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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 382.4
BDBM50129178
Wt: 440.5
BDBM50129183
Wt: 393.4
BDBM50129184
Wt: 421.5
BDBM50129186
Wt: 435.5
BDBM50129187
Wt: 407.5
BDBM50129189
Wt: 407.5
BDBM50129191
Wt: 421.5
BDBM50129192
Wt: 371.8
BDBM50374116
Wt: 356.4
BDBM50374117
Wt: 322.4
BDBM50374118
Wt: 395.4
BDBM50374120
Wt: 365.4
BDBM50374121
Wt: 432.5
BDBM50374123
Wt: 399.8
BDBM50374124
Displayed 1 to 15 (of 291 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 56 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50129178
PNG
((S)-N-(4-Amino-butyl)-2-(3-benzyl-ureido)-4-phenyl...)
Show SMILES NCCCCNC(=O)[C@H](CCc1ccccc1)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C22H30N4O2/c23-15-7-8-16-24-21(27)20(14-13-18-9-3-1-4-10-18)26-22(28)25-17-19-11-5-2-6-12-19/h1-6,9-12,20H,7-8,13-17,23H2,(H,24,27)(H2,25,26,28)/t20-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50374117
PNG
(CHEMBL406651)
Show SMILES O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C23H20N2O2/c26-22-19-13-7-8-14-21(19)25(16-18-11-5-2-6-12-18)23(27)20(24-22)15-17-9-3-1-4-10-17/h1-14,20H,15-16H2,(H,24,26)
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50129184
PNG
(CHEMBL293673 | N-(3-Amino-propyl)-2-((S)-3-benzyl-...)
Show SMILES NCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C22H27N5O2/c23-11-6-12-24-21(28)20(13-17-15-25-19-10-5-4-9-18(17)19)27-22(29)26-14-16-7-2-1-3-8-16/h1-5,7-10,15,20,25H,6,11-14,23H2,(H,24,28)(H2,26,27,29)/t20-/m0/s1
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n/an/an/an/a 5.12E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 1 receptor (mMC1R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50129183
PNG
(2-(3-Benzyl-ureido)-3-(1H-indol-3-yl)-N-(3-methyl-...)
Show SMILES Cc1cccc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C27H28N4O2/c1-19-8-7-11-21(14-19)17-29-26(32)25(15-22-18-28-24-13-6-5-12-23(22)24)31-27(33)30-16-20-9-3-2-4-10-20/h2-14,18,25,28H,15-17H2,1H3,(H,29,32)(H2,30,31,33)/t25-/m0/s1
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n/an/an/an/a 2.80E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 1 receptor (mMC1R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50129184
PNG
(CHEMBL293673 | N-(3-Amino-propyl)-2-((S)-3-benzyl-...)
Show SMILES NCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C22H27N5O2/c23-11-6-12-24-21(28)20(13-17-15-25-19-10-5-4-9-18(17)19)27-22(29)26-14-16-7-2-1-3-8-16/h1-5,7-10,15,20,25H,6,11-14,23H2,(H,24,28)(H2,26,27,29)/t20-/m0/s1
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n/an/an/an/a 3.99E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50129183
PNG
(2-(3-Benzyl-ureido)-3-(1H-indol-3-yl)-N-(3-methyl-...)
Show SMILES Cc1cccc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C27H28N4O2/c1-19-8-7-11-21(14-19)17-29-26(32)25(15-22-18-28-24-13-6-5-12-23(22)24)31-27(33)30-16-20-9-3-2-4-10-20/h2-14,18,25,28H,15-17H2,1H3,(H,29,32)(H2,30,31,33)/t25-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50129186
PNG
(CHEMBL305391 | N-(5-Amino-pentyl)-2-((S)-3-benzyl-...)
Show SMILES NCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C24H31N5O2/c25-13-7-2-8-14-26-23(30)22(15-19-17-27-21-12-6-5-11-20(19)21)29-24(31)28-16-18-9-3-1-4-10-18/h1,3-6,9-12,17,22,27H,2,7-8,13-16,25H2,(H,26,30)(H2,28,29,31)/t22-/m0/s1
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n/an/an/an/a 1.48E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 1 receptor (mMC1R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50129189
PNG
(CHEMBL64954 | N-(4-Amino-butyl)-2-(3-benzyl-ureido...)
