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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 301.2
BDBM263944
Wt: 281.2
BDBM263949
Wt: 293.3
BDBM263970
Wt: 295.2
BDBM263974
Wt: 245.2
BDBM263932
Wt: 279.2
BDBM263942
Wt: 323.3
BDBM264047
Wt: 339.3
BDBM264048
Wt: 315.7
BDBM264073
Wt: 315.7
BDBM264074
Wt: 273.2
BDBM264075
Wt: 309.3
BDBM264077
Wt: 329.7
BDBM264078
Wt: 329.7
BDBM264079
Wt: 329.7
BDBM264080
Displayed 1 to 15 (of 22 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 198 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263974
PNG
(2-(5-(benzyloxy)-1H-pyrazol-1- yl)isonicotinic aci...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccccc1
Show InChI InChI=1S/C16H13N3O3/c20-16(21)13-6-8-17-14(10-13)19-15(7-9-18-19)22-11-12-4-2-1-3-5-12/h1-10H,11H2,(H,20,21)
PDB

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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM263974
PNG
(2-(5-(benzyloxy)-1H-pyrazol-1- yl)isonicotinic aci...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccccc1
Show InChI InChI=1S/C16H13N3O3/c20-16(21)13-6-8-17-14(10-13)19-15(7-9-18-19)22-11-12-4-2-1-3-5-12/h1-10H,11H2,(H,20,21)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
fbxl10


(Homo sapiens (Human))
BDBM264078
PNG
(2-[3-[(2-chlorophenyl)methyl]-5- hydroxypyrazol-1-...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(Cc2ccccc2Cl)cc1O
Show InChI InChI=1S/C16H12ClN3O3/c17-13-4-2-1-3-10(13)7-12-9-15(21)20(19-12)14-8-11(16(22)23)5-6-18-14/h1-6,8-9,21H,7H2,(H,22,23)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
fbxl10


(Homo sapiens (Human))
BDBM264077
PNG
(2-[5-hydroxy-3-(1-phenyl- ethyl)pyrazol-1-yl]pyrid...)
Show SMILES CC(c1cc(O)n(n1)-c1cc(ccn1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C17H15N3O3/c1-11(12-5-3-2-4-6-12)14-10-16(21)20(19-14)15-9-13(17(22)23)7-8-18-15/h2-11,21H,1H3,(H,22,23)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
fbxl10


(Homo sapiens (Human))
BDBM264075
PNG
(2-(3-cyclopentyl-5- hydroxypyrazol-1-yl)pyridine-4...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CCCC1
Show InChI InChI=1S/C14H15N3O3/c18-13-8-11(9-3-1-2-4-9)16-17(13)12-7-10(14(19)20)5-6-15-12/h5-9,18H,1-4H2,(H,19,20)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263974
PNG
(2-(5-(benzyloxy)-1H-pyrazol-1- yl)isonicotinic aci...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccccc1
Show InChI InChI=1S/C16H13N3O3/c20-16(21)13-6-8-17-14(10-13)19-15(7-9-18-19)22-11-12-4-2-1-3-5-12/h1-10H,11H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
fbxl10


(Homo sapiens (Human))
BDBM264074
PNG
(2-[3-(3-chlorophenyl)-5- hydroxypyrazol-1-yl]pyrid...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H10ClN3O3/c16-11-3-1-2-9(6-11)12-8-14(20)19(18-12)13-7-10(15(21)22)4-5-17-13/h1-8,20H,(H,21,22)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
fbxl10


(Homo sapiens (Human))
BDBM264073
PNG
(2-[3-(4-chlorophenyl)-5- hydroxypyrazol-1-yl]pyrid...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H10ClN3O3/c16-11-3-1-9(2-4-11)12-8-14(20)19(18-12)13-7-10(15(21)22)5-6-17-13/h1-8,20H,(H,21,22)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
fbxl10


(Homo sapiens (Human))
BDBM264080
PNG
(2-[3-[(4-chlorophenyl)methyl]-5- hydroxypyrazol-1-...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(Cc2ccc(Cl)cc2)cc1O
Show InChI InChI=1S/C16H12ClN3O3/c17-12-3-1-10(2-4-12)7-13-9-15(21)20(19-13)14-8-11(16(22)23)5-6-18-14/h1-6,8-9,21H,7H2,(H,22,23)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
fbxl10


