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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 221.2
BDBM50129667
Purchase
Wt: 248.2
BDBM50129635
Purchase
Wt: 220.2
BDBM50129653
Wt: 205.2
BDBM50129661
Purchase
Wt: 235.2
BDBM50160050
Wt: 220.2
BDBM50160053
Wt: 220.2
BDBM50160056
Wt: 250.2
BDBM50160059
Wt: 239.6
BDBM50160046
Purchase
Wt: 239.3
BDBM50169680
Wt: 226.2
BDBM50169682
Wt: 253.3
BDBM50169687
Wt: 211.2
BDBM50169662
Wt: 225.2
BDBM50169663
Wt: 255.3
BDBM50170375
Displayed 1 to 15 (of 125 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 40 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169662
PNG
(CHEMBL175540 | Thiazole-4-carboxylic acid thiazol-...)
Show SMILES O=C(Nc1nccs1)c1cscn1
Show InChI InChI=1S/C7H5N3OS2/c11-6(5-3-12-4-9-5)10-7-8-1-2-13-7/h1-4H,(H,8,10,11)
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n/an/a 110n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.005
BindingDB Entry DOI: 10.7270/Q2FN15RH
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169662
PNG
(CHEMBL175540 | Thiazole-4-carboxylic acid thiazol-...)
Show SMILES O=C(Nc1nccs1)c1cscn1
Show InChI InChI=1S/C7H5N3OS2/c11-6(5-3-12-4-9-5)10-7-8-1-2-13-7/h1-4H,(H,8,10,11)
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n/an/a 110n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169680
PNG
(5-Ethyl-thiazole-4-carboxylic acid thiazol-2-ylami...)
Show SMILES CCc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C9H9N3OS2/c1-2-6-7(11-5-15-6)8(13)12-9-10-3-4-14-9/h3-5H,2H2,1H3,(H,10,12,13)
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n/an/a 180n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169663
PNG
(5-Methyl-thiazole-4-carboxylic acid thiazol-2-ylam...)
Show SMILES Cc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C8H7N3OS2/c1-5-6(10-4-14-5)7(12)11-8-9-2-3-13-8/h2-4H,1H3,(H,9,11,12)
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n/an/a 180n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169687
PNG
(5-Isopropyl-thiazole-4-carboxylic acid thiazol-2-y...)
Show SMILES CC(C)c1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C10H11N3OS2/c1-6(2)8-7(12-5-16-8)9(14)13-10-11-3-4-15-10/h3-6H,1-2H3,(H,11,13,14)
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n/an/a 220n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129635
PNG
(3-Formylamino-pyridine-2-carboxylic acid thiazol-2...)
Show SMILES O=CNc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C10H8N4O2S/c15-6-13-7-2-1-3-11-8(7)9(16)14-10-12-4-5-17-10/h1-6H,(H,13,15)(H,12,14,16)
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n/an/a 320n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


J Med Chem 46: 2631-40 (2003)


Article DOI: 10.1021/jm0300532
BindingDB Entry DOI: 10.7270/Q2CF9QTC
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50129635
PNG
(3-Formylamino-pyridine-2-carboxylic acid thiazol-2...)
Show SMILES O=CNc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C10H8N4O2S/c15-6-13-7-2-1-3-11-8(7)9(16)14-10-12-4-5-17-10/h1-6H,(H,13,15)(H,12,14,16)
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n/an/a 330n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 1 from Escherichia coli


J Med Chem 46: 2631-40 (2003)


Article DOI: 10.1021/jm0300532
BindingDB Entry DOI: 10.7270/Q2CF9QTC
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170375
PNG
(5-(2-Hydroxy-ethyl)-thiazole-4-carboxylic acid thi...)
Show SMILES OCCc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C9H9N3O2S2/c13-3-1-6-7(11-5-16-6)8(14)12-9-10-2-4-15-9/h2,4-5,13H,1,3H2,(H,10,12,14)
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n/an/a 470n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.005
BindingDB Entry DOI: 10.7270/Q2FN15RH
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50129653
PNG
(3-Amino-pyridine-2-carboxylic acid thiazol-2-ylami...)
Show SMILES Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C9H8N4OS/c10-6-2-1-3-11-7(6)8(14)13-9-12-4-5-15-9/h1-5H,10H2,(H,12,13,14)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 1 from Escherichia coli


J Med Chem 46: 2631-40 (2003)