Show SMILES NCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C23H29N5O2/c24-12-6-7-13-25-22(29)21(14-18-16-26-20-11-5-4-10-19(18)20)28-23(30)27-15-17-8-2-1-3-9-17/h1-5,8-11,16,21,26H,6-7,12-15,24H2,(H,25,29)(H2,27,28,30)/t21-/m1/s1
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n/an/an/an/a 4.24E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 1 receptor (mMC1R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50129187
PNG
(CHEMBL303283 | N-(6-Amino-hexyl)-2-((S)-3-benzyl-u...)
Show SMILES NCCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C25H33N5O2/c26-14-8-1-2-9-15-27-24(31)23(16-20-18-28-22-13-7-6-12-21(20)22)30-25(32)29-17-19-10-4-3-5-11-19/h3-7,10-13,18,23,28H,1-2,8-9,14-17,26H2,(H,27,31)(H2,29,30,32)/t23-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 4 receptor (mMC4R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50129189
PNG
(CHEMBL64954 | N-(4-Amino-butyl)-2-(3-benzyl-ureido...)
Show SMILES NCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C23H29N5O2/c24-12-6-7-13-25-22(29)21(14-18-16-26-20-11-5-4-10-19(18)20)28-23(30)27-15-17-8-2-1-3-9-17/h1-5,8-11,16,21,26H,6-7,12-15,24H2,(H,25,29)(H2,27,28,30)/t21-/m1/s1
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n/an/an/an/a 1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50129189
PNG
(CHEMBL64954 | N-(4-Amino-butyl)-2-(3-benzyl-ureido...)
Show SMILES NCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C23H29N5O2/c24-12-6-7-13-25-22(29)21(14-18-16-26-20-11-5-4-10-19(18)20)28-23(30)27-15-17-8-2-1-3-9-17/h1-5,8-11,16,21,26H,6-7,12-15,24H2,(H,25,29)(H2,27,28,30)/t21-/m1/s1
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n/an/an/an/a 3.28E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50129191
PNG
(CHEMBL305559 | N-(4-Amino-butyl)-2-(3-benzyl-ureid...)
Show SMILES NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C23H29N5O2/c24-12-6-7-13-25-22(29)21(14-18-16-26-20-11-5-4-10-19(18)20)28-23(30)27-15-17-8-2-1-3-9-17/h1-5,8-11,16,21,26H,6-7,12-15,24H2,(H,25,29)(H2,27,28,30)/t21-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50129186
PNG
(CHEMBL305391 | N-(5-Amino-pentyl)-2-((S)-3-benzyl-...)
Show SMILES NCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C24H31N5O2/c25-13-7-2-8-14-26-23(30)22(15-19-17-27-21-12-6-5-11-20(19)21)29-24(31)28-16-18-9-3-1-4-10-18/h1,3-6,9-12,17,22,27H,2,7-8,13-16,25H2,(H,26,30)(H2,28,29,31)/t22-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50129187
PNG
(CHEMBL303283 | N-(6-Amino-hexyl)-2-((S)-3-benzyl-u...)
Show SMILES NCCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C25H33N5O2/c26-14-8-1-2-9-15-27-24(31)23(16-20-18-28-22-13-7-6-12-21(20)22)30-25(32)29-17-19-10-4-3-5-11-19/h3-7,10-13,18,23,28H,1-2,8-9,14-17,26H2,(H,27,31)(H2,29,30,32)/t23-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50129186
PNG
(CHEMBL305391 | N-(5-Amino-pentyl)-2-((S)-3-benzyl-...)
Show SMILES NCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C24H31N5O2/c25-13-7-2-8-14-26-23(30)22(15-19-17-27-21-12-6-5-11-20(19)21)29-24(31)28-16-18-9-3-1-4-10-18/h1,3-6,9-12,17,22,27H,2,7-8,13-16,25H2,(H,26,30)(H2,28,29,31)/t22-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 4 receptor (mMC4R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50129178
PNG
((S)-N-(4-Amino-butyl)-2-(3-benzyl-ureido)-4-phenyl...)
