11-14(18)16(12)20/h11,17,20H,2-10H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078863
PNG
(CHEMBL3416180)
Show SMILES CCCCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C16H24O4/c1-4-5-6-7-8-9-10-12-15(18)14(19-2)11-13(17)16(12)20-3/h11H,4-10H2,1-3H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078862
PNG
(CHEMBL3416179)
Show SMILES CCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C14H20O4/c1-4-5-6-7-8-10-13(16)12(17-2)9-11(15)14(10)18-3/h9H,4-8H2,1-3H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078880
PNG
(CHEMBL3416167)
Show SMILES CC(C)=CCC\C(C)=C\CC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C16H20O4/c1-10(2)5-4-6-11(3)7-8-12-15(19)13(17)9-14(18)16(12)20/h5,7,9,17,20H,4,6,8H2,1-3H3/b11-7+
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078851
PNG
(CHEMBL3416163)
Show SMILES CCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C16H24O4/c1-2-3-4-5-6-7-8-9-10-12-15(19)13(17)11-14(18)16(12)20/h11,17,20H,2-10H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078873
PNG
(CHEMBL3416354)
Show SMILES CCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C12H16O4/c1-4-5-6-8-11(14)9(13)7-10(15-2)12(8)16-3/h7H,4-6H2,1-3H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078862
PNG
(CHEMBL3416179)
Show SMILES CCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C14H20O4/c1-4-5-6-7-8-10-13(16)12(17-2)9-11(15)14(10)18-3/h9H,4-8H2,1-3H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078874
PNG
(CHEMBL3416355)
Show SMILES CCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C14H20O4/c1-4-5-6-7-8-10-13(16)11(15)9-12(17-2)14(10)18-3/h9H,4-8H2,1-3H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078876
PNG
(CHEMBL3416171)
Show SMILES CCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C15H22O4/c1-3-4-5-6-7-8-9-11-14(17)12(16)10-13(19-2)15(11)18/h10,17H,3-9H2,1-2H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078861
PNG
(CHEMBL3416178)
Show SMILES CCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C12H16O4/c1-4-5-6-8-11(14)10(15-2)7-9(13)12(8)16-3/h7H,4-6H2,1-3H3
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n/an/a 3.30E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078861
PNG
(CHEMBL3416178)
Show SMILES CCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C12H16O4/c1-4-5-6-8-11(14)10(15-2)7-9(13)12(8)16-3/h7H,4-6H2,1-3H3
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n/an/a 3.40E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078853
PNG
(CHEMBL3263323)
Show SMILES CCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C12H16O4/c1-2-3-4-5-6-8-11(15)9(13)7-10(14)12(8)16/h7,13,16H,2-6H2,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078859
PNG
(CHEMBL3416176)
Show SMILES COC1=CC(=O)C(O)=C(C\C=C(/C)CCC=C(C)C)C1=O
Show InChI InChI=1S/C17H22O4/c1-11(2)6-5-7-12(3)8-9-13-16(19)14(18)10-15(21-4)17(13)20/h6,8,10,19H,5,7,9H2,1-4H3/b12-8+
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n/an/a 4.10E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078873
PNG
(CHEMBL3416354)
Show SMILES CCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C12H16O4/c1-4-5-6-8-11(14)9(13)7-10(15-2)12(8)16-3/h7H,4-6H2,1-3H3
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n/an/a 5.10E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078851
PNG
(CHEMBL3416163)
Show SMILES CCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C16H24O4/c1-2-3-4-5-6-7-8-9-10-12-15(19)13(17)11-14(18)16(12)20/h11,17,20H,2-10H2,1H3
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n/an/a 7.10E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078861
PNG
(CHEMBL3416178)
Show SMILES CCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C12H16O4/c1-4-5-6-8-11(14)10(15-2)7-9(13)12(8)16-3/h7H,4-6H2,1-3H3
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n/an/a 7.90E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078852
PNG
(CHEMBL221598)
Show SMILES CCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C14H20O4/c1-2-3-4-5-6-7-8-10-13(17)11(15)9-12(16)14(10)18/h9,15,18H,2-8H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078880
PNG
(CHEMBL3416167)
Show SMILES CC(C)=CCC\C(C)=C\CC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C16H20O4/c1-10(2)5-4-6-11(3)7-8-12-15(19)13(17)9-14(18)16(12)20/h5,7,9,17,20H,4,6,8H2,1-3H3/b11-7+
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078878
PNG
(CHEMBL3416169)
Show SMILES CCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C11H14O4/c1-3-4-5-7-10(13)8(12)6-9(15-2)11(7)14/h6,13H,3-5H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078877
PNG
(CHEMBL3416170)
