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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 203.1
BDBM263966
Wt: 233.2
BDBM263972
Wt: 219.1
BDBM263924
Wt: 245.2
BDBM263932
Wt: 233.2
BDBM263933
Wt: 205.1
BDBM263941
Wt: 229.2
BDBM314097
Wt: 246.2
BDBM314098
Wt: 246.2
BDBM314099
Wt: 246.2
BDBM314100
Wt: 244.2
BDBM314113
Wt: 243.2
BDBM314118
Wt: 242.2
BDBM314120
Wt: 232.2
BDBM314136
Wt: 245.2
BDBM312294
Displayed 1 to 15 (of 462 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 147 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263924
PNG
(2-(5-hydroxy-3-methyl-1H- pyrazol-1-yl)isonicotini...)
Show SMILES Cc1cc(O)n(n1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C10H9N3O3/c1-6-4-9(14)13(12-6)8-5-7(10(15)16)2-3-11-8/h2-5,14H,1H3,(H,15,16)
PDB

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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263941
PNG
(2-(5-hydroxy-1H-pyrazol-1- yl)isonicotinic acid | ...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1O
Show InChI InChI=1S/C9H7N3O3/c13-8-2-4-11-12(8)7-5-6(9(14)15)1-3-10-7/h1-5,13H,(H,14,15)
PDB

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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263941
PNG
(2-(5-hydroxy-1H-pyrazol-1- yl)isonicotinic acid | ...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1O
Show InChI InChI=1S/C9H7N3O3/c13-8-2-4-11-12(8)7-5-6(9(14)15)1-3-10-7/h1-5,13H,(H,14,15)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263933
PNG
(2-(5-hydroxy-3,4- dimethyl-1H-pyrazol-1- yl)isonic...)
Show SMILES Cc1nn(c(O)c1C)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C11H11N3O3/c1-6-7(2)13-14(10(6)15)9-5-8(11(16)17)3-4-12-9/h3-5,15H,1-2H3,(H,16,17)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
fbxl10


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2a


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
fbxl10


(Homo sapiens (Human))
BDBM263941
PNG
(2-(5-hydroxy-1H-pyrazol-1- yl)isonicotinic acid | ...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1O
Show InChI InChI=1S/C9H7N3O3/c13-8-2-4-11-12(8)7-5-6(9(14)15)1-3-10-7/h1-5,13H,(H,14,15)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263933
PNG
(2-(5-hydroxy-3,4- dimethyl-1H-pyrazol-1- yl)isonic...)
Show SMILES Cc1nn(c(O)c1C)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C11H11N3O3/c1-6-7(2)13-14(10(6)15)9-5-8(11(16)17)3-4-12-9/h3-5,15H,1-2H3,(H,16,17)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM263966
PNG
(2-(5-methyl-1H-pyrazol-1- yl)isonicotinic acid | U...)
Show SMILES Cc1ccnn1-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C10H9N3O2/c1-7-2-5-12-13(7)9-6-8(10(14)15)3-4-11-9/h2-6H,1H3,(H,14,15)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM263933
PNG
(2-(5-hydroxy-3,4- dimethyl-1H-pyrazol-1- yl)isonic...)
Show SMILES Cc1nn(c(O)c1C)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C11H11N3O3/c1-6-7(2)13-14(10(6)15)9-5-8(11(16)17)3-4-12-9/h3-5,15H,1-2H3,(H,16,17)
PDB

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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
fbxl10


(Homo sapiens (Human))
BDBM263933
PNG
(2-(5-hydroxy-3,4- dimethyl-1H-pyrazol-1- yl)isonic...)
Show SMILES Cc1nn(c(O)c1C)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C11H11N3O3/c1-6-7(2)13-14(10(6)15)9-5-8(11(16)17)3-4-12-9/h3-5,15H,1-2H3,(H,16,17)
PDB

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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263924
PNG
(2-(5-hydroxy-3-methyl-1H- pyrazol-1-yl)isonicotini...)
Show SMILES Cc1cc(O)n(n1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C10H9N3O3/c1-6-4-9(14)13(12-6)8-5-7(10(15)16)2-3-11-8/h2-5,14H,1H3,(H,15,16)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM263941
PNG
(2-(5-hydroxy-1H-pyrazol-1- yl)isonicotinic acid | ...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1O
Show InChI InChI=1S/C9H7N3O3/c13-8-2-4-11-12(8)7-5-6(9(14)15)1-3-10-7/h1-5,13H,(H,14,15)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM312294
PNG
(2-(3-butyl-1H-pyrazol-1-yl)pyridine-4-carboxylic a...)
Show SMILES CCCCc1ccn(n1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C13H15N3O2/c1-2-3-4-11-6-8-16(15-11)12-9-10(13(17)18)5-7-14-12/h5-9H,2-4H2,1H3,(H,17,18)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
fbxl10


(Homo sapiens (Human))
BDBM263924
PNG
(2-(5-hydroxy-3-methyl-1H- pyrazol-1-yl)isonicotini...)
Show SMILES Cc1cc(O)n(n1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C10H9N3O3/c1-6-4-9(14)13(12-6)8-5-7(10(15)16)2-3-11-8/h2-5,14H,1H3,(H,15,16)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM263924
PNG
(2-(5-hydroxy-3-methyl-1H- pyrazol-1-yl)isonicotini...)
Show SMILES Cc1cc(O)n(n1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C10H9N3O3/c1-6-4-9(14)13(12-6)8-5-7(10(15)16)2-3-11-8/h2-5,14H,1H3,(H,15,16)
PDB

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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM312294
PNG
(2-(3-butyl-1H-pyrazol-1-yl)pyridine-4-carboxylic a...)
Show SMILES CCCCc1ccn(n1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C13H15N3O2/c1-2-3-4-11-6-8-16(15-11)12-9-10(13(17)18)5-7-14-12/h5-9H,2-4H2,1H3,(H,17,18)
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n/an/a 55n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM312294
PNG
(2-(3-butyl-1H-pyrazol-1-yl)pyridine-4-carboxylic a...)
Show SMILES CCCCc1ccn(n1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C13H15N3O2/c1-2-3-4-11-6-8-16(15-11)12-9-10(13(17)18)5-7-14-12/h5-9H,2-4H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9604961 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263924
PNG
(2-(5-hydroxy-3-methyl-1H- pyrazol-1-yl)isonicotini...)
Show SMILES Cc1cc(O)n(n1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C10H9N3O3/c1-6-4-9(14)13(12-6)8-5-7(10(15)16)2-3-11-8/h2-5,14H,1H3,(H,15,16)
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n/an/a<100n/an/an/an/an/a25



Celgene Quantical Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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n/an/a<100n/an/an/an/an/a25



Celgene Quantical Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
PDB

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n/an/a<100n/an/an/an/an/a25



Celgene Quantical Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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Celgene Quantical Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263933
PNG
(2-(5-hydroxy-3,4- dimethyl-1H-pyrazol-1- yl)isonic...)
Show SMILES Cc1nn(c(O)c1C)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C11H11N3O3/c1-6-7(2)13-14(10(6)15)9-5-8(11(16)17)3-4-12-9/h3-5,15H,1-2H3,(H,16,17)
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Celgene Quantical Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263941
PNG
(2-(5-hydroxy-1H-pyrazol-1- yl)isonicotinic acid | ...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1O
Show InChI InChI=1S/C9H7N3O3/c13-8-2-4-11-12(8)7-5-6(9(14)15)1-3-10-7/h1-5,13H,(H,14,15)
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Celgene Quantical Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263941
PNG
(2-(5-hydroxy-1H-pyrazol-1- yl)isonicotinic acid | ...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1O
Show InChI InChI=1S/C9H7N3O3/c13-8-2-4-11-12(8)7-5-6(9(14)15)1-3-10-7/h1-5,13H,(H,14,15)
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Celgene Quantical Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9714230 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263924
PNG
(2-(5-hydroxy-3-methyl-1H- pyrazol-1-yl)isonicotini...)
Show SMILES Cc1cc(O)n(n1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C10H9N3O3/c1-6-4-9(14)13(12-6)8-5-7(10(15)16)2-3-11-8/h2-5,14H,1H3,(H,15,16)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM263932
PNG
(2-(3-cyclopropyl-5-hydroxy-1H- pyrazol-1-yl)isonic...)
Show SMILES OC(=O)c1ccnc(c1)-n1nc(cc1O)C1CC1
Show InChI InChI=1S/C12H11N3O3/c16-11-6-9(7-1-2-7)14-15(11)10-5-8(12(17)18)3-4-13-10/h3-7,16H,1-2H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263933
PNG
(2-(5-hydroxy-3,4- dimethyl-1H-pyrazol-1- yl)isonic...)
Show SMILES Cc1nn(c(O)c1C)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C11H11N3O3/c1-6-7(2)13-14(10(6)15)9-5-8(11(16)17)3-4-12-9/h3-5,15H,1-2H3,(H,16,17)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM263941
PNG
(2-(5-hydroxy-1H-pyrazol-1- yl)isonicotinic acid | ...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1O
Show InChI InChI=1S/C9H7N3O3/c13-8-2-4-11-12(8)7-5-6(9(14)15)1-3-10-7/h1-5,13H,(H,14,15)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM263941
PNG
(2-(5-hydroxy-1H-pyrazol-1- yl)isonicotinic acid | ...)
Show SMILES OC(=O)c1ccnc(c1)-n1nccc1O
Show InChI InChI=1S/C9H7N3O3/c13-8-2-4-11-12(8)7-5-6(9(14)15)1-3-10-7/h1-5,13H,(H,14,15)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10173996 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314097
PNG
(3-(benzylamino)pyridazine-4-carboxylic acid | US10...)
Show SMILES OC(=O)c1ccnnc1NCc1ccccc1
Show InChI InChI=1S/C12H11N3O2/c16-12(17)10-6-7-14-15-11(10)13-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,13,15)(H,16,17)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314097
PNG
(3-(benzylamino)pyridazine-4-carboxylic acid | US10...)
Show SMILES OC(=O)c1ccnnc1NCc1ccccc1
Show InChI InChI=1S/C12H11N3O2/c16-12(17)10-6-7-14-15-11(10)13-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,13,15)(H,16,17)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314098
PNG
(3-[(2-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1F
Show InChI InChI=1S/C13H11FN2O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314098
PNG
(3-[(2-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1F
Show InChI InChI=1S/C13H11FN2O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314098
PNG
(3-[(2-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1F
Show InChI InChI=1S/C13H11FN2O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314099
PNG
(3-[(3-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(F)c1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-2-9(6-10)7-16-12-8-15-5-4-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314099
PNG
(3-[(3-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(F)c1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-2-9(6-10)7-16-12-8-15-5-4-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314099
PNG
(3-[(3-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(F)c1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-2-9(6-10)7-16-12-8-15-5-4-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314100
PNG
(3-[(4-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314100
PNG
(3-[(4-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314100
PNG
(3-[(4-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314113
PNG
(3-[(2-hydroxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1O
Show InChI InChI=1S/C13H12N2O3/c16-12-4-2-1-3-9(12)7-15-11-8-14-6-5-10(11)13(17)18/h1-6,8,15-16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314113
PNG
(3-[(2-hydroxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1O
Show InChI InChI=1S/C13H12N2O3/c16-12-4-2-1-3-9(12)7-15-11-8-14-6-5-10(11)13(17)18/h1-6,8,15-16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314113
PNG
(3-[(2-hydroxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1O
Show InChI InChI=1S/C13H12N2O3/c16-12-4-2-1-3-9(12)7-15-11-8-14-6-5-10(11)13(17)18/h1-6,8,15-16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314118
PNG
(3-[(2-aminobenzyl)amino]pyridine-4-carboxylic acid...)
Show SMILES Nc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C13H13N3O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7,14H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

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Ligand-Target Pair
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