4EWQ: Human p38 alpha MAPK in complex with a pyridazine based inhibitor

PDB ID: 4EWQDownload
MMDB ID: 100910
PDB Deposition Date: 2012/4/27
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 4EWQ: monomeric; determined by author and by software (PISA)
Molecular Components in 4EWQ
Label Count Molecule
Protein (1 molecule)
1
Mitogen-activated Protein Kinase 14
(Gene symbol: MAPK14)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
1
4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE
2
2
3-phenyl-4-(pyridin-4-yl)-6-[4-(pyrimidin-2-yl)piperazin-1-yl]pyridazine3-phenyl-4-(pyridin-4-yl)-6-[4-(pyrimidin-2-yl)piperazin-1-yl]pyridazine
3
1
ZINC IONZINC ION
4
1
CHLORIDE IONCHLORIDE ION
5
1
BETA-MERCAPTOETHANOLBETA-MERCAPTOETHANOL
6
1
GLYCEROLGLYCEROL
7
1
ACETATE IONACETATE ION
8
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303