Article DOI: 10.1021/jm0300532
BindingDB Entry DOI: 10.7270/Q2CF9QTC
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50129667
PNG
(3-Hydroxy-pyridine-2-carboxylic acid thiazol-2-yla...)
Show SMILES Oc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C9H7N3O2S/c13-6-2-1-3-10-7(6)8(14)12-9-11-4-5-15-9/h1-5,13H,(H,11,12,14)
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n/an/a 1.87E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 1 from Escherichia coli


J Med Chem 46: 2631-40 (2003)


Article DOI: 10.1021/jm0300532
BindingDB Entry DOI: 10.7270/Q2CF9QTC
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169682
PNG
(5-Amino-thiazole-4-carboxylic acid thiazol-2-ylami...)
Show SMILES Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C7H6N4OS2/c8-5-4(10-3-14-5)6(12)11-7-9-1-2-13-7/h1-3H,8H2,(H,9,11,12)
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n/an/a 1.97E+3n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160053
PNG
(5-Amino-pyridine-2-carboxylic acid thiazol-2-ylami...)
Show SMILES Nc1ccc(nc1)C(=O)Nc1nccs1
Show InChI InChI=1S/C9H8N4OS/c10-6-1-2-7(12-5-6)8(14)13-9-11-3-4-15-9/h1-5H,10H2,(H,11,13,14)
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n/an/a 2.09E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169662
PNG
(CHEMBL175540 | Thiazole-4-carboxylic acid thiazol-...)
Show SMILES O=C(Nc1nccs1)c1cscn1
Show InChI InChI=1S/C7H5N3OS2/c11-6(5-3-12-4-9-5)10-7-8-1-2-13-7/h1-4H,(H,8,10,11)
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n/an/a 2.26E+3n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169662
PNG
(CHEMBL175540 | Thiazole-4-carboxylic acid thiazol-...)
Show SMILES O=C(Nc1nccs1)c1cscn1
Show InChI InChI=1S/C7H5N3OS2/c11-6(5-3-12-4-9-5)10-7-8-1-2-13-7/h1-4H,(H,8,10,11)
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n/an/a 2.26E+3n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.005
BindingDB Entry DOI: 10.7270/Q2FN15RH
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50160053
PNG
(5-Amino-pyridine-2-carboxylic acid thiazol-2-ylami...)
Show SMILES Nc1ccc(nc1)C(=O)Nc1nccs1
Show InChI InChI=1S/C9H8N4OS/c10-6-1-2-7(12-5-6)8(14)13-9-11-3-4-15-9/h1-5H,10H2,(H,11,13,14)
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n/an/a 2.43E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Saccharomyces cerevisiae methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160059
PNG
(4-Nitrooxy-pyridine-2-carboxylic acid thiazol-2-yl...)
Show SMILES [O-][N+](=O)c1ccnc(c1)C(=O)Nc1nccs1
Show InChI InChI=1S/C9H6N4O3S/c14-8(12-9-11-3-4-17-9)7-5-6(13(15)16)1-2-10-7/h1-5H,(H,11,12,14)
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n/an/a 4.51E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129667
PNG
(3-Hydroxy-pyridine-2-carboxylic acid thiazol-2-yla...)
Show SMILES Oc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C9H7N3O2S/c13-6-2-1-3-10-7(6)8(14)12-9-11-4-5-15-9/h1-5,13H,(H,11,12,14)
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n/an/a 4.86E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


J Med Chem 46: 2631-40 (2003)


Article DOI: 10.1021/jm0300532
BindingDB Entry DOI: 10.7270/Q2CF9QTC
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 1 from Escherichia coli


J Med Chem 46: 2631-40 (2003)


Article DOI: 10.1021/jm0300532
BindingDB Entry DOI: 10.7270/Q2CF9QTC
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.005
BindingDB Entry DOI: 10.7270/Q2FN15RH
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160056
PNG
(4-Amino-pyridine-2-carboxylic acid thiazol-2-ylami...)
Show SMILES Nc1ccnc(c1)C(=O)Nc1nccs1
Show InChI InChI=1S/C9H8N4OS/c10-6-1-2-11-7(5-6)8(14)13-9-12-3-4-15-9/h1-5H,(H2,10,11)(H,12,13,14)
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n/an/a 6.71E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Saccharomyces cerevisiae methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.005
BindingDB Entry DOI: 10.7270/Q2FN15RH
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


J Med Chem 46: 2631-40 (2003)


