BindingDB PrimarySearch_ki

Found 1707 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform'

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM340314((Scheme A): Preparation of 2,2-difluoroethyl (3S)-...)

Ki: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

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Details Article PubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM340336(US9758538, Example 24)

Ki: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM340384(US9758538, Example 72)

Ki: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207378(US9260439, 262)

Ki: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207217(US9260439, 194 | US9260439, 238 | US9260439, 239)

Ki: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

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Details Article PubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207196(US9260439, 173)

Ki: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM340346(US9758538, Example 34)

Ki: 0.0190nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM340391(US9758538, Example 79)

Ki: 0.0210nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207236(US9260439, 213)

Ki: <0.0230nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207028(US9260439, 10 | US9260439, 4)

Ki: 0.0230nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207172(US9260439, 149)

Ki: <0.0290nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207391(US9260439, 275)

Ki: 0.0300nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50145416(GSK2126458 | Omipalisib)

Ki: 0.0600nMAssay Description:Inhibition of human p110alpha/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Purchase MCE
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Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207234(US9260439, 211)

Ki: 0.0780nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207239(US9260439, 216)

Ki: 0.0840nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM340352(US9758538, Example 40)

Ki: 0.0950nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50570237(CHEMBL4864407)

Ki: 0.100nMAssay Description:Inhibition of p110alpha H1047R mutant/p85alpha (unknown origin) using PIP2:3PS lipid kinase as substrate in presence of ATP measured by ADP-Glo lipid...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207061(US9260439, 38)

Ki: 0.120nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM340347(US9758538, Example 35)

Ki: 0.140nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207043(US9260439, 20)

Ki: 0.150nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50570237(CHEMBL4864407)

Ki: 0.160nMAssay Description:Inhibition of human p110alpha/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207061(US9260439, 38)

Ki: 0.228nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

PC cid PC sid PDB

Details US Patent PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207146(US9260439, 123)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207148(US9260439, 125)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207149(US9260439, 126)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207151(US9260439, 128)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207154(US9260439, 131)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207155(US9260439, 132)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207159(US9260439, 136)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207025(US9260439, 1)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207043(US9260439, 20)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207045(US9260439, 22)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207048(US9260439, 25)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207054(US9260439, 31)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207082(US9260439, 59)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207088(US9260439, 65)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207095(US9260439, 72)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207169(US9260439, 146)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207102(US9260439, 79)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207118(US9260439, 95)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207123(US9260439, 100)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207124(US9260439, 101)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207125(US9260439, 102)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207127(US9260439, 104)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207129(US9260439, 106)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207131(US9260439, 108)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207132(US9260439, 109)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207134(US9260439, 111)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details US Patent

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207136(US9260439, 113)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM207138(US9260439, 115)

Ki: <0.229nMAssay Description:PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...More data for this Ligand-Target Pair

PDB Reactome pathway
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Details US Patent

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Targets 3▿
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1705
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [E545K] 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [H1047R] 1
Publications 50▿
- US Patent US9260439 (2016) 131
- US Patent US9321790 (2016) 119
- US Patent US9453031 (2016) 87
- US Patent US10457677 (2019) 57
- Bioorg Med Chem Lett 27: 2536-2543 (2017) 54
- Bioorg Med Chem 25: 5859-5874 (2017) 49
- Eur J Med Chem 157: 37-49 (2018) 47
- Bioorg Med Chem Lett 22: 1874-8 (2012) 45
- J Med Chem 51: 1319-23 (2008) 45
- Bioorg Med Chem Lett 22: 3460-6 (2012) 41
- J Med Chem 63: 638-655 (2020) 40
- J Med Chem 59: 5488-504 (2016) 39
- J Med Chem 63: 11235-11257 (2020) 39
- J Med Chem 60: 4023-4035 (2017) 37
- Bioorg Med Chem 27: 1529-1545 (2019) 36
- J Med Chem 61: 1552-1575 (2018) 34
- J Med Chem 64: 13780-13792 (2021) 34
- Bioorg Med Chem Lett 27: 3117-3122 (2017) 33
- ACS Med Chem Lett 9: 719-724 (2018) 32
- J Med Chem 60: 1555-1567 (2017) 31
- Bioorg Med Chem Lett 27: 679-687 (2017) 30
- ACS Med Chem Lett 11: 1236-1243 (2020) 30
- J Med Chem 62: 8609-8630 (2019) 29
- Eur J Med Chem 197: (2020) 29
- J Med Chem 61: 9551-9567 (2018) 27
- J Med Chem 64: 644-661 (2021) 24
- J Med Chem 52: 5013-6 (2009) 24
- J Med Chem 62: 4370-4382 (2019) 23
- J Med Chem 59: 431-47 (2016) 22
- J Med Chem 52: 7081-9 (2009) 22
- J Med Chem 59: 9228-9242 (2016) 21
- Eur J Med Chem 57: 225-33 (2012) 21
- J Med Chem 55: 7796-816 (2012) 20
- J Med Chem 62: 8873-8879 (2019) 20
- J Med Chem 63: 3028-3046 (2020) 19
- J Med Chem 61: 5435-5441 (2018) 18
- ACS Med Chem Lett 11: 2156-2164 (2020) 18
- Eur J Med Chem 64: 137-47 (2013) 17
- Eur J Med Chem 127: 509-520 (2017) 17
- Bioorg Med Chem 45: (2021) 16
- J Med Chem 63: 13595-13617 (2020) 15
- J Med Chem 60: 7524-7538 (2017) 14
- J Med Chem 51: 5522-32 (2008) 13
- US Patent US10751339 (2020) 13
- J Med Chem 63: 11121-11130 (2020) 13
- J Med Chem 60: 5057-5071 (2017) 11
- Bioorg Med Chem 24: 2897-2906 (2016) 10
- US Patent US9512114 (2016) 10
- US Patent US9670194 (2017) 9
- ACS Med Chem Lett 8: 875-880 (2017) 8
Institutions 32▿
- Pfizer 155
- Spanish National Cancer Research Centre (Cnio) 140
- Sanofi 119
- University Of Auckland 102
- Wyeth Research 91
- FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii 87
- Gilead Sciences 82
- West China Hospital Of Sichuan University 76
- TBA 70
- University Of Basel 58
- Merck Patent 57
- Temple University 51
- Chongqing University 47
- Amgen 42
- Astrazeneca 41
- Glaxosmithkline 40
- Arcus Biosciences 39
- Glaxosmithkline R&D 34
- A*Star 34
- Shanghai Haiyan Pharmaceutical Technology 32
- Guizhou Medical University 29
- Universit£ 21
- Calitor Sciences 19
- East China Normal University 19
- Pharmaron-Beijing 18
- Hangzhou Xixi Hospital 17
- Sungkyunkwan University 16
- Piramed Pharma 13
- Sunshine Lake Pharma 13
- Sphaera Pharma 13
- Chugai Pharmaceutical 10
- Fudan University 8
Affinity: 0.018 to 4.3E+6 nM▿
- Ki 269
- IC50 1378
- Kd 1
- EC50 59
- Affinity ≤ nM
Xtal structures: 9
Docked structures: 0
Catalog Cmpds: 76