Show SMILES NCCCCNC(=O)[C@H](CCc1ccccc1)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C22H30N4O2/c23-15-7-8-16-24-21(27)20(14-13-18-9-3-1-4-10-18)26-22(28)25-17-19-11-5-2-6-12-19/h1-6,9-12,20H,7-8,13-17,23H2,(H,24,27)(H2,25,26,28)/t20-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 4 receptor (mMC4R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50129184
PNG
(CHEMBL293673 | N-(3-Amino-propyl)-2-((S)-3-benzyl-...)
Show SMILES NCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C22H27N5O2/c23-11-6-12-24-21(28)20(13-17-15-25-19-10-5-4-9-18(17)19)27-22(29)26-14-16-7-2-1-3-8-16/h1-5,7-10,15,20,25H,6,11-14,23H2,(H,24,28)(H2,26,27,29)/t20-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 4 receptor (mMC4R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50129178
PNG
((S)-N-(4-Amino-butyl)-2-(3-benzyl-ureido)-4-phenyl...)
Show SMILES NCCCCNC(=O)[C@H](CCc1ccccc1)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C22H30N4O2/c23-15-7-8-16-24-21(27)20(14-13-18-9-3-1-4-10-18)26-22(28)25-17-19-11-5-2-6-12-19/h1-6,9-12,20H,7-8,13-17,23H2,(H,24,27)(H2,25,26,28)/t20-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 1 receptor (mMC1R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50129186
PNG
(CHEMBL305391 | N-(5-Amino-pentyl)-2-((S)-3-benzyl-...)
Show SMILES NCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C24H31N5O2/c25-13-7-2-8-14-26-23(30)22(15-19-17-27-21-12-6-5-11-20(19)21)29-24(31)28-16-18-9-3-1-4-10-18/h1,3-6,9-12,17,22,27H,2,7-8,13-16,25H2,(H,26,30)(H2,28,29,31)/t22-/m0/s1
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n/an/an/an/a 2.00E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50129192
PNG
(CHEMBL431523 | N-(4-Amino-butyl)-3-(1H-indol-3-yl)...)
Show SMILES NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCCc1ccccc1
Show InChI InChI=1S/C24H31N5O2/c25-13-6-7-14-26-23(30)22(16-19-17-28-21-11-5-4-10-20(19)21)29-24(31)27-15-12-18-8-2-1-3-9-18/h1-5,8-11,17,22,28H,6-7,12-16,25H2,(H,26,30)(H2,27,29,31)/t22-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 4 receptor (mMC4R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50129192
PNG
(CHEMBL431523 | N-(4-Amino-butyl)-3-(1H-indol-3-yl)...)
Show SMILES NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCCc1ccccc1
Show InChI InChI=1S/C24H31N5O2/c25-13-6-7-14-26-23(30)22(16-19-17-28-21-11-5-4-10-20(19)21)29-24(31)27-15-12-18-8-2-1-3-9-18/h1-5,8-11,17,22,28H,6-7,12-16,25H2,(H,26,30)(H2,27,29,31)/t22-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50129183
PNG
(2-(3-Benzyl-ureido)-3-(1H-indol-3-yl)-N-(3-methyl-...)
Show SMILES Cc1cccc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C27H28N4O2/c1-19-8-7-11-21(14-19)17-29-26(32)25(15-22-18-28-24-13-6-5-12-23(22)24)31-27(33)30-16-20-9-3-2-4-10-20/h2-14,18,25,28H,15-17H2,1H3,(H,29,32)(H2,30,31,33)/t25-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 4 receptor (mMC4R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50129187
PNG
(CHEMBL303283 | N-(6-Amino-hexyl)-2-((S)-3-benzyl-u...)
Show SMILES NCCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C25H33N5O2/c26-14-8-1-2-9-15-27-24(31)23(16-20-18-28-22-13-7-6-12-21(20)22)30-25(32)29-17-19-10-4-3-5-11-19/h3-7,10-13,18,23,28H,1-2,8-9,14-17,26H2,(H,27,31)(H2,29,30,32)/t23-/m0/s1
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n/an/an/an/a 2.23E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 1 receptor (mMC1R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50129191
PNG
(CHEMBL305559 | N-(4-Amino-butyl)-2-(3-benzyl-ureid...)