Show SMILES CCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C13H18O4/c1-3-4-5-6-7-9-12(15)10(14)8-11(17-2)13(9)16/h8,15H,3-7H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078876
PNG
(CHEMBL3416171)
Show SMILES CCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C15H22O4/c1-3-4-5-6-7-8-9-11-14(17)12(16)10-13(19-2)15(11)18/h10,17H,3-9H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078859
PNG
(CHEMBL3416176)
Show SMILES COC1=CC(=O)C(O)=C(C\C=C(/C)CCC=C(C)C)C1=O
Show InChI InChI=1S/C17H22O4/c1-11(2)6-5-7-12(3)8-9-13-16(19)14(18)10-15(21-4)17(13)20/h6,8,10,19H,5,7,9H2,1-4H3/b12-8+
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078876
PNG
(CHEMBL3416171)
Show SMILES CCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C15H22O4/c1-3-4-5-6-7-8-9-11-14(17)12(16)10-13(19-2)15(11)18/h10,17H,3-9H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078862
PNG
(CHEMBL3416179)
Show SMILES CCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C14H20O4/c1-4-5-6-7-8-10-13(16)12(17-2)9-11(15)14(10)18-3/h9H,4-8H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078863
PNG
(CHEMBL3416180)
Show SMILES CCCCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C16H24O4/c1-4-5-6-7-8-9-10-12-15(18)14(19-2)11-13(17)16(12)20-3/h11H,4-10H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078873
PNG
(CHEMBL3416354)
Show SMILES CCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C12H16O4/c1-4-5-6-8-11(14)9(13)7-10(15-2)12(8)16-3/h7H,4-6H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078874
PNG
(CHEMBL3416355)
Show SMILES CCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C14H20O4/c1-4-5-6-7-8-10-13(16)11(15)9-12(17-2)14(10)18-3/h9H,4-8H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078875
PNG
(CHEMBL3416356)
Show SMILES CCCCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C16H24O4/c1-4-5-6-7-8-9-10-12-15(18)13(17)11-14(19-2)16(12)20-3/h11H,4-10H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078854
PNG
(CHEMBL3416162)
Show SMILES CCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C10H12O4/c1-2-3-4-6-9(13)7(11)5-8(12)10(6)14/h5,11,14H,2-4H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078853
PNG
(CHEMBL3263323)
Show SMILES CCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C12H16O4/c1-2-3-4-5-6-8-11(15)9(13)7-10(14)12(8)16/h7,13,16H,2-6H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078854
PNG
(CHEMBL3416162)
Show SMILES CCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C10H12O4/c1-2-3-4-6-9(13)7(11)5-8(12)10(6)14/h5,11,14H,2-4H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078880
PNG
(CHEMBL3416167)
Show SMILES CC(C)=CCC\C(C)=C\CC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C16H20O4/c1-10(2)5-4-6-11(3)7-8-12-15(19)13(17)9-14(18)16(12)20/h5,7,9,17,20H,4,6,8H2,1-3H3/b11-7+
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078878
PNG
(CHEMBL3416169)
Show SMILES CCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C11H14O4/c1-3-4-5-7-10(13)8(12)6-9(15-2)11(7)14/h6,13H,3-5H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078877
PNG
(CHEMBL3416170)
Show SMILES CCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C13H18O4/c1-3-4-5-6-7-9-12(15)10(14)8-11(17-2)13(9)16/h8,15H,3-7H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078876
PNG
(CHEMBL3416171)
Show SMILES CCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C15H22O4/c1-3-4-5-6-7-8-9-11-14(17)12(16)10-13(19-2)15(11)18/h10,17H,3-9H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078859
PNG
(CHEMBL3416176)
Show SMILES COC1=CC(=O)C(O)=C(C\C=C(/C)CCC=C(C)C)C1=O
Show InChI InChI=1S/C17H22O4/c1-11(2)6-5-7-12(3)8-9-13-16(19)14(18)10-15(21-4)17(13)20/h6,8,10,19H,5,7,9H2,1-4H3/b12-8+
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078853
PNG
(CHEMBL3263323)
Show SMILES CCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C12H16O4/c1-2-3-4-5-6-8-11(15)9(13)7-10(14)12(8)16/h7,13,16H,2-6H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50078854
PNG
(CHEMBL3416162)
Show SMILES CCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C10H12O4/c1-2-3-4-6-9(13)7(11)5-8(12)10(6)14/h5,11,14H,2-4H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078861
PNG
(CHEMBL3416178)
Show SMILES CCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C12H16O4/c1-4-5-6-8-11(14)10(15-2)7-9(13)12(8)16-3/h7H,4-6H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Eur J Med Chem 94: 132-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.042
BindingDB Entry DOI: 10.7270/Q2T72K5H
More data for this
Ligand-Target Pair
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