2HU6: Crystal structure of human MMP-12 in complex with acetohydroxamic acid and a bicyclic inhibitor

PDB ID: 2HU6Download
MMDB ID: 43364
PDB Deposition Date: 2006/7/26
Updated in MMDB: 2021/10
Experimental Method:
x-ray diffraction
Resolution: 1.32  Å
Source Organism:
Similar Structures:
Biological Unit for 2HU6: monomeric; determined by author
Molecular Components in 2HU6
Label Count Molecule
Protein (1 molecule)
1
Macrophage Metalloelastase
(Gene symbol: MMP12)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
2
ZINC IONZINC ION
2
3
CALCIUM IONCALCIUM ION
3
1
(1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE(1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE
4
1
ACETOHYDROXAMIC ACIDACETOHYDROXAMIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303