Show SMILES NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C23H29N5O2/c24-12-6-7-13-25-22(29)21(14-18-16-26-20-11-5-4-10-19(18)20)28-23(30)27-15-17-8-2-1-3-9-17/h1-5,8-11,16,21,26H,6-7,12-15,24H2,(H,25,29)(H2,27,28,30)/t21-/m0/s1
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n/an/an/an/a 5.50E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 1 receptor (mMC1R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50129191
PNG
(CHEMBL305559 | N-(4-Amino-butyl)-2-(3-benzyl-ureid...)
Show SMILES NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C23H29N5O2/c24-12-6-7-13-25-22(29)21(14-18-16-26-20-11-5-4-10-19(18)20)28-23(30)27-15-17-8-2-1-3-9-17/h1-5,8-11,16,21,26H,6-7,12-15,24H2,(H,25,29)(H2,27,28,30)/t21-/m0/s1
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n/an/an/an/a 2.37E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 4 receptor (mMC4R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50129178
PNG
((S)-N-(4-Amino-butyl)-2-(3-benzyl-ureido)-4-phenyl...)
Show SMILES NCCCCNC(=O)[C@H](CCc1ccccc1)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C22H30N4O2/c23-15-7-8-16-24-21(27)20(14-13-18-9-3-1-4-10-18)26-22(28)25-17-19-11-5-2-6-12-19/h1-6,9-12,20H,7-8,13-17,23H2,(H,24,27)(H2,25,26,28)/t20-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50129192
PNG
(CHEMBL431523 | N-(4-Amino-butyl)-3-(1H-indol-3-yl)...)
Show SMILES NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCCc1ccccc1
Show InChI InChI=1S/C24H31N5O2/c25-13-6-7-14-26-23(30)22(16-19-17-28-21-11-5-4-10-20(19)21)29-24(31)27-15-12-18-8-2-1-3-9-18/h1-5,8-11,17,22,28H,6-7,12-16,25H2,(H,26,30)(H2,27,29,31)/t22-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50129189
PNG
(CHEMBL64954 | N-(4-Amino-butyl)-2-(3-benzyl-ureido...)
Show SMILES NCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C23H29N5O2/c24-12-6-7-13-25-22(29)21(14-18-16-26-20-11-5-4-10-19(18)20)28-23(30)27-15-17-8-2-1-3-9-17/h1-5,8-11,16,21,26H,6-7,12-15,24H2,(H,25,29)(H2,27,28,30)/t21-/m1/s1
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n/an/an/an/a 2.37E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 4 receptor (mMC4R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50129192
PNG
(CHEMBL431523 | N-(4-Amino-butyl)-3-(1H-indol-3-yl)...)
Show SMILES NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCCc1ccccc1
Show InChI InChI=1S/C24H31N5O2/c25-13-6-7-14-26-23(30)22(16-19-17-28-21-11-5-4-10-20(19)21)29-24(31)27-15-12-18-8-2-1-3-9-18/h1-5,8-11,17,22,28H,6-7,12-16,25H2,(H,26,30)(H2,27,29,31)/t22-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 1 receptor (mMC1R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50129191
PNG
(CHEMBL305559 | N-(4-Amino-butyl)-2-(3-benzyl-ureid...)
Show SMILES NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C23H29N5O2/c24-12-6-7-13-25-22(29)21(14-18-16-26-20-11-5-4-10-19(18)20)28-23(30)27-15-17-8-2-1-3-9-17/h1-5,8-11,16,21,26H,6-7,12-15,24H2,(H,25,29)(H2,27,28,30)/t21-/m0/s1
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n/an/an/an/a 3.05E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50129187
PNG
(CHEMBL303283 | N-(6-Amino-hexyl)-2-((S)-3-benzyl-u...)
Show SMILES NCCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C25H33N5O2/c26-14-8-1-2-9-15-27-24(31)23(16-20-18-28-22-13-7-6-12-21(20)22)30-25(32)29-17-19-10-4-3-5-11-19/h3-7,10-13,18,23,28H,1-2,8-9,14-17,26H2,(H,27,31)(H2,29,30,32)/t23-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50129184
PNG
(CHEMBL293673 | N-(3-Amino-propyl)-2-((S)-3-benzyl-...)
Show SMILES NCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C22H27N5O2/c23-11-6-12-24-21(28)20(13-17-15-25-19-10-5-4-9-18(17)19)27-22(29)26-14-16-7-2-1-3-8-16/h1-5,7-10,15,20,25H,6,11-14,23H2,(H,24,28)(H2,26,27,29)/t20-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells


Bioorg Med Chem Lett 13: 2079-82 (2003)


Article DOI: 10.1016/s0960-894x(03)00318-4
BindingDB Entry DOI: 10.7270/Q2JD4XBW
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50374116
PNG
(CHEMBL270270)
Show SMILES NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O
Show InChI InChI=1S/C20H22ClN3O2/c21-15-9-10-16-18(12-15)24(13-14-6-2-1-3-7-14)20(26)17(23-19(16)25)8-4-5-11-22/h1-3,6-7,9-10,12,17H,4-5,8,11,13,22H2,(H,23,25)
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n/an/an/an/a 320n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50374117
PNG
(CHEMBL406651)
Show SMILES O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C23H20N2O2/c26-22-19-13-7-8-14-21(19)25(16-18-11-5-2-6-12-18)23(27)20(24-22)15-17-9-3-1-4-10-17/h1-14,20H,15-16H2,(H,24,26)
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50374118
PNG
(CHEMBL270689)
Show SMILES CCCCN1c2ccccc2C(=O)NC(Cc2ccccc2)C1=O
Show InChI InChI=1S/C20H22N2O2/c1-2-3-13-22-18-12-8-7-11-16(18)19(23)21-17(20(22)24)14-15-9-5-4-6-10-15/h4-12,17H,2-3,13-14H2,1H3,(H,21,23)
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50374120
PNG
(CHEMBL272843)
Show SMILES O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H21N3O2/c29-24-20-11-5-7-13-23(20)28(16-17-8-2-1-3-9-17)25(30)22(27-24)14-18-15-26-21-12-6-4-10-19(18)21/h1-13,15,22,26H,14,16H2,(H,27,29)
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50374121
PNG
(CHEMBL272662)
Show SMILES NC(N)=NCCCC1NC(=O)c2ccccc2N(Cc2ccccc2)C1=O
Show InChI InChI=1S/C20H23N5O2/c21-20(22)23-12-6-10-16-19(27)25(13-14-7-2-1-3-8-14)17-11-5-4-9-15(17)18(26)24-16/h1-5,7-9,11,16H,6,10,12-13H2,(H,24,26)(H4,21,22,23)
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50374123
PNG
(CHEMBL273044)
Show SMILES O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C29H24N2O2/c32-28-25-17-9-10-18-27(25)31(29(33)26(30-28)19-21-11-3-1-4-12-21)20-23-15-7-8-16-24(23)22-13-5-2-6-14-22/h1-18,26H,19-20H2,(H,30,32)
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n/an/an/an/a 230n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50374116
PNG
(CHEMBL270270)
Show SMILES NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O
Show InChI InChI=1S/C20H22ClN3O2/c21-15-9-10-16-18(12-15)24(13-14-6-2-1-3-7-14)20(26)17(23-19(16)25)8-4-5-11-22/h1-3,6-7,9-10,12,17H,4-5,8,11,13,22H2,(H,23,25)
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n/an/an/an/a 48n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50374121
PNG
(CHEMBL272662)
Show SMILES NC(N)=NCCCC1NC(=O)c2ccccc2N(Cc2ccccc2)C1=O
Show InChI InChI=1S/C20H23N5O2/c21-20(22)23-12-6-10-16-19(27)25(13-14-7-2-1-3-8-14)17-11-5-4-9-15(17)18(26)24-16/h1-5,7-9,11,16H,6,10,12-13H2,(H,24,26)(H4,21,22,23)
