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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 350.3
BDBM196604
Wt: 337.3
BDBM198592
Wt: 350.3
BDBM196606
Wt: 351.3
BDBM198659
Wt: 351.3
BDBM198919
Wt: 351.3
BDBM198920
Wt: 351.3
BDBM198921
Wt: 350.3
BDBM198930
Wt: 350.3
BDBM196831
Wt: 354.3
BDBM191575
Wt: 350.3
BDBM191578
Wt: 350.3
BDBM191615
Wt: 336.3
BDBM191565
Wt: 354.3
BDBM191566
Wt: 350.3
BDBM191568
Displayed 1 to 15 (of 166 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 30 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM191566
PNG
(5-(4-fluorophenyl)-2-(((2-fluorophenyl)amino)methy...)
Show SMILES Fc1ccc(cc1)N1CCn2nc(CNc3ccccc3F)cc2C1=O
Show InChI InChI=1S/C19H16F2N4O/c20-13-5-7-15(8-6-13)24-9-10-25-18(19(24)26)11-14(23-25)12-22-17-4-2-1-3-16(17)21/h1-8,11,22H,9-10,12H2
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n/an/a 944n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM191575
PNG
(5-(4-fluorophenyl)-2-(((3-fluorophenyl)amino)methy...)
Show SMILES Fc1ccc(cc1)N1CCn2nc(CNc3cccc(F)c3)cc2C1=O
Show InChI InChI=1S/C19H16F2N4O/c20-13-4-6-17(7-5-13)24-8-9-25-18(19(24)26)11-16(23-25)12-22-15-3-1-2-14(21)10-15/h1-7,10-11,22H,8-9,12H2
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Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM196831
PNG
(5-(4-fluorophenyl)-2-((methyl(phenyl)amino)methyl)...)
Show SMILES CN(Cc1cc2C(=O)N(CCn2n1)c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C20H19FN4O/c1-23(17-5-3-2-4-6-17)14-16-13-19-20(26)24(11-12-25(19)22-16)18-9-7-15(21)8-10-18/h2-10,13H,11-12,14H2,1H3
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n/an/a 1.22E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM191565
PNG
(5-(4-fluorophenyl)-2-((phenylamino)methyl)-6,7-dih...)
Show SMILES Fc1ccc(cc1)N1CCn2nc(CNc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H17FN4O/c20-14-6-8-17(9-7-14)23-10-11-24-18(19(23)25)12-16(22-24)13-21-15-4-2-1-3-5-15/h1-9,12,21H,10-11,13H2
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n/an/a 1.32E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM191578
PNG
(5-(4-fluorophenyl)-2-((m-tolylamino)methyl)-6,7-di...)
Show SMILES Cc1cccc(NCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)c1
Show InChI InChI=1S/C20H19FN4O/c1-14-3-2-4-16(11-14)22-13-17-12-19-20(26)24(9-10-25(19)23-17)18-7-5-15(21)6-8-18/h2-8,11-12,22H,9-10,13H2,1H3
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n/an/a 1.35E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM196606
PNG
((s)-5-(4-fluorophenyl)-7-methyl-2-((phenylamino)me...)
Show SMILES C[C@H]1CN(C(=O)c2cc(CNc3ccccc3)nn12)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN4O/c1-14-13-24(18-9-7-15(21)8-10-18)20(26)19-11-17(23-25(14)19)12-22-16-5-3-2-4-6-16/h2-11,14,22H,12-13H2,1H3/t14-/m0/s1
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM196604
PNG
((r)-5-(4-fluorophenyl)-7-methyl-2-((phenylamino)me...)
Show SMILES C[C@@H]1CN(C(=O)c2cc(CNc3ccccc3)nn12)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN4O/c1-14-13-24(18-9-7-15(21)8-10-18)20(26)19-11-17(23-25(14)19)12-22-16-5-3-2-4-6-16/h2-11,14,22H,12-13H2,1H3/t14-/m1/s1
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n/an/a 1.38E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM191615
PNG
(5-(4-fluorophenyl)-2-((p-tolylamino)methyl)-6,7-di...)
Show SMILES Cc1ccc(NCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H19FN4O/c1-14-2-6-16(7-3-14)22-13-17-12-19-20(26)24(10-11-25(19)23-17)18-8-4-15(21)5-9-18/h2-9,12,22H,10-11,13H2,1H3
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n/an/a 1.54E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM198919
PNG
(5-(4-fluorophenyl)-2-(((5-methylpyridin-2-yl)amino...)
Show SMILES Cc1ccc(NCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)nc1
Show InChI InChI=1S/C19H18FN5O/c1-13-2-7-18(21-11-13)22-12-15-10-17-19(26)24(8-9-25(17)23-15)16-5-3-14(20)4-6-16/h2-7,10-11H,8-9,12H2,1H3,(H,21,22)
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n/an/a 1.77E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM191565
PNG
(5-(4-fluorophenyl)-2-((phenylamino)methyl)-6,7-dih...)
Show SMILES Fc1ccc(cc1)N1CCn2nc(CNc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H17FN4O/c20-14-6-8-17(9-7-14)23-10-11-24-18(19(23)25)12-16(22-24)13-21-15-4-2-1-3-5-15/h1-9,12,21H,10-11,13H2
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n/an/a 2.04E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM191575
PNG
(5-(4-fluorophenyl)-2-(((3-fluorophenyl)amino)methy...)
Show SMILES Fc1ccc(cc1)N1CCn2nc(CNc3cccc(F)c3)cc2C1=O
Show InChI InChI=1S/C19H16F2N4O/c20-13-4-6-17(7-5-13)24-8-9-25-18(19(24)26)11-16(23-25)12-22-15-3-1-2-14(21)10-15/h1-7,10-11,22H,8-9,12H2
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n/an/a 2.21E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM191568
PNG
(5-(4-fluorophenyl)-2-((o-tolylamino)methyl)-6,7-di...)
Show SMILES Cc1ccccc1NCc1cc2C(=O)N(CCn2n1)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN4O/c1-14-4-2-3-5-18(14)22-13-16-12-19-20(26)24(10-11-25(19)23-16)17-8-6-15(21)7-9-17/h2-9,12,22H,10-11,13H2,1H3
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n/an/a 2.39E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM191566
PNG
(5-(4-fluorophenyl)-2-(((2-fluorophenyl)amino)methy...)
Show SMILES Fc1ccc(cc1)N1CCn2nc(CNc3ccccc3F)cc2C1=O
