KEGG   Homo sapiens (human): 23621
Entry
23621             CDS       T01001                                 
Symbol
BACE1, ASP2, BACE, HSPC104
Name
(RefSeq) beta-secretase 1
  KO
K04521  beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46]
Organism
hsa  Homo sapiens (human)
Pathway
hsa05010  Alzheimer disease
Drug target
Atabecestat: D11456
Elenbecestat: D11509
Lanabecestat (DG02834): D10946 D10947
Umibecestat: D11690
Verubecestat: D10739
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    23621 (BACE1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    23621 (BACE1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.46  memapsin 2
     23621 (BACE1)
Peptidases and inhibitors [BR:hsa01002]
 Aspartic peptidases
  Family A1: pepsin family
   23621 (BACE1)
SSDB
Motif
Pfam: Asp TAXi_C TAXi_N PE-PGRS_C
Other DBs
NCBI-GeneID: 23621
NCBI-ProteinID: NP_036236
OMIM: 604252
HGNC: 933
Ensembl: ENSG00000186318
UniProt: P56817
Structure
Position
11:complement(117285698..117316256)
AA seq 501 aa
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
NT seq 1506 nt   +upstreamnt  +downstreamnt
atggcccaagccctgccctggctcctgctgtggatgggcgcgggagtgctgcctgcccac
ggcacccagcacggcatccggctgcccctgcgcagcggcctggggggcgcccccctgggg
ctgcggctgccccgggagaccgacgaagagcccgaggagcccggccggaggggcagcttt
gtggagatggtggacaacctgaggggcaagtcggggcagggctactacgtggagatgacc
gtgggcagccccccgcagacgctcaacatcctggtggatacaggcagcagtaactttgca
gtgggtgctgccccccaccccttcctgcatcgctactaccagaggcagctgtccagcaca
taccgggacctccggaagggtgtgtatgtgccctacacccagggcaagtgggaaggggag
ctgggcaccgacctggtaagcatcccccatggccccaacgtcactgtgcgtgccaacatt
gctgccatcactgaatcagacaagttcttcatcaacggctccaactgggaaggcatcctg
gggctggcctatgctgagattgccaggcctgacgactccctggagcctttctttgactct
ctggtaaagcagacccacgttcccaacctcttctccctgcagctttgtggtgctggcttc
cccctcaaccagtctgaagtgctggcctctgtcggagggagcatgatcattggaggtatc
gaccactcgctgtacacaggcagtctctggtatacacccatccggcgggagtggtattat
gaggtgatcattgtgcgggtggagatcaatggacaggatctgaaaatggactgcaaggag
tacaactatgacaagagcattgtggacagtggcaccaccaaccttcgtttgcccaagaaa
gtgtttgaagctgcagtcaaatccatcaaggcagcctcctccacggagaagttccctgat
ggtttctggctaggagagcagctggtgtgctggcaagcaggcaccaccccttggaacatt
ttcccagtcatctcactctacctaatgggtgaggttaccaaccagtccttccgcatcacc
atccttccgcagcaatacctgcggccagtggaagatgtggccacgtcccaagacgactgt
tacaagtttgccatctcacagtcatccacgggcactgttatgggagctgttatcatggag
ggcttctacgttgtctttgatcgggcccgaaaacgaattggctttgctgtcagcgcttgc
catgtgcacgatgagttcaggacggcagcggtggaaggcccttttgtcaccttggacatg
gaagactgtggctacaacattccacagacagatgagtcaaccctcatgaccatagcctat
gtcatggctgccatctgcgccctcttcatgctgccactctgcctcatggtgtgtcagtgg
cgctgcctccgctgcctgcgccagcagcatgatgactttgctgatgacatctccctgctg
aagtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (6)   
   KEGG DRUG (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (57)   
   RefSeq(nuc) (7)   
   GenBank (25)   
   EMBL (25)   
3D Structure (431)   
   PDB (431)   
Protein domain (4)   
   Pfam (4)   
All databases (530)   

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