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n/an/an/an/a 1.65E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50374117
PNG
(CHEMBL406651)
Show SMILES O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C23H20N2O2/c26-22-19-13-7-8-14-21(19)25(16-18-11-5-2-6-12-18)23(27)20(24-22)15-17-9-3-1-4-10-17/h1-14,20H,15-16H2,(H,24,26)
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n/an/an/an/a 3.29E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50374118
PNG
(CHEMBL270689)
Show SMILES CCCCN1c2ccccc2C(=O)NC(Cc2ccccc2)C1=O
Show InChI InChI=1S/C20H22N2O2/c1-2-3-13-22-18-12-8-7-11-16(18)19(23)21-17(20(22)24)14-15-9-5-4-6-10-15/h4-12,17H,2-3,13-14H2,1H3,(H,21,23)
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50374120
PNG
(CHEMBL272843)
Show SMILES O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H21N3O2/c29-24-20-11-5-7-13-23(20)28(16-17-8-2-1-3-9-17)25(30)22(27-24)14-18-15-26-21-12-6-4-10-19(18)21/h1-13,15,22,26H,14,16H2,(H,27,29)
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50374121
PNG
(CHEMBL272662)
Show SMILES NC(N)=NCCCC1NC(=O)c2ccccc2N(Cc2ccccc2)C1=O
Show InChI InChI=1S/C20H23N5O2/c21-20(22)23-12-6-10-16-19(27)25(13-14-7-2-1-3-8-14)17-11-5-4-9-15(17)18(26)24-16/h1-5,7-9,11,16H,6,10,12-13H2,(H,24,26)(H4,21,22,23)
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50374123
PNG
(CHEMBL273044)
Show SMILES O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C29H24N2O2/c32-28-25-17-9-10-18-27(25)31(29(33)26(30-28)19-21-11-3-1-4-12-21)20-23-15-7-8-16-24(23)22-13-5-2-6-14-22/h1-18,26H,19-20H2,(H,30,32)
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n/an/an/an/a 1.97E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50374117
PNG
(CHEMBL406651)
Show SMILES O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C23H20N2O2/c26-22-19-13-7-8-14-21(19)25(16-18-11-5-2-6-12-18)23(27)20(24-22)15-17-9-3-1-4-10-17/h1-14,20H,15-16H2,(H,24,26)
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50374118
PNG
(CHEMBL270689)
Show SMILES CCCCN1c2ccccc2C(=O)NC(Cc2ccccc2)C1=O
Show InChI InChI=1S/C20H22N2O2/c1-2-3-13-22-18-12-8-7-11-16(18)19(23)21-17(20(22)24)14-15-9-5-4-6-10-15/h4-12,17H,2-3,13-14H2,1H3,(H,21,23)
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50374120
PNG
(CHEMBL272843)
Show SMILES O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H21N3O2/c29-24-20-11-5-7-13-23(20)28(16-17-8-2-1-3-9-17)25(30)22(27-24)14-18-15-26-21-12-6-4-10-19(18)21/h1-13,15,22,26H,14,16H2,(H,27,29)
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50374121
PNG
(CHEMBL272662)
Show SMILES NC(N)=NCCCC1NC(=O)c2ccccc2N(Cc2ccccc2)C1=O
Show InChI InChI=1S/C20H23N5O2/c21-20(22)23-12-6-10-16-19(27)25(13-14-7-2-1-3-8-14)17-11-5-4-9-15(17)18(26)24-16/h1-5,7-9,11,16H,6,10,12-13H2,(H,24,26)(H4,21,22,23)
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50374116
PNG
(CHEMBL270270)
Show SMILES NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O
Show InChI InChI=1S/C20H22ClN3O2/c21-15-9-10-16-18(12-15)24(13-14-6-2-1-3-7-14)20(26)17(23-19(16)25)8-4-5-11-22/h1-3,6-7,9-10,12,17H,4-5,8,11,13,22H2,(H,23,25)
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n/an/an/an/a 87n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay


J Med Chem 51: 1423-31 (2008)


Article DOI: 10.1021/jm701303z
BindingDB Entry DOI: 10.7270/Q2KH0P61
More data for this
Ligand-Target Pair
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