KEGG   Homo sapiens (human): 10733
Entry
10733             CDS       T01001                                 
Symbol
PLK4, MCCRP2, SAK, STK18
Name
(RefSeq) polo like kinase 4
  KO
K08863  polo-like kinase 4 [EC:2.7.11.21]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
Disease
H01880  Autosomal recessive microcephaly and chorioretinopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    10733 (PLK4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    10733 (PLK4)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10733 (PLK4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.21  polo kinase
     10733 (PLK4)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  PLK family [OT]
   10733 (PLK4)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    10733 (PLK4)
   Centrosome duplication proteins
    Regulators of centriole replication
     10733 (PLK4)
  Sister chromatid separation proteins
   Polo kinases
    10733 (PLK4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Plk4_PB1 Plk4_PB2 ABC1 POLO_box Pkinase_fungal DUF4520 Kinase-like Haspin_kinase
Other DBs
NCBI-GeneID: 10733
NCBI-ProteinID: NP_055079
OMIM: 605031
HGNC: 11397
Ensembl: ENSG00000142731
UniProt: O00444
Structure
Position
4:127880893..127899224
AA seq 970 aa
MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNE
VKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQI
ITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISP
EIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKD
LIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSST
SISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRV
IQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERY
SPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWF
GNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQ
NTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLK
PIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLA
DRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPG
ADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICL
ALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMH
SAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWAT
QLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILL
MFSNPTPNFH
NT seq 2913 nt   +upstreamnt  +downstreamnt
atggcgacctgcatcggggagaagatcgaggattttaaagttggaaatctgcttggtaaa
ggatcatttgctggtgtctacagagctgagtccattcacactggtttggaagttgcaatc
aaaatgatagataagaaagccatgtacaaagcaggaatggtacagagagtccaaaatgag
gtgaaaatacattgccaattgaaacatccttctatcttggagctttataactattttgaa
gatagcaattatgtgtatctggtattagaaatgtgccataatggagaaatgaacaggtat
ctaaagaatagagtgaaacccttctcagaaaatgaagctcgacacttcatgcaccagatc
atcacagggatgttgtatcttcattctcatggtatactacaccgggacctcacactttct
aacctcctactgactcgtaatatgaacatcaagattgctgattttgggctggcaactcaa
ctgaaaatgccacatgaaaagcactatacattatgtggaactcctaactacatttcacca
gaaattgccactcgaagtgcacatggccttgaatctgatgtttggtccctgggctgtatg
ttttatacattacttatcgggagaccacccttcgacactgacacagtcaagaacacatta
aataaagtagtattggcagattatgaaatgccatcttttttgtcaatagaggccaaggac
cttattcaccagttacttcgtagaaatccagcagatcgtttaagtctgtcttcagtattg
gaccatccttttatgtcccgaaattcttcaacaaaaagtaaagatttaggaactgtggaa
gactcaattgatagtgggcatgccacaatttctactgcaattacagcttcttccagtacc
agtataagtggtagtttatttgacaaaagaagacttttgattggtcagccactcccaaat
aaaatgactgtatttccaaagaataaaagttcaactgatttttcttcttcaggagatgga
aacagtttttatactcagtggggaaatcaagaaaccagtaatagtggaaggggaagagta
attcaagatgcagaagaaaggccacattctcgataccttcgtagagcttattcctctgat
agatctggcacttctaatagtcagtctcaagcaaaaacatatacaatggaacgatgtcac
tcagcagaaatgctttcagtgtccaaaagatcaggaggaggtgaaaatgaagagaggtac
tcacccacagacaacaatgccaacatttttaacttctttaaagaaaagacatccagtagt
tctggatcttttgaaagacctgataacaatcaagcactctccaatcatctttgtccagga
aaaactccttttccatttgcagacccgacacctcagactgaaaccgtacaacagtggttt
gggaatctgcaaataaatgctcatttaagaaaaactactgaatatgacagcatcagccca
aaccgggacttccagggccatccagatttgcagaaggacacatcaaaaaatgcctggact
gatacaaaagtcaaaaagaactctgatgcttctgataatgcacattctgtaaaacagcaa
aataccatgaaatatatgactgcacttcacagtaaacctgagataatccaacaagaatgt
gtttttggctcagatcctctttctgaacagagcaagactaggggtatggagccaccatgg
ggttatcagaatcgtacattaagaagcattacatctccgttggttgctcacaggttaaaa
ccaatcagacagaaaaccaaaaaggctgtggtgagcatacttgattcagaggaggtgtgt
gtggagcttgtaaaggagtatgcatctcaagaatatgtgaaagaagttcttcagatatct
agtgatggaaatacgatcactatttattatccaaatggtggtagaggttttcctcttgct
gatagaccaccctcacctactgacaacatcagtaggtacagctttgacaatttaccagaa
aaatactggcgaaaatatcaatatgcttccaggtttgtacagcttgtaagatctaaatct
cccaaaatcacttattttacaagatatgctaaatgcattttgatggagaattctcctggt
gctgattttgaggtttggttttatgatggggtaaaaatacacaaaacagaagatttcatt
caggtgattgaaaagacagggaagtcttacactttaaaaagtgaaagtgaagttaatagc
ttgaaagaggagataaaaatgtatatggaccatgctaatgagggtcatcgtatttgttta
gcactggaatccataatttcagaagaggaaaggaaaactaggagtgctccctttttccca
ataatcataggaagaaaacctggtagtactagttcacctaaggccttatcacctcctcct
tctgtggattcaaattacccaacgagagagagagcatctttcaacagaatggtcatgcat
agtgctgcttctccaacacaggcaccaatccttaatccctctatggttacaaatgaagga
cttggtcttacaactacagcttctggaacagacatctcttctaatagtctaaaagattgt
cttcctaaatcagcacaacttttgaaatctgtttttgtgaaaaatgttggttgggctaca
cagttaactagtggagctgtgtgggttcagtttaatgatgggtcccagttggttgtgcag
gcaggagtgtcttctatcagttatacctcaccaaatggtcaaacaactaggtatggagaa
aatgaaaaattaccagactacatcaaacagaaattacagtgtctgtcttccatccttttg
atgttttctaatccgactcctaattttcattga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (33)   
   RefSeq(nuc) (9)   
   GenBank (12)   
   EMBL (12)   
3D Structure (15)   
   PDB (15)   
Protein domain (10)   
   Pfam (10)   
All databases (97)   

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