KEGG   COMPOUND: C07369
Entry
C07369                      Compound                               
Name
Prednisolone;
11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione
Formula
C21H28O5
Exact mass
360.1937
Mol weight
360.444
Structure
Remark
Same as: D00472
Brite
Lipids [BR:br08002]
 ST  Sterol lipids
  ST02 Steroids
   ST0203 C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives
    C07369  Prednisolone
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC04 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Prednisolone
   D00472  Prednisolone (JP18/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Prednisolone
    D00472  Prednisolone (JP18/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Prednisolone
     D00472  Prednisolone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D00472  Prednisolone (JP18/USP/INN)
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00472  Prednisolone (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00472  Prednisolone (JP18/USP/INN)
 Agents for dental and stomatological use
  74 Stomatitis remedies
   D00472  Prednisolone (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Prednisolone
    D00472  Prednisolone (JP18/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Prednisolone
    D00472  Prednisolone (JP18/USP/INN)
Animal drugs in Japan [BR:br08331]
 95  Agents for external use
  954  Anti-dermoinfectives
   9549  Other anti-dermoinfectives
    C07369  Prednisolone
 96  Agents affecting metabolism
  961  Hormone preparations (except agents for breeding and external use)
   9612  Adrenal hormone preparations
    C07369  Prednisolone
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D00472  Prednisolone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D00472  Prednisolone
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00472  Prednisolone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00472  Prednisolone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00472  Prednisolone
  D00472  Prednisolone tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00472
Topical steroids potency [br08317.html]
 Classification in Japan
  D00472
Other DBs
CAS: 50-24-8
PubChem: 9573
ChEBI: 8378
LIPIDMAPS: LMST02030179
PDB-CCD: TUA[PDBj]
NIKKAJI: J39.548J
KCF data

ATOM        26
            1   C2x C    18.8829  -19.7684
            2   C5x C    18.8829  -21.1314
            3   C2x C    20.0633  -21.8129
            4   C2y C    21.2437  -21.1314
            5   C1z C    21.2437  -19.7684
            6   C2x C    20.0633  -19.0868
            7   C1x C    22.4241  -21.8129
            8   C1x C    23.6045  -21.1314
            9   C1y C    23.6045  -19.7684
            10  C1y C    22.4241  -19.0868
            11  C1y C    24.7850  -19.0868
            12  C1z C    24.7850  -17.7238
            13  C1x C    23.6045  -17.0423
            14  C1y C    22.4241  -17.7238
            15  C1x C    27.1457  -19.0868
            16  C1x C    27.1457  -17.7238
            17  C1z C    25.9654  -17.0423
            18  O5x O    17.7025  -21.8129
            19  C1a C    21.2437  -18.4053
            20  O1a O    21.2457  -17.0435
            21  C1a C    24.7850  -16.3608
            22  C5a C    25.9654  -15.4748
            23  O1a O    27.1457  -16.3608
            24  C1b C    27.1497  -14.7911
            25  O5a O    24.7889  -14.7955
            26  O1a O    28.3156  -15.4643
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1

» Japanese version

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   KEGG DRUG (1)   
Chemical substance (14)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   HSDB (1)   
   LIPIDBANK (1)   
   LIPIDMAPS (1)   
   MASSBANK (6)   
   NIKKAJI (1)   
   PDB-CCD (1)   
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