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264048
PNG
(2-[5-[(2-methoxy-4- methylphenyl)methoxy]pyrazol-1...)
Show SMILES COc1cc(C)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C18H17N3O4/c1-12-3-4-14(15(9-12)24-2)11-25-17-6-8-20-21(17)16-10-13(18(22)23)5-7-19-16/h3-10H,11H2,1-2H3,(H,22,23)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264048
PNG
(2-[5-[(2-methoxy-4- methylphenyl)methoxy]pyrazol-1...)
Show SMILES COc1cc(C)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C18H17N3O4/c1-12-3-4-14(15(9-12)24-2)11-25-17-6-8-20-21(17)16-10-13(18(22)23)5-7-19-16/h3-10H,11H2,1-2H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264047
PNG
(2-[5-[(2,4- dimethylphenyl)methoxy]pyrazol- 1-yl]p...)
Show SMILES Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)c(C)c1
Show InChI InChI=1S/C18H17N3O3/c1-12-3-4-15(13(2)9-12)11-24-17-6-8-20-21(17)16-10-14(18(22)23)5-7-19-16/h3-10H,11H2,1-2H3,(H,22,23)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264047
PNG
(2-[5-[(2,4- dimethylphenyl)methoxy]pyrazol- 1-yl]p...)
Show SMILES Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)c(C)c1
Show InChI InChI=1S/C18H17N3O3/c1-12-3-4-15(13(2)9-12)11-24-17-6-8-20-21(17)16-10-14(18(22)23)5-7-19-16/h3-10H,11H2,1-2H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2a


(Homo sapiens (Human))
BDBM263974
PNG
(2-(5-(benzyloxy)-1H-pyrazol-1- yl)isonicotinic aci...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccccc1
Show InChI InChI=1S/C16H13N3O3/c20-16(21)13-6-8-17-14(10-13)19-15(7-9-18-19)22-11-12-4-2-1-3-5-12/h1-10H,11H2,(H,20,21)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
fbxl10


(Homo sapiens (Human))
BDBM264079
PNG
(2-[3-[(3-chlorophenyl)methyl]-5- hydroxypyrazol-1-...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(Cc2cccc(Cl)c2)cc1O
Show InChI InChI=1S/C16H12ClN3O3/c17-12-3-1-2-10(6-12)7-13-9-15(21)20(19-13)14-8-11(16(22)23)4-5-18-14/h1-6,8-9,21H,7H2,(H,22,23)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2a


(Homo sapiens (Human))
BDBM264047
PNG
(2-[5-[(2,4- dimethylphenyl)methoxy]pyrazol- 1-yl]p...)
Show SMILES Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)c(C)c1
Show InChI InChI=1S/C18H17N3O3/c1-12-3-4-15(13(2)9-12)11-24-17-6-8-20-21(17)16-10-14(18(22)23)5-7-19-16/h3-10H,11H2,1-2H3,(H,22,23)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM264048
PNG
(2-[5-[(2-methoxy-4- methylphenyl)methoxy]pyrazol-1...)
Show SMILES COc1cc(C)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C18H17N3O4/c1-12-3-4-14(15(9-12)24-2)11-25-17-6-8-20-21(17)16-10-13(18(22)23)5-7-19-16/h3-10H,11H2,1-2H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2a


