KEGG   Homo sapiens (human): 8942
Entry
8942              CDS       T01001                                 
Symbol
KYNU, KYNUU, VCRL2
Name
(RefSeq) kynureninase
  KO
K01556  kynureninase [EC:3.7.1.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00380  Tryptophan metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate
hsa_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD
Network
nt06036  Lysine degradation
  Element
N01723  NAD biosynthesis
Disease
H01583  Hydroxykynureninuria
H02087  Vertebral, cardiac, renal, and limb defects syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    8942 (KYNU)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.7  Acting on carbon-carbon bonds
   3.7.1  In ketonic substances
    3.7.1.3  kynureninase
     8942 (KYNU)
SSDB
Motif
Pfam: Aminotran_5 CaKB DegT_DnrJ_EryC1
Other DBs
NCBI-GeneID: 8942
NCBI-ProteinID: NP_001186170
OMIM: 605197
HGNC: 6469
Ensembl: ENSG00000115919
UniProt: Q16719
Structure
Position
2:142877664..143055833
AA seq 465 aa
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLS
LVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLM
KDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHG
LNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAG
QAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP
ALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKK
SVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEK
RGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN
NT seq 1398 nt   +upstreamnt  +downstreamnt
atggagccttcatctcttgagctgccggctgacacagtgcagcgcattgcggctgaactc
aaatgccacccaacggatgagagggtggctctccacctagatgaggaagataagctgagg
cacttcagggagtgcttttatattcccaaaatacaggatctgcctccagttgatttatca
ttagtgaataaagatgaaaatgccatctatttcttgggaaattctcttggccttcaacca
aaaatggttaaaacatatcttgaagaagaactagataagtgggccaaaatagcagcctat
ggtcatgaagtggggaagcgtccttggattacaggagatgagagtattgtaggccttatg
aaggacattgtaggagccaatgagaaagaaatagccctaatgaatgctttgactgtaaat
ttacatcttctaatgttatcattttttaagcctacgccaaaacgatataaaattcttcta
gaagccaaagccttcccttctgatcattatgctattgagtcacaactacaacttcacgga
cttaacattgaagaaagtatgcggatgataaagccaagagagggggaagaaaccttaaga
atagaggatatccttgaagtaattgagaaggaaggagactcaattgcagtgatcctgttc
agtggggtgcatttttacactggacagcactttaatattcctgccatcacaaaagctgga
caagcgaagggttgttatgttggctttgatctagcacatgcagttggaaatgttgaactc
tacttacatgactggggagttgattttgcctgctggtgttcctacaagtatttaaatgca
ggagcaggaggaattgctggtgccttcattcatgaaaagcatgcccatacgattaaacct
gcattagtgggatggtttggccatgaactcagcaccagatttaagatggataacaaactg
cagttaatccctggggtctgtggattccgaatttcaaatcctcccattttgttggtctgt
tccttgcatgctagtttagagatctttaagcaagcgacaatgaaggcattgcggaaaaaa
tctgttttgctaactggctatctggaatacctgatcaagcataactatggcaaagataaa
gcagcaaccaagaaaccagttgtgaacataattactccgtctcatgtagaggagcggggg
tgccagctaacaataacattttctgttccaaacaaagatgttttccaagaactagaaaaa
agaggagtggtttgtgacaagcggaatccaaatggcattcgagtggctccagttcctctc
tataattctttccatgatgtttataaatttaccaatctgctcacttctatacttgactct
gcagaaacaaaaaattag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (3)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (34)   
   RefSeq(nuc) (12)   
   GenBank (11)   
   EMBL (11)   
3D Structure (3)   
   PDB (3)   
Protein domain (3)   
   Pfam (3)   
All databases (90)   

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