Show InChI InChI=1S/C19H16F2N4O/c20-13-5-7-15(8-6-13)24-9-10-25-18(19(24)26)11-14(23-25)12-22-17-4-2-1-3-16(17)21/h1-8,11,22H,9-10,12H2
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n/an/a 2.47E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM198930
PNG
(5-(4-fluorophenyl)-2-(1-(phenylamino)ethyl)-6,7-di...)
Show SMILES CC(Nc1ccccc1)c1cc2C(=O)N(CCn2n1)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN4O/c1-14(22-16-5-3-2-4-6-16)18-13-19-20(26)24(11-12-25(19)23-18)17-9-7-15(21)8-10-17/h2-10,13-14,22H,11-12H2,1H3
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n/an/a 2.85E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM198592
PNG
(5-(4-fluorophenyl)-2-((pyridin-2-ylamino)methyl)-6...)
Show SMILES Fc1ccc(cc1)N1CCn2nc(CNc3ccccn3)cc2C1=O
Show InChI InChI=1S/C18H16FN5O/c19-13-4-6-15(7-5-13)23-9-10-24-16(18(23)25)11-14(22-24)12-21-17-3-1-2-8-20-17/h1-8,11H,9-10,12H2,(H,20,21)
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n/an/a 3.19E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM198659
PNG
(5-(4-fluorophenyl)-2-(((6-methylpyridin-2-yl)amino...)
Show SMILES Cc1cccc(NCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)n1
Show InChI InChI=1S/C19H18FN5O/c1-13-3-2-4-18(22-13)21-12-15-11-17-19(26)24(9-10-25(17)23-15)16-7-5-14(20)6-8-16/h2-8,11H,9-10,12H2,1H3,(H,21,22)
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n/an/a 3.21E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM198921
PNG
(5-(4-fluorophenyl)-2-(((4-methylpyridin-2-yl)amino...)
Show SMILES Cc1ccnc(NCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)c1
Show InChI InChI=1S/C19H18FN5O/c1-13-6-7-21-18(10-13)22-12-15-11-17-19(26)24(8-9-25(17)23-15)16-4-2-14(20)3-5-16/h2-7,10-11H,8-9,12H2,1H3,(H,21,22)
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n/an/a 3.75E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM198920
PNG
(5-(4-fluorophenyl)-2-(((3-methylpyridin-2-yl)amino...)
Show SMILES Cc1cccnc1NCc1cc2C(=O)N(CCn2n1)c1ccc(F)cc1
Show InChI InChI=1S/C19H18FN5O/c1-13-3-2-8-21-18(13)22-12-15-11-17-19(26)24(9-10-25(17)23-15)16-6-4-14(20)5-7-16/h2-8,11H,9-10,12H2,1H3,(H,21,22)
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n/an/a 4.70E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM196604
PNG
((r)-5-(4-fluorophenyl)-7-methyl-2-((phenylamino)me...)
Show SMILES C[C@@H]1CN(C(=O)c2cc(CNc3ccccc3)nn12)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN4O/c1-14-13-24(18-9-7-15(21)8-10-18)20(26)19-11-17(23-25(14)19)12-22-16-5-3-2-4-6-16/h2-11,14,22H,12-13H2,1H3/t14-/m1/s1
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n/an/a 4.81E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM191578
PNG
(5-(4-fluorophenyl)-2-((m-tolylamino)methyl)-6,7-di...)
Show SMILES Cc1cccc(NCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)c1
Show InChI InChI=1S/C20H19FN4O/c1-14-3-2-4-16(11-14)22-13-17-12-19-20(26)24(9-10-25(19)23-17)18-7-5-15(21)6-8-18/h2-8,11-12,22H,9-10,13H2,1H3
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n/an/a 5.96E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM196606
PNG
((s)-5-(4-fluorophenyl)-7-methyl-2-((phenylamino)me...)
Show SMILES C[C@H]1CN(C(=O)c2cc(CNc3ccccc3)nn12)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN4O/c1-14-13-24(18-9-7-15(21)8-10-18)20(26)19-11-17(23-25(14)19)12-22-16-5-3-2-4-6-16/h2-11,14,22H,12-13H2,1H3/t14-/m0/s1
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n/an/a 8.11E+3n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM191568
PNG
(5-(4-fluorophenyl)-2-((o-tolylamino)methyl)-6,7-di...)
Show SMILES Cc1ccccc1NCc1cc2C(=O)N(CCn2n1)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN4O/c1-14-4-2-3-5-18(14)22-13-16-12-19-20(26)24(10-11-25(19)23-16)17-8-6-15(21)7-9-17/h2-9,12,22H,10-11,13H2,1H3
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UniChem
n/an/a 1.00E+4n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM198592
PNG
(5-(4-fluorophenyl)-2-((pyridin-2-ylamino)methyl)-6...)
Show SMILES Fc1ccc(cc1)N1CCn2nc(CNc3ccccn3)cc2C1=O
Show InChI InChI=1S/C18H16FN5O/c19-13-4-6-15(7-5-13)23-9-10-24-16(18(23)25)11-14(22-24)12-21-17-3-1-2-8-20-17/h1-8,11H,9-10,12H2,(H,20,21)
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM198930
PNG
(5-(4-fluorophenyl)-2-(1-(phenylamino)ethyl)-6,7-di...)
Show SMILES CC(Nc1ccccc1)c1cc2C(=O)N(CCn2n1)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN4O/c1-14(22-16-5-3-2-4-6-16)18-13-19-20(26)24(11-12-25(19)23-18)17-9-7-15(21)8-10-17/h2-10,13-14,22H,11-12H2,1H3
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n/an/a 3.00E+4n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM198921
PNG
(5-(4-fluorophenyl)-2-(((4-methylpyridin-2-yl)amino...)
Show SMILES Cc1ccnc(NCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)c1
Show InChI InChI=1S/C19H18FN5O/c1-13-6-7-21-18(10-13)22-12-15-11-17-19(26)24(8-9-25(17)23-15)16-4-2-14(20)3-5-16/h2-7,10-11H,8-9,12H2,1H3,(H,21,22)
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM198920
PNG
(5-(4-fluorophenyl)-2-(((3-methylpyridin-2-yl)amino...)
Show SMILES Cc1cccnc1NCc1cc2C(=O)N(CCn2n1)c1ccc(F)cc1
Show InChI InChI=1S/C19H18FN5O/c1-13-3-2-8-21-18(13)22-12-15-11-17-19(26)24(9-10-25(17)23-15)16-6-4-14(20)5-7-16/h2-8,11H,9-10,12H2,1H3,(H,21,22)
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n/an/a 3.00E+4n/an/an/an/an/a25



Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM198919
PNG
(5-(4-fluorophenyl)-2-(((5-methylpyridin-2-yl)amino...)
Show SMILES Cc1ccc(NCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)nc1
Show InChI InChI=1S/C19H18FN5O/c1-13-2-7-18(21-11-13)22-12-15-10-17-19(26)24(8-9-25(17)23-15)16-5-3-14(20)4-6-16/h2-7,10-11H,8-9,12H2,1H3,(H,21,22)
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM198659
PNG
(5-(4-fluorophenyl)-2-(((6-methylpyridin-2-yl)amino...)
Show SMILES Cc1cccc(NCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)n1
Show InChI InChI=1S/C19H18FN5O/c1-13-3-2-4-18(22-13)21-12-15-11-17-19(26)24(9-10-25(17)23-15)16-7-5-14(20)6-8-16/h2-8,11H,9-10,12H2,1H3,(H,21,22)
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM196831
PNG
(5-(4-fluorophenyl)-2-((methyl(phenyl)amino)methyl)...)
Show SMILES CN(Cc1cc2C(=O)N(CCn2n1)c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C20H19FN4O/c1-23(17-5-3-2-4-6-17)14-16-13-19-20(26)24(11-12-25(19)22-16)18-9-7-15(21)8-10-18/h2-10,13H,11-12,14H2,1H3
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5 (mGlu5)


(Rattus norvegicus (Rat))
BDBM191615
PNG
(5-(4-fluorophenyl)-2-((p-tolylamino)methyl)-6,7-di...)
Show SMILES Cc1ccc(NCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H19FN4O/c1-14-2-6-16(7-3-14)22-13-17-12-19-20(26)24(10-11-25(19)23-17)18-8-4-15(21)5-9-18/h2-9,12,22H,10-11,13H2,1H3
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Vanderbilt University

US Patent


Assay Description
Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...


US Patent US9676782 (2017)


BindingDB Entry DOI: 10.7270/Q2B8569W
More data for this
Ligand-Target Pair