(Homo sapiens (Human))
BDBM264048
PNG
(2-[5-[(2-methoxy-4- methylphenyl)methoxy]pyrazol-1...)
Show SMILES COc1cc(C)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C18H17N3O4/c1-12-3-4-14(15(9-12)24-2)11-25-17-6-8-20-21(17)16-10-13(18(22)23)5-7-19-16/h3-10H,11H2,1-2H3,(H,22,23)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264075
PNG
(2-(3-cyclopentyl-5- hydroxypyrazol-1-yl)pyridine-4...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CCCC1
Show InChI InChI=1S/C14H15N3O3/c18-13-8-11(9-3-1-2-4-9)16-17(13)12-7-10(14(19)20)5-6-15-12/h5-9,18H,1-4H2,(H,19,20)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264080
PNG
(2-[3-[(4-chlorophenyl)methyl]-5- hydroxypyrazol-1-...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(Cc2ccc(Cl)cc2)cc1O
Show InChI InChI=1S/C16H12ClN3O3/c17-12-3-1-10(2-4-12)7-13-9-15(21)20(19-13)14-8-11(16(22)23)5-6-18-14/h1-6,8-9,21H,7H2,(H,22,23)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM264047
PNG
(2-[5-[(2,4- dimethylphenyl)methoxy]pyrazol- 1-yl]p...)
Show SMILES Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)c(C)c1
Show InChI InChI=1S/C18H17N3O3/c1-12-3-4-15(13(2)9-12)11-24-17-6-8-20-21(17)16-10-14(18(22)23)5-7-19-16/h3-10H,11H2,1-2H3,(H,22,23)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM263970
PNG
(2-(3-phenethyl-1H-pyrazol-1- yl)isonicotinic acid ...)
Show SMILES OC(=O)c1ccnc(c1)-n1ccc(CCc2ccccc2)n1
Show InChI InChI=1S/C17H15N3O2/c21-17(22)14-8-10-18-16(12-14)20-11-9-15(19-20)7-6-13-4-2-1-3-5-13/h1-5,8-12H,6-7H2,(H,21,22)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263970
PNG
(2-(3-phenethyl-1H-pyrazol-1- yl)isonicotinic acid ...)
Show SMILES OC(=O)c1ccnc(c1)-n1ccc(CCc2ccccc2)n1
Show InChI InChI=1S/C17H15N3O2/c21-17(22)14-8-10-18-16(12-14)20-11-9-15(19-20)7-6-13-4-2-1-3-5-13/h1-5,8-12H,6-7H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263970
PNG
(2-(3-phenethyl-1H-pyrazol-1- yl)isonicotinic acid ...)
Show SMILES OC(=O)c1ccnc(c1)-n1ccc(CCc2ccccc2)n1
Show InChI InChI=1S/C17H15N3O2/c21-17(22)14-8-10-18-16(12-14)20-11-9-15(19-20)7-6-13-4-2-1-3-5-13/h1-5,8-12H,6-7H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2a


(Homo sapiens (Human))
BDBM263949
PNG
(2-(5-(3-hydroxyphenyl)-1H- pyrazol-1-yl)isonicotin...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1-c1cccc(O)c1
Show InChI InChI=1S/C15H11N3O3/c19-12-3-1-2-10(8-12)13-5-7-17-18(13)14-9-11(15(20)21)4-6-16-14/h1-9,19H,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM263949
PNG
(2-(5-(3-hydroxyphenyl)-1H- pyrazol-1-yl)isonicotin...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1-c1cccc(O)c1
Show InChI InChI=1S/C15H11N3O3/c19-12-3-1-2-10(8-12)13-5-7-17-18(13)14-9-11(15(20)21)4-6-16-14/h1-9,19H,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263949
PNG
(2-(5-(3-hydroxyphenyl)-1H- pyrazol-1-yl)isonicotin...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1-c1cccc(O)c1
Show InChI InChI=1S/C15H11N3O3/c19-12-3-1-2-10(8-12)13-5-7-17-18(13)14-9-11(15(20)21)4-6-16-14/h1-9,19H,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263949
PNG
(2-(5-(3-hydroxyphenyl)-1H- pyrazol-1-yl)isonicotin...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1-c1cccc(O)c1
Show InChI InChI=1S/C15H11N3O3/c19-12-3-1-2-10(8-12)13-5-7-17-18(13)14-9-11(15(20)21)4-6-16-14/h1-9,19H,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2a


(Homo sapiens (Human))
BDBM263944
PNG
(2-(5-(2,4-difluorophenyl)-1H- pyrazol-1-yl)isonico...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1-c1ccc(F)cc1F
Show InChI InChI=1S/C15H9F2N3O2/c16-10-1-2-11(12(17)8-10)13-4-6-19-20(13)14-7-9(15(21)22)3-5-18-14/h1-8H,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM263944
PNG
(2-(5-(2,4-difluorophenyl)-1H- pyrazol-1-yl)isonico...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1-c1ccc(F)cc1F
Show InChI InChI=1S/C15H9F2N3O2/c16-10-1-2-11(12(17)8-10)13-4-6-19-20(13)14-7-9(15(21)22)3-5-18-14/h1-8H,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263944
PNG
(2-(5-(2,4-difluorophenyl)-1H- pyrazol-1-yl)isonico...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1-c1ccc(F)cc1F
Show InChI InChI=1S/C15H9F2N3O2/c16-10-1-2-11(12(17)8-10)13-4-6-19-20(13)14-7-9(15(21)22)3-5-18-14/h1-8H,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263944
PNG
(2-(5-(2,4-difluorophenyl)-1H- pyrazol-1-yl)isonico...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1-c1ccc(F)cc1F
Show InChI InChI=1S/C15H9F2N3O2/c16-10-1-2-11(12(17)8-10)13-4-6-19-20(13)14-7-9(15(21)22)3-5-18-14/h1-8H,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2a


(Homo sapiens (Human))
BDBM263942
PNG
(2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...)
Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM263942
PNG
(2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...)
Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263942
PNG
(2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...)
Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263942
PNG
(2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...)
Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2a


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2a


(Homo sapiens (Human))
BDBM263970
PNG
(2-(3-phenethyl-1H-pyrazol-1- yl)isonicotinic acid ...)
Show SMILES OC(=O)c1ccnc(c1)-n1ccc(CCc2ccccc2)n1
Show InChI InChI=1S/C17H15N3O2/c21-17(22)14-8-10-18-16(12-14)20-11-9-15(19-20)7-6-13-4-2-1-3-5-13/h1-5,8-12H,6-7H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264047
PNG
(2-[5-[(2,4- dimethylphenyl)methoxy]pyrazol- 1-yl]p...)
Show SMILES Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)c(C)c1
Show InChI InChI=1S/C18H17N3O3/c1-12-3-4-15(13(2)9-12)11-24-17-6-8-20-21(17)16-10-14(18(22)23)5-7-19-16/h3-10H,11H2,1-2H3,(H,22,23)
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Celgene Quantical Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM264080
PNG
(2-[3-[(4-chlorophenyl)methyl]-5- hydroxypyrazol-1-...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(Cc2ccc(Cl)cc2)cc1O
Show InChI InChI=1S/C16H12ClN3O3/c17-12-3-1-10(2-4-12)7-13-9-15(21)20(19-13)14-8-11(16(22)23)5-6-18-14/h1-6,8-9,21H,7H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM264048
PNG
(2-[5-[(2-methoxy-4- methylphenyl)methoxy]pyrazol-1...)
Show SMILES COc1cc(C)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C18H17N3O4/c1-12-3-4-14(15(9-12)24-2)11-25-17-6-8-20-21(17)16-10-13(18(22)23)5-7-19-16/h3-10H,11H2,1-2H3,(H,22,23)
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Celgene Quantical Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM264048
PNG
(2-[5-[(2-methoxy-4- methylphenyl)methoxy]pyrazol-1...)
Show SMILES COc1cc(C)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C18H17N3O4/c1-12-3-4-14(15(9-12)24-2)11-25-17-6-8-20-21(17)16-10-13(18(22)23)5-7-19-16/h3-10H,11H2,1-2H3,(H,22,23)
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Celgene Quantical Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM264073
PNG
(2-[3-(4-chlorophenyl)-5- hydroxypyrazol-1-yl]pyrid...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H10ClN3O3/c16-11-3-1-9(2-4-11)12-8-14(20)19(18-12)13-7-10(15(21)22)5-6-17-13/h1-8,20H,(H,21,22)
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Celgene Quantical Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM264074
PNG
(2-[3-(3-chlorophenyl)-5- hydroxypyrazol-1-yl]pyrid...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H10ClN3O3/c16-11-3-1-2-9(6-11)12-8-14(20)19(18-12)13-7-10(15(21)22)4-5-17-13/h1-8,20H,(H,21,22)
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US Patent
n/an/a<100n/an/an/an/an/a25



Celgene Quantical Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM264075
PNG
(2-(3-cyclopentyl-5- hydroxypyrazol-1-yl)pyridine-4...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CCCC1
Show InChI InChI=1S/C14H15N3O3/c18-13-8-11(9-3-1-2-4-9)16-17(13)12-7-10(14(19)20)5-6-15-12/h5-9,18H,1-4H2,(H,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Celgene Quantical Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM264077
PNG
(2-[5-hydroxy-3-(1-phenyl- ethyl)pyrazol-1-yl]pyrid...)
Show SMILES CC(c1cc(O)n(n1)-c1cc(ccn1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C17H15N3O3/c1-11(12-5-3-2-4-6-12)14-10-16(21)20(19-14)15-9-13(17(22)23)7-8-18-15/h2-11,21H,1H3,(H,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Celgene Quantical Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
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