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Found 1039 Enz. Inhib. hit(s) with Target = 'Myeloperoxidase'
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133601(CHEMBL3633251)
Affinity DataKi:  151nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133602(CHEMBL3633250)
Affinity DataKi:  174nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)
Affinity DataKi:  316nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133596(CHEMBL3633459)
Affinity DataKi:  347nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133603(CHEMBL3633248)
Affinity DataKi:  372nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM119872(3‐(2‐ethoxypropyl)‐2‐sulfa...)
Affinity DataKi:  413nMpH: 7.4Assay Description:Assay mixtures (100 µL) contained 50 mM NaPi (pH 7.4), 150 mM NaCl, 1 mM DTPA, 2% DMSO, the indicated concentrations of H2O2, and Amplex Red. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM119874(3‐[(2S)‐2‐ethoxypropyl]‐2&...)
Affinity DataKi:  429nMpH: 7.4Assay Description:Assay mixtures (100 µL) contained 50 mM NaPi (pH 7.4), 150 mM NaCl, 1 mM DTPA, 2% DMSO, the indicated concentrations of H2O2, and Amplex Red. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133600(CHEMBL3633457)
Affinity DataKi:  501nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM119873(3‐[(2R)‐2‐ethoxypropyl]‐2&...)
Affinity DataKi:  546nMpH: 7.4Assay Description:Assay mixtures (100 µL) contained 50 mM NaPi (pH 7.4), 150 mM NaCl, 1 mM DTPA, 2% DMSO, the indicated concentrations of H2O2, and Amplex Red. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50554034(CHEMBL4747269)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50554035(CHEMBL4790231)
Affinity DataIC50:  1nMAssay Description:Inhibition of MPO (unknown origin) chlorination activity incubated for 10 mins followed by NaCl addition by aminophenyl fluorescein assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50554035(CHEMBL4790231)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50554052(CHEMBL4763667)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50554050(CHEMBL4752248)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50432573(CHEMBL2347170)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant MPO-mediated taurine chlorination after 5 mins by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50595667(CHEMBL5181350)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50432575(CHEMBL2347168)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant MPO-mediated taurine chlorination after 5 mins by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50507392(CHEMBL4548537 | US10981879, Example 11)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human PMN leukocytes MPO peroxidation activity using H2O2 as substrate preincubated for 10 mins followed by H2O2 addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50554057(CHEMBL4740830)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM434866(7-[(3R,4S,6S,10R)-4-Benzyl-2-oxa-7,13,14-triazatet...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MPO (unknown origin) chlorination activity incubated for 10 mins followed by NaCl addition by aminophenyl fluorescein assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50595661(CHEMBL5197968)
Affinity DataIC50:  5nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50595661(CHEMBL5197968)
Affinity DataIC50:  5nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50238843(CHEMBL4068067)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332590(5-(5-fluoro-1H-indol-3-yl)pentan-1-amine | CHEMBL1...)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332590(5-(5-fluoro-1H-indol-3-yl)pentan-1-amine | CHEMBL1...)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant MPO mediated LDL oxidation using MPO/Cl-/H2O2 systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50432568(CHEMBL2347177)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant MPO-mediated taurine chlorination after 5 mins by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM217354(2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...)
Affinity DataIC50:  5.01nMpH: 6.5Assay Description:Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta...More data for this Ligand-Target Pair
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50554056(CHEMBL4782307)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50432573(CHEMBL2347170)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant MPO-mediated LDL oxidation after 5 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50432580(CHEMBL2347032)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant MPO-mediated taurine chlorination after 5 mins by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50507396(CHEMBL4453728)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human PMN leukocytes MPO peroxidation activity using H2O2 as substrate preincubated for 10 mins followed by H2O2 addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50507390(CHEMBL4482878 | US10981879, Example 3)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human PMN leukocytes MPO chlorination activity using H2O2 as substrate preincubated for 10 mins followed by H2O2 addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM434867(7-[(17S)-18-Phenyl-16-oxa-2,8,9-triazapentacyclo[1...)
Affinity DataIC50:  7nMAssay Description:Inhibition of MPO (unknown origin) chlorination activity incubated for 10 mins followed by NaCl addition by aminophenyl fluorescein assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50507390(CHEMBL4482878 | US10981879, Example 3)
Affinity DataIC50:  7nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen catalog #A12222) which ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM492844(7-(((5-chloro-3-methyl-1- phenyl-1H-pyrazol-4- yl)...)
Affinity DataIC50:  7nMAssay Description:MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen catal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM312171(1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3...)
Affinity DataIC50:  7nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)
Affinity DataIC50:  7nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM312171(1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3...)
Affinity DataIC50:  7nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)
Affinity DataIC50:  7nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM312171(1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3...)
Affinity DataIC50:  7nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)
Affinity DataIC50:  7nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM434851(7-{17-Oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,...)
Affinity DataIC50:  8nMAssay Description:Inhibition of MPO (unknown origin) chlorination activity incubated for 10 mins followed by NaCl addition by aminophenyl fluorescein assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM413387(US10407422, Example 130)
Affinity DataIC50:  8nMAssay Description:EPX bromination activity was measured in 100 mM KPi (pH 7.4) by monitoring the H2O2 catalyzed formation of 3-bromo tyrosine from tyrosine and potassi...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332589(4-(5-fluoro-1H-indol-3-yl)butan-1-amine | CHEMBL16...)
Affinity DataIC50:  8nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332590(5-(5-fluoro-1H-indol-3-yl)pentan-1-amine | CHEMBL1...)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant MPO mediated taurine chlorination by microplate reader methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50432575(CHEMBL2347168)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant MPO-mediated LDL oxidation after 5 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50507391(CHEMBL4594116 | US10981879, Example 153)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human PMN leukocytes MPO peroxidation activity using H2O2 as substrate preincubated for 10 mins followed by H2O2 addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM312157(1-{2-[(1R)-1-Aminopropyl]-4-chlorobenzyl}-2-thioxo...)
Affinity DataIC50:  8.60nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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