Article DOI: 10.1021/jm0300532
BindingDB Entry DOI: 10.7270/Q2CF9QTC
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169687
PNG
(5-Isopropyl-thiazole-4-carboxylic acid thiazol-2-y...)
Show SMILES CC(C)c1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C10H11N3OS2/c1-6(2)8-7(12-5-16-8)9(14)13-10-11-3-4-15-10/h3-6H,1-2H3,(H,11,13,14)
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n/an/a 7.20E+3n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169680
PNG
(5-Ethyl-thiazole-4-carboxylic acid thiazol-2-ylami...)
Show SMILES CCc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C9H9N3OS2/c1-2-6-7(11-5-15-6)8(13)12-9-10-3-4-14-9/h3-5H,2H2,1H3,(H,10,12,13)
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n/an/a 7.64E+3n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 8.10E+3n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1


Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160050
PNG
(4-Methoxy-pyridine-2-carboxylic acid thiazol-2-yla...)
Show SMILES COc1ccnc(c1)C(=O)Nc1nccs1
Show InChI InChI=1S/C10H9N3O2S/c1-15-7-2-3-11-8(6-7)9(14)13-10-12-4-5-16-10/h2-6H,1H3,(H,12,13,14)
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n/an/a 9.22E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169663
PNG
(5-Methyl-thiazole-4-carboxylic acid thiazol-2-ylam...)
Show SMILES Cc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C8H7N3OS2/c1-5-6(10-4-14-5)7(12)11-8-9-2-3-13-8/h2-4H,1H3,(H,9,11,12)
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n/an/a 9.82E+3n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170375
PNG
(5-(2-Hydroxy-ethyl)-thiazole-4-carboxylic acid thi...)
Show SMILES OCCc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C9H9N3O2S2/c13-3-1-6-7(11-5-16-6)8(14)12-9-10-2-4-15-9/h2,4-5,13H,1,3H2,(H,10,12,14)
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n/an/a 1.04E+4n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.005
BindingDB Entry DOI: 10.7270/Q2FN15RH
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169682
PNG
(5-Amino-thiazole-4-carboxylic acid thiazol-2-ylami...)
Show SMILES Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C7H6N4OS2/c8-5-4(10-3-14-5)6(12)11-7-9-1-2-13-7/h1-3H,8H2,(H,9,11,12)
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n/an/a 1.32E+4n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 2.58E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells


Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129653
PNG
(3-Amino-pyridine-2-carboxylic acid thiazol-2-ylami...)
Show SMILES Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C9H8N4OS/c10-6-2-1-3-11-7(6)8(14)13-9-12-4-5-15-9/h1-5H,10H2,(H,12,13,14)
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n/an/a 3.28E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


J Med Chem 46: 2631-40 (2003)


Article DOI: 10.1021/jm0300532
BindingDB Entry DOI: 10.7270/Q2CF9QTC
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50160046
PNG
(4-Chloro-pyridine-2-carboxylic acid thiazol-2-ylam...)
Show SMILES Clc1ccnc(c1)C(=O)Nc1nccs1
Show InChI InChI=1S/C9H6ClN3OS/c10-6-1-2-11-7(5-6)8(14)13-9-12-3-4-15-9/h1-5H,(H,12,13,14)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Saccharomyces cerevisiae methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160046
PNG
(4-Chloro-pyridine-2-carboxylic acid thiazol-2-ylam...)
Show SMILES Clc1ccnc(c1)C(=O)Nc1nccs1
Show InChI InChI=1S/C9H6ClN3OS/c10-6-1-2-11-7(5-6)8(14)13-9-12-3-4-15-9/h1-5H,(H,12,13,14)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50160050
PNG
(4-Methoxy-pyridine-2-carboxylic acid thiazol-2-yla...)
Show SMILES COc1ccnc(c1)C(=O)Nc1nccs1
Show InChI InChI=1S/C10H9N3O2S/c1-15-7-2-3-11-8(6-7)9(14)13-10-12-4-5-16-10/h2-6H,1H3,(H,12,13,14)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Saccharomyces cerevisiae methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50160059
PNG
(4-Nitrooxy-pyridine-2-carboxylic acid thiazol-2-yl...)
Show SMILES [O-][N+](=O)c1ccnc(c1)C(=O)Nc1nccs1
Show InChI InChI=1S/C9H6N4O3S/c14-8(12-9-11-3-4-17-9)7-5-6(13(15)16)1-2-10-7/h1-5H,(H,11,12,14)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Saccharomyces cerevisiae methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50160056
PNG
(4-Amino-pyridine-2-carboxylic acid thiazol-2-ylami...)
Show SMILES Nc1ccnc(c1)C(=O)Nc1nccs1
Show InChI InChI=1S/C9H8N4OS/c10-6-1-2-11-7(5-6)8(14)13-9-12-3-4-15-9/h1-5H,(H2,10,11)(H,12,13,14)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Saccharomyces cerevisiae methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair