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Compile Data Set for Download or QSAR

Marvin 2D Structure

Wt: 387.4
BDBM293659
Wt: 387.4
BDBM293660
Wt: 326.3
BDBM293757
Wt: 388.4
BDBM293669
Wt: 359.4
BDBM293683
Wt: 388.4
BDBM293684
Wt: 350.3
BDBM293686
Wt: 374.4
BDBM293687
Wt: 376.4
BDBM293796
Wt: 374.4
BDBM293689
Wt: 366.4
BDBM293691
Wt: 366.4
BDBM293692
Wt: 380.4
BDBM293694
Wt: 380.4
BDBM293695
Wt: 388.4
BDBM293849
Displayed 1 to 15 (of 58 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 30 hits in this display   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
jmjd3


(Homo sapiens (Human))
BDBM293686
PNG
(3-({[7-(furan-3-yl)-3,4-dihydro-2H-1-benzopyran-4-...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(ccc12)-c1ccoc1
Show InChI InChI=1S/C20H18N2O4/c23-20(24)17-3-6-21-11-18(17)22-10-14-5-8-26-19-9-13(1-2-16(14)19)15-4-7-25-12-15/h1-4,6-7,9,11-12,14,22H,5,8,10H2,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293691
PNG
(3-({[(4S)-7-(thiophen-3-yl)-3,4-dihydro-2H-1-benzo...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)-c1ccsc1
Show InChI InChI=1S/C20H18N2O3S/c23-20(24)17-3-6-21-11-18(17)22-10-14-4-7-25-19-9-13(1-2-16(14)19)15-5-8-26-12-15/h1-3,5-6,8-9,11-12,14,22H,4,7,10H2,(H,23,24)/t14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293796
PNG
(3-({[(4R)-7-(2-hydroxyphenyl)-3,4-dihydro-2H-1-ben...)
Show SMILES OC(=O)c1ccncc1NC[C@@H]1CCOc2cc(ccc12)-c1ccccc1O
Show InChI InChI=1S/C22H20N2O4/c25-20-4-2-1-3-16(20)14-5-6-17-15(8-10-28-21(17)11-14)12-24-19-13-23-9-7-18(19)22(26)27/h1-7,9,11,13,15,24-25H,8,10,12H2,(H,26,27)/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293757
PNG
(3-({[(1R)-6-methoxy-5-methyl-1,2,3,4-tetrahydronap...)
Show SMILES COc1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1C
Show InChI InChI=1S/C19H22N2O3/c1-12-14-5-3-4-13(15(14)6-7-18(12)24-2)10-21-17-11-20-9-8-16(17)19(22)23/h6-9,11,13,21H,3-5,10H2,1-2H3,(H,22,23)/t13-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293757
PNG
(3-({[(1R)-6-methoxy-5-methyl-1,2,3,4-tetrahydronap...)
Show SMILES COc1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1C
Show InChI InChI=1S/C19H22N2O3/c1-12-14-5-3-4-13(15(14)6-7-18(12)24-2)10-21-17-11-20-9-8-16(17)19(22)23/h6-9,11,13,21H,3-5,10H2,1-2H3,(H,22,23)/t13-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293686
PNG
(3-({[7-(furan-3-yl)-3,4-dihydro-2H-1-benzopyran-4-...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(ccc12)-c1ccoc1
Show InChI InChI=1S/C20H18N2O4/c23-20(24)17-3-6-21-11-18(17)22-10-14-5-8-26-19-9-13(1-2-16(14)19)15-4-7-25-12-15/h1-4,6-7,9,11-12,14,22H,5,8,10H2,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293694
PNG
(3-({[(4S)-7-(2-methylthiophen-3-yl)-3,4-dihydro-2H...)
Show SMILES Cc1sccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C21H20N2O3S/c1-13-16(6-9-27-13)14-2-3-17-15(5-8-26-20(17)10-14)11-23-19-12-22-7-4-18(19)21(24)25/h2-4,6-7,9-10,12,15,23H,5,8,11H2,1H3,(H,24,25)/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293669
PNG
(3-({[(1R)-6-[methyl(pyridin-2-yl)amino]-1,2,3,4- |...)
Show SMILES CN(c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1)c1ccccn1
Show InChI InChI=1S/C23H24N4O2/c1-27(22-7-2-3-11-25-22)18-8-9-19-16(13-18)5-4-6-17(19)14-26-21-15-24-12-10-20(21)23(28)29/h2-3,7-13,15,17,26H,4-6,14H2,1H3,(H,28,29)/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293684
PNG
(3-[({2-[methyl(phenyl)amino]-5,6,7,8-tetrahydroqui...)
Show SMILES CN(c1ccccc1)c1ccc2C(CNc3cnccc3C(O)=O)CCCc2n1
Show InChI InChI=1S/C23H24N4O2/c1-27(17-7-3-2-4-8-17)22-11-10-18-16(6-5-9-20(18)26-22)14-25-21-15-24-13-12-19(21)23(28)29/h2-4,7-8,10-13,15-16,25H,5-6,9,14H2,1H3,(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293692
PNG
(3-({[(4R)-7-(thiophen-3-yl)-3,4-dihydro-2H-1-benzo...)
Show SMILES OC(=O)c1ccncc1NC[C@@H]1CCOc2cc(ccc12)-c1ccsc1
Show InChI InChI=1S/C20H18N2O3S/c23-20(24)17-3-6-21-11-18(17)22-10-14-4-7-25-19-9-13(1-2-16(14)19)15-5-8-26-12-15/h1-3,5-6,8-9,11-12,14,22H,4,7,10H2,(H,23,24)/t14-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293683
PNG
(3-{[(2-phenyl-5,6,7,8-tetrahydroquinolin-5- | US10...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2nc(ccc12)-c1ccccc1
Show InChI InChI=1S/C22H21N3O2/c26-22(27)18-11-12-23-14-21(18)24-13-16-7-4-8-20-17(16)9-10-19(25-20)15-5-2-1-3-6-15/h1-3,5-6,9-12,14,16,24H,4,7-8,13H2,(H,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293687
PNG
(3-({[(4S)-7-(3-methylphenyl)-3,4-dihydro-2H-1-benz...)
Show SMILES Cc1cccc(c1)-c1ccc2[C@@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C23H22N2O3/c1-15-3-2-4-16(11-15)17-5-6-19-18(8-10-28-22(19)12-17)13-25-21-14-24-9-7-20(21)23(26)27/h2-7,9,11-12,14,18,25H,8,10,13H2,1H3,(H,26,27)/t18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293683
PNG
(3-{[(2-phenyl-5,6,7,8-tetrahydroquinolin-5- | US10...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2nc(ccc12)-c1ccccc1
Show InChI InChI=1S/C22H21N3O2/c26-22(27)18-11-12-23-14-21(18)24-13-16-7-4-8-20-17(16)9-10-19(25-20)15-5-2-1-3-6-15/h1-3,5-6,9-12,14,16,24H,4,7-8,13H2,(H,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293689
PNG
(3-({[(4S)-7-(4-methylphenyl)-3,4-dihydro-2H-1-benz...)
Show SMILES Cc1ccc(cc1)-c1ccc2[C@@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C23H22N2O3/c1-15-2-4-16(5-3-15)17-6-7-19-18(9-11-28-22(19)12-17)13-25-21-14-24-10-8-20(21)23(26)27/h2-8,10,12,14,18,25H,9,11,13H2,1H3,(H,26,27)/t18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293849
PNG
(3-({[(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Show SMILES CN(c1ccccc1)c1ccc2[C@H](CNc3nnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C23H24N4O2/c1-27(18-8-3-2-4-9-18)19-10-11-20-16(14-19)6-5-7-17(20)15-24-22-21(23(28)29)12-13-25-26-22/h2-4,8-14,17H,5-7,15H2,1H3,(H,24,26)(H,28,29)/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293660
PNG
(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Show SMILES CN(c1ccccc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C24H25N3O2/c1-27(19-8-3-2-4-9-19)20-10-11-21-17(14-20)6-5-7-18(21)15-26-23-16-25-13-12-22(23)24(28)29/h2-4,8-14,16,18,26H,5-7,15H2,1H3,(H,28,29)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293796
PNG
(3-({[(4R)-7-(2-hydroxyphenyl)-3,4-dihydro-2H-1-ben...)
Show SMILES OC(=O)c1ccncc1NC[C@@H]1CCOc2cc(ccc12)-c1ccccc1O
Show InChI InChI=1S/C22H20N2O4/c25-20-4-2-1-3-16(20)14-5-6-17-15(8-10-28-21(17)11-14)12-24-19-13-23-9-7-18(19)22(26)27/h1-7,9,11,13,15,24-25H,8,10,12H2,(H,26,27)/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293695
PNG
(3-({[(4R)-7-(2-methylthiophen-3-yl)-3,4-dihydro-2H...)
Show SMILES Cc1sccc1-c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C21H20N2O3S/c1-13-16(6-9-27-13)14-2-3-17-15(5-8-26-20(17)10-14)11-23-19-12-22-7-4-18(19)21(24)25/h2-4,6-7,9-10,12,15,23H,5,8,11H2,1H3,(H,24,25)/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293695
PNG
(3-({[(4R)-7-(2-methylthiophen-3-yl)-3,4-dihydro-2H...)
Show SMILES Cc1sccc1-c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C21H20N2O3S/c1-13-16(6-9-27-13)14-2-3-17-15(5-8-26-20(17)10-14)11-23-19-12-22-7-4-18(19)21(24)25/h2-4,6-7,9-10,12,15,23H,5,8,11H2,1H3,(H,24,25)/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293694
PNG
(3-({[(4S)-7-(2-methylthiophen-3-yl)-3,4-dihydro-2H...)
Show SMILES Cc1sccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C21H20N2O3S/c1-13-16(6-9-27-13)14-2-3-17-15(5-8-26-20(17)10-14)11-23-19-12-22-7-4-18(19)21(24)25/h2-4,6-7,9-10,12,15,23H,5,8,11H2,1H3,(H,24,25)/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293692
PNG
(3-({[(4R)-7-(thiophen-3-yl)-3,4-dihydro-2H-1-benzo...)
Show SMILES OC(=O)c1ccncc1NC[C@@H]1CCOc2cc(ccc12)-c1ccsc1
Show InChI InChI=1S/C20H18N2O3S/c23-20(24)17-3-6-21-11-18(17)22-10-14-4-7-25-19-9-13(1-2-16(14)19)15-5-8-26-12-15/h1-3,5-6,8-9,11-12,14,22H,4,7,10H2,(H,23,24)/t14-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293691
PNG
(3-({[(4S)-7-(thiophen-3-yl)-3,4-dihydro-2H-1-benzo...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)-c1ccsc1
Show InChI InChI=1S/C20H18N2O3S/c23-20(24)17-3-6-21-11-18(17)22-10-14-4-7-25-19-9-13(1-2-16(14)19)15-5-8-26-12-15/h1-3,5-6,8-9,11-12,14,22H,4,7,10H2,(H,23,24)/t14-/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293689
PNG
(3-({[(4S)-7-(4-methylphenyl)-3,4-dihydro-2H-1-benz...)
Show SMILES Cc1ccc(cc1)-c1ccc2[C@@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C23H22N2O3/c1-15-2-4-16(5-3-15)17-6-7-19-18(9-11-28-22(19)12-17)13-25-21-14-24-10-8-20(21)23(26)27/h2-8,10,12,14,18,25H,9,11,13H2,1H3,(H,26,27)/t18-/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293687
PNG
(3-({[(4S)-7-(3-methylphenyl)-3,4-dihydro-2H-1-benz...)
Show SMILES Cc1cccc(c1)-c1ccc2[C@@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C23H22N2O3/c1-15-3-2-4-16(11-15)17-5-6-19-18(8-10-28-22(19)12-17)13-25-21-14-24-9-7-20(21)23(26)27/h2-7,9,11-12,14,18,25H,8,10,13H2,1H3,(H,26,27)/t18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293684
PNG
(3-[({2-[methyl(phenyl)amino]-5,6,7,8-tetrahydroqui...)
Show SMILES CN(c1ccccc1)c1ccc2C(CNc3cnccc3C(O)=O)CCCc2n1
Show InChI InChI=1S/C23H24N4O2/c1-27(17-7-3-2-4-8-17)22-11-10-18-16(6-5-9-20(18)26-22)14-25-21-15-24-13-12-19(21)23(28)29/h2-4,7-8,10-13,15-16,25H,5-6,9,14H2,1H3,(H,28,29)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293669
PNG
(3-({[(1R)-6-[methyl(pyridin-2-yl)amino]-1,2,3,4- |...)
Show SMILES CN(c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1)c1ccccn1
Show InChI InChI=1S/C23H24N4O2/c1-27(22-7-2-3-11-25-22)18-8-9-19-16(13-18)5-4-6-17(19)14-26-21-15-24-12-10-20(21)23(28)29/h2-3,7-13,15,17,26H,4-6,14H2,1H3,(H,28,29)/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293660
PNG
(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Show SMILES CN(c1ccccc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C24H25N3O2/c1-27(19-8-3-2-4-9-19)20-10-11-21-17(14-20)6-5-7-18(21)15-26-23-16-25-13-12-22(23)24(28)29/h2-4,8-14,16,18,26H,5-7,15H2,1H3,(H,28,29)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293849
PNG
(3-({[(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Show SMILES CN(c1ccccc1)c1ccc2[C@H](CNc3nnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C23H24N4O2/c1-27(18-8-3-2-4-9-18)19-10-11-20-16(14-19)6-5-7-17(20)15-24-22-21(23(28)29)12-13-25-26-22/h2-4,8-14,17H,5-7,15H2,1H3,(H,24,26)(H,28,29)/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293659
PNG
(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Show SMILES CN(c1ccccc1)c1ccc2[C@@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C24H25N3O2/c1-27(19-8-3-2-4-9-19)20-10-11-21-17(14-20)6-5-7-18(21)15-26-23-16-25-13-12-22(23)24(28)29/h2-4,8-14,16,18,26H,5-7,15H2,1H3,(H,28,29)/t18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293659
PNG
(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Show SMILES CN(c1ccccc1)c1ccc2[C@@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C24H25N3O2/c1-27(19-8-3-2-4-9-19)20-10-11-21-17(14-20)6-5-7-18(21)15-26-23-16-25-13-12-22(23)24(28)29/h2-4,8-14,16,18,26H,5-7,15H2,1H3,(H,28,29)/t18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair